JP2005536516A5 - - Google Patents
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- Publication number
- JP2005536516A5 JP2005536516A5 JP2004522555A JP2004522555A JP2005536516A5 JP 2005536516 A5 JP2005536516 A5 JP 2005536516A5 JP 2004522555 A JP2004522555 A JP 2004522555A JP 2004522555 A JP2004522555 A JP 2004522555A JP 2005536516 A5 JP2005536516 A5 JP 2005536516A5
- Authority
- JP
- Japan
- Prior art keywords
- alcohol
- weight
- amount
- buffer
- cetrimide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 9
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 4
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 3
- 229960000686 benzalkonium chloride Drugs 0.000 description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
- 229960002798 cetrimide Drugs 0.000 description 3
- 229960000541 cetyl alcohol Drugs 0.000 description 3
- 229940067107 phenylethyl alcohol Drugs 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 229940046303 sodium cetostearyl sulfate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- CLBALUNQCMWJSU-UHFFFAOYSA-L sodium;hexadecyl sulfate;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O CLBALUNQCMWJSU-UHFFFAOYSA-L 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39786502P | 2002-07-23 | 2002-07-23 | |
| PCT/EP2003/008005 WO2004009056A1 (en) | 2002-07-23 | 2003-07-22 | Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012014297A Division JP2012087146A (ja) | 2002-07-23 | 2012-01-26 | 薬剤、軟膏基剤および可溶化剤／分散剤を含む、眼科用軟膏組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536516A JP2005536516A (ja) | 2005-12-02 |
| JP2005536516A5 true JP2005536516A5 (enExample) | 2006-09-07 |
Family
ID=30771133
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004522555A Withdrawn JP2005536516A (ja) | 2002-07-23 | 2003-07-22 | 薬剤、軟膏基剤および可溶化剤／分散剤を含む、眼科用軟膏組成物 |
| JP2012014297A Pending JP2012087146A (ja) | 2002-07-23 | 2012-01-26 | 薬剤、軟膏基剤および可溶化剤／分散剤を含む、眼科用軟膏組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012014297A Pending JP2012087146A (ja) | 2002-07-23 | 2012-01-26 | 薬剤、軟膏基剤および可溶化剤／分散剤を含む、眼科用軟膏組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20060115500A1 (enExample) |
| EP (2) | EP2319493A3 (enExample) |
| JP (2) | JP2005536516A (enExample) |
| CN (2) | CN101897662B (enExample) |
| AU (1) | AU2003254566A1 (enExample) |
| BR (1) | BR0312817A (enExample) |
| CA (1) | CA2492989C (enExample) |
| WO (1) | WO2004009056A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006019851A1 (en) * | 2004-07-23 | 2006-02-23 | Eli Lilly And Company | Methods for diagnosing and treating diabetic microvascular complications |
| CN101123948A (zh) * | 2005-02-17 | 2008-02-13 | 千寿制药株式会社 | 眼科用固体外用药剂 |
| US20080112895A1 (en) * | 2006-08-04 | 2008-05-15 | Insys Therapeutics Inc. | Aqueous dronabinol formulations |
| MX2010004373A (es) * | 2007-11-01 | 2010-05-05 | Bausch & Lomb | Materiales miscibles en agua no acuosos como vehiculos para suministro de farmacos. |
| BR112012013812A2 (pt) | 2009-12-08 | 2018-05-29 | Healthpoint Ltd | "composições para desbridamento enzimático de feridas com atividade enzimática melhorada" |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| CN108472312A (zh) | 2015-09-28 | 2018-08-31 | 阿祖拉眼科有限公司 | 用于增加睑板腺脂质分泌物的含硫醇及二硫化物的药剂 |
| CA3019349A1 (en) | 2016-04-14 | 2017-10-19 | Azura Ophthalmics Ltd. | Selenium disulfide compositions for use in treating meibomian gland dysfunction |
| EP3741367A1 (en) * | 2019-05-21 | 2020-11-25 | Premark Pharma GmbH | Treatment of ocular disease |
| CA3166357A1 (en) | 2020-01-10 | 2021-07-15 | Azura Ophthalmics Ltd. | Instructions for composition and sensitivity |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3134718A (en) * | 1963-12-12 | 1964-05-26 | Schering Corp | Pregna-1,4-dienes and compositions containing same |
| US3453257A (en) | 1967-02-13 | 1969-07-01 | Corn Products Co | Cyclodextrin with cationic properties |
| GB1537047A (en) * | 1975-10-03 | 1978-12-29 | Fisons Ltd | Eye ointment |
| US4432964A (en) * | 1981-08-24 | 1984-02-21 | Alza Corporation | Topical composition containing steroid in two forms released independently from polymeric carrier |
| CA1196284A (en) * | 1982-05-28 | 1985-11-05 | Joshua Oduro-Yeboah | Pharmaceutical formulations |
| US4966773A (en) * | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| IL86632A0 (en) * | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| JPS644125A (en) * | 1987-06-26 | 1989-01-09 | Hitachi Ltd | Communication satellite identification system |
| IT1222309B (it) * | 1987-07-08 | 1990-09-05 | Menarini Sas | Utilizzazione di forme farmaceutiche per uso topico contenenti miocamicina per la terapia delle infezione da germi sensibili alla miocamicina stessa |
| JP2865324B2 (ja) * | 1989-09-29 | 1999-03-08 | 東京田辺製薬株式会社 | ９―メチル―３―（１Ｈ―テトラゾール―５―イル）―４Ｈ―ピリド［１，２―ａ］ピリミジン―４―オン又はその塩の軟膏剤 |
| DK0427680T3 (da) | 1989-11-09 | 1995-12-18 | Sandoz Ltd | Heteroatom-holdige cykliske forbindelser |
| US5241059A (en) | 1990-05-21 | 1993-08-31 | Toppan Printing Co., Ltd. | Cyclodextrin derivatives |
| DE69125230T2 (de) | 1990-09-04 | 1997-07-10 | Fujisawa Pharmaceutical Co | Tricyclische Verbindungen enthaltende Salben |
| DK196591D0 (da) * | 1991-12-05 | 1991-12-05 | Mouritsen & Elsner Aps | Anvendelse af en kendt kemisk forbindelse til fremstilling af et farmaceutisk paraeparat til topisk applikation |
| HUT66531A (en) | 1992-05-07 | 1994-12-28 | Sandoz Ag | Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them |
| MY110603A (en) | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
| WO1995022331A1 (en) * | 1994-02-18 | 1995-08-24 | Cephalon, Inc. | Aqueous indolocarbazole solutions |
| CA2201134A1 (en) * | 1994-10-10 | 1996-04-18 | Alfred Sallmann | Ophthalmic and aural compositions containing diclofenac potassium |
| EP0711556A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Intravenöse Lösungen für ein Staurosporinderivat |
| WO1997008182A1 (en) | 1995-08-24 | 1997-03-06 | Merck & Co., Inc. | Process for the preparation of imidazolyl macrolide immunosuppressants |
| JPH0977662A (ja) * | 1995-09-11 | 1997-03-25 | Zeria Pharmaceut Co Ltd | 軟膏剤 |
| UA54427C2 (uk) * | 1996-05-01 | 2003-03-17 | Елі Ліллі Енд Компані | Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту |
| JPH10203979A (ja) * | 1997-01-24 | 1998-08-04 | Rohto Pharmaceut Co Ltd | チアプロフェン酸を含有する抗眼炎症剤 |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| IT1295423B1 (it) * | 1997-10-10 | 1999-05-12 | Medivis S R L | Uso della flunarizina nella terapia topica del glaucoma |
| FR2772271B1 (fr) * | 1997-12-11 | 2000-09-01 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| CN1175904C (zh) * | 1998-05-15 | 2004-11-17 | 若素制药株式会社 | 抗炎滴眼剂 |
| US6200968B1 (en) * | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| US6291519B1 (en) * | 1998-10-14 | 2001-09-18 | Novartis Ag | Method of preventing damage to eye tissue |
| DE69912304T2 (de) * | 1998-11-23 | 2004-07-22 | Novartis Ag | Verwendung von staurosporine derivaten zur behandlung von okularen neovaskularen erkrankungen |
| GB9903547D0 (en) * | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
| ITMI991453A1 (it) * | 1999-07-01 | 2001-01-01 | Farmila Farma Milano | Composizioni oftalmiche in forma di gel acquosi |
| US6271233B1 (en) | 1999-08-10 | 2001-08-07 | Ciba Vision Corporation | Method for treating ocular neovascular diseases |
| HU226058B1 (en) * | 2000-06-14 | 2008-04-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing sterile acyclovir cream |
| CN1127955C (zh) * | 2000-07-07 | 2003-11-19 | 中山医科大学中山眼科中心 | 一种眼前段及眼表免疫相关性疾病治疗药物 |
| AR038628A1 (es) * | 2002-03-04 | 2005-01-19 | Novartis Ag | Composicion oftalmica |
-
2003
- 2003-07-22 WO PCT/EP2003/008005 patent/WO2004009056A1/en not_active Ceased
- 2003-07-22 EP EP10177243A patent/EP2319493A3/en not_active Withdrawn
- 2003-07-22 BR BR0312817-2A patent/BR0312817A/pt not_active IP Right Cessation
- 2003-07-22 CN CN2010102484792A patent/CN101897662B/zh not_active Expired - Fee Related
- 2003-07-22 AU AU2003254566A patent/AU2003254566A1/en not_active Abandoned
- 2003-07-22 JP JP2004522555A patent/JP2005536516A/ja not_active Withdrawn
- 2003-07-22 EP EP03765094A patent/EP1531793A1/en not_active Withdrawn
- 2003-07-22 CA CA2492989A patent/CA2492989C/en not_active Expired - Fee Related
- 2003-07-22 CN CN038172089A patent/CN1674868B/zh not_active Expired - Fee Related
- 2003-07-22 US US10/521,946 patent/US20060115500A1/en not_active Abandoned
-
2012
- 2012-01-26 JP JP2012014297A patent/JP2012087146A/ja active Pending
-
2013
- 2013-06-27 US US13/929,023 patent/US20140005171A1/en not_active Abandoned
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