CN101619033B - 莫达非尼多晶型 - Google Patents
莫达非尼多晶型 Download PDFInfo
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- CN101619033B CN101619033B CN 200910203850 CN200910203850A CN101619033B CN 101619033 B CN101619033 B CN 101619033B CN 200910203850 CN200910203850 CN 200910203850 CN 200910203850 A CN200910203850 A CN 200910203850A CN 101619033 B CN101619033 B CN 101619033B
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Images
Abstract
Description
阶段1第1天 | 阶段2第8天 | 阶段3第15天 | |
狗1 | B | C | A |
狗2 | C | A | B |
狗3 | A | B | C |
狗4 | C | B | A |
狗5 | B | A | C |
狗6 | A | C | B |
晶型 | Cmax(μg/ml) | C4h(μg/ml) | AUC0-24h(h.μg/ml) | 标准化的AUC |
I | 18.60±2.30 | 15.37±2.56 | 164.80±23.75 | 5.49 |
IV | 24.98±1.12 | 21.23±1.88 | 200.69±18.09 | 6.69 |
晶型 | MRT(h) | C1h(μg/ml) | C1.5h(μg/ml) | C2h(μg/ml) | C2.5h(μg/ml) | Cmax(μg/ml) | Tmax(h) |
I | 6.91±0.53 | 8.81±2.45 | 12.73±2.39 | 14.16±2.23 | 14.23±1.95 | 18.60±2.30 | 3.00 |
V | 6.11±0.36 | 12.41±2.07 | 15.31±2.06 | 16.56±2.48 | 16.37±2.38 | 18.72±2.09 | 1.67 |
Claims (11)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40206402P | 2002-08-09 | 2002-08-09 | |
US60/402,064 | 2002-08-09 | ||
US10/635,445 | 2003-08-07 | ||
US10/635,445 US6992219B2 (en) | 2002-08-09 | 2003-08-07 | Modafinil polymorphic forms |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB038190850A Division CN100506790C (zh) | 2002-08-09 | 2003-08-08 | 莫达非尼多晶型 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101619033A CN101619033A (zh) | 2010-01-06 |
CN101619033B true CN101619033B (zh) | 2013-07-31 |
Family
ID=41512453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200910203850 Expired - Fee Related CN101619033B (zh) | 2002-08-09 | 2003-08-08 | 莫达非尼多晶型 |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN101619033B (zh) |
AR (1) | AR040831A1 (zh) |
TW (1) | TW200413296A (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4177290A (en) * | 1977-03-31 | 1979-12-04 | Laboratoire L. Lafon | Acetamide derivatives |
WO2002010125A1 (en) * | 2000-07-27 | 2002-02-07 | Teva Pharmaceutical Industries Ltd. | Crystalline and pure modafinil, and process of preparing the same |
-
2003
- 2003-08-06 TW TW92121505A patent/TW200413296A/zh unknown
- 2003-08-08 CN CN 200910203850 patent/CN101619033B/zh not_active Expired - Fee Related
- 2003-08-08 AR ARP030102871 patent/AR040831A1/es unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4177290A (en) * | 1977-03-31 | 1979-12-04 | Laboratoire L. Lafon | Acetamide derivatives |
WO2002010125A1 (en) * | 2000-07-27 | 2002-02-07 | Teva Pharmaceutical Industries Ltd. | Crystalline and pure modafinil, and process of preparing the same |
Also Published As
Publication number | Publication date |
---|---|
TW200413296A (en) | 2004-08-01 |
CN101619033A (zh) | 2010-01-06 |
AR040831A1 (es) | 2005-04-20 |
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