JP2005531614A5 - - Google Patents
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- Publication number
- JP2005531614A5 JP2005531614A5 JP2004512791A JP2004512791A JP2005531614A5 JP 2005531614 A5 JP2005531614 A5 JP 2005531614A5 JP 2004512791 A JP2004512791 A JP 2004512791A JP 2004512791 A JP2004512791 A JP 2004512791A JP 2005531614 A5 JP2005531614 A5 JP 2005531614A5
- Authority
- JP
- Japan
- Prior art keywords
- pora
- vesicle
- meningococcal
- deficient
- strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 claims 11
- 230000002950 deficient Effects 0.000 claims 10
- 229960005486 vaccines Drugs 0.000 claims 7
- 241000588653 Neisseria Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000287798 Neisseria meningitidis CU385 Species 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Claims (12)
- PorAの量が株H44/76から作製された同量の小胞と比較して80％未満である、PorAを欠損した小胞調製物、および株H44/76から作製された小胞と比較してPorAを欠損していない小胞調製物を含む、多価髄膜炎菌小胞組成物。
- PorAを欠損していない小胞調製物が、使用する国で流行する血清亜型を有する髄膜炎菌株由来である、請求項１記載の多価髄膜炎菌小胞組成物。
- PorAを欠損した小胞調製物が、全小胞タンパク質の22％未満のPorAを有するかまたはPorAを全く有しない、請求項１または２記載の多価髄膜炎菌小胞組成物。
- PorAを欠損していない小胞調製物が、全小胞タンパク質の28％を超えるPorAを有する、請求項１〜３のいずれか1項に記載の多価髄膜炎菌小胞組成物。
- PorAを欠損した小胞調製物が髄膜炎菌CU-385株由来である、請求項１〜４のいずれか1項に記載の多価髄膜炎菌小胞組成物。
- 請求項１〜５のいずれか1項に記載の多価髄膜炎菌小胞組成物、および製薬上許容され得る賦形剤を含む、ナイセリア性、好ましくは髄膜炎菌性の疾患の治療のためのワクチン。
- 1つ以上のそのままかまたはコンジュゲートされた、以下の血清型A、C、YおよびWより選択される髄膜炎菌莢膜多糖体をさらに含む、請求項６記載のワクチン。
- PorAを欠損していない小胞調製物が、P1.4の血清亜型を有する髄膜炎菌株由来である、ニュージーランドまたはヨーロッパでの使用に適した請求項６または７記載のワクチン。
- PorAを欠損していない小胞調製物が、P1.7,16の血清亜型を有する髄膜炎菌株由来である、アメリカ合衆国での使用に適した、請求項６または７記載のワクチン。
- PorAを欠損していない小胞調製物が、P1.16の血清亜型を有する髄膜炎菌株由来である、ノルウェーでの使用に適した請求項６または７記載のワクチン。
- PorAを欠損していない小胞調製物とPorAを欠損する小胞調製物とを混合するステップを含む、請求項１〜５のいずれか1項に記載の多価髄膜炎菌小胞組成物、または請求項６〜１０のいずれか1項に記載のワクチンを製造する方法。
- ナイセリア性の、好ましくは髄膜炎菌性の疾患の予防または治療のための薬物の製造における、免疫学的に有効な量の請求項６〜１０のいずれか1項に記載のワクチンの使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0213622.4A GB0213622D0 (en) | 2002-06-13 | 2002-06-13 | Vaccine Corporation |
| PCT/EP2003/006094 WO2003105890A2 (en) | 2002-06-13 | 2003-06-10 | Vaccine composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531614A JP2005531614A (ja) | 2005-10-20 |
| JP2005531614A5 true JP2005531614A5 (ja) | 2006-07-27 |
Family
ID=9938532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004512791A Pending JP2005531614A (ja) | 2002-06-13 | 2003-06-10 | ワクチン組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20060110412A1 (ja) |
| EP (1) | EP1565211A2 (ja) |
| JP (1) | JP2005531614A (ja) |
| KR (1) | KR20050049431A (ja) |
| CN (1) | CN100387298C (ja) |
| AR (1) | AR040204A1 (ja) |
| AU (1) | AU2003236734A1 (ja) |
| BR (1) | BR0311777A (ja) |
| CA (1) | CA2488782A1 (ja) |
| CL (1) | CL2003001192A1 (ja) |
| CU (1) | CU23552A1 (ja) |
| GB (1) | GB0213622D0 (ja) |
| MX (1) | MXPA04012568A (ja) |
| NO (1) | NO20050132L (ja) |
| NZ (1) | NZ560766A (ja) |
| PE (1) | PE20040562A1 (ja) |
| RU (1) | RU2005100509A (ja) |
| UY (1) | UY27843A1 (ja) |
| WO (1) | WO2003105890A2 (ja) |
| ZA (1) | ZA200409547B (ja) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2416137C (en) | 2000-07-27 | 2013-01-29 | Dan Granoff | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| GB2414667A (en) * | 2004-06-03 | 2005-12-07 | Isis Innovation | Vaccine compositions of N. meningitidis PorA and FetA antigens |
| GB0419627D0 (en) * | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| EP2682126B1 (en) | 2005-01-27 | 2016-11-23 | Children's Hospital & Research Center at Oakland | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| AR058592A1 (es) * | 2005-12-22 | 2008-02-13 | Glaxosmithkline Biolog Sa | Vacuna |
| PL2097102T3 (pl) | 2006-09-07 | 2012-10-31 | Glaxosmithkline Biologicals Sa | Szczepionka skojarzona o zmniejszonej ilości antygenu wirusa polio |
| PT2200642E (pt) | 2007-10-19 | 2012-05-30 | Novartis Ag | Formulações de vacinas meningocócicas |
| WO2009062132A2 (en) | 2007-11-09 | 2009-05-14 | California Institute Of Technology | Immunomodulating compounds and related compositions and methods |
| JP5697991B2 (ja) * | 2008-02-01 | 2015-04-08 | サノフィ パストゥール リミテッドＳａｎｏｆｉ Ｐａｓｔｅｕｒ Ｌｉｍｉｔｅｄ | 診断的アッセイ |
| PT2268618E (pt) | 2008-03-03 | 2015-10-12 | Novartis Ag | Compostos e composições moduladores da actividade tlr |
| US20100189737A1 (en) | 2008-12-17 | 2010-07-29 | Arico Beatrice | Meningococcal vaccines including hemoglobin receptor |
| WO2010144734A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| NZ598459A (en) | 2009-08-27 | 2014-03-28 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| TWI445708B (zh) | 2009-09-02 | 2014-07-21 | Irm Llc | 作為ｔｌｒ活性調節劑之化合物及組合物 |
| US8691522B2 (en) * | 2009-10-08 | 2014-04-08 | Aeon Medix Inc. | Composition comprising extracellular membrane vesicles derived from indoor air, and use thereof |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| AU2010339921B2 (en) | 2009-12-15 | 2016-08-11 | Glaxosmithkline Biologicals S.A. | Homogeneous suspension of immunopotentiating compounds and uses thereof |
| AU2010335970B2 (en) * | 2009-12-22 | 2016-11-03 | Sanofi Pasteur Limited | Immunogenic compositions |
| JP2013522287A (ja) | 2010-03-18 | 2013-06-13 | ノバルティス アーゲー | 血清群ｂ髄膜炎菌のためのアジュバント添加ワクチン |
| WO2011119759A1 (en) | 2010-03-23 | 2011-09-29 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| WO2011127302A2 (en) | 2010-04-07 | 2011-10-13 | Yue Shen | Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems |
| AU2011300418B2 (en) | 2010-09-10 | 2016-05-12 | Glaxosmithkline Biologicals Sa | Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom |
| EP2707009A1 (en) | 2011-05-12 | 2014-03-19 | Novartis AG | Antipyretics to enhance tolerability of vesicle-based vaccines |
| WO2013009945A1 (en) | 2011-07-12 | 2013-01-17 | The Brigham And Women's Hospital, Inc. | Lipid-containing psa compositions, methods of isolation and methods of use thereof |
| BR112014019166A2 (pt) | 2012-02-02 | 2017-07-04 | Novartis Ag | promotores para expressão aumentada de proteína em meningococos |
| EP2823312B1 (en) | 2012-03-08 | 2019-08-07 | GlaxoSmithKline Biologicals SA | In vitro potency assay for protein-based meningococcal vaccines |
| JP2015521595A (ja) | 2012-06-14 | 2015-07-30 | ノバルティス アーゲー | 血清群ｘ髄膜炎菌のためのワクチン |
| RU2015106930A (ru) | 2012-09-06 | 2016-10-20 | Новартис Аг | Комбинированные вакцины с менингококком серогруппы в и к/д/с |
| US11331335B2 (en) | 2015-06-10 | 2022-05-17 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| CN108135167B (zh) | 2015-08-19 | 2021-07-09 | 哈佛学院院长及董事 | 脂化psa组合物和方法 |
| WO2018014012A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| AU2017321039B2 (en) | 2016-09-02 | 2021-03-18 | Glaxosmithkline Biologicals Sa | Vaccines for Neisseria gonorrhoeae |
| KR20230112625A (ko) * | 2020-10-23 | 2023-07-27 | 옴백스 인코포레이티드 | 나이세리아 고노레아에 대한 백신접종을 위한 조성물 및 방법 |
| GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9811475A (pt) * | 1997-07-17 | 2000-08-15 | North American Vaccine Inc | Conjugados imunogênicos compreendendo uma porina meningocóccica de grupo b e um polissacarìdeo de h. influenzae |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| CA2416137C (en) * | 2000-07-27 | 2013-01-29 | Dan Granoff | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
-
2002
- 2002-06-13 GB GBGB0213622.4A patent/GB0213622D0/en not_active Ceased
-
2003
- 2003-06-10 US US10/529,064 patent/US20060110412A1/en not_active Abandoned
- 2003-06-10 EP EP03735599A patent/EP1565211A2/en not_active Ceased
- 2003-06-10 NZ NZ560766A patent/NZ560766A/en not_active IP Right Cessation
- 2003-06-10 RU RU2005100509/13A patent/RU2005100509A/ru not_active Application Discontinuation
- 2003-06-10 MX MXPA04012568A patent/MXPA04012568A/es not_active Application Discontinuation
- 2003-06-10 CA CA002488782A patent/CA2488782A1/en not_active Abandoned
- 2003-06-10 JP JP2004512791A patent/JP2005531614A/ja active Pending
- 2003-06-10 BR BR0311777-4A patent/BR0311777A/pt not_active IP Right Cessation
- 2003-06-10 WO PCT/EP2003/006094 patent/WO2003105890A2/en active Application Filing
- 2003-06-10 KR KR1020047019991A patent/KR20050049431A/ko not_active Application Discontinuation
- 2003-06-10 CN CNB038162822A patent/CN100387298C/zh not_active Expired - Fee Related
- 2003-06-10 AU AU2003236734A patent/AU2003236734A1/en not_active Abandoned
- 2003-06-10 CL CL200301192A patent/CL2003001192A1/es unknown
- 2003-06-11 PE PE2003000583A patent/PE20040562A1/es not_active Application Discontinuation
- 2003-06-11 AR ARP030102096A patent/AR040204A1/es not_active Application Discontinuation
- 2003-06-11 UY UY27843A patent/UY27843A1/es unknown
-
2004
- 2004-11-25 ZA ZA200409547A patent/ZA200409547B/en unknown
- 2004-12-10 CU CU20040285A patent/CU23552A1/es active IP Right Grant
-
2005
- 2005-01-11 NO NO20050132A patent/NO20050132L/no not_active Application Discontinuation
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