JP2014227377A - Agent for parakeratosis suppression, whitening, water retention, removing waste material, and skin reproduction, skin differentiation promoter, and skin care external preparation and cosmetic including the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an agent for parakeratosis suppression, whitening, water retention, removing waste material, and skin reproduction, and a skin differentiation promoter, which have no adverse effect and are excellent in safety, and a skin care external preparation and a cosmetic including the same.SOLUTION: An agent for parakeratosis suppression, whitening, water retention, removing waste material, and skin reproduction and a skin differentiation promoter include an active ingredient extracted from a crispa, or β-glucan extracted from the crispa as the active ingredient. A skin care external preparation and a cosmetic include the same. The active ingredient extracted from the crispa consists of the specific components including a polymeric polysaccharide and the like as main components obtained by the following steps: mashing the fresh crispa; breaking cell wall thereof by hot water or alkali into solution to extract liquid; adding alcohol to precipitate insoluble fraction; and collecting the precipitate to separate.

Description

  The present invention improves the barrier function of the skin and is applied to the treatment or prevention of various dermatitis such as atopic dermatitis, psoriasis, psoriasis, rough skin, dandruff of the scalp, whitening, The present invention relates to a water retentivity, a waste removal, a skin regeneration agent, an epidermal differentiation promoter, a skin external preparation containing them, and a cosmetic.

  The stratum corneum located on the outermost side of the epidermis has a barrier function against physical and chemical stimuli and a barrier function that prevents moisture evaporation in the skin. It is the epidermis cells that form the stratum corneum, and the epidermis cells repeat cell division in the basal layer and differentiate into the stratum corneum through the spinous layer and the granule layer. The differentiated stratum corneum is formed by being stacked to be pushed up by new cells, and the old stratum corneum peels from the epidermis. This series of mechanisms is called turnover and contributes to the formation of a healthy stratum corneum.

  In normal skin turnover, nucleated cells disappear due to epidermal cell differentiation and a mature stratum corneum is formed. When turnover abnormalities occur due to external factors such as ultraviolet rays, dryness and stress, or aging, nucleated cells are observed on the skin surface, and an abnormal keratinization called defective keratinization occurs.

  Aberrant keratinization is an abnormal differentiation of epidermal cells. In the skin where keratinization has occurred, the skin barrier function is reduced, and various skins such as atopic dermatitis, psoriasis, psoriasis, rough skin, scalp dandruff, etc. It is thought to lead to the onset or exacerbation of flame. In addition, it has been reported that parakeratosis tends to cause delamination of the stratum corneum, which causes enlargement of the vicinity of the pores and the opening of the pores to be noticeable. Therefore, it can be said that it is important in terms of cosmetic significance to maintain the barrier function of the skin and to suppress the keratinization by normalizing the differentiation of epidermal cells and to form a mature stratum corneum.

  Conventionally, as means for solving skin dryness, various dermatitis and skin troubles, it has been practiced to apply a synthetic or natural moisturizing component to prevent skin dryness and moisturize. For example, the above skin troubles can be prevented or improved by using skin preparations and cosmetics containing moisturizers such as free amino acids, organic acids, urea, inorganic ions, collagen and hyaluronic acid, vitamins and their derivatives, etc. Attempts have been made.

  However, the effect is to temporarily give moisture to the skin to improve the skin condition, but not to improve the essential skin barrier function.

  On the other hand, as a means to normalize abnormal keratinization, for example, a cornification normalizing agent extracted from plants has been reported, but a safer and more stable active ingredient is desired, and more effective cornification normalization Agents, ie, suppression of keratinization, whitening, water retention, waste removal, and skin regeneration are desired.

  The present invention has been made in view of the above-mentioned problems, has no side effects, is excellent in safety, and has excellent safety, whitening, water retention, waste removal, skin regeneration and epidermal differentiation promoter, It is another object of the present invention to provide an external preparation for skin and cosmetics containing them.

  As a result of intensive studies to achieve the above-mentioned object, the present inventors have promoted the differentiation of epidermal cells with active ingredients extracted from Hanabiratake, and suppressed keratinization. As a result, the present inventors have found that waste removal can be achieved, and the present invention has been completed.

  That is, according to the present invention, the one that suppresses keratinization, whitens, retains water, removes waste products, and regenerates skin is characterized by having an active ingredient extracted from Hanabiratake or β-glucan extracted from Hanabiratake as an active ingredient.

  In addition, in the present invention for inhibiting keratinization, whitening, water retention, waste removal, and skin regeneration, the active ingredient extracted from the above-mentioned Hanabiratake crushes fresh Hanabiratake, and the cell wall is formed by hot water or alkali. It is preferably composed of an extract containing a β-glucan polysaccharide and a whitening component, which is obtained by extraction from a solution obtained by breaking.

  In addition, in the present invention for performing keratinization suppression, whitening, water retention, waste removal, and skin regeneration, the β-glucan extracted from Hanabira bamboo is obtained by adding alcohol to the active ingredient extracted from Hanabira bamboo, It is preferable that it consists of a specific component containing as a main component a high molecular polysaccharide obtained by precipitating an insoluble fraction and separating the precipitate by collecting the precipitate.

  In addition, in the present invention for suppressing keratinization, whitening, water retention, waste removal, and skin regeneration, it is preferable that the active ingredient extracted from the flower is highly pure.

  In addition, in the present invention for inhibiting keratinization, whitening, water retention, waste removal, and skin regeneration, it is preferable that the β-glucan extracted from the alga is highly pure and does not contain a protein.

  Moreover, the external preparation for skin and cosmetics according to the present invention are characterized in that they contain any of the above-mentioned inventions for inhibiting keratinization, whitening, water retention, waste removal, and skin regeneration.

  In addition, the epidermal differentiation promoter according to the present invention is characterized in that an active ingredient extracted from garlic mushroom or β-glucan extracted from garlic mushroom is used as an active ingredient.

  Moreover, in the epidermal differentiation promoter of the present invention, the active ingredient extracted from the above-mentioned Hanabira bamboo was obtained by grinding fresh Hanabira bamboo and extracting it from a solution obtained by breaking the cell wall with hot water or alkali, It preferably comprises an extract containing β-glucan polysaccharide and a whitening component.

  Further, in the epidermal differentiation promoter of the present invention, the β-glucan extracted from the alga is added with alcohol to the active ingredient extracted from the alga so that the insoluble fraction is precipitated with the alcohol, and the precipitate is recovered. It is preferable to consist of the specific component which contains as a main component the high molecular polysaccharide etc. which were obtained by isolate | separating by this.

  Moreover, in the epidermal differentiation promoting agent of the present invention, it is preferable that the active ingredient extracted from the bamboo shoot is highly pure.

  Moreover, in the epidermal differentiation promoting agent of the present invention, it is preferable that the β-glucan extracted from the alga is highly pure and does not contain a protein.

  Moreover, the skin external preparation and cosmetics by this invention are characterized by including the epidermis differentiation promoter of the said this invention.

  The active ingredient extracted from the flower of the present invention suppresses the keratinization observed due to abnormal skin turnover by promoting the differentiation of human normal epidermal cells, and is highly safe. Therefore, it can be expected to contribute to the formation of a mature stratum corneum by using the active ingredient extracted from Hanabiratake of the present invention as an agent for inhibiting keratinization, whitening, water retention, waste removal, and skin regeneration. Furthermore, it can be used as an external preparation for skin and cosmetics for the purpose of treating or preventing keratosis disorders such as atopic dermatitis, preventing and improving rough skin, and further improving the skin barrier function.

  The active ingredient extracted from Hanabira bamboo is an extract obtained by grinding fresh and extracting it from a solution obtained by destroying the cell wall with hot water or alkali. The β-glucan polysaccharide and whitening ingredient derived from the raw material An extract containing In addition, β-glucan extracted from Hanabira bamboo, alcohol is added to the active ingredient extracted from Hanabira bamboo, a fraction insoluble in alcohol is precipitated, and the precipitate is recovered to separate and obtain a specific component. This main component contains a polymeric polysaccharide and the like.

The production method of the active ingredient extracted from the bamboo shoot and the β-glucan extracted from the bamboo shoot is as follows.
The optimum conditions for the production method of the active ingredients extracted from Hanabiratake were studied. Grind the raw bamboo shoots, add 3 to 10 times pure water and dilute it and heat it at 80 ° C or higher to increase the pressure and dissolve the cells, or use alkali to destroy the cells, Extract the ingredients, and extract the active ingredients such as β-glucan and whitening ingredients separately from other ingredients using alcohol etc. for the extract. The solution can be further heated to evaporate the water, or can be produced as a solid or concentrated aqueous solution by evaporating the water using freeze-drying technology or the like.

  The β-glucan extracted from the flower is produced by adding an alcohol to the active ingredient extracted from the flower, depositing a fraction insoluble in the alcohol, and collecting the precipitate.

  Moreover, although the active ingredient extracted from the above-mentioned Hanabira bamboo can be extracted using a dried product in addition to fresh, it is desirable to use Hanabira bamboo (fresh) in order to extract the active ingredient efficiently.

  The present invention is not particularly limited as a skin external preparation or cosmetic preparation containing skin keratinization inhibiting, whitening, water retention, waste removal, skin regeneration, or an epidermal differentiation promoter, but it is not particularly limited. , Essence, cleansing cream, cleansing cream, pack, shaving cream, sun cream, sunscreen cream, sunscreen lotion, sunscreen lotion, soap, foundation, funny, powder, lipstick, lip balm, eye Examples include cosmetics classified as various cosmetics and quasi-drugs, so-called medicinal cosmetics, such as liners, eye creams, eye shadows, mascaras, bath cosmetics, shampoos, rinses, hair dyes, and hair cosmetics. The blending amount of the agent for inhibiting keratinization, whitening, water retention, waste removal, skin regeneration, or epidermal differentiation promoter can be included in the composition, preferably 0.01 to 10%. %.

  In the present invention, those for inhibiting keratinization, whitening, water retention, waste removal, skin regeneration, or epidermal differentiation promoting agents are usually used in skin external preparations such as cosmetics and various cosmetics as shown below. A skin external preparation and cosmetics can be produced by arbitrarily selecting and using those suitable for the application from the components and additives.

  For example, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, safflower oil, shea fat, Soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, owl, palm oil, beef tallow, pig Fats and oils such as fats, or hydrogenated products of these fats and oils (hardened oil, etc.).

  Waxes such as beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax. Mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microkristane wax, squalene, squalane and pristane. Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid.

  Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid. Natural alcohols such as ethanol, isopropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol. Synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

  Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol , Polyhydric alcohols such as glycerin, pentaerythritol, sorbitol, mannitol.

  Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate Esters such as dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate.

  Metal soap such as aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate.

  Gum arabic, benzoin rubber, danmar gum, guaiac gum, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, Carrageenan, succinyl chitosan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan with addition of alkylene (C2-C4) oxide such as ethylene oxide, low molecular chitin or chitosan, chitosan salt, sulfated chitin or Chitosan, phosphorylated chitin or chitosan, alginic acid and its salt, hyaluronic acid and its salt, chondroitin sulfate and its salt, heparin, ethylcellulose, methylcellulose, Ruboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide, polypropylene oxide, etc. Gums such as polyalkylene oxide or its crosslinked polymer, carboxyvinyl polymer, polyethyleneimine, saccharides and water-soluble polymer compounds;

  Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant, carboxylic acid Type amphoteric surfactant (amino type, β-in type), sulfate type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants (natural surfactants, Derivatives of protein hydrolysates, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants) How surfactant.

  Retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin ( Vitamin B12), folic acids, nicotinic acids, pantothenic acids, biotins, choline, inositols, ascorbic acid and its derivatives, ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotachysterol, tocopherol and its Derivatives, ubiquinones, phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carni Down, ferulic acid, γ- oryzanol, orotic acid, vitamin P compounds (rutin, Elio citrine, hesperidin), vitamins such as vitamin U.

  Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And amino acids such as sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acids.

  Microbial culture metabolites such as yeast metabolites, yeast extract, rice fermented extract, rice bran fermented extract, Euglena extract and trehalose or its derivatives. Α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid and lactic acid.

  Silica, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Inorganic pigments such as Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine.

  p-aminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, UV absorbers / blockers such as allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin .

Whitening agents such as arbutin, guaiazulene, shikonin, baicalin, baicalein and berberine.
Ascorbic acid and derivatives thereof, hydroquinone and glycosides thereof, kojic acid and derivatives thereof, placenta extract, silk peptide, plant extract (mulberry, honeysuckle, wormwood, mugwort, honeysuckle, yellowfin, dokudami, matsuhod, pearl barley, oleander, hawthorn, Eucalyptus, Achillea millefolium, Altea, Keihi, Mankeishi, Hamameris, Yamagua, Prolonged grass, Kikyo, Toshishi, Seicho, Ishiboshi, Mao, Senkyu, Dokatsu, Psycho, Bowfish, Hamaboufu, Ogon, Peonies, Genus Shouko, Licorice, Pyrus Tyrosinase activity inhibitors such as aloe, shouma, safflower, and assen.

  Melanin pigment reducing / decomposing agents such as hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide.

  Hydroquinone, Lactic acid bacteria extract, Placenta extract, Ganoderma extract, Vitamin A, Vitamin E, Allantoin, Spleen extract, Thymus extract, Yeast extract, Fermented milk extract, Plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock, Shikon, Carrot, Activators / cell activators of turnover, such as hamamelis, hops, yokuinin, nettle, sea bream, cypress, red bellflower, achacha, hypericum, cucumber, ginger, rosemary, parsley, etc.

  Astringents such as succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, and tannic acid (including catechin compounds).

Active oxygen scavengers such as SOD, catalase, glutathione peroxidase.
Ascorbic acid and its salt, stearic acid ester, tocopherol and its ester derivative, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Antioxidants such as sesamorin and gossypol.

  Lipid peroxide production inhibitors such as β-carotene, plant extracts (sesame cultured cells, amacha, hypericum, hamamelis, clove, melissa, enamel, birch, sage, rosemary, nantenami, kina, ages, ginkgo, etc.).

  Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salt, glycyrrhetinic acid and its salt, Anti-inflammatory agents such as licorice extract ingredients, sicon extract, and ages extract.

  Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, isopropylmethylphenol, triclosan, kudin Disinfectant / disinfectant.

  Moisturizing such as glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salt, polyethylene glycol, chondroitin sulfate and its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid and its salt, sodium lactate, mini sasanishiki extract Agent.

For hair such as selenium disulfide, alkylisoquinolinium bromide, zinc pyrithione, biphenamine, thianthol, castari tincture, ginger tincture, red pepper tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid Agent.

  Antiandrogens such as follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone.

  Peripheral blood flow promoters such as vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil.

  Topical stimulants such as pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate.

  Photoactive element 301, hinokitiol, pantothenic acid and its derivatives, allantoin, placental extract, biotin, pentadecanoic acid glycerides and the like.

Antiseborrheic agents such as pyridoxine and its derivatives, sulfur and vitamin B6.
A stratum corneum solubilizer such as resorcin, salicylic acid, lactic acid.

  Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate Oxidants such as sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, and mushroom extract.

  Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate, etc. ) And other hair removal agents.

Hair swelling agents such as ethanolamine, urea, and guanidine.
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol Paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picramate, N ′, N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, Orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitrosulfate Lutophenylenediamine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, fluorologlucin, gallic acid , Resorcinol, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sodium sulfonate, hematein and the like.

  Natural animal fragrances such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, western mint essential oil, dairy perfume essential oil, tuberose essential oil, Clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, salmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peruvian balsa Essential oils, bois de rose essential oil, Yoshikusunoki essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavoring such as Japanese mint essential oils, perfumes and other synthetic fragrances.

  Red cabbage dye, red rice dye, red dye, anato dye, scum dye, turmeric dye, enju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, corn dye, onion dye, tamarind dye, spirulina dye, Pigments and colorants such as buckwheat whole pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment and rutin.

In addition, almond (nong peach), eye (indigo leaf), blue quail (Keifu Fuji), Aotsuki rafuji (wooden moth), aonoo agave, fuchlin agave, acacia, red currant fruit, red grape, redwood (logwood), red bud (red bud), Akane (Azalea), Akajiojio Jiou (Gizo), Agi (Atsu), Akinire (Chizome), Akebiki (Kitsu), Asa (Asako Jin), Maruasaagao or Asagao (Toshigyu), Ashitaba (Tomorrow) Leaf), azuki bean (red bean), acerola, asenyaku (Asen Yaku), anise, abemaki fruit, avocado, flax, achacha (Amacha), achacharu, amadokoro (tamatake), amigasayuri (shellfish mother), Altea, Arnica, aloe (蘆薈), aloe vera, angelica, apricot honanzu (Anzujin), Ansokkou (benzoic incense), igakozolina (Gold head), Japanese knotweed (tiger cane), strawberry, Fig (no flower fruit) or its leaves, Ichibi (Winter coconut), Ichiyakuso, Ginkgo (Ginkgo leaves, Ginkgo), Japanese peas (Garden), Carob, rice seed or seed coat, Inondo seed, Ibukizasou, nettle, ylang-ylang, fennel Ayaka), Ukiyagara (Sanryo), Uguisukagura fruit, Himewikyo, Turmeric (Urban), Usubasaishin Keirinsaishin (spicy), Usbeniaoi, Usubenitachiaoi, Morayella (Summer hay), Udo or Shishido )茸), Ebisu rush (Keiko), Elderberry fruit , Elemi, Elingi (pre-lotus eringi), Enju (槐花, 槐花 米), Ogi Kibanaogi (yellow 耆), Oulen (yellow ream), Okarasuuri (Karonin), Otsu ヅ rafuji (prevention), Psyllium (car) Maeko (carrot), toucan beetle (lion), Ovana okera okera (white birch), Obayaya shabushi fruit, sea hawthorn hawthorn (Yamakoko), Ohisanoyuki, Sasanoyuki, barley (barley), oguruma (turnover), okrajin, okraine・ Tochibaninjin (carrot), Hypericum, Kogomeba Otogiriso, Hypericum perforatum (brother cut grass), Odorikosou (interrupted), Onamomi (Circle ear), Onigurumi, Oninoyagara (Tempa), Onyuri Sasayuri, Hakatayuri (Lily)楡), Ominae (losing sauce), Dutch strawberry, Dutch mustard (watercress), Dutch jelly, Oran Honey bees, olives, oregano, orange fruit or skin, coconut moth (ripening yellow), cacao seeds, oysters or their leaves (crabs), scabbard (fish), cassia, casino berries (fruits), gadgets (crabs) , Oak wrinkles, oak leaves, cascarilla, cynomolgus (Kinshato), valerian (valerian), birch or fern birch (white birch), pumpkin, kapok seeds, kahoku salamander (carp), gama (carp yellow), chamomile・ Roman chamomile, Camille deer (weed), Cam cam / duck duck, Calla cucumber (Royal moth), Crow bishak (Half summer), Oats, Garana seeds, Caraho (Park), Karaya, Karin (Kiso), Garcinia, Kawayanagi, Kawaratake, Kawara mugwort (Sardine Chin), Kansui (Sweet), Licorice (licorice), Kantara Asa, Candelilla, Kantou, Kanna, Raspberry, Kiwi Fruit, Kikaras Cucumber (Koryo, Kikyo), Chrysanthemum (Chrysanthemum), Chrysanthemum (Cruciferous), Gigiri (Shione), Pheasant (Cultivation), Kizuta, Kidachi Aloe, Kidachi Hakka, Kina, Kinaki ), Yellowfin, yellowtail, cabbage, cabbage, immature fruit, cucumber, Kiraja saponaria, quilla, kumquat fruit, betel, kinzhiki (Sentsukakusa), guava fruit, guayule, quellus infectria (garlic) , Wolfberry (bamboo shoots, coconut tree, cocoon leaf, earth bone bark), cedar kazura (Tenmon winter), camphor tree, gooseberry fruit, gardenia (mountain lion), kunugi (bamboo grass), kumazasa, pine moth (clasp grass), clara (bitter) ), Cranberry fruit, chestnut or its astringent skin, curculigo latifolia fruit, grapefruit, buckthorn, black sage Ji (Necessary), Kurobana toukikoshi, Clove (Cycho, Dingko), Keigai (Akatsuki, Ayuho), Keito (Couple flower, Chicken clover), Bay bay (Laurel tree), Kenashi Sartori Ibara (Tsumago, Mountain return), Gentiana, Gennoshouko (Old-weed grass), Kouji / Tachibana / Obenimikan / Ponkan / Santara (Tachibana bark), Koshinbara (monthly flower), Kousei mint, Kozo fruit, Kocha (tea), Kohone (river bone), Kohon (Tsubakimoto, Karasumoto) ), Koryang, Cilantro fruit, Koganebana (Yellow Gon), Cowberry (Etsutachibana), Coconut fruit, Goshuyu (Golden cucumber), Gosho strawberry (Golden bonsai), Pepper (Pepper), Copaiba balsam, Coffee beans, Kobushi magnolia ), Burdock (beef bowl, beef eggplant), coconut lees, sesame seeds (sesame seeds), sesame seeds (genus ginseng), trash (savory), sakanekazura, binankazura, matsubusa Wheat (wheat), rice / rice bran (red cocoon, white birch), rice oil, cola acuminata seeds, cola vera seeds, fenugreek fruit, colombo, condurango, kombu, konjak, comfrey (sardine grass), sisal, sisal asa Leaf, flower, fruit, and bark (cherry tree) , Cherries, pomegranates, sasa, sasanqua, sasmodaka, sweet potatoes, sugar cane, sugar beet, saffron jujube (acid sour), saffron (bansho, west safflower), pomelo fruit, savanna, salmon berry, salamander ), Salvia (Sage), Sagaki Kyo (Sankyo) ), Sawagurumi (Sancho), Sanshinin carrot (37 ginseng), Sanshuyu (Yamamuro), Sansho (Yamamuro), Sandskon (Yamazune), Shea (Kalite), Cyano fruit, Shiitake mushroom (Shiitake), Sion ( Shiki), Dikitaris, Shikunshi (Amiko), Shiso Aojiso Chiri Menzoso Katamenjiso (Shiyo leaf, Shisoko), Rosewood, Linden, Syringae, Shirarenyou (ream), Shimakaniku (Chrysanthemum flower), Shimeji (Himushijiji, Shakashimeji, Hatakeshijiji , Oshiroi shimeji, beech shimeji mushroom, shimotsukeso, potato, peonies (shakuyaku), shajin (shasan), janohi (barley winter), juzudama, palm fruit, ginger (ginger), ginger (root), Shozuk fruit, white-bellied seeds, white-faced butterfly seeds, white plant flowers, white minten (southern fruit), cinchonasacill La, Cinnamon, Watermelon (Sairan), Honeysuckle (Gin Silver Flower, Shinobu), Sorrel (Acid), Swimberry Fruit, Stevia, Strawberry Fruit, Sugina (Question), Plum Fruit, Scots pine cone, Larch Kizuta, Japanese walnut, Japanese hawthorn, Japanese dandelion, Japanese horse chestnut fruit, Japanese pear fruit, Japanese cherry tree, elder, Japanese elephant, Japanese juniper, Japanese yarrow (milfoil), American rose, Japanese butterfly , Mistletoe, mint, yellow mint, horseradish, peony (stone radish), mallow, hirosanega, senega, seri, celery, nematode (river cucumber), sendan, assembly (this drug), senna fruit or leaf, senni Saw (Daisen), Soka (grass), Buckwheat seed, Somer potato, Daio (Dahi), Daikon, Soybean, Daidai (Orange peel, Kashimi), Takatodai (Daikon), Takarabi (Cirrus), Dark sweet cherry fruit , Hollyhock, red pepper (thyme, perilla), red willow, tamarind seeds, onion, tanshiba (hot pepper), tanoki or its root bark, tanjin, dandelion or dandelion, dandelion, cherry fruit, Chigaya or its root (Sone), Chikutsujinjin (Bamboo Ginseng), Chicory, Ginseng (Gomiko), Ginseng (Daido), Korean ginger (Ginseng), Ginseng (Ginseng), Ginseng (Ginseng leaves), Cho Reimaitake mushroom, camellia, Tsukuritake (mushroom), camellia, camellia, clover (lacquered grass), ayu Sasa (duck cocoon grass), vine azuki (red red beans), tsurudokudami (what neck candy), tsuruna (apricot anther), tsuru carrot (four leaf ginseng), tsuwabuki, daiko, teuchigurumi, duberry fruit, tengusa, tencha (salmon tea), tender yam (glaze) , Toga (Winter Lion), Pepper (Banban), Toki (Toki), Toki Sengka (Marigold), Corn or Corn Hair (Southern Shark), Scotch Mochi (Sadako), Torindo (Ryokuri), Dokudami ( 10 medicines), Tokon (root), Toshishi-Mamedaoshi-Nenka-kazura, Tochu (Tochu, Tochu-nakaba), Tomato, Tragacanth, Triacanthus seeds, Tormentilla, Doronoki, Torooaoi, Neiseria berry fruit, Nagaimo yam (mountain medicine), Nagi Ikada (Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Natsumi, Jujube (Otsuka), Nani Waibara (Gold) Child), Nameko, Naruko Yuri (yellow spirit), peanut (peanut), Nanten (Southern fruit), Nigaki (Nagiki), Nigamugi (Plitter), Nikuzu, Kay Nikkei (Kaishin), Keishi (Katsura), Japanese leek ( Fruits, flowers or stems of elder), elderberry (bone grafts), garlic (large coral), nulde (pentose), leek, white thistle (large coral), wild rose (fruit), yarrow, wild boar, wild rose, peach , Palm, pineapple fruit, hibiscus (bushroom, furinbushige, roselle), hakamarabosi (bone crush), hakusen (white crust), hakuruberry fruit, chickweed (breeding), hazelnut (coconut), ashridokoro (roth root), basil, Lotus (lotus, lotus, lotus), parsley (holland jellied), hadakamugi, batata, beech mushroom (bamboo jar), patchouli, mint (thin load, light load leaf), pearl barley (yokuinin), Hanasuge (my mother), banana , Hanahakka, Vanilla Bins, Papaya, Hakhakogusa (Harimugusa), Hub Grass, Paprika, Hamagou Mitsubahago (Vulgaris), Hamasuge (Katsukiko), Hamabishi (Shitsukoshi), Hamanasu (Maikai Flower), Hamaboufu ), Hamamelis, Rose (rose), Agaric (Agaricus, White-faced agaric, Ukimorimorikasa), Parietalia, Harunire (Crustacea, White Crustaceae, Bamboo Leaves), Panoki, Chickweed Carrot (Participant), Pecan Nuts, Bumblebee (Ishibuchi) , Jinjushahua), toads (longevity grass), tossed (hijimi), pistachios, beets, hitshi (stone wall), cypresses (cow knee), cypress, hiba, castor, sunflower, bell peppers, himema (incense) , Himematsutake, Kawariharatake, Hiromatsutake, Pimenta fruit, Bikaku, Byakku, Ayu fruit, Bellows aoi, Hirohaokinagususa (white) (Head shark), loquat (bamboo shoot, cocoon leaf), betel nut (large clothes skin, coconut), Japanese quail (southern rattan), buffalo, dandelion poppy (striated winter flower, symbiotic winter leaf), FUJIBAKAMA (Orchid), FUJIMAME (Japanese pea), grape Fruit or pericarp / seeds / leaves, beech, Fuyumushinatsutake (active ingredient extracted from Hanabiratake), Brazilian licorice, black currant fruit, blackberry, plum fruit, full celaria, blueberry (Prunus japonica), prunes, blond Psyllium, bundo (mung bean), loofah, safflower (safflower), henenken, belladonna, berry fruit, pervianburg, boysenberry fruit, bowfish (windproof), spinach, physalis (Tororoot), honoki (Japanese rustic, park), Bokeh (Kiso), Hosobanaokera (Kashiwa), Hosobabarengiku, Bodaiju (Koki), Buttons (peony, peony skin), Jojoba, Hua Tulberry fruit, Honshimeji, Mizurutennansho (Tennansei), Maitake (maiko), Maou (mao), Macadamia nuts, Macri (marine grass), Muwa (mulberry white bark, mulberry leaves), Magnolia splengeri, Matatabi (tree) Tenchu), Matsukasa, Matsuba, Matsuhodo (Mushroom), Mayorum (Hanahakka), Malvano Jazine (Bitter), Mulberry fruit, Quince, Mango, Mangosteen, Manshugurumi, Mandarin fruit, Mannentake (Ganoderma), Citrus genus fruit ( (Fruit), Mishima Saiko (Saihu), Mizokakushi (Harenen), Misohagi (Chinese cucumber), Mitsugasiwa, Mitsuba, Green mint, Mimosa, Mioga, Miracle fruit fruit, Myrrh, Milobaran, Mukuge (mushroom), Mokunoki, Mukuroji, Murasaki (purple root), purple corn, swordfish (beneficial mother grass), burdock, melaroika, melissa, meri Over door, melon fruit, Moukoyomogi,
Mosouchiku, mokko (wooden incense), Japanese maple leaf, peach leaf (peach leaf) / fruit / seed (peach seed), coconut palm, morello cherry fruit, morohaya (burlap), yakawa muraki, yakuchi (masashi), cornflower ( Cornflower), cornflower mint, yashabushi (arrow wheel), yachi willow, hornbill (octagonal gold plate), mistletoe (willow parasite), willow leaves, yabgarashi, yabukouji (purple gold beef), pokeweed (shoku land), yamahanoki (yamabuchi), Bayberry, sagebrush, eucalyptus, yukinoshita (tiger ear grass), yucca flavifolia, yuzu fruit, lily, crocodile, European raspberry, mugwort (lime leaves), lime fruit, rye, peanut seed coat, lacanca fruit, raspberry leaf Fruit, lavender, ryokcha (green tea), apple fruit, gentian, lubus suabisimus (cool), lettuce, red currant fruit , Lemon fruit, lemongrass, forsythia, forsythia, wax palm, locon (Yoshi: root) logan berry fruit, rosemary (mannenrou), rosehip (nobara), wasabi, bracken Green algae such as Chlorella vulgaris, Chlorella pyrenoids, Chlorella ellipsoidia, Aonori (Usuba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoedaonori) Giant kelp (Macrocystis pirifera, Macrocystis integrofolia, Neocities rueto keana), brown algae such as hijiki, hibamata, and hijirimen, maca (Tengusa), Hiraksa, Onyxa, Oba Sasa, Kata-bucka, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Scotskin's Giraffe, Tsunogata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunotakata, Togetsuna Seaweeds, Chlamydomonas, Dunaliella, Chlorococcus, Quercus firaceae, Volby, Sunflower, Vulva, Palmera, Hizaori, Aomuiro, Aoumisano, Aoumia, Osamidae, Aoumiao, Aoshima, Aoumiao, Aoumiao, Aoumiao, Aoumiao, Aoumiao, Aoshima , Flitched gills, giant rush, assami cricket, kawaji rush, Mali , Tamagobaronia, tamabaronia, tamatamamuro, fusawaiwata, suri-gi-gita, heraiwata, blackwood, hanemo, mill, chromyl, sakibuchimiru, nagamil, hiramil, casanori, ftjusmo, tamajusmo, mizojuhimo, sakakihigaku Green algae such as Ushi-Hexa, Japanese-Apricot, Sayamidro, Kunshomo, Sumiremo, Hoshimidoro, Fushinashimidoro, and blue-green algae such as Suizinori, Aoko, Kawatake, Ishijelly, Hirasai, Yuremo, Spirulina, Trichodesmium Senkurogashira, Kashirazaki, Muchimo, Hiramchimo, Quercus crickets, Amygusa, Sakibiro amiji, Sanadagusa, Fukuro Amiji, Common Rabbit, Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigumigusa, Umiuchiwa, Konanumiuchiwa, Akabaumuchiuchiwa, Hirunamimakura, Someraceae, Navaimo, Motsukisokumen, Matsumo, Nagamushimok, Okinawamokoku , Iroro, Ichimegasa, Quail, Cyprinus, Urushigusa, Eurasian rush, Tobacco rush, Crested beetle, Dermatophyllus, Havanori, Eurasian winged, Common bukuro, Ezoburo , Shark, sujime, misji kombu, tsuba misji kombu, tsugara kumbu, oyster kumbu, o Nikonbu, Gohei Kombu, Nagacomb, Pea Kombu, Ouchiji Kombu, Trollo Kombu, Antokume, Kajime, Tsuruarame, Kurome, Kikuishi Kombu, Nejikcombu, Kuroshiome, Nekoashi Kombu, Arame, Ainu Wakame, Chigaiso, Ezo Shige, Mohama Moe Tamanashimoku, Isomoku, Nagashimamok, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawara, Tatsuri, Yatsumatamok, Umitoranoo, Oobamoku, Fusushimoku, Hahamoku, Togemoku, Yoremomoku, Yokomokumoku And oxenori, funorinoushisuke, asakusanori, susabinori, upulinori, onimanori, tasa, fu Iritasa, Benitasa, Milnobeni, Akebono Mozuku, Haikonahada, Yogorekonahada, Aokonahada, Cyprinus, Tsukumonori, Kamamogi nori, Benimozuku, Hosobenimozu, Kasamatsu, Fusanago, Hasegawara , Oobusa, Nambugusa, Kohira, Yohira, Kinukusa, Hibirodo, Himebiro, Isomumedo, Michigaeso, Ryumonso, HeraRyumon, Nisekarekigusa, Oobaokitsubara, Aqaba, Maruba Akano, Akasamana Centipede, Sujimkade, Katanori, Hiramuka , Kyounohi, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Nuraksa, Chronouraxa, Oomkadenori, Hirakintoki, Matabo, Chabokintoki, Kintoki, Matsunori, Rice-necked, Tosakamatsu, Nigiri-fusuna Prunus scorpion, Shiromoda, Yatsudegatatosakamodoki, Kurotosakamodoki, Nezushinotosakamodoki, Kinu Hada, Ezotosaka, Enashikarimenia, Otsukasanori, Hanagasukameni Mirin, Hosobamilin, Kikutosaka, Ezonameshi, Isomokka, Yukari, Hosoyukari, Ibaranori, Saidaibara, Tachii La, Kaguyabaranori, Phalaenopsis, Isodantsu, Atsubanori, Ogonori, Tsurushiramo, Shiramo, Giant Plover, Mizookonori, Birch, Hachijosamodomo, Fushikenori, Namiiwatake, Nymphaea Ginnanso, Akabaginanso, Hishibukuro, Togemadara, Etsukimadara, Taoyagisou, Hanasakura, Otsunogi, Sugikonori, Hananoeda, Hirataoyagi, Darus, Masagoshibari, Anadus, Weibusa, Hanafutsuna , Keigis, Harigigi, Hanegisu, Amixa, Egonori, Futogigis, Sae Da, Chirmomi, Habutenori, Konohanori, Suzuronori, Usbeni, Hasujiginu, Nagakonohanori, Suzyginu, Abasbasginu, Kagiousbanori, Yareusbanori, Susiusbanori, Haiusbanori, Usubarimodoki, Ayanishimo, Yayanishimo Hana willow, Yuna, Willow tree, Mosle Yuna, Venetian butterfly, Moth willow, Sasayanagi nori, Kurosozo, Kobosozo, Hanezozo, Sozonohana, Hanegusa, Kehanegusa, Kozanemo, Isomurasaki, Hisogosuke, Himegoke , Hazel mushrooms, river mozuku, aokawa Red algae such as Zuku, Himekawa Mozuku, Ide Yugogome, Ochimo Mozuku, Chino Rimo, Chisujinori, Axia algae such as Shajikumo, Shiratamamo, Hoshitsurimo, Rikunotamusu, Hime flaskmo, Chaboflaskmo, Tripera, and other algae such as Hikarimo Algae and chicken crown extract, cattle / human placenta extract, pig / cow stomach, duodenum or intestinal extract or degradation product, pig / cow spleen extract or degradation product, pig / cow brain Tissue extract, collagen derivatives such as water-soluble collagen, acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product Or their derivatives, porcine and bovine blood cell protein degradation products (globin pep Chido), porcine / cow hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or their derivatives, skim milk powder and their degradation products or their derivatives, lactoferrin or their degradation The raw materials derived from animal materials such as food products, egg components, and fish decomposition products are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, washing, hydrolysis, fermentation, Purify, squeeze, extract, fractionate, filter, dry, pulverize, granulate, dissolve, sterilize, adjust pH, deodorize, decolorize, etc.) And serve. The solvent used for the extraction may be selected in consideration of the processing performed later. Usually, water, a water-soluble organic solvent (for example, ethanol, propylene glycol, 1,3-butylene glycol, acetone) It is desirable to use one or a mixture of two or more selected from among the above. However, when it is not preferable to contain an organic solvent depending on the application, only water may be used, or ethanol that can be easily removed after extraction may be used alone or in any mixture with water.

  Others, moisturizers, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animals and plants Saccharides and their degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, antiallergic agents, suppression of keratinization, whitening, water retention, waste product removal, skin regeneration, normalization of keratinization Agents, cell activators, keratolytic agents, wound treatment agents, foam enhancers, thickeners, oral preparations, deodorants / deodorants, bittering agents, enzymes, etc. Various synergistic effects can be expected.

  In addition, about the method for adding keratinization suppression, whitening, water retention, waste removal, skin regeneration or epidermal differentiation promoter of the present invention, it may be added in advance or during the production, and workability May be selected as appropriate.

  The active ingredient extracted from the flower of the present invention or β-glucan extracted from the flower of the flower of the present invention has a remarkably high inhibitory effect on keratinization, treatment or prevention of abnormal keratinization, prevention and improvement of rough skin, and skin barrier function It can be used as a skin external preparation or cosmetic for the purpose of improving the above.

Claims (12)

  An active ingredient extracted from garlic mushroom or β-glucan extracted from garlic mushroom is used as an active ingredient to inhibit keratinization, whitening, water retention, waste removal, and skin regeneration.   From an extract containing β-glucan polysaccharide and a whitening ingredient, obtained by extracting the active ingredient extracted from the garlic mushroom from a crushed fresh garlic mushroom and pulverizing the cell wall with hot water or alkali. 2. The method according to claim 1, wherein the treatment is performed for inhibiting keratinization, whitening, water retention, waste removal, and skin regeneration.   The β-glucan extracted from Hanabiratake is a high molecular polysaccharide obtained by adding alcohol to the active ingredient extracted from Hanabiratake, precipitating an insoluble fraction with alcohol, and recovering the precipitate. It comprises a specific component containing, for example, as a main component, and performs blind cornering suppression, whitening, water retention, waste removal, and skin regeneration according to claim 1 or 2.   The active ingredient extracted from the bamboo shoot is highly pure, and performs keratinization suppression, whitening, water retention, waste product removal, and skin regeneration according to any one of claims 1 to 3.   The β-glucan extracted from the garlic mushroom has high purity and does not contain a protein. 5. Aberrant keratinization suppression, whitening, water retention, waste removal, skin Things to play.   An external preparation for skin and cosmetics, comprising the agent for suppressing keratinization, whitening, water retention, waste removal, and skin regeneration according to any one of claims 1 to 5.   An epidermal differentiation promoting agent comprising an active ingredient extracted from agaric bamboo or a β-glucan extracted from agaric bamboo.   From an extract containing β-glucan polysaccharide and a whitening ingredient, obtained by extracting the active ingredient extracted from the garlic mushroom from a crushed fresh garlic mushroom and pulverizing the cell wall with hot water or alkali. The epidermal differentiation promoter according to claim 7, wherein   The β-glucan extracted from Hanabiratake is a high molecular polysaccharide obtained by adding alcohol to the active ingredient extracted from Hanabiratake, precipitating an insoluble fraction with alcohol, and recovering the precipitate. The epidermal differentiation promoting agent according to claim 7 or 8, comprising a specific component containing, for example, as a main component.   The epidermal differentiation promoting agent according to any one of claims 7 to 9, wherein the active ingredient extracted from the flower is a high purity.   The epidermal differentiation promoting agent according to any one of claims 7 to 10, wherein the β-glucan extracted from the alga is highly pure and does not contain a protein.   The skin external preparation and cosmetics containing the epidermis differentiation promoter in any one of Claims 7-11.