DE69609054D1 - A PROCESS FOR THE PRODUCTION OF FACTOR IX BIOLOGICAL ORIGIN - Google Patents

A PROCESS FOR THE PRODUCTION OF FACTOR IX BIOLOGICAL ORIGIN

Info

Publication number
DE69609054D1
DE69609054D1 DE69609054T DE69609054T DE69609054D1 DE 69609054 D1 DE69609054 D1 DE 69609054D1 DE 69609054 T DE69609054 T DE 69609054T DE 69609054 T DE69609054 T DE 69609054T DE 69609054 D1 DE69609054 D1 DE 69609054D1
Authority
DE
Germany
Prior art keywords
pct
factor
production
biological origin
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69609054T
Other languages
German (de)
Other versions
DE69609054T2 (en
Inventor
Djuro Josic
Lutz Hoffer
Frank Morfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octapharma AG
Original Assignee
Octapharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Octapharma AG filed Critical Octapharma AG
Priority to DE69609054T priority Critical patent/DE69609054T2/en
Application granted granted Critical
Publication of DE69609054D1 publication Critical patent/DE69609054D1/en
Publication of DE69609054T2 publication Critical patent/DE69609054T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

PCT No. PCT/EP96/00636 Sec. 371 Date Nov. 26, 1997 Sec. 102(e) Date Nov. 26, 1997 PCT Filed Feb. 14, 1996 PCT Pub. No. WO96/27003 PCT Pub. Date Sep. 6, 1996A process for the preparation of factor IX from a biological source by chromatography involves prior treatment with ammonium sulfate as a protein precipitant at a concentration of from 1.5-2.3 mol/l.
DE69609054T 1995-02-25 1996-02-14 A PROCESS FOR THE PRODUCTION OF FACTOR IX BIOLOGICAL ORIGIN Expired - Lifetime DE69609054T2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69609054T DE69609054T2 (en) 1995-02-25 1996-02-14 A PROCESS FOR THE PRODUCTION OF FACTOR IX BIOLOGICAL ORIGIN

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19506633A DE19506633A1 (en) 1995-02-25 1995-02-25 Process for the preparation of factor IX from biological sources
PCT/EP1996/000636 WO1996027003A1 (en) 1995-02-25 1996-02-14 A process for the preparation of factor ix from biological sources
DE69609054T DE69609054T2 (en) 1995-02-25 1996-02-14 A PROCESS FOR THE PRODUCTION OF FACTOR IX BIOLOGICAL ORIGIN

Publications (2)

Publication Number Publication Date
DE69609054D1 true DE69609054D1 (en) 2000-08-03
DE69609054T2 DE69609054T2 (en) 2001-03-08

Family

ID=7755037

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19506633A Ceased DE19506633A1 (en) 1995-02-25 1995-02-25 Process for the preparation of factor IX from biological sources
DE69609054T Expired - Lifetime DE69609054T2 (en) 1995-02-25 1996-02-14 A PROCESS FOR THE PRODUCTION OF FACTOR IX BIOLOGICAL ORIGIN

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19506633A Ceased DE19506633A1 (en) 1995-02-25 1995-02-25 Process for the preparation of factor IX from biological sources

Country Status (20)

Country Link
US (1) US5919909A (en)
EP (1) EP0811058B1 (en)
JP (1) JPH11500910A (en)
KR (1) KR100436857B1 (en)
CN (1) CN1105779C (en)
AT (1) ATE194167T1 (en)
AU (1) AU697217B2 (en)
CA (1) CA2213577C (en)
DE (2) DE19506633A1 (en)
DK (1) DK0811058T3 (en)
EA (1) EA000222B1 (en)
ES (1) ES2147365T3 (en)
FI (1) FI119377B (en)
GR (1) GR3034035T3 (en)
IL (1) IL117157A (en)
MY (1) MY119366A (en)
PT (1) PT811058E (en)
UA (1) UA46005C2 (en)
WO (1) WO1996027003A1 (en)
ZA (1) ZA961450B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19506633A1 (en) * 1995-02-25 1996-08-29 Octapharma Ag Process for the preparation of factor IX from biological sources
AT405608B (en) * 1997-04-08 1999-10-25 Immuno Ag METHOD FOR INACTIVATING PATHOGENS, ESPECIALLY VIRUSES, IN A BIOLOGICAL MATERIAL
JP4855074B2 (en) * 2003-09-30 2012-01-18 一般財団法人化学及血清療法研究所 High-purity blood coagulation factor IX preparation and purification method thereof
KR100567448B1 (en) * 2003-11-05 2006-04-04 주식회사 인투젠 Methods of preparation of milk from transgenic animals and their use for the purification of human proteins in milk
ATE489105T1 (en) 2004-03-19 2010-12-15 Baxter Int FACTOR IXA FOR THE TREATMENT OF BLEEDING DISORDERS
US10434492B2 (en) * 2007-01-26 2019-10-08 Sigma-Aldrich Co. Llc Compositions and methods for solid phase extraction of lipids
US10928366B2 (en) * 2007-01-26 2021-02-23 Sigma-Aldrich Co. Llc Compositions and methods for combining protein precipitation and solid phase extraction
EP3133157B1 (en) * 2010-03-30 2019-05-08 Octapharma AG A process for purifying vitamin k dependent proteins
CN104560925B (en) * 2014-12-30 2017-11-03 山东泰邦生物制品有限公司 A kind of method that activation prepares human thrombin in chromatography waste liquid from humanclottingfactorⅨ
CN107540743A (en) * 2017-10-11 2018-01-05 南岳生物制药有限公司 A kind of method that bilayer chromatography prepares human fibrinogen
CN111378029B (en) * 2018-12-29 2023-05-05 四川远大蜀阳药业有限责任公司 Preparation method of human coagulation factor IX

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124506B1 (en) * 1983-05-02 1988-08-17 IMMUNO Aktiengesellschaft für chemisch-medizinische Produkte Method of inactivating pathogens
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
ES2045167T5 (en) * 1987-10-23 1996-07-01 Centre Regional De Transfusion PREPARATION OF HUMAN FACTOR IX CONCENTRATE OF HIGH PURITY AND OTHER PLASMA PROTEINS.
AT402261B (en) * 1991-01-25 1997-03-25 Immuno Ag COMPLEX CONTAINING THE coagulation factor IX
EP0573605B1 (en) * 1991-03-01 2000-08-30 Rhone-Poulenc Rorer International (Holdings) Inc. Preparation of factor ix
CA2155337A1 (en) 1993-02-09 1994-08-18 Monika Stadler Method for inactivating viruses devoid of lipid envelopes
DE19506633A1 (en) * 1995-02-25 1996-08-29 Octapharma Ag Process for the preparation of factor IX from biological sources

Also Published As

Publication number Publication date
CN1181782A (en) 1998-05-13
UA46005C2 (en) 2002-05-15
DE69609054T2 (en) 2001-03-08
CA2213577A1 (en) 1996-09-06
ZA961450B (en) 1996-08-27
FI973469A (en) 1997-08-22
FI119377B (en) 2008-10-31
WO1996027003A1 (en) 1996-09-06
AU697217B2 (en) 1998-10-01
DE19506633A1 (en) 1996-08-29
MY119366A (en) 2005-05-31
AU4876196A (en) 1996-09-18
CA2213577C (en) 2005-01-04
CN1105779C (en) 2003-04-16
IL117157A (en) 1999-12-22
KR100436857B1 (en) 2004-09-21
US5919909A (en) 1999-07-06
FI973469A0 (en) 1997-08-22
ATE194167T1 (en) 2000-07-15
EP0811058B1 (en) 2000-06-28
DK0811058T3 (en) 2000-10-16
PT811058E (en) 2000-10-31
EP0811058A1 (en) 1997-12-10
JPH11500910A (en) 1999-01-26
EA199700196A1 (en) 1998-02-26
IL117157A0 (en) 1996-06-18
ES2147365T3 (en) 2000-09-01
GR3034035T3 (en) 2000-11-30
KR19980702453A (en) 1998-07-15
EA000222B1 (en) 1998-12-24

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: OCTAPHARMA AG, LACHEN, CH

8364 No opposition during term of opposition