JP2010504358A5 - - Google Patents
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- Publication number
- JP2010504358A5 JP2010504358A5 JP2009529404A JP2009529404A JP2010504358A5 JP 2010504358 A5 JP2010504358 A5 JP 2010504358A5 JP 2009529404 A JP2009529404 A JP 2009529404A JP 2009529404 A JP2009529404 A JP 2009529404A JP 2010504358 A5 JP2010504358 A5 JP 2010504358A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- concentration
- borate
- less
- zinc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 127
- 229920005862 polyol Polymers 0.000 claims description 29
- 150000003077 polyols Chemical class 0.000 claims description 29
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 27
- 150000001450 anions Chemical class 0.000 claims description 20
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 18
- 229910052725 zinc Inorganic materials 0.000 claims description 18
- 239000011701 zinc Substances 0.000 claims description 18
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 18
- 239000011592 zinc chloride Substances 0.000 claims description 9
- 235000005074 zinc chloride Nutrition 0.000 claims description 9
- 230000000845 anti-microbial effect Effects 0.000 claims description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 42
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 13
- 150000001768 cations Chemical class 0.000 claims 11
- 229960002368 travoprost Drugs 0.000 claims 10
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 9
- 125000000129 anionic group Chemical group 0.000 claims 9
- 239000000600 sorbitol Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 229910052751 metal Inorganic materials 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 4
- 101000939135 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 27 Proteins 0.000 claims 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 102100029736 Ubiquitin carboxyl-terminal hydrolase 27 Human genes 0.000 claims 4
- 230000000844 anti-bacterial effect Effects 0.000 claims 4
- 239000004327 boric acid Substances 0.000 claims 4
- 239000002736 nonionic surfactant Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 2
- 229960002470 bimatoprost Drugs 0.000 claims 2
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims 2
- 229960001160 latanoprost Drugs 0.000 claims 2
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 2
- 229960004317 unoprostone Drugs 0.000 claims 2
- TVHAZVBUYQMHBC-SNHXEXRGSA-N unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O TVHAZVBUYQMHBC-SNHXEXRGSA-N 0.000 claims 2
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims 1
- 125000005619 boric acid group Chemical group 0.000 claims 1
- 150000001642 boronic acid derivatives Chemical class 0.000 claims 1
- 239000002563 ionic surfactant Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82652906P | 2006-09-21 | 2006-09-21 | |
| US60/826,529 | 2006-09-21 | ||
| US82741106P | 2006-09-28 | 2006-09-28 | |
| US60/827,411 | 2006-09-28 | ||
| PCT/US2007/079082 WO2008036847A2 (en) | 2006-09-21 | 2007-09-20 | Self preserved aqueous pharmaceutical compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011154267A Division JP5411897B2 (ja) | 2006-09-21 | 2011-07-12 | 自己保存型水性医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010504358A JP2010504358A (ja) | 2010-02-12 |
| JP2010504358A5 true JP2010504358A5 (enExample) | 2011-06-30 |
| JP4785970B2 JP4785970B2 (ja) | 2011-10-05 |
Family
ID=39156274
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009529404A Active JP4785970B2 (ja) | 2006-09-21 | 2007-09-20 | 自己保存型水性医薬組成物 |
| JP2011154267A Active JP5411897B2 (ja) | 2006-09-21 | 2011-07-12 | 自己保存型水性医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011154267A Active JP5411897B2 (ja) | 2006-09-21 | 2011-07-12 | 自己保存型水性医薬組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US8268299B2 (enExample) |
| EP (1) | EP2068822B2 (enExample) |
| JP (2) | JP4785970B2 (enExample) |
| KR (1) | KR101021933B1 (enExample) |
| AR (1) | AR062929A1 (enExample) |
| AT (1) | ATE531358T1 (enExample) |
| AU (1) | AU2007299727B2 (enExample) |
| BR (1) | BRPI0717067A2 (enExample) |
| CA (1) | CA2606370C (enExample) |
| CL (1) | CL2007002705A1 (enExample) |
| CY (1) | CY1112138T1 (enExample) |
| DK (1) | DK2068822T4 (enExample) |
| ES (1) | ES2374444T5 (enExample) |
| MX (1) | MX2009002221A (enExample) |
| PL (1) | PL2068822T5 (enExample) |
| PT (1) | PT2068822E (enExample) |
| RU (1) | RU2436568C2 (enExample) |
| SI (1) | SI2068822T2 (enExample) |
| TW (1) | TWI394564B (enExample) |
| UY (1) | UY30605A1 (enExample) |
| WO (1) | WO2008036847A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767217B2 (en) | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
| TWI394564B (zh) | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
| KR101421519B1 (ko) * | 2006-09-28 | 2014-07-30 | 알콘 리서치, 리미티드 | 자기 보존 수성 약제학적 조성물 |
| TW200904485A (en) * | 2007-05-18 | 2009-02-01 | Alcon Res Ltd | Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions |
| CN101959500A (zh) * | 2008-03-17 | 2011-01-26 | 爱尔康研究有限公司 | 包含硼酸类化合物-多元醇络合物的水性药物组合物 |
| JP2009256281A (ja) * | 2008-04-21 | 2009-11-05 | Teika Seiyaku Kk | イソプロピルウノプロストン含有点眼剤組成物 |
| TW201010727A (en) * | 2008-09-03 | 2010-03-16 | Alcon Res Ltd | Pharmaceutical composition having relatively low ionic strength |
| RU2011130552A (ru) * | 2008-12-22 | 2013-01-27 | Алькон Рисерч, Лтд. | Композиции местных глазных растворов для доставки эффективных концентраций активного агента в задний сегмент глаза |
| EP2228058A1 (en) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
| EP2389939A1 (en) | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
| WO2011084473A1 (en) * | 2009-12-15 | 2011-07-14 | Foresight Biotherapeutics, Inc. | Non-irritating ophthalmic povidone-iodine compositions |
| TW201127423A (en) * | 2009-12-17 | 2011-08-16 | Alcon Res Ltd | Ophthalmic solutions with improved disinfection profiles |
| EP3597182A1 (en) | 2011-03-04 | 2020-01-22 | Grünenthal GmbH | Aqueous pharmaceutical formulation of tapentadol for oral administration |
| CN103501775A (zh) * | 2011-03-04 | 2014-01-08 | 格吕伦塔尔有限公司 | 他喷他多的胃肠外给药 |
| JP6150510B2 (ja) * | 2011-12-12 | 2017-06-21 | ロート製薬株式会社 | 眼科用水性組成物 |
| EP2630952A1 (en) | 2012-02-23 | 2013-08-28 | Novagali Pharma S.A. | Self-preserved oil dispersions comprising boric acid |
| TW201417814A (zh) * | 2012-09-28 | 2014-05-16 | Otsuka Pharma Co Ltd | 包括瑞巴派特之醫藥組成物 |
| WO2014126266A1 (en) * | 2013-02-15 | 2014-08-21 | Senju Pharmaceutical Co., Ltd. | Difluprednate emulsion composition containing zinc |
| CN105263476A (zh) | 2013-03-13 | 2016-01-20 | 库尔制药开发公司 | 用于治疗炎症的免疫修饰性颗粒 |
| EP3037094A1 (en) | 2014-12-23 | 2016-06-29 | Poifa Warszawa SA | Ophthalmic pharmaceutical composition |
| CN107847471A (zh) | 2015-03-27 | 2018-03-27 | 格吕伦塔尔有限公司 | 他喷他多肠胃外给药的稳定制剂 |
| US11458041B2 (en) | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
| US10632202B2 (en) | 2016-03-04 | 2020-04-28 | Johnson & Johnson Consumer Inc. | Preservative containing compositions |
| PE20190908A1 (es) | 2016-09-23 | 2019-06-26 | Gruenenthal Chemie | Formulacion estable para la administracion parenteral de tapentadol |
| WO2019123266A1 (en) | 2017-12-20 | 2019-06-27 | Novartis Ag | Ophthalmic composition having a prostaglandin and a beta-blocker |
| CA3166738A1 (en) | 2020-02-06 | 2021-08-12 | Charles D. Blizzard | Travoprost compositions and methods for treating ocular diseases |
| EP4142664A4 (en) | 2020-04-27 | 2024-05-29 | Ocular Therapeutix, Inc. | METHODS FOR TREATING ALLERGIC CONJUNCTIVITIS |
| US20220031739A1 (en) * | 2020-07-31 | 2022-02-03 | Eye Therapies Llc | Anti-viral compositions and methods of use thereof |
| US20240390416A1 (en) | 2021-09-30 | 2024-11-28 | Rohto Pharmaceutical Co., Ltd. | Ophthalmological composition |
| WO2024003078A1 (en) * | 2022-06-27 | 2024-01-04 | Warszawskie Zaklady Farmaceutyczne Polfa Sa | Preservative-free ophthalmic composition comprising a prostaglandin analogue |
| US20250381275A1 (en) | 2022-07-06 | 2025-12-18 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic composition |
| EP4309644A1 (en) * | 2022-07-22 | 2024-01-24 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Preservative-free ophthalmic composition comprising an antiglaucoma agent |
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| JP4863589B2 (ja) † | 2001-09-28 | 2012-01-25 | ロート製薬株式会社 | 水性組成物 |
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| TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
-
2007
- 2007-09-17 TW TW096134677A patent/TWI394564B/zh active
- 2007-09-20 AR ARP070104170A patent/AR062929A1/es unknown
- 2007-09-20 ES ES07842914T patent/ES2374444T5/es active Active
- 2007-09-20 WO PCT/US2007/079082 patent/WO2008036847A2/en not_active Ceased
- 2007-09-20 EP EP07842914.9A patent/EP2068822B2/en active Active
- 2007-09-20 CA CA2606370A patent/CA2606370C/en not_active Expired - Fee Related
- 2007-09-20 JP JP2009529404A patent/JP4785970B2/ja active Active
- 2007-09-20 BR BRPI0717067-0A2A patent/BRPI0717067A2/pt not_active Application Discontinuation
- 2007-09-20 DK DK07842914.9T patent/DK2068822T4/da active
- 2007-09-20 US US11/858,781 patent/US8268299B2/en active Active
- 2007-09-20 PT PT07842914T patent/PT2068822E/pt unknown
- 2007-09-20 KR KR1020097007721A patent/KR101021933B1/ko not_active Expired - Fee Related
- 2007-09-20 MX MX2009002221A patent/MX2009002221A/es active IP Right Grant
- 2007-09-20 PL PL07842914.9T patent/PL2068822T5/pl unknown
- 2007-09-20 SI SI200730811T patent/SI2068822T2/sl unknown
- 2007-09-20 CL CL200702705A patent/CL2007002705A1/es unknown
- 2007-09-20 AU AU2007299727A patent/AU2007299727B2/en not_active Ceased
- 2007-09-20 AT AT07842914T patent/ATE531358T1/de active
- 2007-09-20 RU RU2009114849/15A patent/RU2436568C2/ru active
- 2007-09-21 UY UY30605A patent/UY30605A1/es not_active Application Discontinuation
-
2011
- 2011-04-14 US US13/086,950 patent/US8323630B2/en active Active
- 2011-07-12 JP JP2011154267A patent/JP5411897B2/ja active Active
- 2011-12-02 CY CY20111101200T patent/CY1112138T1/el unknown
-
2012
- 2012-10-30 US US13/664,049 patent/US20130053440A1/en not_active Abandoned
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