JP2006328073A5 - - Google Patents
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- Publication number
- JP2006328073A5 JP2006328073A5 JP2006157094A JP2006157094A JP2006328073A5 JP 2006328073 A5 JP2006328073 A5 JP 2006328073A5 JP 2006157094 A JP2006157094 A JP 2006157094A JP 2006157094 A JP2006157094 A JP 2006157094A JP 2006328073 A5 JP2006328073 A5 JP 2006328073A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- het
- halo
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **c1ccc(*)cc1* Chemical compound **c1ccc(*)cc1* 0.000 description 7
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13213099P | 1999-04-30 | 1999-04-30 | |
| US60/132,130 | 1999-04-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000615356A Division JP3901945B2 (ja) | 1999-04-30 | 2000-03-27 | グルココルチコイド受容体モジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006328073A JP2006328073A (ja) | 2006-12-07 |
| JP2006328073A5 true JP2006328073A5 (OSRAM) | 2007-05-10 |
| JP4815566B2 JP4815566B2 (ja) | 2011-11-16 |
Family
ID=22452621
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000615356A Expired - Fee Related JP3901945B2 (ja) | 1999-04-30 | 2000-03-27 | グルココルチコイド受容体モジュレーター |
| JP2006157094A Expired - Fee Related JP4815566B2 (ja) | 1999-04-30 | 2006-06-06 | グルココルチコイド受容体モジュレーター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000615356A Expired - Fee Related JP3901945B2 (ja) | 1999-04-30 | 2000-03-27 | グルココルチコイド受容体モジュレーター |
Country Status (45)
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0201243A3 (en) * | 1999-04-30 | 2002-11-28 | Pfizer Prod Inc | Glucocorticoid receptor modulators, pharmaceutical compositions containing them and their use |
| US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| SI1305329T2 (sl) | 2000-08-05 | 2015-07-31 | Glaxo Group Limited | S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-(2-furanilkarboksil)oksi-11beta-hidroksi- 16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo |
| GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
| IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
| ES2262612T3 (es) * | 2000-10-28 | 2006-12-01 | Pfizer Products Inc. | Moduladpres del receptor de glucocorticoides. |
| DE60113032T2 (de) | 2000-10-30 | 2006-07-06 | Pfizer Products Inc., Groton | Glukokortikoidrezeptor-Modulatoren |
| CA2445839A1 (en) | 2001-04-30 | 2002-11-07 | Glaxo Group Limited | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
| US8193172B2 (en) | 2001-11-23 | 2012-06-05 | Pop Test Cortisol Llc | Methods for the treatment of major depressive disorder using glucocorticoid receptor antagonists |
| US20060148725A1 (en) * | 2001-12-21 | 2006-07-06 | The Miriam Hospital | Selective 11beta HSD inhibitors and methods of use thereof |
| AU2002361861A1 (en) * | 2001-12-21 | 2003-07-30 | Rhode Island Hospital | SELECTIVE 11Beta-HSD INHIBITORS AND METHODS FOR USE THEREOF |
| CA2472746A1 (en) | 2002-01-14 | 2003-07-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof |
| DE60318188T2 (de) | 2002-03-26 | 2008-12-11 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung |
| JP2005521717A (ja) | 2002-03-26 | 2005-07-21 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用 |
| US7186864B2 (en) | 2002-05-29 | 2007-03-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US7074806B2 (en) | 2002-06-06 | 2006-07-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| EP1521733B1 (en) * | 2002-07-08 | 2014-08-20 | Pfizer Products Inc. | Modulators of the glucocorticoid receptor |
| WO2004018429A2 (en) | 2002-08-21 | 2004-03-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| KR20050036982A (ko) * | 2002-08-29 | 2005-04-20 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | 염증, 알러지 및 증식성 질환의 치료에 글루코코르티코이드모사체로 사용하기 위한 3-(설폰아미도에틸)-인돌 유도체 |
| US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| AU2003267728A1 (en) * | 2002-10-18 | 2004-05-04 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| CA2504751C (en) * | 2002-11-05 | 2013-02-05 | Corcept Therapeutics, Inc. | Methods for treating gastroesophageal reflux disease |
| US20060052354A1 (en) * | 2002-11-05 | 2006-03-09 | Corcept Therapeutics, Inc. | Methods for treating migraine |
| EP1583745A1 (en) | 2003-01-03 | 2005-10-12 | Boehringer Ingelheim Pharmaceuticals Inc. | 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands |
| TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| WO2004097002A2 (en) * | 2003-04-29 | 2004-11-11 | The Miriam Hospital | SELECTIVE TESTICULAR 11β-HSD INHIBITORS AND METHODS OF USE THEREOF |
| NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
| US8097606B2 (en) | 2003-07-23 | 2012-01-17 | Corcept Therapeutics, Inc. | Antiglucocorticoids for the treatment of catatonia |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| EP1675839B1 (en) | 2003-10-16 | 2007-07-11 | Boehringer Ingelheim Pharmaceuticals Inc. | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols |
| WO2005047254A1 (en) * | 2003-11-13 | 2005-05-26 | Pfizer Products Inc. | Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators |
| EP1689390B1 (en) | 2003-11-21 | 2011-02-09 | Zalicus Inc. | Methods and reagents for the treatment of inflammatory disorders |
| US7253283B2 (en) * | 2004-01-16 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| US7795272B2 (en) * | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| US20050261292A1 (en) * | 2004-05-19 | 2005-11-24 | Solvay Pharmaceuticals Gmbh | Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions |
| US20090156565A1 (en) * | 2004-12-03 | 2009-06-18 | The Children's Hospital Of Philadelphia | Composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug |
| ES2326907T3 (es) | 2004-12-27 | 2009-10-21 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y su uso. |
| TWI435729B (zh) | 2005-11-09 | 2014-05-01 | Combinatorx Inc | 治療病症之方法,組合物及套組 |
| US7640389B2 (en) * | 2006-02-28 | 2009-12-29 | Freescale Semiconductor, Inc. | Non-volatile memory having a multiple block erase mode and method therefor |
| US20080045475A1 (en) * | 2006-08-20 | 2008-02-21 | Phillip Edward Littmann | Elemental cellular therapy is a genetic, cellular and disease-modifying therapy which enhances the systemic conduct of genetic and cellular transmethylation activity resulting in enhancement of concerted genetic and cellular metabolic, physiologic and homeostatic processes |
| BRPI0720131A2 (pt) * | 2006-12-06 | 2014-02-04 | Boehringer Ingelheim Int | Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos. |
| AP2411A (en) * | 2007-02-02 | 2012-05-30 | Pfizer Prod Inc | Tricyclic compounds and their use as glucocorticoid receptor modulators |
| CA2676670C (en) * | 2007-02-02 | 2012-03-13 | Pfizer Products Inc. | Tricyclic compounds, compositions, and methods |
| KR20110020902A (ko) * | 2008-06-06 | 2011-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 유사체, 이의 제조방법, 약제학적 조성물 및 이의 용도 |
| BRPI0917212A2 (pt) | 2008-07-28 | 2015-11-10 | Pfizer | compostos de fenantrenona, seus usos na preparação de composições, e composições compreendendo os referidos compostos |
| WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| CN101338200B (zh) * | 2008-08-20 | 2011-08-17 | 石家庄国大工业有限公司 | 一种tn型液晶材料的混合物 |
| US9216221B2 (en) * | 2008-11-07 | 2015-12-22 | University Of Sheffield | Medicament and method of diagnosis for treating subclinical Cushing's syndrome |
| EP2459524A2 (en) | 2009-07-31 | 2012-06-06 | Cadila Healthcare Limited | Novel compounds as modulators of glucocorticoid receptors |
| NZ598462A (en) | 2009-08-31 | 2012-12-21 | Merck Sharp & Dohme | Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators |
| EP2632892B1 (en) * | 2010-10-27 | 2014-07-30 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Diterpenoid derivatives endowed of biological properties |
| MX2013010576A (es) * | 2011-03-15 | 2014-03-12 | Abbvie Inc | Moduladores de receptores de hormonas nucleares. |
| US9573898B2 (en) | 2011-09-21 | 2017-02-21 | Givaudan S.A. | Pyridine derivates and their use as Umami tastants |
| TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| EP2935284A4 (en) * | 2012-12-21 | 2016-04-27 | Abbvie Inc | HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS |
| SG11201506796XA (en) * | 2013-03-14 | 2015-09-29 | Bristol Myers Squibb Co | Bicyclo [2.2.1] acid gpr120 modulators |
| CZ2014575A3 (cs) * | 2014-08-26 | 2016-02-24 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | Amfifilní sloučeniny s neuroprotektivními účinky |
| SK592017A3 (sk) * | 2017-07-04 | 2019-01-08 | Saneca Pharmaceuticals A. S. | Spôsob prípravy morfínanových zlúčenín |
| EP3821220B1 (en) | 2018-08-22 | 2024-11-13 | University of Utah Research Foundation | Force and torque sensor for prosthetic and orthopedic devices |
| WO2020047043A1 (en) | 2018-08-28 | 2020-03-05 | Lenzi Tommaso | Variable transmission for assistive prosthesis device |
| ES2980934T3 (es) | 2019-01-22 | 2024-10-03 | Akribes Biomedical Gmbh | Modificadores selectivos del receptor de glucocorticoides para tratar la cicatrización alterada de heridas en la piel |
| US20220288091A1 (en) * | 2019-03-18 | 2022-09-15 | Lynnette K. NIEMAN | Method for Improving Insulin Sensitivity |
| JP7716113B2 (ja) | 2020-03-20 | 2025-07-31 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | 受動型および動力付き外骨格における自己整列機構 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4514056Y1 (OSRAM) | 1965-09-09 | 1970-06-15 | ||
| US3516993A (en) * | 1967-03-15 | 1970-06-23 | Sandoz Ag | Benzylidene-substituted nitrogenous heterocyclic compounds |
| US3683091A (en) | 1967-11-13 | 1972-08-08 | Wataru Nagata | Certain phenanthrene compounds for treatment of acne |
| JPS50111098A (OSRAM) * | 1974-02-18 | 1975-09-01 | ||
| JPS6183138A (ja) | 1984-09-28 | 1986-04-26 | Harima Kasei Kogyo Kk | 3−デオキシアフィディコリンの製造方法 |
| FR2576025B1 (fr) * | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
| JPS61271216A (ja) | 1985-05-27 | 1986-12-01 | Mitsubishi Chem Ind Ltd | 抗腫瘍剤 |
| JPS6256422A (ja) | 1985-09-04 | 1987-03-12 | Mitsubishi Chem Ind Ltd | 抗菌剤 |
| JPH07100357B2 (ja) | 1986-03-11 | 1995-11-01 | 三菱化学株式会社 | 繊維補強セメントモルタル成形体 |
| US5039706A (en) | 1987-11-30 | 1991-08-13 | Du Pont Merck Pharmaceutical Company | Antiinflammatory PLA2 inhibitors |
| US5116865A (en) * | 1990-09-05 | 1992-05-26 | Peters Richard H | 15,16-seco-19-nor progestins |
| JPH06263688A (ja) | 1991-09-04 | 1994-09-20 | Otsuka Pharmaceut Factory Inc | フェナンスレン誘導体 |
| EP0676196A1 (en) | 1993-10-13 | 1995-10-11 | Otsuka Pharmaceutical Co., Ltd. | Nitrogen monoxide synthesis inhibitor |
| CA2149496C (en) | 1994-05-19 | 2006-12-19 | Ronald Gebhard | 11,21-bisphenyl-19-norpregnane derivatives |
| JPH0952899A (ja) | 1994-09-30 | 1997-02-25 | Tsumura & Co | ロイコトリエン拮抗剤 |
| US5693646A (en) | 1994-12-22 | 1997-12-02 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| US5767113A (en) | 1995-05-10 | 1998-06-16 | The Salk Institute For Biological Studies | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance |
| US5725694A (en) * | 1996-11-25 | 1998-03-10 | Reynolds Metals Company | Free-machining aluminum alloy and method of use |
| FR2757400B1 (fr) | 1996-12-19 | 1999-12-17 | Hoechst Marion Roussel Inc | Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs |
| AU5729098A (en) | 1996-12-24 | 1998-07-17 | Zymogenetics Inc. | Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes |
| IL122740A (en) * | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| EP0903146A1 (en) | 1997-09-23 | 1999-03-24 | Applied Research Systems ARS Holdings N.V. | 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid |
| HUP0201243A3 (en) * | 1999-04-30 | 2002-11-28 | Pfizer Prod Inc | Glucocorticoid receptor modulators, pharmaceutical compositions containing them and their use |
-
2000
- 2000-03-27 HU HU0201243A patent/HUP0201243A3/hu unknown
- 2000-03-27 AU AU33165/00A patent/AU776608B2/en not_active Ceased
- 2000-03-27 CZ CZ2001-3797A patent/CZ304203B6/cs not_active IP Right Cessation
- 2000-03-27 CN CNB008069492A patent/CN1275917C/zh not_active Expired - Fee Related
- 2000-03-27 HR HR20010804A patent/HRP20010804B1/xx not_active IP Right Cessation
- 2000-03-27 PL PL353438A patent/PL207610B1/pl unknown
- 2000-03-27 NZ NZ514465A patent/NZ514465A/en not_active IP Right Cessation
- 2000-03-27 HK HK02104625.3A patent/HK1042889B/zh not_active IP Right Cessation
- 2000-03-27 RS YU76001A patent/RS52134B/sr unknown
- 2000-03-27 EE EEP200100567A patent/EE05584B1/xx not_active IP Right Cessation
- 2000-03-27 UA UA2001107363A patent/UA74145C2/uk unknown
- 2000-03-27 CN CNB2005101288464A patent/CN100400487C/zh not_active Expired - Fee Related
- 2000-03-27 MX MXPA01011018A patent/MXPA01011018A/es active IP Right Grant
- 2000-03-27 GE GE4658A patent/GEP20053474B/en unknown
- 2000-03-27 JP JP2000615356A patent/JP3901945B2/ja not_active Expired - Fee Related
- 2000-03-27 CA CA002372173A patent/CA2372173A1/en not_active Withdrawn
- 2000-03-27 WO PCT/IB2000/000366 patent/WO2000066522A1/en not_active Ceased
- 2000-03-27 EA EA200400337A patent/EA007483B1/ru not_active IP Right Cessation
- 2000-03-27 OA OA1200100284A patent/OA11877A/en unknown
- 2000-03-27 EA EA200101019A patent/EA004886B1/ru not_active IP Right Cessation
- 2000-03-27 TR TR2001/03104T patent/TR200103104T2/xx unknown
- 2000-03-27 CA CA2635196A patent/CA2635196C/en not_active Expired - Lifetime
- 2000-03-27 EP EP00911172.5A patent/EP1175383B1/en not_active Expired - Lifetime
- 2000-03-27 KR KR10-2001-7013842A patent/KR100511585B1/ko not_active Expired - Fee Related
- 2000-03-27 BR BRPI0010138-9A patent/BR0010138B1/pt not_active IP Right Cessation
- 2000-03-27 IL IL14545000A patent/IL145450A0/xx active IP Right Grant
- 2000-03-27 AP APAP/P/2001/002308A patent/AP1542A/en active
- 2000-03-27 SK SK1544-2001A patent/SK287535B6/sk not_active IP Right Cessation
- 2000-04-04 CO CO00024428A patent/CO5280071A1/es active IP Right Grant
- 2000-04-12 PA PA20008493801A patent/PA8493801A1/es unknown
- 2000-04-24 TW TW094138885A patent/TWI309566B/zh not_active IP Right Cessation
- 2000-04-24 TW TWGLUCOCORTA patent/TWI272264B/zh not_active IP Right Cessation
- 2000-04-26 TN TNTNSN00093A patent/TNSN00093A1/fr unknown
- 2000-04-26 GT GT200000053A patent/GT200000053A/es unknown
- 2000-04-26 DZ DZ000079A patent/DZ3038A1/xx active
- 2000-04-26 MA MA25962A patent/MA26729A1/fr unknown
- 2000-04-27 MY MYPI20001835A patent/MY133378A/en unknown
- 2000-04-27 US US09/559,384 patent/US6380223B1/en not_active Expired - Lifetime
- 2000-04-27 AR ARP000102009A patent/AR032128A1/es active IP Right Grant
- 2000-04-27 UY UY26129A patent/UY26129A1/es not_active Application Discontinuation
- 2000-04-28 SV SV2000000061A patent/SV2004000061A/es unknown
- 2000-04-28 PE PE2000000400A patent/PE20010112A1/es not_active Application Discontinuation
- 2000-04-29 EG EG2000040548A patent/EG25606A/xx active
-
2001
- 2001-09-13 IL IL145450A patent/IL145450A/en not_active IP Right Cessation
- 2001-09-25 IS IS6082A patent/IS2743B/is unknown
- 2001-10-09 CR CR6478A patent/CR6478A/es not_active Application Discontinuation
- 2001-10-19 CU CU238A patent/CU23111A3/es unknown
- 2001-10-26 ZA ZA200108846A patent/ZA200108846B/xx unknown
- 2001-10-29 NO NO20015272A patent/NO327612B1/no not_active IP Right Cessation
- 2001-11-23 BG BG110227A patent/BG110227A/en unknown
- 2001-11-23 BG BG106142A patent/BG65642B1/bg unknown
-
2002
- 2002-02-19 US US10/080,174 patent/US6699893B2/en not_active Expired - Lifetime
-
2003
- 2003-11-25 US US10/721,318 patent/US7166593B2/en not_active Expired - Fee Related
-
2006
- 2006-06-06 JP JP2006157094A patent/JP4815566B2/ja not_active Expired - Fee Related
-
2007
- 2007-01-08 IL IL180603A patent/IL180603A/en not_active IP Right Cessation
-
2008
- 2008-10-06 BG BG10110227A patent/BG66055B1/bg unknown
-
2012
- 2012-03-13 CR CR20120119A patent/CR20120119A/es unknown
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