CY1112138T1 - Αυτο-συντηρημενες υδατικες φαρμακευτικες συνθεσεις - Google Patents
Αυτο-συντηρημενες υδατικες φαρμακευτικες συνθεσειςInfo
- Publication number
- CY1112138T1 CY1112138T1 CY20111101200T CY111101200T CY1112138T1 CY 1112138 T1 CY1112138 T1 CY 1112138T1 CY 20111101200 T CY20111101200 T CY 20111101200T CY 111101200 T CY111101200 T CY 111101200T CY 1112138 T1 CY1112138 T1 CY 1112138T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compositions
- amount
- balanced
- present
- concentration
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Η παρούσα εφεύρεση απευθύνεται στην παραδοχή των αυτο-συντηρημένων οφθαλμικών συνθέσεων, πολλαπλών-δόσεων. Οι συνθέσεις κατέχουν επαρκή αντιμικροβιακή δραστηριότητα για να ικανοποιηθούν οι απαιτήσεις συντηρητικής αποτελεσματικότητας της USP (Φαρμακοποιία των Ηνωμένων Πολιτειών), ως επίσης και παρόμοιων συντηρητικών προτύπων (π.χ., τα ΕΡ και JP), χωρίς να απαιτείται η παρουσία συμβατικών αντι-μικροβιακών συντηρητικών παραγόντων, όπως είναι το χλωριούχο βενζαλκόνιο. Οι συνθέσεις συντηρούνται αποτελεσματικά μέσω ενός ισοσταθμισμένου ιονικού ρυθμιστικού συστήματος περιέχοντος ιόντα ψευδαργύρου σε μια συγκέντρωση των 0.04 έως 0.9 mM, κατά προτίμηση των 0.04 έως 0.4 mM. Μια άποψη του θέματος του ισοσταθμισμένου ρυθμιστικού συστήματος είναι ο περιορισμός της ποσότητας των ρυθμιστικών ανιόντων που εμφανίζονται σε μια συγκέντρωση των 15 mM ή λιγότερο, κατά προτίμηση των 5 mM ή λιγότερο. Σε μια προτιμώμενη ενσωμάτωση, οι συνθέσεις περιέχουν επίσης βορικό ή, το πλείστον κατά προτίμηση, ένα ή περισσότερα σύμπλοκα βορικού/πολυόλης. Η χρήση προπυλενγλυκόλης ως η πολυόλη σε τέτοια σύμπλοκα προτιμάται σθεναρά. Ο περιορισμός της ποσότητας των δισθενών μετάλλων άλλων από τον ψευδάργυρο και η ποσότητα των ιοντισμένων αλάτων που εμφανίζονται έχει επίσης προσδιοριστεί ότι είναι σημαντική στην μεγιστοποίηση της αντιμικροβιακής δραστηριότητας των ισοσταθμισμένων ρυθμιστικών συστημάτων.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82652906P | 2006-09-21 | 2006-09-21 | |
US82741106P | 2006-09-28 | 2006-09-28 | |
EP07842914.9A EP2068822B2 (en) | 2006-09-21 | 2007-09-20 | Self preserved aqueous pharmaceutical compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112138T1 true CY1112138T1 (el) | 2015-11-04 |
Family
ID=39156274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111101200T CY1112138T1 (el) | 2006-09-21 | 2011-12-02 | Αυτο-συντηρημενες υδατικες φαρμακευτικες συνθεσεις |
Country Status (22)
Country | Link |
---|---|
US (3) | US8268299B2 (el) |
EP (1) | EP2068822B2 (el) |
JP (2) | JP4785970B2 (el) |
KR (1) | KR101021933B1 (el) |
AR (1) | AR062929A1 (el) |
AT (1) | ATE531358T1 (el) |
AU (1) | AU2007299727B2 (el) |
BR (1) | BRPI0717067A2 (el) |
CA (1) | CA2606370C (el) |
CL (1) | CL2007002705A1 (el) |
CY (1) | CY1112138T1 (el) |
DK (1) | DK2068822T4 (el) |
ES (1) | ES2374444T5 (el) |
HK (1) | HK1126667A1 (el) |
MX (1) | MX2009002221A (el) |
PL (1) | PL2068822T5 (el) |
PT (1) | PT2068822E (el) |
RU (1) | RU2436568C2 (el) |
SI (1) | SI2068822T2 (el) |
TW (1) | TWI394564B (el) |
UY (1) | UY30605A1 (el) |
WO (1) | WO2008036847A2 (el) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7767217B2 (en) | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
JP5394927B2 (ja) | 2006-09-28 | 2014-01-22 | アルコン リサーチ, リミテッド | 自己保存性水性医薬品組成物 |
TW200904485A (en) * | 2007-05-18 | 2009-02-01 | Alcon Res Ltd | Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions |
MX2010009336A (es) * | 2008-03-17 | 2010-09-24 | Alcon Res Ltd | Composiciones farmaceuticas acuosas que contienen complejos de borato-poliol. |
JP2009256281A (ja) * | 2008-04-21 | 2009-11-05 | Teika Seiyaku Kk | イソプロピルウノプロストン含有点眼剤組成物 |
TW201010727A (en) * | 2008-09-03 | 2010-03-16 | Alcon Res Ltd | Pharmaceutical composition having relatively low ionic strength |
BRPI0923502A2 (pt) * | 2008-12-22 | 2019-09-24 | Alcon Res Ltd | composições de soluções oculares tópicas para fornecer concentrações eficiêntes de agente ativo no segmento posterior do olho |
EP2228058A1 (en) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸-多元醇錯合物之水性藥學組成物 |
EP2389939A1 (en) | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
KR20190049931A (ko) * | 2009-12-15 | 2019-05-09 | 포어사이트 바이오쎄라퓨틱스, 인코퍼레이티드 | 무자극성 안과용 포비돈-요오드 조성물 |
TW201127423A (en) * | 2009-12-17 | 2011-08-16 | Alcon Res Ltd | Ophthalmic solutions with improved disinfection profiles |
MX351584B (es) | 2011-03-04 | 2017-10-20 | Gruenenthal Gmbh | Formulacion farmaceutica acuosa de tapentadol para administracion oral. |
CN103501775A (zh) * | 2011-03-04 | 2014-01-08 | 格吕伦塔尔有限公司 | 他喷他多的胃肠外给药 |
JP6150510B2 (ja) * | 2011-12-12 | 2017-06-21 | ロート製薬株式会社 | 眼科用水性組成物 |
EP2630952A1 (en) | 2012-02-23 | 2013-08-28 | Novagali Pharma S.A. | Self-preserved oil dispersions comprising boric acid |
TW201417814A (zh) * | 2012-09-28 | 2014-05-16 | Otsuka Pharma Co Ltd | 包括瑞巴派特之醫藥組成物 |
RU2675813C2 (ru) * | 2013-02-15 | 2018-12-25 | Сэндзю Фармацевтикал Ко., Лтд. | Эмульсионная композиция дифлупредната, содержащая цинк |
IL303425A (en) | 2013-03-13 | 2023-08-01 | Cour Pharmaceuticals Dev Company | Secondary vaccine particles for the treatment of inflammation |
EP3037094A1 (en) | 2014-12-23 | 2016-06-29 | Poifa Warszawa SA | Ophthalmic pharmaceutical composition |
RS58301B1 (sr) | 2015-03-27 | 2019-03-29 | Gruenenthal Gmbh | Stabilne formulacije za parenteralnu primenu tapentadola |
WO2017062770A1 (en) | 2015-10-08 | 2017-04-13 | Silverberg Noah | Punctal plug and bioadhesives |
US10632202B2 (en) | 2016-03-04 | 2020-04-28 | Johnson & Johnson Consumer Inc. | Preservative containing compositions |
AU2017329964B2 (en) | 2016-09-23 | 2022-10-06 | Grünenthal GmbH | Stable formulation for parenteral administration of Tapentadol |
WO2019123266A1 (en) | 2017-12-20 | 2019-06-27 | Novartis Ag | Ophthalmic composition having a prostaglandin and a beta-blocker |
IL295357A (en) | 2020-02-06 | 2022-10-01 | Ocular Therapeutix Inc | Preparations and methods for the treatment of eye diseases |
WO2023054669A1 (ja) | 2021-09-30 | 2023-04-06 | ロート製薬株式会社 | 眼科組成物 |
WO2024003078A1 (en) * | 2022-06-27 | 2024-01-04 | Warszawskie Zaklady Farmaceutyczne Polfa Sa | Preservative-free ophthalmic composition comprising a prostaglandin analogue |
EP4309644A1 (en) * | 2022-07-22 | 2024-01-24 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Preservative-free ophthalmic composition comprising an antiglaucoma agent |
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AR031417A1 (es) | 2000-11-29 | 2003-09-24 | Novartis Ag | Sistemas desinfectantes acuosos |
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JP4863589B2 (ja) | 2001-09-28 | 2012-01-25 | ロート製薬株式会社 | 水性組成物 |
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TWI394564B (zh) | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
-
2007
- 2007-09-17 TW TW096134677A patent/TWI394564B/zh active
- 2007-09-20 PL PL07842914.9T patent/PL2068822T5/pl unknown
- 2007-09-20 EP EP07842914.9A patent/EP2068822B2/en active Active
- 2007-09-20 SI SI200730811T patent/SI2068822T2/sl unknown
- 2007-09-20 WO PCT/US2007/079082 patent/WO2008036847A2/en active Application Filing
- 2007-09-20 US US11/858,781 patent/US8268299B2/en active Active
- 2007-09-20 RU RU2009114849/15A patent/RU2436568C2/ru active
- 2007-09-20 PT PT07842914T patent/PT2068822E/pt unknown
- 2007-09-20 JP JP2009529404A patent/JP4785970B2/ja active Active
- 2007-09-20 DK DK07842914.9T patent/DK2068822T4/da active
- 2007-09-20 AT AT07842914T patent/ATE531358T1/de active
- 2007-09-20 KR KR1020097007721A patent/KR101021933B1/ko active IP Right Grant
- 2007-09-20 BR BRPI0717067-0A2A patent/BRPI0717067A2/pt not_active Application Discontinuation
- 2007-09-20 AR ARP070104170A patent/AR062929A1/es unknown
- 2007-09-20 CA CA2606370A patent/CA2606370C/en not_active Expired - Fee Related
- 2007-09-20 CL CL200702705A patent/CL2007002705A1/es unknown
- 2007-09-20 AU AU2007299727A patent/AU2007299727B2/en not_active Ceased
- 2007-09-20 ES ES07842914T patent/ES2374444T5/es active Active
- 2007-09-20 MX MX2009002221A patent/MX2009002221A/es active IP Right Grant
- 2007-09-21 UY UY30605A patent/UY30605A1/es not_active Application Discontinuation
-
2009
- 2009-06-19 HK HK09105567.3A patent/HK1126667A1/xx not_active IP Right Cessation
-
2011
- 2011-04-14 US US13/086,950 patent/US8323630B2/en active Active
- 2011-07-12 JP JP2011154267A patent/JP5411897B2/ja active Active
- 2011-12-02 CY CY20111101200T patent/CY1112138T1/el unknown
-
2012
- 2012-10-30 US US13/664,049 patent/US20130053440A1/en not_active Abandoned
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