KR100619515B1 - 디아미노티아졸 - Google Patents

디아미노티아졸 Download PDF

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Publication number
KR100619515B1
KR100619515B1 KR1020047018605A KR20047018605A KR100619515B1 KR 100619515 B1 KR100619515 B1 KR 100619515B1 KR 1020047018605 A KR1020047018605 A KR 1020047018605A KR 20047018605 A KR20047018605 A KR 20047018605A KR 100619515 B1 KR100619515 B1 KR 100619515B1
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KR
South Korea
Prior art keywords
amino
thiazol
phenylamino
phenyl
methanone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020047018605A
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English (en)
Korean (ko)
Other versions
KR20050006261A (ko
Inventor
추신-제
딩칭제
지앙난
김경진
러비앨런존
맥코마스워런윌리엄
뮬린존길포일주니어
틸리제퍼슨라이트
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20050006261A publication Critical patent/KR20050006261A/ko
Application granted granted Critical
Publication of KR100619515B1 publication Critical patent/KR100619515B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020047018605A 2002-05-17 2003-05-12 디아미노티아졸 Expired - Fee Related KR100619515B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38151302P 2002-05-17 2002-05-17
US60/381,513 2002-05-17
PCT/EP2003/004939 WO2003097048A1 (en) 2002-05-17 2003-05-12 Diaminothiazoles

Publications (2)

Publication Number Publication Date
KR20050006261A KR20050006261A (ko) 2005-01-15
KR100619515B1 true KR100619515B1 (ko) 2006-09-08

Family

ID=29550137

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047018605A Expired - Fee Related KR100619515B1 (ko) 2002-05-17 2003-05-12 디아미노티아졸

Country Status (16)

Country Link
US (1) US6818663B2 (https=)
EP (1) EP1507530B1 (https=)
JP (1) JP4308133B2 (https=)
KR (1) KR100619515B1 (https=)
CN (1) CN100400041C (https=)
AR (1) AR040078A1 (https=)
AT (1) ATE308323T1 (https=)
AU (1) AU2003232754B2 (https=)
BR (1) BR0310081A (https=)
CA (1) CA2485367A1 (https=)
DE (1) DE60302152T2 (https=)
ES (1) ES2251697T3 (https=)
MX (1) MXPA04011372A (https=)
PL (1) PL374581A1 (https=)
RU (1) RU2311414C2 (https=)
WO (1) WO2003097048A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070167329A1 (en) * 2003-12-24 2007-07-19 Bayer Cropscience Gmbh Plant growth regulation
US7211576B2 (en) * 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
US7405220B2 (en) 2004-06-09 2008-07-29 Hoffmann-La Roche Inc. Pyrazolopyrimidines
US7705009B2 (en) * 2005-11-22 2010-04-27 Hoffman-La Roche Inc. 4-aminopyrimidine-5-thione derivatives
CA2668210C (en) 2006-10-31 2013-03-12 Schering Corporation Anilinopiperazine derivatives and methods of use thereof
AR063531A1 (es) 2006-10-31 2009-01-28 Schering Corp Derivados de anilinopiperazina y composicion farmaceutica
US8502401B2 (en) * 2008-08-12 2013-08-06 Delsper LP Polymeric compositions comprising per(phenylethynyl) arene derivatives
ES2718637T3 (es) * 2010-08-24 2019-07-03 Gtx Inc Compuestos para el tratamiento del cáncer
WO2013074120A1 (en) 2011-11-18 2013-05-23 Greene, Tweed & Co. Crosslinking compounds for high glass transition temperature polymers
CA2909683A1 (en) 2013-04-16 2014-10-23 Memorial Sloan-Kettering Cancer Center Companion diagnostic for cdk4 inhibitors
WO2015051525A1 (en) * 2013-10-11 2015-04-16 Rhodia Operations Synthesis of acetal/ketal
WO2017156263A1 (en) 2016-03-09 2017-09-14 Memorial Sloan-Kettering Cancer Center Enigma and cdh18 as companion diagnostics for cdk4 inhibitors
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2018089902A1 (en) * 2016-11-13 2018-05-17 Apogee Biotechnology Corporation Diaminothiazole compounds, compositions and methods of use
CN110950848B (zh) * 2018-09-27 2024-03-26 徐诺药业 新型氨基吡唑类衍生物的合成与应用
AU2020266083A1 (en) 2019-04-30 2021-09-23 Instituto de Medicina Molecular João Lobo Antunes Rank pathway inhibitors in combination with CDK inhibitors
WO2026024674A1 (en) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Methods of treating skp2-associated cancers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714059B1 (fr) * 1993-12-21 1996-03-08 Sanofi Elf Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
NZ503788A (en) * 1997-10-27 2002-11-26 Agouron Pharma 4-aminothiazole derivatives and their use as inhibitors of cyclin-dependent kinases
UA71971C2 (en) * 1999-06-04 2005-01-17 Agoron Pharmaceuticals Inc Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
EP1307462A2 (en) * 2000-08-09 2003-05-07 Agouron Pharmaceuticals, Inc. Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity

Also Published As

Publication number Publication date
RU2311414C2 (ru) 2007-11-27
JP4308133B2 (ja) 2009-08-05
CA2485367A1 (en) 2003-11-27
WO2003097048A1 (en) 2003-11-27
AU2003232754A1 (en) 2003-12-02
CN1652780A (zh) 2005-08-10
RU2004137110A (ru) 2005-08-20
AR040078A1 (es) 2005-03-16
US6818663B2 (en) 2004-11-16
KR20050006261A (ko) 2005-01-15
PL374581A1 (en) 2005-10-31
ES2251697T3 (es) 2006-05-01
DE60302152T2 (de) 2006-07-13
BR0310081A (pt) 2005-02-15
DE60302152D1 (de) 2005-12-08
JP2005530783A (ja) 2005-10-13
US20040006058A1 (en) 2004-01-08
ATE308323T1 (de) 2005-11-15
EP1507530B1 (en) 2005-11-02
AU2003232754B2 (en) 2009-03-12
EP1507530A1 (en) 2005-02-23
MXPA04011372A (es) 2005-08-15
CN100400041C (zh) 2008-07-09

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