JP2005529610A5 - - Google Patents
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- Publication number
- JP2005529610A5 JP2005529610A5 JP2004513497A JP2004513497A JP2005529610A5 JP 2005529610 A5 JP2005529610 A5 JP 2005529610A5 JP 2004513497 A JP2004513497 A JP 2004513497A JP 2004513497 A JP2004513497 A JP 2004513497A JP 2005529610 A5 JP2005529610 A5 JP 2005529610A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polypeptide expression
- interest
- functional
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 4
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108700026244 Open Reading Frames Proteins 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 101710197208 Regulatory protein cro Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02077350 | 2002-06-14 | ||
| PCT/NL2003/000432 WO2003106684A2 (en) | 2002-06-14 | 2003-06-13 | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009184727A Division JP5095690B2 (ja) | 2002-06-14 | 2009-08-07 | 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005529610A JP2005529610A (ja) | 2005-10-06 |
| JP2005529610A5 true JP2005529610A5 (https=) | 2006-08-03 |
| JP4647309B2 JP4647309B2 (ja) | 2011-03-09 |
Family
ID=29724494
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513497A Expired - Fee Related JP4647309B2 (ja) | 2002-06-14 | 2003-06-13 | 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 |
| JP2009184727A Expired - Fee Related JP5095690B2 (ja) | 2002-06-14 | 2009-08-07 | 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 |
| JP2009203428A Expired - Fee Related JP5095693B2 (ja) | 2002-06-14 | 2009-09-03 | 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009184727A Expired - Fee Related JP5095690B2 (ja) | 2002-06-14 | 2009-08-07 | 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 |
| JP2009203428A Expired - Fee Related JP5095693B2 (ja) | 2002-06-14 | 2009-09-03 | 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7364878B2 (https=) |
| EP (1) | EP1513937B1 (https=) |
| JP (3) | JP4647309B2 (https=) |
| AT (1) | ATE500331T1 (https=) |
| AU (1) | AU2003238719B2 (https=) |
| CA (3) | CA2489475C (https=) |
| DE (1) | DE60336228D1 (https=) |
| DK (1) | DK1513937T3 (https=) |
| ES (1) | ES2362273T3 (https=) |
| NZ (1) | NZ537073A (https=) |
| WO (1) | WO2003106684A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5654442A (en) * | 1989-11-14 | 1997-08-05 | The Perkin-Elmer Corporation | 4,7-dichlorofluorescein dyes as molecular probes |
| CA2403090C (en) * | 2000-03-17 | 2014-06-10 | Anticancer, Inc. | Whole-body optical imaging of gene expression and uses thereof |
| ATE466941T1 (de) * | 2001-07-04 | 2010-05-15 | Chromagenics Bv | Dns-sequenzen mit anti-repressor-aktivität |
| CA2489475C (en) | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
| AU2003243059A1 (en) * | 2002-06-14 | 2003-12-31 | Chromagenics B.V. | Use of repression blocking sequences in methods for enhancing gene expression |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| EP1573058B1 (en) * | 2002-12-18 | 2011-09-14 | ChromaGenics B.V. | A method for improving protein production |
| ATE354645T1 (de) | 2002-12-20 | 2007-03-15 | Chromagenics Bv | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
| ES2408582T3 (es) | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| DK1737971T3 (da) | 2004-01-20 | 2017-11-13 | Merus Nv | Blandinger af bindingsproteiner |
| PT1763586E (pt) * | 2004-07-08 | 2008-02-25 | Chromagenics Bv | Nova sequência para melhorar a expressão de ácido nucleico |
| US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
| US20060172382A1 (en) * | 2004-11-08 | 2006-08-03 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| EP1809750B1 (en) * | 2004-11-08 | 2012-03-21 | ChromaGenics B.V. | Selection of host cells expressing protein at high levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20070042397A1 (en) * | 2005-03-03 | 2007-02-22 | International Business Machines Corporation | Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof |
| PT1987150E (pt) * | 2006-02-21 | 2011-09-08 | Chromagenics Bv | Selecção de células hospedeiras expressando níveis elevados de proteína |
| US20080293086A1 (en) * | 2006-09-18 | 2008-11-27 | Cobalt Technologies, Inc. A Delaware Corporation | Real time monitoring of microbial enzymatic pathways |
| JP2010504507A (ja) * | 2006-09-20 | 2010-02-12 | インスティチュート・パスツール・コリア | 細胞におけるターゲットタンパク質候補の発現を検出および／または定量する方法、ならびに小分子モデュレーターのターゲットタンパク質を同定する方法 |
| US20090081715A1 (en) * | 2007-09-07 | 2009-03-26 | Cobalt Technologies, Inc., A Delaware Corporation | Engineered Light-Emitting Reporter Genes |
| WO2009126795A2 (en) | 2008-04-09 | 2009-10-15 | Cobalt Technologies, Inc. | Immobilized product tolerant microorganisms |
| EP2443239B1 (en) | 2009-06-15 | 2015-11-25 | Cellagenics B.V. | Novel stringent selectable markers |
| RU2011153546A (ru) * | 2009-06-26 | 2013-08-10 | Кобальт Текнолоджиз, Инк. | Способ и комплексная система для получения биопродукта |
| CN103038352B (zh) | 2010-06-15 | 2015-12-16 | 萨拉基尼克有限公司 | 用于增强基因表达的新型基因间元件 |
| CN103180443B (zh) | 2010-09-01 | 2016-01-13 | 萨拉基尼克有限公司 | 用于增强基因表达的来自核糖体蛋白启动子的核酸片段 |
| US9617329B2 (en) | 2010-10-01 | 2017-04-11 | Csl Limited | Method of cloning nucleic acid |
| WO2013078433A1 (en) | 2011-11-23 | 2013-05-30 | University Of Hawaii | Auto-processing domains for polypeptide expression |
| SI2838917T1 (sl) | 2012-04-20 | 2019-11-29 | Merus Nv | Postopki in sredstva za produkcijo heterodimernih IG-podobnih molekul |
| JP6343011B2 (ja) * | 2013-10-07 | 2018-06-13 | プレステージ バイオファーマ プライベート リミテッド | 抗体発現用バイシストロニック発現ベクター及びそれを用いた抗体の生産方法 |
| US20260041746A1 (en) * | 2022-08-09 | 2026-02-12 | Geg Tech | Transient expression system for rna, for vaccination |
| EP4569107A1 (en) * | 2022-08-09 | 2025-06-18 | GEG Tech | Transient expression system for rna, for gene editing |
| EP4569106A1 (en) * | 2022-08-09 | 2025-06-18 | GEG Tech | Transient expression system for rna, for cosmetic uses |
| WO2024033441A1 (en) * | 2022-08-09 | 2024-02-15 | Geg Tech | Transient expression system for rna |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4228458A1 (de) * | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
| US5610053A (en) | 1993-04-07 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells |
| US5972605A (en) | 1994-07-07 | 1999-10-26 | Geron Corporation | Assays for regulators of mammalian telomerase expression |
| US5773695A (en) | 1996-01-26 | 1998-06-30 | North Carolina State University | Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| US6149212A (en) * | 1997-07-02 | 2000-11-21 | Eagle Inventors, Llc | Adjustable door stop |
| CN100365127C (zh) | 1998-07-21 | 2008-01-30 | 密理博公司 | 具有遍在染色质开放表达元件(ucoe)的聚核苷酸 |
| DK1104490T3 (da) * | 1998-08-14 | 2008-01-02 | Chromagenics Bv | Fremgangsmåde til påvisning af en DNA-sekvens, DNA-sekvens, fremgangsmåde til fremstilling af en DNA-konstruktion samt anvendelse deraf |
| US6800457B2 (en) | 1998-09-22 | 2004-10-05 | Bristol-Myers Squibb Company | Expression vectors containing hot spot for increased recombinant protein expression in transfected cells |
| US6521419B1 (en) | 1998-09-22 | 2003-02-18 | Kanakaraju Koduri | Expression vectors containing hot spot for increased recombinant protein expression in transfected cells |
| AU1128400A (en) | 1998-10-22 | 2000-05-08 | Medical College Of Georgia Institute, Inc. | Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors |
| US6586205B1 (en) | 2000-02-11 | 2003-07-01 | Millennium Pharmaceuticals, Inc. | 43239 a novel GPCR-like molecule and uses thereof |
| US20030166042A1 (en) | 2000-02-11 | 2003-09-04 | Millennium Pharmaceuticals, Inc. | Novel seven-transmembrane proteins/G-protein coupled receptors |
| EP1430124B1 (en) | 2000-09-20 | 2013-11-06 | EMD Millipore Corporation | Artificial ubiquitous chromatin opening elements (ucoe) |
| ATE466941T1 (de) | 2001-07-04 | 2010-05-15 | Chromagenics Bv | Dns-sequenzen mit anti-repressor-aktivität |
| EP1273666A1 (en) | 2001-07-04 | 2003-01-08 | Chromagenics B.V. | Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity |
| AU2003243059A1 (en) * | 2002-06-14 | 2003-12-31 | Chromagenics B.V. | Use of repression blocking sequences in methods for enhancing gene expression |
| CA2489475C (en) | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
| EP1573058B1 (en) | 2002-12-18 | 2011-09-14 | ChromaGenics B.V. | A method for improving protein production |
| ATE354645T1 (de) | 2002-12-20 | 2007-03-15 | Chromagenics Bv | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
| US7384878B2 (en) * | 2004-05-20 | 2008-06-10 | International Business Machines Corporation | Method for applying a layer to a hydrophobic surface |
-
2003
- 2003-06-13 CA CA2489475A patent/CA2489475C/en not_active Expired - Lifetime
- 2003-06-13 AT AT03733632T patent/ATE500331T1/de active
- 2003-06-13 CA CA2723500A patent/CA2723500C/en not_active Expired - Lifetime
- 2003-06-13 AU AU2003238719A patent/AU2003238719B2/en not_active Ceased
- 2003-06-13 CA CA2722998A patent/CA2722998C/en not_active Expired - Lifetime
- 2003-06-13 DE DE60336228T patent/DE60336228D1/de not_active Expired - Lifetime
- 2003-06-13 DK DK03733632.8T patent/DK1513937T3/da active
- 2003-06-13 WO PCT/NL2003/000432 patent/WO2003106684A2/en not_active Ceased
- 2003-06-13 EP EP03733632A patent/EP1513937B1/en not_active Expired - Lifetime
- 2003-06-13 JP JP2004513497A patent/JP4647309B2/ja not_active Expired - Fee Related
- 2003-06-13 NZ NZ537073A patent/NZ537073A/en not_active IP Right Cessation
- 2003-06-13 ES ES03733632T patent/ES2362273T3/es not_active Expired - Lifetime
-
2004
- 2004-12-14 US US11/013,031 patent/US7364878B2/en not_active Expired - Lifetime
-
2007
- 2007-10-26 US US11/978,134 patent/US7901908B2/en not_active Expired - Fee Related
- 2007-10-26 US US11/978,109 patent/US7960143B2/en not_active Expired - Fee Related
-
2009
- 2009-08-07 JP JP2009184727A patent/JP5095690B2/ja not_active Expired - Fee Related
- 2009-09-03 JP JP2009203428A patent/JP5095693B2/ja not_active Expired - Fee Related
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