JP2012510991A5 - - Google Patents
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- JP2012510991A5 JP2012510991A5 JP2011539518A JP2011539518A JP2012510991A5 JP 2012510991 A5 JP2012510991 A5 JP 2012510991A5 JP 2011539518 A JP2011539518 A JP 2011539518A JP 2011539518 A JP2011539518 A JP 2011539518A JP 2012510991 A5 JP2012510991 A5 JP 2012510991A5
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- Prior art keywords
- alkyl
- disease
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 21
- 101001117089 Drosophila melanogaster Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 Proteins 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims 43
- 150000003839 salts Chemical group 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000005843 halogen group Chemical group 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 9
- 206010026749 Mania Diseases 0.000 claims 7
- -1 hydroxy, carboxy Chemical group 0.000 claims 7
- 238000011282 treatment Methods 0.000 claims 7
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims 6
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 6
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 6
- 208000020925 Bipolar disease Diseases 0.000 claims 6
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
- 208000003532 hypothyroidism Diseases 0.000 claims 6
- 230000002989 hypothyroidism Effects 0.000 claims 6
- 238000011321 prophylaxis Methods 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- 208000028017 Psychotic disease Diseases 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000005549 heteroarylene group Chemical group 0.000 claims 5
- 201000000980 schizophrenia Diseases 0.000 claims 5
- 208000028698 Cognitive impairment Diseases 0.000 claims 4
- 206010057671 Female sexual dysfunction Diseases 0.000 claims 4
- 208000018737 Parkinson disease Diseases 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 201000003631 narcolepsy Diseases 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229960003387 progesterone Drugs 0.000 claims 4
- 239000000186 progesterone Substances 0.000 claims 4
- 208000017194 Affective disease Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 206010001928 Amenorrhoea Diseases 0.000 claims 3
- 201000005670 Anovulation Diseases 0.000 claims 3
- 206010002659 Anovulatory cycle Diseases 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 206010003805 Autism Diseases 0.000 claims 3
- 208000020706 Autistic disease Diseases 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 102000004076 Dopamine D1 Receptors Human genes 0.000 claims 3
- 108090000511 Dopamine D1 Receptors Proteins 0.000 claims 3
- 208000012661 Dyskinesia Diseases 0.000 claims 3
- 206010014733 Endometrial cancer Diseases 0.000 claims 3
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 3
- 208000001914 Fragile X syndrome Diseases 0.000 claims 3
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 208000023105 Huntington disease Diseases 0.000 claims 3
- 206010020772 Hypertension Diseases 0.000 claims 3
- 206010027304 Menopausal symptoms Diseases 0.000 claims 3
- 206010027339 Menstruation irregular Diseases 0.000 claims 3
- 208000019022 Mood disease Diseases 0.000 claims 3
- 208000016285 Movement disease Diseases 0.000 claims 3
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 208000005107 Premature Birth Diseases 0.000 claims 3
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 206010038743 Restlessness Diseases 0.000 claims 3
- 206010039085 Rhinitis allergic Diseases 0.000 claims 3
- 201000001880 Sexual dysfunction Diseases 0.000 claims 3
- 208000006011 Stroke Diseases 0.000 claims 3
- 208000000323 Tourette Syndrome Diseases 0.000 claims 3
- 208000016620 Tourette disease Diseases 0.000 claims 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
- 206010044565 Tremor Diseases 0.000 claims 3
- 201000010105 allergic rhinitis Diseases 0.000 claims 3
- 230000001668 ameliorated effect Effects 0.000 claims 3
- 231100000552 anovulation Toxicity 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 230000001363 autoimmune Effects 0.000 claims 3
- 208000026106 cerebrovascular disease Diseases 0.000 claims 3
- 206010013663 drug dependence Diseases 0.000 claims 3
- 201000003914 endometrial carcinoma Diseases 0.000 claims 3
- 201000006828 endometrial hyperplasia Diseases 0.000 claims 3
- 239000000262 estrogen Substances 0.000 claims 3
- 229940011871 estrogen Drugs 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 3
- 208000000509 infertility Diseases 0.000 claims 3
- 231100000535 infertility Toxicity 0.000 claims 3
- 230000036512 infertility Effects 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 230000009245 menopause Effects 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 201000000484 premenstrual tension Diseases 0.000 claims 3
- 239000003368 psychostimulant agent Substances 0.000 claims 3
- 208000002815 pulmonary hypertension Diseases 0.000 claims 3
- 231100000872 sexual dysfunction Toxicity 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 230000007781 signaling event Effects 0.000 claims 3
- 208000011117 substance-related disease Diseases 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 230000009529 traumatic brain injury Effects 0.000 claims 3
- 208000037853 Abnormal uterine bleeding Diseases 0.000 claims 2
- 201000000736 Amenorrhea Diseases 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
- 208000024254 Delusional disease Diseases 0.000 claims 2
- 241000531897 Loma Species 0.000 claims 2
- 206010036590 Premature baby Diseases 0.000 claims 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 231100000540 amenorrhea Toxicity 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229960005309 estradiol Drugs 0.000 claims 2
- 229930182833 estradiol Natural products 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000004410 intraocular pressure Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000002851 paranoid schizophrenia Diseases 0.000 claims 2
- 201000004240 prostatic hypertrophy Diseases 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 230000000698 schizophrenic effect Effects 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 208000020685 sleep-wake disease Diseases 0.000 claims 2
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 claims 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 1
- 206010020880 Hypertrophy Diseases 0.000 claims 1
- 241000023320 Luma <angiosperm> Species 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 208000027099 Paranoid disease Diseases 0.000 claims 1
- 208000020186 Schizophreniform disease Diseases 0.000 claims 1
- 206010046814 Uterine prolapse Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 239000002269 analeptic agent Substances 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229940005513 antidepressants Drugs 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 claims 1
- 229960001348 estriol Drugs 0.000 claims 1
- 210000000720 eyelash Anatomy 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims 1
- 229960001165 modafinil Drugs 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 239000000583 progesterone congener Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 0 CCN(N)I(C(*C)=C(*)C1*)=C1N(C)* Chemical compound CCN(N)I(C(*C)=C(*)C1*)=C1N(C)* 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- IQQLHYIZFKVCBQ-UHFFFAOYSA-N CC(C)CN(c1c(C)[n](Cc(cc2)ccc2-[n]2ncnc2)c(Nc2ccccc2)c1C(N1C)=O)C1=O Chemical compound CC(C)CN(c1c(C)[n](Cc(cc2)ccc2-[n]2ncnc2)c(Nc2ccccc2)c1C(N1C)=O)C1=O IQQLHYIZFKVCBQ-UHFFFAOYSA-N 0.000 description 1
- DBQBWDGOQXQWLT-UHFFFAOYSA-N CC(C)CN(c1c(Nc2ccccc2)[n](Cc2ccc(C(F)(F)F)cc2)cc1C(N1C)=O)C1=O Chemical compound CC(C)CN(c1c(Nc2ccccc2)[n](Cc2ccc(C(F)(F)F)cc2)cc1C(N1C)=O)C1=O DBQBWDGOQXQWLT-UHFFFAOYSA-N 0.000 description 1
- LYTAIMGNAPQBPP-UHFFFAOYSA-N CC(C)CN(c1c[n](Cc(cc2)ccc2-[n]2cncc2)c(N(C)c2ccccc2)c1C(N1C)=O)C1=O Chemical compound CC(C)CN(c1c[n](Cc(cc2)ccc2-[n]2cncc2)c(N(C)c2ccccc2)c1C(N1C)=O)C1=O LYTAIMGNAPQBPP-UHFFFAOYSA-N 0.000 description 1
- VRSRWPBCMKIUBV-UHFFFAOYSA-N CC(C)CN(c1c[n](Cc(cc2)ccc2-[n]2nccc2)c(Nc2ccccc2)c1C(N1C)=O)C1=O Chemical compound CC(C)CN(c1c[n](Cc(cc2)ccc2-[n]2nccc2)c(Nc2ccccc2)c1C(N1C)=O)C1=O VRSRWPBCMKIUBV-UHFFFAOYSA-N 0.000 description 1
- AAKVKNGFYFCJRZ-UHFFFAOYSA-N CC(C)CN(c1c[n](Cc(cc2)ccc2-c2ncccc2)c(N(C)c2ccccc2)c1C(N1C)=O)C1=O Chemical compound CC(C)CN(c1c[n](Cc(cc2)ccc2-c2ncccc2)c(N(C)c2ccccc2)c1C(N1C)=O)C1=O AAKVKNGFYFCJRZ-UHFFFAOYSA-N 0.000 description 1
- CNPNYKNJEOOSPW-UHFFFAOYSA-N CC(C)CN(c1c[n](Cc(cc2)ccc2-c2ncccc2)c(Nc(cc2)ccc2F)c1C(N1C)=O)C1=O Chemical compound CC(C)CN(c1c[n](Cc(cc2)ccc2-c2ncccc2)c(Nc(cc2)ccc2F)c1C(N1C)=O)C1=O CNPNYKNJEOOSPW-UHFFFAOYSA-N 0.000 description 1
- CTCISNRXJXEXGA-UHFFFAOYSA-N CC(C)CN(c1c[n](Cc2ccc(C(F)(F)F)cc2)c(Nc2ccccc2)c1C(N1C)=O)C1=O Chemical compound CC(C)CN(c1c[n](Cc2ccc(C(F)(F)F)cc2)c(Nc2ccccc2)c1C(N1C)=O)C1=O CTCISNRXJXEXGA-UHFFFAOYSA-N 0.000 description 1
- 102100024316 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Human genes 0.000 description 1
- 101001117044 Homo sapiens Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Proteins 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12044308P | 2008-12-06 | 2008-12-06 | |
| US61/120,443 | 2008-12-06 | ||
| US23588809P | 2009-08-21 | 2009-08-21 | |
| US61/235,888 | 2009-08-21 | ||
| PCT/US2009/006437 WO2010065147A1 (en) | 2008-12-06 | 2009-12-07 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012510991A JP2012510991A (ja) | 2012-05-17 |
| JP2012510991A5 true JP2012510991A5 (enExample) | 2014-07-31 |
| JP5710492B2 JP5710492B2 (ja) | 2015-04-30 |
Family
ID=42233531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539518A Expired - Fee Related JP5710492B2 (ja) | 2008-12-06 | 2009-12-07 | 有機化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8927556B2 (enExample) |
| EP (1) | EP2367428B1 (enExample) |
| JP (1) | JP5710492B2 (enExample) |
| KR (1) | KR20110098730A (enExample) |
| CN (1) | CN102238873A (enExample) |
| AU (1) | AU2009322899A1 (enExample) |
| BR (1) | BRPI0922809A2 (enExample) |
| CA (1) | CA2740385A1 (enExample) |
| CO (1) | CO6390080A2 (enExample) |
| CR (1) | CR20110311A (enExample) |
| DO (1) | DOP2011000171A (enExample) |
| EA (1) | EA201170768A1 (enExample) |
| EC (1) | ECSP11011185A (enExample) |
| ES (1) | ES2580759T3 (enExample) |
| IL (1) | IL213316A0 (enExample) |
| MA (1) | MA32939B1 (enExample) |
| MX (1) | MX2011005935A (enExample) |
| PE (1) | PE20110834A1 (enExample) |
| TN (1) | TN2011000244A1 (enExample) |
| WO (1) | WO2010065147A1 (enExample) |
| ZA (1) | ZA201103630B (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101248050B (zh) | 2005-06-06 | 2013-07-17 | 武田药品工业株式会社 | 有机化合物 |
| EP2023729B1 (en) | 2006-06-06 | 2016-05-04 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP2081431B1 (en) * | 2006-11-13 | 2013-01-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP5837278B2 (ja) | 2006-12-05 | 2015-12-24 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規使用 |
| ES2588238T3 (es) * | 2007-12-06 | 2016-10-31 | Intra-Cellular Therapies, Inc. | Derivados de pirazolopirimidin-4,6-diona y su uso como producto farmacéutico |
| CA2707349C (en) | 2007-12-06 | 2014-05-27 | Intra-Cellular Therapies, Inc. | Organic compounds useful as inhibitors of phosphodiesterase 1 |
| WO2010065151A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
| MX2011005934A (es) | 2008-12-06 | 2011-12-16 | Intra Cellular Therapies Inc | Compuestos organicos. |
| WO2010065153A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CA2740388A1 (en) * | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
| AU2009322901A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2010098839A1 (en) | 2009-02-25 | 2010-09-02 | Intra-Cellular Therapies, Inc. | Pde 1 inhibitors for ophthalmic disorders |
| EP2434895A4 (en) | 2009-05-13 | 2013-08-07 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
| JP2013507360A (ja) | 2009-10-08 | 2013-03-04 | イントラ−セルラー・セラピーズ・インコーポレイテッド | ホスホジエステラーゼ１−標的トレーサーおよび方法 |
| US9763948B2 (en) | 2010-05-31 | 2017-09-19 | Intra-Cellular Therapies, Inc. | PDE1 inhibitory compounds and methods |
| JP5894148B2 (ja) * | 2010-05-31 | 2016-03-23 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| US9434730B2 (en) | 2010-05-31 | 2016-09-06 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
| TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
| JP6051210B2 (ja) | 2011-06-10 | 2016-12-27 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2014127331A1 (en) * | 2013-02-17 | 2014-08-21 | Intra-Cellular Therapies, Inc. | Novel uses |
| ES2836129T3 (es) | 2013-03-15 | 2021-06-24 | Intra Cellular Therapies Inc | Compuestos orgánicos |
| EP2968338B1 (en) | 2013-03-15 | 2019-01-09 | Intra-Cellular Therapies, Inc. | Pde1 inhibitors for use in the treatment and/or prevention of cns injuries, and pns diseases, disorders or injuries |
| US9849132B2 (en) | 2014-01-08 | 2017-12-26 | Intra-Cellular Therapies, Inc. | Products and pharmaceutical compositions |
| EP3134404A1 (en) * | 2014-04-25 | 2017-03-01 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| ES2732442T3 (es) | 2014-06-20 | 2019-11-22 | Intra Cellular Therapies Inc | Compuestos orgánicos |
| US10098894B2 (en) | 2014-07-29 | 2018-10-16 | Therapeuticsmd, Inc. | Transdermal cream |
| US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
| TWI686394B (zh) | 2014-08-07 | 2020-03-01 | 美商內胞醫療公司 | 有機化合物 |
| US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2016044667A1 (en) | 2014-09-17 | 2016-03-24 | Intra-Cellular Therapies, Inc. | Compounds and methods |
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-
2009
- 2009-12-07 EA EA201170768A patent/EA201170768A1/ru unknown
- 2009-12-07 BR BRPI0922809A patent/BRPI0922809A2/pt not_active IP Right Cessation
- 2009-12-07 WO PCT/US2009/006437 patent/WO2010065147A1/en not_active Ceased
- 2009-12-07 EP EP09830742.4A patent/EP2367428B1/en active Active
- 2009-12-07 PE PE2011001168A patent/PE20110834A1/es not_active Application Discontinuation
- 2009-12-07 JP JP2011539518A patent/JP5710492B2/ja not_active Expired - Fee Related
- 2009-12-07 US US13/133,147 patent/US8927556B2/en active Active
- 2009-12-07 MA MA33970A patent/MA32939B1/fr unknown
- 2009-12-07 AU AU2009322899A patent/AU2009322899A1/en not_active Abandoned
- 2009-12-07 CN CN2009801483001A patent/CN102238873A/zh active Pending
- 2009-12-07 CA CA2740385A patent/CA2740385A1/en not_active Abandoned
- 2009-12-07 KR KR1020117013107A patent/KR20110098730A/ko not_active Withdrawn
- 2009-12-07 ES ES09830742.4T patent/ES2580759T3/es active Active
- 2009-12-07 MX MX2011005935A patent/MX2011005935A/es not_active Application Discontinuation
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- 2011-06-02 IL IL213316A patent/IL213316A0/en unknown
- 2011-06-06 DO DO2011000171A patent/DOP2011000171A/es unknown
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