JP2005535698A5 - - Google Patents
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- Publication number
- JP2005535698A5 JP2005535698A5 JP2004527153A JP2004527153A JP2005535698A5 JP 2005535698 A5 JP2005535698 A5 JP 2005535698A5 JP 2004527153 A JP2004527153 A JP 2004527153A JP 2004527153 A JP2004527153 A JP 2004527153A JP 2005535698 A5 JP2005535698 A5 JP 2005535698A5
- Authority
- JP
- Japan
- Prior art keywords
- modafinil
- crl
- solvate
- dose
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 claims 93
- 229960001165 modafinil Drugs 0.000 claims 54
- 239000012453 solvate Substances 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 22
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 18
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 18
- 239000002904 solvent Substances 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 17
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 16
- 238000000634 powder X-ray diffraction Methods 0.000 claims 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 9
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 8
- 206010022437 insomnia Diseases 0.000 claims 7
- 239000000243 solution Substances 0.000 claims 7
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 6
- 208000032140 Sleepiness Diseases 0.000 claims 6
- 206010041349 Somnolence Diseases 0.000 claims 6
- 230000037321 sleepiness Effects 0.000 claims 6
- 239000006104 solid solution Substances 0.000 claims 6
- 238000010438 heat treatment Methods 0.000 claims 5
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 4
- 206010020765 hypersomnia Diseases 0.000 claims 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 4
- 201000003631 narcolepsy Diseases 0.000 claims 4
- 201000002859 sleep apnea Diseases 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 241000282412 Homo Species 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 238000004807 desolvation Methods 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000003756 stirring Methods 0.000 claims 3
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 208000016588 Idiopathic hypersomnia Diseases 0.000 claims 2
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 229940035676 analgesics Drugs 0.000 claims 2
- 239000000730 antalgic agent Substances 0.000 claims 2
- 239000002948 appetite stimulant Substances 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 210000005013 brain tissue Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- QBKFLYWZRMHHRS-UHFFFAOYSA-N chloroform;1,4-dioxane Chemical compound ClC(Cl)Cl.C1COCCO1 QBKFLYWZRMHHRS-UHFFFAOYSA-N 0.000 claims 2
- NWSBNVVOFKKFNV-UHFFFAOYSA-N chloroform;oxolane Chemical compound ClC(Cl)Cl.C1CCOC1 NWSBNVVOFKKFNV-UHFFFAOYSA-N 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 2
- 239000006194 liquid suspension Substances 0.000 claims 2
- 229960005181 morphine Drugs 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000001797 obstructive sleep apnea Diseases 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 1
- 206010000117 Abnormal behaviour Diseases 0.000 claims 1
- 206010013954 Dysphoria Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000020595 eating behavior Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- -1 lyophilizates Substances 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 230000036651 mood Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 238000007614 solvation Methods 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40206402P | 2002-08-09 | 2002-08-09 | |
| US60/402,064 | 2002-08-09 | ||
| US10/635,445 US6992219B2 (en) | 2002-08-09 | 2003-08-07 | Modafinil polymorphic forms |
| US10/635,445 | 2003-08-07 | ||
| PCT/IB2003/003215 WO2004014846A1 (en) | 2002-08-09 | 2003-08-08 | Modafinil polymorphic forms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010235766A Division JP5307106B2 (ja) | 2002-08-09 | 2010-10-20 | モダフィニル多形相 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005535698A JP2005535698A (ja) | 2005-11-24 |
| JP2005535698A5 true JP2005535698A5 (enExample) | 2006-09-07 |
| JP4718177B2 JP4718177B2 (ja) | 2011-07-06 |
Family
ID=31720568
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004527153A Expired - Fee Related JP4718177B2 (ja) | 2002-08-09 | 2003-08-08 | モダフィニル多形相 |
| JP2010235766A Expired - Fee Related JP5307106B2 (ja) | 2002-08-09 | 2010-10-20 | モダフィニル多形相 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010235766A Expired - Fee Related JP5307106B2 (ja) | 2002-08-09 | 2010-10-20 | モダフィニル多形相 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6992219B2 (enExample) |
| EP (2) | EP1575915A1 (enExample) |
| JP (2) | JP4718177B2 (enExample) |
| CN (3) | CN102875429B (enExample) |
| AU (1) | AU2003253128B2 (enExample) |
| CA (4) | CA2804385A1 (enExample) |
| IL (3) | IL166301A (enExample) |
| MX (1) | MXPA05001506A (enExample) |
| NZ (1) | NZ537840A (enExample) |
| WO (1) | WO2004014846A1 (enExample) |
| ZA (1) | ZA200500411B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03000747A (es) | 2000-07-27 | 2003-06-04 | Teva Pharma | Modafinilo cristalino y puro y proceso para prepararlo. |
| ATE374028T1 (de) * | 2001-03-27 | 2007-10-15 | Dainippon Sumitomo Pharma Co | Kristallines isoxazol-derivat und medizinisches präparat daraus |
| US6992219B2 (en) * | 2002-08-09 | 2006-01-31 | Cephalon France | Modafinil polymorphic forms |
| FR2849029B1 (fr) * | 2002-12-20 | 2005-03-18 | Lafon Labor | Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. |
| WO2004075841A2 (en) * | 2003-02-24 | 2004-09-10 | Mallinckrodt Inc. | Process for preparing benzhydrylthioacetamide |
| WO2004083183A1 (en) * | 2003-03-21 | 2004-09-30 | Hetero Drugs Limited | Novel crystalline forms of aripiprazole |
| AU2003223105A1 (en) * | 2003-03-24 | 2004-10-18 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| WO2004085426A1 (en) * | 2003-03-27 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of candesartan cilexetil |
| WO2004087660A1 (en) * | 2003-04-02 | 2004-10-14 | Hetero Drugs Limited | A novel process for amorphous form of donepezil hydrochloride |
| US7560560B2 (en) * | 2003-04-16 | 2009-07-14 | Hetero Drugs Limited | Crystalline forms of donepezil hydrochloride |
| US20040253308A1 (en) * | 2003-04-29 | 2004-12-16 | Barr Laboratories, Inc. | Surface-treated modafinil particles |
| ES2330321T3 (es) | 2003-05-16 | 2009-12-09 | Cephalon France | Procedimiento de sintesis de modafinilo. |
| US7368591B2 (en) | 2003-09-19 | 2008-05-06 | Cephalon France | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
| ES2803516T3 (es) | 2003-10-16 | 2021-01-27 | Symed Labs Ltd | Una forma cristalina de linezolid |
| US20090018202A1 (en) | 2004-02-06 | 2009-01-15 | Cephalon, Inc. | Modafinil compositions |
| EP2292213A1 (en) * | 2004-02-06 | 2011-03-09 | Cephalon, Inc. | Compositions comprising a polymorphic form of armodafinil |
| WO2005099822A2 (en) * | 2004-04-13 | 2005-10-27 | Cephalon, Inc. | Reduction of drug / drug interactions with modafinil |
| ES2294494T3 (es) * | 2004-04-19 | 2008-04-01 | Symed Labs Limited | Un nuevo procedimiento para la preparacion de linezolid y compuestos relacionados. |
| ATE483455T1 (de) | 2004-05-28 | 2010-10-15 | Transform Pharmaceuticals Inc | Mischkristalle sowie sie enthaltende pharmazeutische zusammensetzungen |
| CA2754932C (en) | 2004-07-20 | 2014-04-01 | Warner-Lambert Company Llc | Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
| WO2006018853A2 (en) | 2004-08-19 | 2006-02-23 | Hetero Drugs Limited | Novel polymorphs of efavirenz |
| EP1909573A4 (en) * | 2005-07-21 | 2010-09-22 | Neurohealing Pharmaceuticals I | SHORT-TERM EFFECTIVE MODAFINIL COMPOSITIONS WITH A RAPID INITIAL EFFECT, AND METHOD FOR THEIR USE |
| US7518019B2 (en) * | 2006-06-01 | 2009-04-14 | Hetero Drugs Limited | Processes for preparing sertraline hydrochloride crystalline forms |
| JP2009543803A (ja) * | 2006-07-12 | 2009-12-10 | エラン・ファルマ・インターナショナル・リミテッド | モダフィニルのナノ粒子製剤 |
| DK2056811T3 (en) * | 2006-08-14 | 2018-05-22 | Neurohealing Pharmaceuticals Inc | Modafinil-based treatment for premature ejaculation |
| EP2083628A1 (en) | 2006-11-10 | 2009-08-05 | Basf Se | Crystalline modification of fipronil |
| UA110598C2 (uk) | 2006-11-10 | 2016-01-25 | Басф Се | Спосіб одержання кристалічної модифікації фіпронілу |
| HRP20110641T4 (hr) | 2006-11-10 | 2015-05-22 | Basf Se | Kristalna modifikacija fipronila |
| US20100093804A1 (en) * | 2006-12-07 | 2010-04-15 | Hetero Drugs Limited | novel crystalline form of lansoprazole |
| CN101641090B (zh) * | 2006-12-19 | 2012-12-05 | 亚勒斯有限公司 | 莫达非尼在制备治疗多动腿综合征的药物中的应用 |
| CA2688430A1 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Novel process |
| FR2923482B1 (fr) * | 2007-11-09 | 2010-01-29 | Servier Lab | Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| AR066166A1 (es) * | 2007-09-21 | 2009-07-29 | Organon Nv | Sistema de suministro de droga |
| US20090105346A1 (en) * | 2007-10-02 | 2009-04-23 | Alexandr Jegorov | Novel crystalline forms of armodafinil and preparation thereof |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| WO2015086489A1 (en) | 2013-12-11 | 2015-06-18 | Merck Sharp & Dohme B.V. | Drug delivery system for delivery of anti-virals |
| US10413504B2 (en) | 2013-12-11 | 2019-09-17 | Merck Sharp & Dohme Corp. | Intravaginal ring drug delivery system |
| US9616068B2 (en) | 2014-10-27 | 2017-04-11 | Pohela LLC | Animal training using cognitive enhancement |
| ES3060948T3 (en) | 2020-09-14 | 2026-03-30 | Pharma Cinq Llc | 2',3'-diacetyluridine substituted with acetoacetyl at the 5' position |
| DK4255563T3 (da) | 2020-12-01 | 2026-03-16 | Pharma Cinq Llc | 5´-o-phenylacetyluridin og terapeutisk anvendelse |
| EP4294405A4 (en) | 2021-02-21 | 2025-01-29 | Pharma Cinq, LLC | COMPOSITIONS AND COMPOUNDS FOR CO-ADMINISTRATION OF URIDINE AND KETOLEUCINE |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1520812A (en) * | 1975-10-02 | 1978-08-09 | Lafon Labor | Benzhydrylsulphinyl derivatives |
| GB1584462A (en) * | 1977-03-31 | 1981-02-11 | Lafon Labor | N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them |
| FR2593809B1 (fr) * | 1986-01-31 | 1988-07-22 | Lafon Labor | Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique |
| FR2663225B1 (fr) | 1990-06-14 | 1994-11-04 | Lafon Labor | Nouvelle utilisation du modafinil. |
| FR2684875B1 (fr) | 1991-12-13 | 1995-05-24 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique. |
| FR2697162B1 (fr) | 1992-10-23 | 1995-01-13 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux. |
| FR2706767B1 (enExample) | 1993-06-22 | 1995-09-08 | Lafon Labor | |
| FR2707637B1 (fr) * | 1993-06-30 | 1995-10-06 | Lafon Labor | Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique. |
| US5618845A (en) | 1994-10-06 | 1997-04-08 | Cephalon, Inc. | Acetamide derivative having defined particle size |
| FR2771004B1 (fr) * | 1997-11-19 | 2000-02-18 | Inst Curie | Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse |
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| IL128989A0 (en) | 1999-03-15 | 2000-02-17 | Popov Sergey | Safety trocar assembly |
| US6346548B1 (en) * | 1999-08-16 | 2002-02-12 | Cephalon, Inc. | Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue |
| US6455588B1 (en) | 1999-08-20 | 2002-09-24 | Cephalon, Inc. | Compositions including modafinil for treatment of eating disorders and for appetite stimulation |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| FR2804322B1 (fr) * | 2000-01-31 | 2002-04-19 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies |
| US6492396B2 (en) * | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
| MXPA03000747A (es) * | 2000-07-27 | 2003-06-04 | Teva Pharma | Modafinilo cristalino y puro y proceso para prepararlo. |
| US6489363B2 (en) * | 2000-10-11 | 2002-12-03 | Cephalon, Inc. | Pharmaceutical solutions of modafinil compounds |
| CN1551880A (zh) * | 2001-09-07 | 2004-12-01 | ������ҩ��ҵ����˾ | 阿昔洛韦缬氨酸酯盐酸盐的晶型 |
| US6875893B2 (en) * | 2002-05-23 | 2005-04-05 | Cephalon, Inc. | Preparations of a sulfinyl acetamide |
| US6992219B2 (en) * | 2002-08-09 | 2006-01-31 | Cephalon France | Modafinil polymorphic forms |
| AR045314A1 (es) * | 2003-05-13 | 2005-10-26 | Cephalon Inc | Composiciones farmaceuticas de analepticos y antidepresivos |
| US20040242698A1 (en) * | 2003-05-13 | 2004-12-02 | Cephalon Inc. | Analeptic and antidepressant combinations |
| US20040229941A1 (en) * | 2003-05-13 | 2004-11-18 | Cephalon, Inc. | Analeptic and antidepressant combinations |
| AR045423A1 (es) * | 2003-05-13 | 2005-10-26 | Cephalon Inc | Combinaciones de analiticos y antidepresivos |
| ES2330321T3 (es) | 2003-05-16 | 2009-12-09 | Cephalon France | Procedimiento de sintesis de modafinilo. |
| US20040229943A1 (en) * | 2003-05-16 | 2004-11-18 | Cephalon Inc | Analeptic and drug combinations |
-
2003
- 2003-08-07 US US10/635,445 patent/US6992219B2/en not_active Expired - Fee Related
- 2003-08-08 CN CN201210395545.8A patent/CN102875429B/zh not_active Expired - Fee Related
- 2003-08-08 MX MXPA05001506A patent/MXPA05001506A/es active IP Right Grant
- 2003-08-08 CA CA2804385A patent/CA2804385A1/en not_active Abandoned
- 2003-08-08 CA CA2840721A patent/CA2840721C/en not_active Expired - Fee Related
- 2003-08-08 AU AU2003253128A patent/AU2003253128B2/en not_active Ceased
- 2003-08-08 CA CA2746788A patent/CA2746788C/en not_active Expired - Fee Related
- 2003-08-08 CA CA2494010A patent/CA2494010C/en not_active Expired - Fee Related
- 2003-08-08 JP JP2004527153A patent/JP4718177B2/ja not_active Expired - Fee Related
- 2003-08-08 CN CN2012103955547A patent/CN102875430A/zh active Pending
- 2003-08-08 EP EP03784340A patent/EP1575915A1/en not_active Withdrawn
- 2003-08-08 NZ NZ537840A patent/NZ537840A/en not_active IP Right Cessation
- 2003-08-08 WO PCT/IB2003/003215 patent/WO2004014846A1/en not_active Ceased
- 2003-08-08 CN CNB038190850A patent/CN100506790C/zh not_active Expired - Fee Related
- 2003-08-08 EP EP11171058A patent/EP2402311A1/en not_active Withdrawn
-
2005
- 2005-01-13 IL IL166301A patent/IL166301A/en not_active IP Right Cessation
- 2005-01-17 ZA ZA2005/00411A patent/ZA200500411B/en unknown
- 2005-10-12 US US11/248,442 patent/US7405323B2/en not_active Expired - Fee Related
-
2007
- 2007-12-14 US US11/956,877 patent/US7649020B2/en not_active Expired - Fee Related
-
2010
- 2010-10-20 JP JP2010235766A patent/JP5307106B2/ja not_active Expired - Fee Related
- 2010-12-13 IL IL209966A patent/IL209966A/en not_active IP Right Cessation
- 2010-12-13 IL IL209965A patent/IL209965A0/en unknown
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