ATE229980T1 - GLYCOSILATED AND NON-GLYCOLIZED BACTERICIDES/PERMEABILITY-INCREASE PROTEINS AND METHODS FOR THEIR PRODUCTION - Google Patents

GLYCOSILATED AND NON-GLYCOLIZED BACTERICIDES/PERMEABILITY-INCREASE PROTEINS AND METHODS FOR THEIR PRODUCTION

Info

Publication number
ATE229980T1
ATE229980T1 AT94921451T AT94921451T ATE229980T1 AT E229980 T1 ATE229980 T1 AT E229980T1 AT 94921451 T AT94921451 T AT 94921451T AT 94921451 T AT94921451 T AT 94921451T AT E229980 T1 ATE229980 T1 AT E229980T1
Authority
AT
Austria
Prior art keywords
bactericidal
permeability
cell
production
increasing protein
Prior art date
Application number
AT94921451T
Other languages
German (de)
Inventor
Marian N Marra
Randal W Scott
John C Lane
James L Snable
Original Assignee
Incyte Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc filed Critical Incyte Pharma Inc
Application granted granted Critical
Publication of ATE229980T1 publication Critical patent/ATE229980T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The subject invention provides a method for producing non-glycosylated Bactericidal/Permeability Increasing Protein using a gram-negative bacterial cell, which comprises transfecting the cell with a vector encoding Bactericidal/Permeability Increasing Protein; culturing the cell so transfected under conditions permitting the production of non-glycosylated Bactericidal/Permeability Increasing Protein in the cell; and recovering from the cell the non-glycosylated, Bactericidal/Permeability Increasing Protein so produced. Finally, the subject invention provides the non-glycosylated Bactericidal/Permeability Increasing Protein produced by the method of the subject invention.
AT94921451T 1993-07-02 1994-07-01 GLYCOSILATED AND NON-GLYCOLIZED BACTERICIDES/PERMEABILITY-INCREASE PROTEINS AND METHODS FOR THEIR PRODUCTION ATE229980T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8748493A 1993-07-02 1993-07-02
PCT/US1994/007466 WO1995001428A1 (en) 1993-07-02 1994-07-01 Glycosylated and non-glycosylated bactericidal/permeability increasing proteins, and methods for producing same

Publications (1)

Publication Number Publication Date
ATE229980T1 true ATE229980T1 (en) 2003-01-15

Family

ID=22205464

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94921451T ATE229980T1 (en) 1993-07-02 1994-07-01 GLYCOSILATED AND NON-GLYCOLIZED BACTERICIDES/PERMEABILITY-INCREASE PROTEINS AND METHODS FOR THEIR PRODUCTION

Country Status (7)

Country Link
EP (1) EP0726944B1 (en)
JP (1) JPH09500269A (en)
AT (1) ATE229980T1 (en)
AU (1) AU7217094A (en)
CA (1) CA2166488A1 (en)
DE (1) DE69431922T2 (en)
WO (1) WO1995001428A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5830860A (en) * 1994-03-24 1998-11-03 Regents Of The University Of Minnesota Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5786324A (en) * 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
EP0839156A1 (en) * 1995-07-20 1998-05-06 Xoma Corporation Anti-fungal peptides
ATE198050T1 (en) 1996-05-10 2000-12-15 Xoma Technology Ltd THERAPEUTIC USES OF BPI PROTEIN PRODUCTS FOR THE TREATMENT OF HUMAN MENINGOCOCCEMIA
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
JP2000511190A (en) * 1996-05-23 2000-08-29 ゾーマ コーポレイション Therapeutic use of BPI protein products in humans suffering from bleeding due to trauma
WO1997044354A2 (en) 1996-05-24 1997-11-27 Regents Of The University Of Minnesota Synthesis of soluble beta-sheet forming peptides
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
ATE286120T1 (en) * 1996-09-13 2005-01-15 Transkaryotic Therapies Inc THERAPY FOR ALPHA GALACTOSIDASE A INSUFFICIENCY
US6482796B2 (en) 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
US6013631A (en) 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
AU1782601A (en) * 1999-11-19 2001-05-30 Hyseq, Inc. Methods and compositions relating to bactericidal/permeability increasing factor-like polypeptides and polynucleotides
EP1572719A4 (en) 2002-02-20 2007-11-14 Univ Minnesota Partial peptide mimetics and methods
EP1539798B1 (en) 2002-09-06 2010-11-24 Genentech, Inc. Process for protein extraction

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171739A (en) * 1989-02-14 1992-12-15 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein

Also Published As

Publication number Publication date
DE69431922D1 (en) 2003-01-30
DE69431922T2 (en) 2003-11-13
CA2166488A1 (en) 1995-01-12
EP0726944B1 (en) 2002-12-18
EP0726944A4 (en) 1997-01-29
EP0726944A1 (en) 1996-08-21
JPH09500269A (en) 1997-01-14
WO1995001428A1 (en) 1995-01-12
AU7217094A (en) 1995-01-24

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