DE69431922T2 - Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung - Google Patents

Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung

Info

Publication number
DE69431922T2
DE69431922T2 DE69431922T DE69431922T DE69431922T2 DE 69431922 T2 DE69431922 T2 DE 69431922T2 DE 69431922 T DE69431922 T DE 69431922T DE 69431922 T DE69431922 T DE 69431922T DE 69431922 T2 DE69431922 T2 DE 69431922T2
Authority
DE
Germany
Prior art keywords
permeability increasing
bactericidal
cell
production
increasing protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431922T
Other languages
English (en)
Other versions
DE69431922D1 (de
Inventor
N Marra
W Scott
C Lane
L Snable
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69431922D1 publication Critical patent/DE69431922D1/de
Publication of DE69431922T2 publication Critical patent/DE69431922T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE69431922T 1993-07-02 1994-07-01 Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung Expired - Fee Related DE69431922T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8748493A 1993-07-02 1993-07-02
PCT/US1994/007466 WO1995001428A1 (en) 1993-07-02 1994-07-01 Glycosylated and non-glycosylated bactericidal/permeability increasing proteins, and methods for producing same

Publications (2)

Publication Number Publication Date
DE69431922D1 DE69431922D1 (de) 2003-01-30
DE69431922T2 true DE69431922T2 (de) 2003-11-13

Family

ID=22205464

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431922T Expired - Fee Related DE69431922T2 (de) 1993-07-02 1994-07-01 Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung

Country Status (7)

Country Link
EP (1) EP0726944B1 (de)
JP (1) JPH09500269A (de)
AT (1) ATE229980T1 (de)
AU (1) AU7217094A (de)
CA (1) CA2166488A1 (de)
DE (1) DE69431922T2 (de)
WO (1) WO1995001428A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5830860A (en) * 1994-03-24 1998-11-03 Regents Of The University Of Minnesota Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5786324A (en) * 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
WO1997004008A1 (en) * 1995-07-20 1997-02-06 Xoma Corporation Anti-fungal peptides
EP0914144B1 (de) * 1996-05-10 2000-12-13 XOMA Technology Ltd. Therapeutische anwendungen von bpi-protein-produkten zur behandlung von humaner meningococcämia
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
US5945399A (en) * 1996-05-23 1999-08-31 Xoma Corporation Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma
WO1997044354A2 (en) 1996-05-24 1997-11-27 Regents Of The University Of Minnesota Synthesis of soluble beta-sheet forming peptides
US5888973A (en) * 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
CN1268741C (zh) * 1996-09-13 2006-08-09 超卡里奥迪克治疗学股份有限公司 半乳糖苷酶a缺乏症的治疗
US6482796B2 (en) 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
US6013631A (en) 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
AU1782601A (en) * 1999-11-19 2001-05-30 Hyseq, Inc. Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides
EP1572719A4 (de) 2002-02-20 2007-11-14 Univ Minnesota Partielle peptidmimetika und verfahren
DE60335119D1 (de) 2002-09-06 2011-01-05 Genentech Inc Verfahren zur proteinextraktion

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171739A (en) * 1989-02-14 1992-12-15 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein

Also Published As

Publication number Publication date
WO1995001428A1 (en) 1995-01-12
ATE229980T1 (de) 2003-01-15
EP0726944B1 (de) 2002-12-18
EP0726944A4 (de) 1997-01-29
AU7217094A (en) 1995-01-24
CA2166488A1 (en) 1995-01-12
JPH09500269A (ja) 1997-01-14
EP0726944A1 (de) 1996-08-21
DE69431922D1 (de) 2003-01-30

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee