JP2005539016A5 - - Google Patents
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- JP2005539016A5 JP2005539016A5 JP2004526857A JP2004526857A JP2005539016A5 JP 2005539016 A5 JP2005539016 A5 JP 2005539016A5 JP 2004526857 A JP2004526857 A JP 2004526857A JP 2004526857 A JP2004526857 A JP 2004526857A JP 2005539016 A5 JP2005539016 A5 JP 2005539016A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- carbon atoms
- halogen atom
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 48
- 125000004432 carbon atom Chemical group C* 0.000 claims 44
- 125000005843 halogen group Chemical group 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 125000002252 acyl group Chemical group 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 125000002877 alkyl aryl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 229940011871 estrogen Drugs 0.000 claims 4
- 239000000262 estrogen Substances 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 230000035558 fertility Effects 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 201000000736 Amenorrhea Diseases 0.000 claims 1
- 206010001928 Amenorrhoea Diseases 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- 231100000540 amenorrhea Toxicity 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 0 C[C@](C[C@@]1c2ccc(C=NO*)cc2)(C(C(*)C2*)C(CC3)C1=C(CC1)C3=C(*)C1=O)[C@@]2(*)O* Chemical compound C[C@](C[C@@]1c2ccc(C=NO*)cc2)(C(C(*)C2*)C(CC3)C1=C(CC1)C3=C(*)C1=O)[C@@]2(*)O* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40006502P | 2002-08-02 | 2002-08-02 | |
| DE10236405A DE10236405A1 (de) | 2002-08-02 | 2002-08-02 | Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie |
| PCT/EP2003/008572 WO2004014935A1 (de) | 2002-08-02 | 2003-08-01 | Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005539016A JP2005539016A (ja) | 2005-12-22 |
| JP2005539016A5 true JP2005539016A5 (enExample) | 2006-09-14 |
Family
ID=31716602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526857A Pending JP2005539016A (ja) | 2002-08-02 | 2003-08-01 | 女性用受胎調節及びホルモン置換療法のための高められた抗ゴナドトロピン活性を有するプロゲステロン受容体モジュレーター |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1525215B1 (enExample) |
| JP (1) | JP2005539016A (enExample) |
| AT (1) | ATE338763T1 (enExample) |
| AU (1) | AU2003255355A1 (enExample) |
| DE (1) | DE50304970D1 (enExample) |
| DK (1) | DK1525215T3 (enExample) |
| ES (1) | ES2273061T3 (enExample) |
| WO (1) | WO2004014935A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20011762A1 (it) | 2001-08-10 | 2003-02-10 | Cosmo Spa | Esteri di 17alfa,21-diidrossipregnene, loro uso come agenti anti-androgenetici e procedimenti per la loro preparazione |
| DE102006018869A1 (de) * | 2006-04-13 | 2007-10-18 | Bayer Schering Pharma Ag | 17alpha-substituierte 4-(3-Oxoestra-4,9-dien-11beta-yl)-benzoesäure, deren Derivate und Verfahren zu ihrer Herstellung |
| BRPI0702900A2 (pt) * | 2006-06-28 | 2011-03-15 | Teva Pharma | formas cristalinas da atorvastatina |
| JP5583976B2 (ja) | 2007-03-07 | 2014-09-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的プロゲステロン受容体モジュレーターとしてのステロイド誘導体 |
| ITMI20071616A1 (it) | 2007-08-03 | 2009-02-04 | Cosmo Spa | Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati. |
| WO2010010201A1 (es) | 2008-07-22 | 2010-01-28 | Equipo Ivi Investigacion Sl | Perfil de expresion genetica como marcador de la receptividad endometrial |
| DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| EP2348318A1 (en) * | 2010-01-21 | 2011-07-27 | Equipo Ivi Investigación, S.L. | Diagnostic method for endometrial receptivity |
| DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
| HUE067463T2 (hu) | 2014-06-17 | 2024-10-28 | Asherman Therapy S L | Õssejtterápia endometriális patológiás állapotokban |
| EP3108879A1 (en) | 2015-06-25 | 2016-12-28 | Cassiopea S.p.A. | High concentration formulation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3504421A1 (de) * | 1985-02-07 | 1986-08-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE4332283A1 (de) * | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE4332284C2 (de) * | 1993-09-20 | 1997-05-28 | Jenapharm Gmbh | 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19745085A1 (de) * | 1997-10-11 | 1999-04-15 | Jenapharm Gmbh | 11ß-Benzaldoxim-9alpha,10alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| DE19809845A1 (de) * | 1998-03-03 | 1999-09-09 | Jenapharm Gmbh | S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| KR20080066095A (ko) * | 1999-08-31 | 2008-07-15 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 양성 호르몬 의존성 부인과 질병의 치료 및 예방을 위한메조프로게스틴 (프로게스테론 수용체 조절물질) |
| AR025455A1 (es) * | 1999-08-31 | 2002-11-27 | Schering Ag | Mesoprogestinas (moduladores de receptores de progesterona) como componentes de anticonceptivos femeninos |
| UA75339C2 (en) * | 1999-08-31 | 2006-04-17 | Schering Ag | Use of mesoprogestins (progesterone receptor modulators) as pharmaceutical components for manufacture of medicament for hormone replacement therapy (hrt) |
| DE19961219A1 (de) * | 1999-12-15 | 2001-07-19 | Jenapharm Gmbh | 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
-
2003
- 2003-08-01 AT AT03784154T patent/ATE338763T1/de not_active IP Right Cessation
- 2003-08-01 WO PCT/EP2003/008572 patent/WO2004014935A1/de not_active Ceased
- 2003-08-01 EP EP03784154A patent/EP1525215B1/de not_active Expired - Lifetime
- 2003-08-01 DK DK03784154T patent/DK1525215T3/da active
- 2003-08-01 AU AU2003255355A patent/AU2003255355A1/en not_active Abandoned
- 2003-08-01 DE DE50304970T patent/DE50304970D1/de not_active Expired - Lifetime
- 2003-08-01 JP JP2004526857A patent/JP2005539016A/ja active Pending
- 2003-08-01 ES ES03784154T patent/ES2273061T3/es not_active Expired - Lifetime
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