JP2005531321A - マーカー遺伝子 - Google Patents

マーカー遺伝子 Download PDF

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Publication number
JP2005531321A
JP2005531321A JP2004518691A JP2004518691A JP2005531321A JP 2005531321 A JP2005531321 A JP 2005531321A JP 2004518691 A JP2004518691 A JP 2004518691A JP 2004518691 A JP2004518691 A JP 2004518691A JP 2005531321 A JP2005531321 A JP 2005531321A
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Japan
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aldolase
nephrotoxicity
gene expression
egf
clusterin
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Pending
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JP2004518691A
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Japanese (ja)
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JP2005531321A5 (https=
Inventor
サラ−ディーヌ・チボ
オリヴィエ・グレネ
ジョルジュ・イムベール
ジャンヌ・ケラン
フランク・シュテットラー
カート・ダグラス・ウルフガング
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ノバルティス アクチエンゲゼルシャフト
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Publication of JP2005531321A publication Critical patent/JP2005531321A/ja
Publication of JP2005531321A5 publication Critical patent/JP2005531321A5/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2004518691A 2002-07-04 2003-07-03 マーカー遺伝子 Pending JP2005531321A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0215509.1A GB0215509D0 (en) 2002-07-04 2002-07-04 Marker genes
PCT/EP2003/007111 WO2004005544A2 (en) 2002-07-04 2003-07-03 Marker genes for determining renal toxicity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009233624A Division JP2010042019A (ja) 2002-07-04 2009-10-07 マーカー遺伝子

Publications (2)

Publication Number Publication Date
JP2005531321A true JP2005531321A (ja) 2005-10-20
JP2005531321A5 JP2005531321A5 (https=) 2006-08-17

Family

ID=9939850

Family Applications (2)

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JP2004518691A Pending JP2005531321A (ja) 2002-07-04 2003-07-03 マーカー遺伝子
JP2009233624A Pending JP2010042019A (ja) 2002-07-04 2009-10-07 マーカー遺伝子

Family Applications After (1)

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JP2009233624A Pending JP2010042019A (ja) 2002-07-04 2009-10-07 マーカー遺伝子

Country Status (10)

Country Link
US (1) US20060008804A1 (https=)
EP (2) EP1925677A3 (https=)
JP (2) JP2005531321A (https=)
CN (1) CN1688715A (https=)
AU (1) AU2003250879B2 (https=)
BR (1) BR0312405A (https=)
CA (1) CA2493860A1 (https=)
GB (1) GB0215509D0 (https=)
IL (1) IL165883A0 (https=)
WO (1) WO2004005544A2 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508382A (ja) * 2008-11-10 2012-04-05 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2012510058A (ja) * 2008-11-22 2012-04-26 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2012524883A (ja) * 2008-08-14 2012-10-18 ホスピタル クリニク アイ プロビンシアル デ バルセロナ 腎臓障害生物マーカとしてのwnt1
JP2013031375A (ja) * 2011-07-29 2013-02-14 Medichrome:Kk 遺伝子発現変動解析による化学物質の毒性評価方法
JP2016504017A (ja) * 2012-10-24 2016-02-12 リージェンメドティーエックス, エルエルシー 腎細胞集団及びその使用
JP2016515514A (ja) * 2013-03-15 2016-05-30 ライフライン サイエンティフィック インコーポレイテッドLifeline Scientific, Inc. 臓器または組織の生存性を判定するためのグルコースセンサを備えた搬送装置

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ATE425249T1 (de) 2000-06-16 2009-03-15 Biogen Idec Inc Renale regulatorische elemente und deren verwendung
DK1401869T3 (da) 2001-06-01 2008-04-28 Biogen Idec Inc Molekyler og fremgangsmåder til inhibering af udskillkelse af kim 1
EP2025345A1 (en) 2002-12-30 2009-02-18 Biogen Idec MA Inc. KIM-1 antagonists and use to modulate immune system
CA2565701A1 (en) * 2004-05-06 2005-11-17 Jonathan M. Barasch Ngal for reduction and amelioration of ischemic and nephrotoxic injuries
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
ES2818028T3 (es) * 2004-12-20 2021-04-09 Antibodyshop As Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales
KR101213894B1 (ko) 2005-03-02 2012-12-20 바이오겐 아이덱 엠에이 인코포레이티드 Th2 매개성 병태를 치료하기 위한 kim-1 항체
US20070037232A1 (en) * 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US20070087387A1 (en) 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
US7700299B2 (en) * 2005-08-12 2010-04-20 Hoffmann-La Roche Inc. Method for predicting the response to a treatment
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
PL2035835T3 (pl) 2006-05-30 2012-05-31 Antibodyshop As Sposoby szybkiej oceny ciężkości urazu
WO2008017306A1 (en) * 2006-08-07 2008-02-14 Antibodyshop A/S Diagnostic test to exclude significant renal injury
WO2008113363A1 (en) 2007-03-21 2008-09-25 Bioporto Diagnostics A/S Diagnostic test for renal injury
CN103399155A (zh) * 2007-03-26 2013-11-20 诺瓦提斯公司 用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签
US20090104649A1 (en) 2007-06-11 2009-04-23 Garovic Vesna D Markers for preeclampsia
US8846036B2 (en) 2007-10-19 2014-09-30 Abbott Laboratories Antibodies that bind to mammalian NGAL and uses thereof
ES2475990T5 (es) * 2007-11-15 2017-07-06 Bioporto Diagnostics A/S Uso diagnóstico de formas moleculares individuales de un biomarcador
EP2075343A1 (en) * 2007-12-21 2009-07-01 Gert Mayer A method of diagnosing a progressive disease
EP2279270B1 (en) * 2008-04-15 2014-06-18 Oberbauer, Rainer Markers of acute kidney failure
US7977110B2 (en) 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions
JP2012508177A (ja) * 2008-11-05 2012-04-05 アボット・ラボラトリーズ 尿および組換えチャイニーズハムスター卵巣(cho)細胞から濃縮された好中球ゼラチナーゼ関連リポカリン(ngal)タンパク質アイソフォーム、ならびに関連する組成物、抗体、ならびに濃縮、分析および使用の方法
CN102301008B (zh) * 2009-01-19 2015-05-13 生物梅里埃公司 用于确定患者发生医院内感染的易感性以及确立败血性综合征进展的预后的方法
PT2391653E (pt) 2009-01-28 2015-02-13 Ind Tech Res Inst Biomarcadores associados a nefropatia
US20110065599A1 (en) * 2009-08-07 2011-03-17 Rules-Based Medicine, Inc. Methods and Devices for Detecting Kidney Damage
WO2011084791A2 (en) * 2009-12-21 2011-07-14 Mayo Foundation For Medical Education And Research Early marker of proteinuria in patients treated with an anti-vegf treatment
EP2517020B1 (en) 2009-12-23 2015-10-21 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a canine
WO2011149962A1 (en) 2010-05-24 2011-12-01 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2625189B1 (en) 2010-10-01 2018-06-27 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CN106018783A (zh) * 2011-09-14 2016-10-12 巴斯夫欧洲公司 用于评估肾毒性的手段和方法
DE19216461T1 (de) 2011-10-03 2021-10-07 Modernatx, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
EP2925337B1 (en) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
PL2922554T3 (pl) 2012-11-26 2022-06-20 Modernatx, Inc. Na zmodyfikowany na końcach
EP2971165A4 (en) 2013-03-15 2016-11-23 Moderna Therapeutics Inc DISSOLUTION OF DNA FRAGMENTS IN MRNA MANUFACTURING METHODS
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014182330A1 (en) 2013-05-06 2014-11-13 Hitachi Chemical Company Ltd Devices and methods for capturing target molecules
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2015153860A1 (en) * 2014-04-04 2015-10-08 Somalogic, Inc. Glomerular filtration rate biomarkers and uses thereof
WO2015160805A1 (en) * 2014-04-15 2015-10-22 The Brigham And Women's Hospital, Inc. Circulating kim-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney
US10712349B2 (en) 2014-04-15 2020-07-14 The Brigham And Women's Hospital, Inc. Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney
EP3189164B1 (en) 2014-09-05 2021-11-10 American University Of Beirut Determination of risk for development of cardiovascular disease by measuring urinary levels of podocin and nephrin messenger rna
EP3218521B1 (en) * 2014-11-12 2019-12-25 Hitachi Chemical Co., Ltd. Method for diagnosing organ injury
WO2016208776A1 (ja) 2015-06-25 2016-12-29 株式会社国際電気通信基礎技術研究所 多器官連関システムを基盤とした予測装置、及び予測プログラム
DE112016003948T5 (de) 2015-08-31 2018-05-09 City Of Sapporo Molekulare verfahren zum beurteilen einer urothelialen erkrankung
JP6432962B2 (ja) 2016-03-29 2018-12-05 株式会社国際電気通信基礎技術研究所 腎機能低下、慢性腎疾患及び腎不全からなる群から選択される少なくとも一種の疾患を予防、又は治療するための有効成分の候補物質のスクリーニング方法
EP3466446B1 (en) 2016-03-29 2023-12-27 Karydo Therapeutix, Inc. Pharmaceutical composition or food composition, and method for assessing effect of active ingredient in vivo
JP7012033B2 (ja) * 2016-06-17 2022-02-10 エフ.ホフマン-ラ ロシュ アーゲー インビトロ腎毒性スクリーニングアッセイ
EP3695224A4 (en) * 2017-10-12 2021-12-29 Cedars-Sinai Medical Center Prognosis and progression biomarkers for chronic kidney disease

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WO2000012760A2 (en) * 1998-08-28 2000-03-09 Incyte Pharmaceuticals, Inc. Toxicological response markers
WO2001094636A2 (en) * 2000-06-05 2001-12-13 Genetics Inst Compositions, kits, and methods for identification and modulation of type i diabetes
WO2001098539A2 (en) * 2000-06-21 2001-12-27 Hitachi Chemical Co., Ltd. Gene markers for lung cancer
WO2002010453A2 (en) * 2000-07-31 2002-02-07 Gene Logic, Inc. Molecular toxicology modeling

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012524883A (ja) * 2008-08-14 2012-10-18 ホスピタル クリニク アイ プロビンシアル デ バルセロナ 腎臓障害生物マーカとしてのwnt1
JP2012508382A (ja) * 2008-11-10 2012-04-05 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2012510058A (ja) * 2008-11-22 2012-04-26 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2015064381A (ja) * 2008-11-22 2015-04-09 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
JP2013031375A (ja) * 2011-07-29 2013-02-14 Medichrome:Kk 遺伝子発現変動解析による化学物質の毒性評価方法
JP2016504017A (ja) * 2012-10-24 2016-02-12 リージェンメドティーエックス, エルエルシー 腎細胞集団及びその使用
JP2019141067A (ja) * 2012-10-24 2019-08-29 インリージェン 腎細胞集団及びその使用
US11369639B2 (en) 2012-10-24 2022-06-28 Prokidney Renal cell populations and uses thereof
US12409191B2 (en) 2012-10-24 2025-09-09 Prokidney Renal cell populations and uses thereof
JP2016515514A (ja) * 2013-03-15 2016-05-30 ライフライン サイエンティフィック インコーポレイテッドLifeline Scientific, Inc. 臓器または組織の生存性を判定するためのグルコースセンサを備えた搬送装置
US10420337B2 (en) 2013-03-15 2019-09-24 Lifeline Scientific, Inc. Transporter with a glucose sensor for determining viability of an organ or tissue

Also Published As

Publication number Publication date
IL165883A0 (en) 2006-01-15
BR0312405A (pt) 2005-04-26
JP2010042019A (ja) 2010-02-25
WO2004005544A3 (en) 2004-04-22
EP1925677A3 (en) 2008-07-02
US20060008804A1 (en) 2006-01-12
EP1925677A2 (en) 2008-05-28
AU2003250879A1 (en) 2004-01-23
AU2003250879B2 (en) 2007-07-26
GB0215509D0 (en) 2002-08-14
EP1521847A2 (en) 2005-04-13
CN1688715A (zh) 2005-10-26
CA2493860A1 (en) 2004-01-15
WO2004005544A2 (en) 2004-01-15

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