JP2005536453A5 - - Google Patents
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- Publication number
- JP2005536453A5 JP2005536453A5 JP2003569658A JP2003569658A JP2005536453A5 JP 2005536453 A5 JP2005536453 A5 JP 2005536453A5 JP 2003569658 A JP2003569658 A JP 2003569658A JP 2003569658 A JP2003569658 A JP 2003569658A JP 2005536453 A5 JP2005536453 A5 JP 2005536453A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- peptide mimetic
- partial peptide
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 40
- 108090000765 processed proteins & peptides Proteins 0.000 claims 37
- 125000003275 alpha amino acid group Chemical group 0.000 claims 29
- 210000004027 cell Anatomy 0.000 claims 22
- TXCDCPKCNAJMEE-UHFFFAOYSA-N dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 claims 20
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 18
- 230000001939 inductive effect Effects 0.000 claims 18
- 150000001413 amino acids Chemical class 0.000 claims 16
- 238000000338 in vitro Methods 0.000 claims 14
- 239000012634 fragment Substances 0.000 claims 13
- 230000002401 inhibitory effect Effects 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 230000000694 effects Effects 0.000 claims 10
- 239000000816 peptidomimetic Substances 0.000 claims 10
- 230000033115 angiogenesis Effects 0.000 claims 7
- 230000004663 cell proliferation Effects 0.000 claims 7
- 210000002889 endothelial cell Anatomy 0.000 claims 7
- 210000005260 human cell Anatomy 0.000 claims 6
- 210000004962 mammalian cell Anatomy 0.000 claims 6
- 102000016289 Cell Adhesion Molecules Human genes 0.000 claims 5
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 5
- 239000002870 angiogenesis inducing agent Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 239000000512 collagen gel Substances 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- 208000037487 Endotoxemia Diseases 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims 3
- 239000000470 constituent Substances 0.000 claims 3
- 239000003899 bactericide agent Substances 0.000 claims 2
- 230000034303 cell budding Effects 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- 230000009144 enzymatic modification Effects 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000005740 tumor formation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35927202P | 2002-02-20 | 2002-02-20 | |
| PCT/US2003/005106 WO2003070751A2 (en) | 2002-02-20 | 2003-02-20 | Partial peptide mimetics and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536453A JP2005536453A (ja) | 2005-12-02 |
| JP2005536453A5 true JP2005536453A5 (enExample) | 2006-04-06 |
Family
ID=27757772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569658A Pending JP2005536453A (ja) | 2002-02-20 | 2003-02-20 | 部分的なペプチド擬似物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7056514B2 (enExample) |
| EP (1) | EP1572719A4 (enExample) |
| JP (1) | JP2005536453A (enExample) |
| AU (1) | AU2003211163A1 (enExample) |
| CA (1) | CA2476427A1 (enExample) |
| WO (1) | WO2003070751A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000511892A (ja) * | 1996-05-24 | 2000-09-12 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 可溶性ベーターシート形成性ペプチドの合成 |
| EP1572719A4 (en) * | 2002-02-20 | 2007-11-14 | Univ Minnesota | PARTIAL PEPTIDE MIMETICS AND METHOD |
| US20060128615A1 (en) * | 2002-09-18 | 2006-06-15 | Pierrette Gaudreau | Ghrh analogues |
| JP2007512234A (ja) * | 2003-10-17 | 2007-05-17 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 治療活性を有する修飾ポリペプチド及びその使用方法 |
| US7505989B2 (en) | 2004-09-03 | 2009-03-17 | Biowisdom Limited | System and method for creating customized ontologies |
| US7496593B2 (en) | 2004-09-03 | 2009-02-24 | Biowisdom Limited | Creating a multi-relational ontology having a predetermined structure |
| US7493333B2 (en) | 2004-09-03 | 2009-02-17 | Biowisdom Limited | System and method for parsing and/or exporting data from one or more multi-relational ontologies |
| US20060053172A1 (en) * | 2004-09-03 | 2006-03-09 | Biowisdom Limited | System and method for creating, editing, and using multi-relational ontologies |
| PT1802291E (pt) | 2004-10-04 | 2012-03-12 | Univ Minnesota | Miméticos conformacionais de péptidos à base de calixareno, métodos de utilização e métodos de preparação |
| WO2008108944A2 (en) * | 2007-03-01 | 2008-09-12 | Mallinckrodt Inc. | Integrated photoactive small molecules and uses thereof |
| CN101626786A (zh) * | 2007-03-01 | 2010-01-13 | 马林克罗特公司 | 整合光敏肽及其应用 |
| JP2010535240A (ja) * | 2007-07-31 | 2010-11-18 | マリンクロッド・インコーポレイテッド | 一体化光活性薬剤およびその使用 |
| JP2021529163A (ja) | 2018-06-29 | 2021-10-28 | グリコス バイオメディカル オーワイ | コンジュゲート |
| US20230038373A1 (en) | 2019-12-18 | 2023-02-09 | Glykos Biomedical Oy | Stabile conjugate |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198541A (en) | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
| EP1659132A1 (en) | 1987-08-11 | 2006-05-24 | New York University | Biologically active bactericidal/permeability-increasing protein fragments |
| US5171739A (en) | 1989-02-14 | 1992-12-15 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and preventation thereof using a BPI protein |
| US5089274A (en) | 1989-02-14 | 1992-02-18 | Incyte Pharmaceuticals, Inc. | Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders |
| US5234912A (en) | 1989-02-14 | 1993-08-10 | Incyte Pharmaceuticals, Inc. | Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof |
| US5334584A (en) | 1989-02-14 | 1994-08-02 | Incyte Pharamaceuticals, Inc. | Recombinant, non-glycosylated bpi protein and uses thereof |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US5595887A (en) | 1990-07-16 | 1997-01-21 | Bionebraska, Inc. | Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment |
| DE69133317T2 (de) | 1990-11-28 | 2004-07-22 | E.I. Du Pont De Nemours And Co., Wilmington | Strukturproteine durch künstliche Gene |
| DE69128968T2 (de) | 1990-12-03 | 1998-10-08 | Univ New York | Biologisch aktive bakterizide/permeabilitätserhöhende proteinbruchstücke |
| US5190873A (en) | 1991-06-21 | 1993-03-02 | California Institute Of Biological Research | Hybrid tryptophan aporepressor containing ligand binding sites |
| US5643570A (en) | 1992-05-19 | 1997-07-01 | Xoma Corporation | BPI-immunoglobulin fusion proteins |
| WO1994014819A1 (fr) | 1992-12-28 | 1994-07-07 | Nippon Shinyaku Co., Ltd. | Derive d'acide carboxyquinolinique et procede d'obtention de ce derive |
| US5420019A (en) | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
| US5488034A (en) | 1993-02-02 | 1996-01-30 | Xoma Corporation | Pharmaceutical composition comprising BPI proteins |
| US5348942A (en) | 1993-03-12 | 1994-09-20 | Xoma Corporation | Therapeutic uses of bactericidal/permeability increasing protein products |
| CA2158058C (en) | 1993-03-12 | 2000-08-01 | Roger G. Ii Little | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
| JPH08511682A (ja) | 1993-04-30 | 1996-12-10 | インサイト ファーマシューティカルズ，インク． | 組み換えｂｐｉ蛋白およびｌｂｐ蛋白、それをコードする核酸分子、その生産方法並びにそれらの使用 |
| US5731415A (en) | 1993-06-17 | 1998-03-24 | Xoma Corporation | Lipopolysaccharide binding protein derivatives |
| DE69431922T2 (de) | 1993-07-02 | 2003-11-13 | Incyte Pharmaceuticals, Inc. | Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung |
| WO1995002414A1 (en) | 1993-07-14 | 1995-01-26 | Xoma Corporation | Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products |
| US5447913A (en) | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
| US5830860A (en) | 1994-03-24 | 1998-11-03 | Regents Of The University Of Minnesota | Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
| US5786324A (en) | 1994-03-24 | 1998-07-28 | Regents Of The University Of Minnesota | Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
| US5837682A (en) | 1996-03-08 | 1998-11-17 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
| US5639725A (en) | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
| GB9506806D0 (en) | 1995-04-01 | 1995-05-24 | Univ Leeds | Improvements relating to polymers |
| AU5874796A (en) | 1995-05-26 | 1996-12-11 | Torrey Pines Institute For Molecular Studies | Polypeptide compounds that form beta sheets |
| US5854205A (en) | 1995-10-23 | 1998-12-29 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
| US5955577A (en) * | 1996-06-27 | 1999-09-21 | Regents Of The University Of Minnesota | Method for synthesizing a water-soluble β-sheet forming peptide |
| JP2000511892A (ja) * | 1996-05-24 | 2000-09-12 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 可溶性ベーターシート形成性ペプチドの合成 |
| WO2001053335A2 (en) | 2000-01-20 | 2001-07-26 | Regents Of The University Of Minnesota | Peptides with antibacterial activity |
| EP1572719A4 (en) * | 2002-02-20 | 2007-11-14 | Univ Minnesota | PARTIAL PEPTIDE MIMETICS AND METHOD |
| JP2007512234A (ja) | 2003-10-17 | 2007-05-17 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 治療活性を有する修飾ポリペプチド及びその使用方法 |
| ITPD20040171A1 (it) | 2004-06-29 | 2004-09-29 | Maus Spa | Dispositivo per il bloccaggio di pezzi soggetti a lavorazioni meccaniche e macchina utensile includente detto dispositivo |
| PT1802291E (pt) | 2004-10-04 | 2012-03-12 | Univ Minnesota | Miméticos conformacionais de péptidos à base de calixareno, métodos de utilização e métodos de preparação |
| US20070010438A1 (en) * | 2005-07-08 | 2007-01-11 | Mayo Kevin H | Tumor treatment using beta-sheet peptides and radiotherapy |
-
2003
- 2003-02-20 EP EP03742842A patent/EP1572719A4/en not_active Withdrawn
- 2003-02-20 CA CA002476427A patent/CA2476427A1/en not_active Abandoned
- 2003-02-20 AU AU2003211163A patent/AU2003211163A1/en not_active Abandoned
- 2003-02-20 JP JP2003569658A patent/JP2005536453A/ja active Pending
- 2003-02-20 US US10/371,406 patent/US7056514B2/en not_active Expired - Lifetime
- 2003-02-20 WO PCT/US2003/005106 patent/WO2003070751A2/en not_active Ceased
-
2006
- 2006-02-02 US US11/346,504 patent/US7339023B2/en not_active Expired - Lifetime
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