ATE229980T1 - Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung - Google Patents

Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung

Info

Publication number
ATE229980T1
ATE229980T1 AT94921451T AT94921451T ATE229980T1 AT E229980 T1 ATE229980 T1 AT E229980T1 AT 94921451 T AT94921451 T AT 94921451T AT 94921451 T AT94921451 T AT 94921451T AT E229980 T1 ATE229980 T1 AT E229980T1
Authority
AT
Austria
Prior art keywords
bactericidal
permeability
cell
production
increasing protein
Prior art date
Application number
AT94921451T
Other languages
English (en)
Inventor
Marian N Marra
Randal W Scott
John C Lane
James L Snable
Original Assignee
Incyte Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc filed Critical Incyte Pharma Inc
Application granted granted Critical
Publication of ATE229980T1 publication Critical patent/ATE229980T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94921451T 1993-07-02 1994-07-01 Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung ATE229980T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8748493A 1993-07-02 1993-07-02
PCT/US1994/007466 WO1995001428A1 (en) 1993-07-02 1994-07-01 Glycosylated and non-glycosylated bactericidal/permeability increasing proteins, and methods for producing same

Publications (1)

Publication Number Publication Date
ATE229980T1 true ATE229980T1 (de) 2003-01-15

Family

ID=22205464

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94921451T ATE229980T1 (de) 1993-07-02 1994-07-01 Glycosilierte und nichtglycolisierte bakterizide/die permeabilität erhoehende proteine und methoden zu ihrer herstellung

Country Status (7)

Country Link
EP (1) EP0726944B1 (de)
JP (1) JPH09500269A (de)
AT (1) ATE229980T1 (de)
AU (1) AU7217094A (de)
CA (1) CA2166488A1 (de)
DE (1) DE69431922T2 (de)
WO (1) WO1995001428A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5786324A (en) * 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5830860A (en) * 1994-03-24 1998-11-03 Regents Of The University Of Minnesota Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
CA2227292A1 (en) * 1995-07-20 1997-02-06 Xoma Corporation Anti-fungal peptides
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
CA2253837C (en) * 1996-05-10 2002-07-02 Xoma Corporation Therapeutic uses of bpi protein products for human meningococcemia
US5945399A (en) * 1996-05-23 1999-08-31 Xoma Corporation Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma
JP2000511892A (ja) 1996-05-24 2000-09-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 可溶性ベーターシート形成性ペプチドの合成
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
WO1998011206A2 (en) * 1996-09-13 1998-03-19 Transkaryotic Therapies, Inc. THERAPY FOR α-GALACTOSIDASE A DEFICIENCY
US6482796B2 (en) 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
US6013631A (en) 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
AU1782601A (en) * 1999-11-19 2001-05-30 Hyseq, Inc. Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides
EP1572719A4 (de) 2002-02-20 2007-11-14 Univ Minnesota Partielle peptidmimetika und verfahren
EP2292637B1 (de) 2002-09-06 2016-01-06 Genentech, Inc. Verfahren zur Proteinextraktion

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171739A (en) * 1989-02-14 1992-12-15 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein

Also Published As

Publication number Publication date
EP0726944A1 (de) 1996-08-21
CA2166488A1 (en) 1995-01-12
AU7217094A (en) 1995-01-24
EP0726944B1 (de) 2002-12-18
WO1995001428A1 (en) 1995-01-12
JPH09500269A (ja) 1997-01-14
DE69431922T2 (de) 2003-11-13
DE69431922D1 (de) 2003-01-30
EP0726944A4 (de) 1997-01-29

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