JP2005539016A - 女性用受胎調節及びホルモン置換療法のための高められた抗ゴナドトロピン活性を有するプロゲステロン受容体モジュレーター - Google Patents

女性用受胎調節及びホルモン置換療法のための高められた抗ゴナドトロピン活性を有するプロゲステロン受容体モジュレーター Download PDF

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JP2005539016A
JP2005539016A JP2004526857A JP2004526857A JP2005539016A JP 2005539016 A JP2005539016 A JP 2005539016A JP 2004526857 A JP2004526857 A JP 2004526857A JP 2004526857 A JP2004526857 A JP 2004526857A JP 2005539016 A JP2005539016 A JP 2005539016A
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benzaldehyde
oxoestradi
dien
oxime
hydroxy
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JP2004526857A
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Japanese (ja)
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JP2005539016A5 (enExample
Inventor
ヒリッシュ，アレクサンダー
エルゲル，バルター
シューベルト，ゲルト
シュナイダー，ビルギット
レッデルセン，グードルン
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シエーリング アクチエンゲゼルシャフト
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Priority claimed from DE10236405A external-priority patent/DE10236405A1/de
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Publication of JP2005539016A publication Critical patent/JP2005539016A/ja
Publication of JP2005539016A5 publication Critical patent/JP2005539016A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004526857A 2002-08-02 2003-08-01 女性用受胎調節及びホルモン置換療法のための高められた抗ゴナドトロピン活性を有するプロゲステロン受容体モジュレーター Pending JP2005539016A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40006502P 2002-08-02 2002-08-02
DE10236405A DE10236405A1 (de) 2002-08-02 2002-08-02 Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
PCT/EP2003/008572 WO2004014935A1 (de) 2002-08-02 2003-08-01 Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie

Publications (2)

Publication Number Publication Date
JP2005539016A true JP2005539016A (ja) 2005-12-22
JP2005539016A5 JP2005539016A5 (enExample) 2006-09-14

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Family Applications (1)

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JP2004526857A Pending JP2005539016A (ja) 2002-08-02 2003-08-01 女性用受胎調節及びホルモン置換療法のための高められた抗ゴナドトロピン活性を有するプロゲステロン受容体モジュレーター

Country Status (8)

Country Link
EP (1) EP1525215B1 (enExample)
JP (1) JP2005539016A (enExample)
AT (1) ATE338763T1 (enExample)
AU (1) AU2003255355A1 (enExample)
DE (1) DE50304970D1 (enExample)
DK (1) DK1525215T3 (enExample)
ES (1) ES2273061T3 (enExample)
WO (1) WO2004014935A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008007507A (ja) * 2006-06-28 2008-01-17 Teva Pharmaceutical Industries Ltd 結晶形アトルバスタチン
JP2013518244A (ja) * 2010-01-21 2013-05-20 エキポ アイヴィイー インヴェスティガシオン エス．エル． 子宮内膜受容性の診断方法
JP2013163683A (ja) * 2007-08-03 2013-08-22 Cosmo Spa コルテキソロンの１７α−モノエステルおよび／またはその９，１１−デヒドロ誘導体を得るための酵素的方法
US9211295B2 (en) 2001-08-10 2015-12-15 Cassiopea S.P.A. 17 alpha, 21-dihydroxypregnene esters as antiandrogenic agents
US10081840B2 (en) 2008-07-22 2018-09-25 Igenomix S.L. Gene expression profile as an endometrial receptivity marker
US10603327B2 (en) 2015-06-22 2020-03-31 Cassiopea S.P.A. High concentration formulation
US11129851B2 (en) 2014-06-17 2021-09-28 Igenomix S.L. Stem cell therapy in endometrial pathologies

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006018869A1 (de) * 2006-04-13 2007-10-18 Bayer Schering Pharma Ag 17alpha-substituierte 4-(3-Oxoestra-4,9-dien-11beta-yl)-benzoesäure, deren Derivate und Verfahren zu ihrer Herstellung
JP5583976B2 (ja) 2007-03-07 2014-09-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的プロゲステロン受容体モジュレーターとしてのステロイド誘導体
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07149789A (ja) * 1993-09-20 1995-06-13 Jenapharm Gmbh 新規な１１−ベンズアルドキシム−エストラ−ジエン誘導体とその製造方法、及びその化合物を含有する医薬製剤
JPH07149790A (ja) * 1993-09-20 1995-06-13 Jenapharm Gmbh 新規な１１−ベンズアルドキシム−１７β−メトキシ−１７α−メトキシメチル−エストラジエン誘導体、その製法およびその物質を含有する医薬製剤
EP0909764A1 (de) * 1997-10-11 1999-04-21 JENAPHARM GmbH 11 Beta-Benzaldoxim-9 Alpha, 10 Alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
WO2001015679A2 (en) * 1999-08-31 2001-03-08 Jenapharm Gmbh & Co. Kg Mesoprogestins for the treatment and prevention of benign hormone dependent gynecological disorders
WO2001026603A2 (en) * 1999-08-31 2001-04-19 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
WO2001034126A2 (en) * 1999-08-31 2001-05-17 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
WO2001044267A1 (de) * 1999-12-15 2001-06-21 Jenapharm Gmbh & Co. Kg 11-β-PHENYLESTRADIEN-DERIVATE MIT FLUORALKYLGRUPPEN IN DER AROMATISCHEN SEITENKETTE, DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
JP2002505335A (ja) * 1998-03-03 2002-02-19 イエナフアルム ゲーエムベーハー ウント ツェーオー． カーゲー Ｓ−置換１１β−ベンズアルドキシム−エストラ−４，９−ジエン−炭酸チオールエステル、その製造法および該化合物を含有する製薬学的調剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3504421A1 (de) * 1985-02-07 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07149789A (ja) * 1993-09-20 1995-06-13 Jenapharm Gmbh 新規な１１−ベンズアルドキシム−エストラ−ジエン誘導体とその製造方法、及びその化合物を含有する医薬製剤
JPH07149790A (ja) * 1993-09-20 1995-06-13 Jenapharm Gmbh 新規な１１−ベンズアルドキシム−１７β−メトキシ−１７α−メトキシメチル−エストラジエン誘導体、その製法およびその物質を含有する医薬製剤
EP0909764A1 (de) * 1997-10-11 1999-04-21 JENAPHARM GmbH 11 Beta-Benzaldoxim-9 Alpha, 10 Alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
JP2002505335A (ja) * 1998-03-03 2002-02-19 イエナフアルム ゲーエムベーハー ウント ツェーオー． カーゲー Ｓ−置換１１β−ベンズアルドキシム−エストラ−４，９−ジエン−炭酸チオールエステル、その製造法および該化合物を含有する製薬学的調剤
WO2001015679A2 (en) * 1999-08-31 2001-03-08 Jenapharm Gmbh & Co. Kg Mesoprogestins for the treatment and prevention of benign hormone dependent gynecological disorders
WO2001026603A2 (en) * 1999-08-31 2001-04-19 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
WO2001034126A2 (en) * 1999-08-31 2001-05-17 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
WO2001044267A1 (de) * 1999-12-15 2001-06-21 Jenapharm Gmbh & Co. Kg 11-β-PHENYLESTRADIEN-DERIVATE MIT FLUORALKYLGRUPPEN IN DER AROMATISCHEN SEITENKETTE, DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9211295B2 (en) 2001-08-10 2015-12-15 Cassiopea S.P.A. 17 alpha, 21-dihydroxypregnene esters as antiandrogenic agents
US9895379B2 (en) 2001-08-10 2018-02-20 Cassiopea S.P.A. 17alpha, 21-dihydroxypregnene esters as antiandrogenic agents
JP2008007507A (ja) * 2006-06-28 2008-01-17 Teva Pharmaceutical Industries Ltd 結晶形アトルバスタチン
US10166245B2 (en) 2007-08-03 2019-01-01 Cassiopea S.P.A. Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
US11207332B2 (en) 2007-08-03 2021-12-28 Cassiopea S.P.A. Enzymatic process for obtaining 17 α-monoesters of cortexolone and/or its 9,11-dehydroderivatives
US9433628B2 (en) 2007-08-03 2016-09-06 Cassiopea Spa Enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9,11-dehydroderivatives
US9486458B2 (en) 2007-08-03 2016-11-08 Cassiopea Spa Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
JP2013163683A (ja) * 2007-08-03 2013-08-22 Cosmo Spa コルテキソロンの１７α−モノエステルおよび／またはその９，１１−デヒドロ誘導体を得るための酵素的方法
JP2016014045A (ja) * 2007-08-03 2016-01-28 カシオペア ソシエタ ペル アチオニ コルテキソロンの１７α−モノエステルおよび／またはその９，１１−デヒドロ誘導体を得るための酵素的方法
US10159682B2 (en) 2007-08-03 2018-12-25 Cassiopea S.P.A. Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
US12337002B2 (en) 2007-08-03 2025-06-24 Cassiopea S.P.A. Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
US11938141B2 (en) 2007-08-03 2024-03-26 Cassiopea S.P.A. Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
US10716796B2 (en) 2007-08-03 2020-07-21 Cassiopea S.P.A. Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
US10081840B2 (en) 2008-07-22 2018-09-25 Igenomix S.L. Gene expression profile as an endometrial receptivity marker
JP2013518244A (ja) * 2010-01-21 2013-05-20 エキポ アイヴィイー インヴェスティガシオン エス．エル． 子宮内膜受容性の診断方法
US11129851B2 (en) 2014-06-17 2021-09-28 Igenomix S.L. Stem cell therapy in endometrial pathologies
US10980819B2 (en) 2015-06-22 2021-04-20 Cassiopea S.P.A. High concentration formulation
US11213531B2 (en) 2015-06-22 2022-01-04 Cassiopea S.P.A. High concentration formulation
US11883415B2 (en) 2015-06-22 2024-01-30 Cassiopea S.P.A. High concentration formulation
US10603327B2 (en) 2015-06-22 2020-03-31 Cassiopea S.P.A. High concentration formulation

Also Published As

Publication number Publication date
DK1525215T3 (da) 2007-01-15
AU2003255355A1 (en) 2004-02-25
WO2004014935A1 (de) 2004-02-19
EP1525215B1 (de) 2006-09-06
DE50304970D1 (de) 2006-10-19
ES2273061T3 (es) 2007-05-01
EP1525215A1 (de) 2005-04-27
ATE338763T1 (de) 2006-09-15

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