JP2005529960A5 - - Google Patents

Info

Publication number

JP2005529960A5

JP2005529960A5 JP2004514431A JP2004514431A JP2005529960A5 JP 2005529960 A5 JP2005529960 A5 JP 2005529960A5 JP 2004514431 A JP2004514431 A JP 2004514431A JP 2004514431 A JP2004514431 A JP 2004514431A JP 2005529960 A5 JP2005529960 A5 JP 2005529960A5

Authority

JP

Japan

Prior art keywords

antigen

vaccine

propionibacterium

tuberculosis

ienseni

Prior art date

2003-06-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000427 antigen Substances 0.000 claims 24
• 102000036639 antigens Human genes 0.000 claims 24
• 108091007433 antigens Proteins 0.000 claims 24
• 229960005486 vaccine Drugs 0.000 claims 15
• 241000187479 Mycobacterium tuberculosis Species 0.000 claims 13
• 241000186429 Propionibacterium Species 0.000 claims 13
• 235000013305 food Nutrition 0.000 claims 11
• 230000001413 cellular effect Effects 0.000 claims 10
• 102000004169 proteins and genes Human genes 0.000 claims 9
• 108090000623 proteins and genes Proteins 0.000 claims 9
• 201000008827 tuberculosis Diseases 0.000 claims 8
• 230000028993 immune response Effects 0.000 claims 7
• 241000186359 Mycobacterium Species 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 239000002671 adjuvant Substances 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 239000006041 probiotic Substances 0.000 claims 4
• 235000018291 probiotics Nutrition 0.000 claims 4
• 239000013589 supplement Substances 0.000 claims 4
• 238000002360 preparation method Methods 0.000 claims 3
• 230000000529 probiotic effect Effects 0.000 claims 3
• 241000894006 Bacteria Species 0.000 claims 2
• 230000001580 bacterial effect Effects 0.000 claims 2
• FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 2
• 239000000706 filtrate Substances 0.000 claims 2
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
• 244000005700 microbiome Species 0.000 claims 2
• 230000016379 mucosal immune response Effects 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• 239000000047 product Substances 0.000 claims 2
• 230000007420 reactivation Effects 0.000 claims 2
• 241000894007 species Species 0.000 claims 2
• 230000009885 systemic effect Effects 0.000 claims 2
• 239000003826 tablet Substances 0.000 claims 2
• 239000011782 vitamin Substances 0.000 claims 2
• 229930003231 vitamin Natural products 0.000 claims 2
• 235000013343 vitamin Nutrition 0.000 claims 2
• 229940088594 vitamin Drugs 0.000 claims 2
• 150000003722 vitamin derivatives Chemical group 0.000 claims 2
• 241000186000 Bifidobacterium Species 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 102000053187 Glucuronidase Human genes 0.000 claims 1
• 108010060309 Glucuronidase Proteins 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 201000010538 Lactose Intolerance Diseases 0.000 claims 1
• 241000187488 Mycobacterium sp. Species 0.000 claims 1
• 235000015063 acidophilus milk Nutrition 0.000 claims 1
• 239000000443 aerosol Substances 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 235000015496 breakfast cereal Nutrition 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 235000013339 cereals Nutrition 0.000 claims 1
• 235000014048 cultured milk product Nutrition 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• 229940124447 delivery agent Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 239000003623 enhancer Substances 0.000 claims 1
• 238000000855 fermentation Methods 0.000 claims 1
• 230000004151 fermentation Effects 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 239000008187 granular material Substances 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 239000007952 growth promoter Substances 0.000 claims 1
• 235000015220 hamburgers Nutrition 0.000 claims 1
• 208000019622 heart disease Diseases 0.000 claims 1
• ZTVZLYBCZNMWCF-UHFFFAOYSA-N homocystine Chemical compound [O-]C(=O)C([NH3+])CCSSCCC([NH3+])C([O-])=O ZTVZLYBCZNMWCF-UHFFFAOYSA-N 0.000 claims 1
• 210000000987 immune system Anatomy 0.000 claims 1
• 208000026278 immune system disease Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 238000002955 isolation Methods 0.000 claims 1
• 230000037356 lipid metabolism Effects 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 239000002609 medium Substances 0.000 claims 1
• 235000013336 milk Nutrition 0.000 claims 1
• 239000008267 milk Substances 0.000 claims 1
• 210000004080 milk Anatomy 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 229940126578 oral vaccine Drugs 0.000 claims 1
• 239000006072 paste Substances 0.000 claims 1
• 230000002062 proliferating effect Effects 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 238000000926 separation method Methods 0.000 claims 1
• 238000000527 sonication Methods 0.000 claims 1
• 239000007921 spray Substances 0.000 claims 1
• 230000000638 stimulation Effects 0.000 claims 1
• 238000003860 storage Methods 0.000 claims 1
• 238000002255 vaccination Methods 0.000 claims 1