JP2005530783A5 - - Google Patents
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- Publication number
- JP2005530783A5 JP2005530783A5 JP2004505047A JP2004505047A JP2005530783A5 JP 2005530783 A5 JP2005530783 A5 JP 2005530783A5 JP 2004505047 A JP2004505047 A JP 2004505047A JP 2004505047 A JP2004505047 A JP 2004505047A JP 2005530783 A5 JP2005530783 A5 JP 2005530783A5
- Authority
- JP
- Japan
- Prior art keywords
- ester
- formula
- lower alkyl
- hydrogen
- ochr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 6
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- -1 acyloxyalkyl ester Chemical class 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical group CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38151302P | 2002-05-17 | 2002-05-17 | |
| PCT/EP2003/004939 WO2003097048A1 (en) | 2002-05-17 | 2003-05-12 | Diaminothiazoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005530783A JP2005530783A (ja) | 2005-10-13 |
| JP2005530783A5 true JP2005530783A5 (https=) | 2009-01-22 |
| JP4308133B2 JP4308133B2 (ja) | 2009-08-05 |
Family
ID=29550137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004505047A Expired - Fee Related JP4308133B2 (ja) | 2002-05-17 | 2003-05-12 | Ｃｄｋ４の選択的インヒビターとして有用なジアミノチアゾール |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6818663B2 (https=) |
| EP (1) | EP1507530B1 (https=) |
| JP (1) | JP4308133B2 (https=) |
| KR (1) | KR100619515B1 (https=) |
| CN (1) | CN100400041C (https=) |
| AR (1) | AR040078A1 (https=) |
| AT (1) | ATE308323T1 (https=) |
| AU (1) | AU2003232754B2 (https=) |
| BR (1) | BR0310081A (https=) |
| CA (1) | CA2485367A1 (https=) |
| DE (1) | DE60302152T2 (https=) |
| ES (1) | ES2251697T3 (https=) |
| MX (1) | MXPA04011372A (https=) |
| PL (1) | PL374581A1 (https=) |
| RU (1) | RU2311414C2 (https=) |
| WO (1) | WO2003097048A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070167329A1 (en) * | 2003-12-24 | 2007-07-19 | Bayer Cropscience Gmbh | Plant growth regulation |
| US7211576B2 (en) * | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| US7705009B2 (en) * | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
| CA2668210C (en) | 2006-10-31 | 2013-03-12 | Schering Corporation | Anilinopiperazine derivatives and methods of use thereof |
| AR063531A1 (es) | 2006-10-31 | 2009-01-28 | Schering Corp | Derivados de anilinopiperazina y composicion farmaceutica |
| US8502401B2 (en) * | 2008-08-12 | 2013-08-06 | Delsper LP | Polymeric compositions comprising per(phenylethynyl) arene derivatives |
| ES2718637T3 (es) * | 2010-08-24 | 2019-07-03 | Gtx Inc | Compuestos para el tratamiento del cáncer |
| WO2013074120A1 (en) | 2011-11-18 | 2013-05-23 | Greene, Tweed & Co. | Crosslinking compounds for high glass transition temperature polymers |
| CA2909683A1 (en) | 2013-04-16 | 2014-10-23 | Memorial Sloan-Kettering Cancer Center | Companion diagnostic for cdk4 inhibitors |
| WO2015051525A1 (en) * | 2013-10-11 | 2015-04-16 | Rhodia Operations | Synthesis of acetal/ketal |
| WO2017156263A1 (en) | 2016-03-09 | 2017-09-14 | Memorial Sloan-Kettering Cancer Center | Enigma and cdh18 as companion diagnostics for cdk4 inhibitors |
| WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2018089902A1 (en) * | 2016-11-13 | 2018-05-17 | Apogee Biotechnology Corporation | Diaminothiazole compounds, compositions and methods of use |
| CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
| AU2020266083A1 (en) | 2019-04-30 | 2021-09-23 | Instituto de Medicina Molecular João Lobo Antunes | Rank pathway inhibitors in combination with CDK inhibitors |
| WO2026024674A1 (en) | 2024-07-22 | 2026-01-29 | Genesis Therapeutics, Inc. | Methods of treating skp2-associated cancers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2714059B1 (fr) * | 1993-12-21 | 1996-03-08 | Sanofi Elf | Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| NZ503788A (en) * | 1997-10-27 | 2002-11-26 | Agouron Pharma | 4-aminothiazole derivatives and their use as inhibitors of cyclin-dependent kinases |
| UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
| EP1307462A2 (en) * | 2000-08-09 | 2003-05-07 | Agouron Pharmaceuticals, Inc. | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases |
| US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
-
2003
- 2003-05-05 US US10/429,551 patent/US6818663B2/en not_active Expired - Fee Related
- 2003-05-12 EP EP03752731A patent/EP1507530B1/en not_active Expired - Lifetime
- 2003-05-12 AT AT03752731T patent/ATE308323T1/de not_active IP Right Cessation
- 2003-05-12 DE DE60302152T patent/DE60302152T2/de not_active Expired - Fee Related
- 2003-05-12 KR KR1020047018605A patent/KR100619515B1/ko not_active Expired - Fee Related
- 2003-05-12 AU AU2003232754A patent/AU2003232754B2/en not_active Ceased
- 2003-05-12 CN CNB038111314A patent/CN100400041C/zh not_active Expired - Fee Related
- 2003-05-12 MX MXPA04011372A patent/MXPA04011372A/es active IP Right Grant
- 2003-05-12 CA CA002485367A patent/CA2485367A1/en not_active Abandoned
- 2003-05-12 JP JP2004505047A patent/JP4308133B2/ja not_active Expired - Fee Related
- 2003-05-12 PL PL03374581A patent/PL374581A1/xx not_active Application Discontinuation
- 2003-05-12 BR BR0310081-2A patent/BR0310081A/pt not_active IP Right Cessation
- 2003-05-12 ES ES03752731T patent/ES2251697T3/es not_active Expired - Lifetime
- 2003-05-12 RU RU2004137110/04A patent/RU2311414C2/ru active
- 2003-05-12 WO PCT/EP2003/004939 patent/WO2003097048A1/en not_active Ceased
- 2003-05-15 AR ARP030101692A patent/AR040078A1/es not_active Application Discontinuation
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