JP2005533770A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005533770A5 JP2005533770A5 JP2004508811A JP2004508811A JP2005533770A5 JP 2005533770 A5 JP2005533770 A5 JP 2005533770A5 JP 2004508811 A JP2004508811 A JP 2004508811A JP 2004508811 A JP2004508811 A JP 2004508811A JP 2005533770 A5 JP2005533770 A5 JP 2005533770A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- liquid pharmaceutical
- pharmaceutical formulation
- subject
- tobacco
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims 61
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 54
- 229960002715 nicotine Drugs 0.000 claims 51
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 51
- 239000008194 pharmaceutical composition Substances 0.000 claims 48
- 238000000034 method Methods 0.000 claims 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 15
- 241000208125 Nicotiana Species 0.000 claims 14
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 14
- 239000008280 blood Substances 0.000 claims 14
- 210000004369 blood Anatomy 0.000 claims 14
- 230000000391 smoking effect Effects 0.000 claims 14
- 239000000825 pharmaceutical preparation Substances 0.000 claims 11
- 238000010521 absorption reaction Methods 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical class CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000000779 smoke Substances 0.000 claims 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 4
- 239000006172 buffering agent Substances 0.000 claims 4
- 230000003139 buffering effect Effects 0.000 claims 4
- 239000012458 free base Substances 0.000 claims 4
- 210000004072 lung Anatomy 0.000 claims 4
- 238000010979 pH adjustment Methods 0.000 claims 4
- 230000002685 pulmonary effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- 239000007791 liquid phase Substances 0.000 claims 3
- 210000000214 mouth Anatomy 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 208000025569 Tobacco Use disease Diseases 0.000 claims 2
- 239000002253 acid Chemical class 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 2
- 229940112822 chewing gum Drugs 0.000 claims 2
- 235000015218 chewing gum Nutrition 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 239000007937 lozenge Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- -1 monocarbonates Chemical class 0.000 claims 2
- 239000007922 nasal spray Substances 0.000 claims 2
- 229940097496 nasal spray Drugs 0.000 claims 2
- 229910017604 nitric acid Inorganic materials 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 230000003068 static effect Effects 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-M L-tartrate(1-) Chemical compound OC(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-M 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- FDIWRLNJDKKDHB-UHFFFAOYSA-N azanium;2-aminoacetate Chemical compound [NH4+].NCC([O-])=O FDIWRLNJDKKDHB-UHFFFAOYSA-N 0.000 claims 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims 1
- 239000000920 calcium hydroxide Substances 0.000 claims 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims 1
- 239000000292 calcium oxide Substances 0.000 claims 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940050410 gluconate Drugs 0.000 claims 1
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 230000021962 pH elevation Effects 0.000 claims 1
- 230000020477 pH reduction Effects 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 230000037221 weight management Effects 0.000 claims 1
- 239000002888 zwitterionic surfactant Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201669-9 | 2002-06-03 | ||
| SE0201669A SE0201669D0 (sv) | 2002-06-03 | 2002-06-03 | New formulation and use thereof |
| PCT/SE2003/000890 WO2003101454A1 (en) | 2002-06-03 | 2003-05-30 | A buffered, liquid nicotine composition for pulmonary administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010208203A Division JP5430525B2 (ja) | 2002-06-03 | 2010-09-16 | 肺投与のための緩衝化液状ニコチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005533770A JP2005533770A (ja) | 2005-11-10 |
| JP2005533770A5 true JP2005533770A5 (https=) | 2006-06-22 |
| JP4745658B2 JP4745658B2 (ja) | 2011-08-10 |
Family
ID=20288046
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508811A Expired - Lifetime JP4745658B2 (ja) | 2002-06-03 | 2003-05-30 | 肺投与のための緩衝化液状ニコチン組成物 |
| JP2010208203A Expired - Lifetime JP5430525B2 (ja) | 2002-06-03 | 2010-09-16 | 肺投与のための緩衝化液状ニコチン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010208203A Expired - Lifetime JP5430525B2 (ja) | 2002-06-03 | 2010-09-16 | 肺投与のための緩衝化液状ニコチン組成物 |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1509227B9 (https=) |
| JP (2) | JP4745658B2 (https=) |
| CN (1) | CN100500148C (https=) |
| AR (1) | AR039947A1 (https=) |
| AT (1) | ATE444753T1 (https=) |
| AU (1) | AU2003243074B2 (https=) |
| BR (1) | BR0311451A (https=) |
| CA (1) | CA2487699C (https=) |
| DE (1) | DE60329592D1 (https=) |
| DK (1) | DK1509227T3 (https=) |
| ES (1) | ES2332405T3 (https=) |
| IL (1) | IL165195A0 (https=) |
| MX (1) | MXPA04012041A (https=) |
| NZ (1) | NZ536863A (https=) |
| RU (1) | RU2283111C2 (https=) |
| SE (1) | SE0201669D0 (https=) |
| TW (1) | TW200407142A (https=) |
| WO (1) | WO2003101454A1 (https=) |
| ZA (1) | ZA200409793B (https=) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| CN100381083C (zh) | 2003-04-29 | 2008-04-16 | 韩力 | 一种非可燃性电子喷雾香烟 |
| CN2719043Y (zh) | 2004-04-14 | 2005-08-24 | 韩力 | 雾化电子烟 |
| RS56037B1 (sr) | 2004-06-24 | 2017-09-29 | Vertex Pharma | Modulatori atp-vezujućih kasetnih transportera |
| US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
| EP3219705B1 (en) | 2005-12-28 | 2020-03-11 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| CN201067079Y (zh) | 2006-05-16 | 2008-06-04 | 韩力 | 仿真气溶胶吸入器 |
| NZ620027A (en) * | 2007-09-14 | 2015-05-29 | Vertex Pharma | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| AT507187B1 (de) | 2008-10-23 | 2010-03-15 | Helmut Dr Buchberger | Inhalator |
| CN201379072Y (zh) | 2009-02-11 | 2010-01-13 | 韩力 | 一种改进的雾化电子烟 |
| PL2408750T3 (pl) | 2009-03-20 | 2016-02-29 | Vertex Pharma | Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy |
| NZ599060A (en) * | 2009-09-16 | 2014-10-31 | Philip Morris Products Sa | Improved device and method for delivery of a medicament |
| AT510837B1 (de) | 2011-07-27 | 2012-07-15 | Helmut Dr Buchberger | Inhalatorkomponente |
| EP2672847B1 (de) | 2011-02-11 | 2015-04-22 | Batmark Limited | Inhalatorkomponente |
| US8903228B2 (en) | 2011-03-09 | 2014-12-02 | Chong Corporation | Vapor delivery devices and methods |
| US9399110B2 (en) | 2011-03-09 | 2016-07-26 | Chong Corporation | Medicant delivery system |
| WO2012120487A2 (en) | 2011-03-09 | 2012-09-13 | Chong Corporation | Medicant delivery system |
| KR102196913B1 (ko) | 2011-09-06 | 2020-12-30 | 니코벤처스 트레이딩 리미티드 | 가열식 흡연가능 재료 |
| KR101752639B1 (ko) | 2011-09-06 | 2017-06-30 | 브리티시 아메리칸 토바코 (인베스트먼츠) 리미티드 | 가열식 끽연 가능 물질 |
| US9907748B2 (en) * | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| AT511344B1 (de) | 2011-10-21 | 2012-11-15 | Helmut Dr Buchberger | Inhalatorkomponente |
| JP2015511583A (ja) | 2012-02-27 | 2015-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的組成物およびその投与 |
| GB201207039D0 (en) | 2012-04-23 | 2012-06-06 | British American Tobacco Co | Heating smokeable material |
| GB2504076A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| GB2504075A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| GB201215273D0 (en) * | 2012-08-28 | 2012-10-10 | Kind Consumer Ltd | Nicotine composition |
| GB201215282D0 (en) | 2012-08-28 | 2012-10-10 | Kind Consumer Ltd | An inhaler |
| US10279934B2 (en) | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| GB2513637A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
| GB2513639A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
| WO2014182736A1 (en) * | 2013-05-06 | 2014-11-13 | Ploom, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
| WO2014190079A2 (en) | 2013-05-22 | 2014-11-27 | Njoy, Inc. | Compositions, devices, and methods for nicotine aerosol delivery |
| GB2514893B (en) | 2013-06-04 | 2017-12-06 | Nicoventures Holdings Ltd | Container |
| US10251422B2 (en) | 2013-07-22 | 2019-04-09 | Altria Client Services Llc | Electronic smoking article |
| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
| US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
| DE202014011261U1 (de) | 2013-12-23 | 2018-11-13 | Juul Labs Uk Holdco Limited | Systeme für eine Verdampfungsvorrichtung |
| USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
| US9839238B2 (en) | 2014-02-28 | 2017-12-12 | Rai Strategic Holdings, Inc. | Control body for an electronic smoking article |
| GB201407426D0 (en) | 2014-04-28 | 2014-06-11 | Batmark Ltd | Aerosol forming component |
| US9896429B2 (en) | 2014-05-27 | 2018-02-20 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| US10508096B2 (en) | 2014-05-27 | 2019-12-17 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| CN113754634A (zh) | 2014-05-27 | 2021-12-07 | R.J.雷诺兹烟草公司 | 烟碱盐、共晶体和盐共晶体络合物 |
| GB2528673B (en) | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| GB2535427A (en) * | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
| GB2532062A (en) * | 2014-11-07 | 2016-05-11 | Nicoventures Holdings Ltd | Container |
| EP3821735B1 (en) | 2014-12-05 | 2024-11-20 | Juul Labs, Inc. | Calibrated dose control |
| GB2533135B (en) | 2014-12-11 | 2020-11-11 | Nicoventures Holdings Ltd | Aerosol provision systems |
| GB201505597D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Article for use with apparatus for heating smokable material |
| GB201505595D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Cartridge for use with apparatus for heating smokeable material |
| GB201511361D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| GB201511349D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
| US11924930B2 (en) | 2015-08-31 | 2024-03-05 | Nicoventures Trading Limited | Article for use with apparatus for heating smokable material |
| US20170055584A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Article for use with apparatus for heating smokable material |
| GB201516729D0 (en) * | 2015-09-22 | 2015-11-04 | The Technology Partnership Plc | Liquid nicotine formulation |
| GB2542838B (en) | 2015-10-01 | 2022-01-12 | Nicoventures Trading Ltd | Aerosol provision system |
| US20170119046A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Apparatus for Heating Smokable Material |
| DK3379952T3 (da) * | 2015-11-25 | 2024-01-08 | Reynolds Tobacco Co R | Nikotinsalte, co-krystaller og salt-co-krystalkomplekser |
| US9867397B2 (en) | 2016-01-11 | 2018-01-16 | Patrick Beymer | Nicotine delivery system |
| EP3413960B1 (en) | 2016-02-11 | 2021-03-31 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| EA039727B1 (ru) | 2016-02-11 | 2022-03-04 | Джуул Лэбз, Инк. | Надежно прикрепляющиеся картриджи для испарительных устройств |
| JP2019512470A (ja) * | 2016-02-29 | 2019-05-16 | ニコゲン リミテッド | ニコチン配合物及びエアロゾル |
| US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
| WO2017187148A1 (en) | 2016-04-27 | 2017-11-02 | Nicoventures Holdings Limited | Electronic aerosol provision system and vaporizer therefor |
| USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
| USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
| USD848057S1 (en) | 2016-06-23 | 2019-05-07 | Pax Labs, Inc. | Lid for a vaporizer |
| USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
| CN111212576A (zh) * | 2017-06-26 | 2020-05-29 | 纳德尼古丁公司 | 烟碱盐及其制备和使用方法 |
| USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
| GB2569940B (en) * | 2017-11-01 | 2022-10-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| EP3574902A1 (en) * | 2018-06-01 | 2019-12-04 | Yatzz Limited | Nicotine formulation and mode of delivery |
| GB201817860D0 (en) | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolised formulation |
| GB201817864D0 (en) | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB201817863D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB201817867D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB201817859D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| DK3773494T3 (da) | 2019-06-07 | 2022-05-02 | Ncp Nextgen As | Nikotinposesammensætning og pose dermed |
| PL3905908T3 (pl) | 2019-06-20 | 2025-03-24 | Shaheen Innovations Holding Limited | Ultradźwiękowe urządzenie rozpylające do użytku osobistego |
| US11589610B2 (en) | 2019-12-15 | 2023-02-28 | Shaheen Innovations Holding Limited | Nicotine delivery device having a mist generator device and a driver device |
| PL4292632T3 (pl) | 2019-12-15 | 2025-11-24 | Shaheen Innovations Holding Limited | Ultradźwiękowy inhalator mgiełki |
| US11666713B2 (en) | 2019-12-15 | 2023-06-06 | Shaheen Innovations Holding Limited | Mist inhaler devices |
| JP7583061B2 (ja) | 2019-12-15 | 2024-11-13 | シャヒーン イノベーションズ ホールディング リミテッド | 超音波ミスト吸入器 |
| US11911559B2 (en) | 2019-12-15 | 2024-02-27 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler |
| ES3014051T3 (en) | 2019-12-15 | 2025-04-16 | Shaheen Innovations Holding Ltd | Mist inhaler devices |
| US12538944B2 (en) | 2019-12-15 | 2026-02-03 | Shaheen Innovations Holding Limited | Nicotine delivery device with identification arrangement |
| US12121056B2 (en) | 2019-12-15 | 2024-10-22 | Shaheen Innovations Holding Limited | Hookah device |
| US12233207B2 (en) | 2019-12-15 | 2025-02-25 | Shaheen Innovations Holding Limited | Mist inhaler devices |
| US11730193B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
| US12201144B2 (en) | 2019-12-15 | 2025-01-21 | Shaheen Innovations Holding Limited | Hookah device |
| US12213516B2 (en) | 2019-12-15 | 2025-02-04 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler |
| US11944120B2 (en) | 2019-12-15 | 2024-04-02 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler with capillary retainer |
| US11730191B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
| US20230188901A1 (en) | 2021-12-15 | 2023-06-15 | Shaheen Innovations Holding Limited | Apparatus for transmitting ultrasonic waves |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2030862A (en) * | 1978-04-10 | 1980-04-16 | Smith A | A composition for treating drug addiction such as smoking nicotine-containing products |
| DE3241437A1 (de) * | 1982-11-10 | 1984-05-10 | Ferdinand Prof. Dr.med. 6901 Wilhelmsfeld Schmidt | Mittel zum zwecke der raucherentwoehnung und/oder fuer nebenwirkungsfreien nikotingenuss bei suchtrauchern |
| GB8301659D0 (en) * | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
| US4953572A (en) * | 1985-04-25 | 1990-09-04 | Rose Jed E | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
| US4920989A (en) * | 1985-04-25 | 1990-05-01 | Regents Of The University Of California | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
| US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5135753A (en) * | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| GB9200047D0 (en) * | 1992-01-03 | 1992-02-26 | Univ Alberta | Nicotine-containing nasal spray |
| RU2108089C1 (ru) * | 1995-05-19 | 1998-04-10 | Акционерное общество "Афродита" | Шампунь для мытья волос |
| PT906089E (pt) * | 1996-05-13 | 2004-01-30 | Novartis Consumer Health Sa | Sistema de administracao bucal |
-
2002
- 2002-06-03 SE SE0201669A patent/SE0201669D0/xx unknown
-
2003
- 2003-05-27 TW TW092114309A patent/TW200407142A/zh unknown
- 2003-05-30 RU RU2004139067/15A patent/RU2283111C2/ru active
- 2003-05-30 MX MXPA04012041A patent/MXPA04012041A/es active IP Right Grant
- 2003-05-30 JP JP2004508811A patent/JP4745658B2/ja not_active Expired - Lifetime
- 2003-05-30 ES ES03756140T patent/ES2332405T3/es not_active Expired - Lifetime
- 2003-05-30 CA CA2487699A patent/CA2487699C/en not_active Expired - Lifetime
- 2003-05-30 DE DE60329592T patent/DE60329592D1/de not_active Expired - Lifetime
- 2003-05-30 CN CNB038128098A patent/CN100500148C/zh not_active Expired - Lifetime
- 2003-05-30 DK DK03756140.4T patent/DK1509227T3/da active
- 2003-05-30 WO PCT/SE2003/000890 patent/WO2003101454A1/en not_active Ceased
- 2003-05-30 AT AT03756140T patent/ATE444753T1/de not_active IP Right Cessation
- 2003-05-30 NZ NZ536863A patent/NZ536863A/en not_active IP Right Cessation
- 2003-05-30 BR BR0311451-1A patent/BR0311451A/pt not_active Application Discontinuation
- 2003-05-30 EP EP03756140A patent/EP1509227B9/en not_active Expired - Lifetime
- 2003-05-30 AU AU2003243074A patent/AU2003243074B2/en not_active Expired
- 2003-06-02 AR ARP030101967A patent/AR039947A1/es unknown
-
2004
- 2004-11-14 IL IL16519504A patent/IL165195A0/xx unknown
- 2004-12-02 ZA ZA200409793A patent/ZA200409793B/en unknown
-
2010
- 2010-09-16 JP JP2010208203A patent/JP5430525B2/ja not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005533770A5 (https=) | ||
| RU2004139067A (ru) | Забуференная жидкая никотиновая композиция для легочного введения | |
| US7767698B2 (en) | Formulation and use thereof | |
| RU2279871C2 (ru) | Жидкая фармацевтическая композиция, содержащая никотин, для введения в полость рта | |
| EP1648421B1 (en) | Orally dissolving films | |
| US20130237570A1 (en) | Formulation and Use and Manufacture Thereof | |
| CA2687085A1 (en) | Anti-insomnia compositions and methods | |
| US20240350476A1 (en) | Smoking Cessation Aid | |
| US20030171408A1 (en) | Therapeutic method of delivering a medicament to avoid irritating effects on membranes of user | |
| HK1169802B (en) | Orally dissolving films |