JP2003523769A5 - - Google Patents
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- Publication number
- JP2003523769A5 JP2003523769A5 JP2001562693A JP2001562693A JP2003523769A5 JP 2003523769 A5 JP2003523769 A5 JP 2003523769A5 JP 2001562693 A JP2001562693 A JP 2001562693A JP 2001562693 A JP2001562693 A JP 2001562693A JP 2003523769 A5 JP2003523769 A5 JP 2003523769A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorescent protein
- functional
- red fluorescent
- protein
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010054624 red fluorescent protein Proteins 0.000 description 33
- 102000039446 nucleic acids Human genes 0.000 description 14
- 108020004707 nucleic acids Proteins 0.000 description 14
- 150000007523 nucleic acids Chemical class 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 11
- 241000238631 Hexapoda Species 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 9
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 9
- 239000005090 green fluorescent protein Substances 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 108091006047 fluorescent proteins Proteins 0.000 description 4
- 102000034287 fluorescent proteins Human genes 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 102220479067 CD5 antigen-like_Y72F_mutation Human genes 0.000 description 3
- 102220485980 Dihydropteridine reductase_Q66R_mutation Human genes 0.000 description 3
- 102220507725 GTP-binding protein RAD_Q66P_mutation Human genes 0.000 description 3
- 102220547511 Glucocorticoid receptor_F65V_mutation Human genes 0.000 description 3
- 102220545761 HLA class II histocompatibility antigen, DQ alpha 1 chain_V73L_mutation Human genes 0.000 description 3
- 102220465273 Interferon alpha-8_F65Y_mutation Human genes 0.000 description 3
- 102220481503 Podocan_V73A_mutation Human genes 0.000 description 3
- 102220481306 Podocan_V73I_mutation Human genes 0.000 description 3
- 102220481317 Podocan_V73S_mutation Human genes 0.000 description 3
- 102220527094 Polycomb group RING finger protein 6_S69A_mutation Human genes 0.000 description 3
- 102220548995 Translin-associated factor X-interacting protein 1_Q64T_mutation Human genes 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 102220364176 c.205T>A Human genes 0.000 description 3
- 102220361662 c.208A>C Human genes 0.000 description 3
- 102220201129 rs1010098398 Human genes 0.000 description 3
- 102220244622 rs1555369198 Human genes 0.000 description 3
- 102200033503 rs1555826433 Human genes 0.000 description 3
- 102200133077 rs199473646 Human genes 0.000 description 3
- 102220068408 rs57932685 Human genes 0.000 description 3
- 102220049906 rs587783531 Human genes 0.000 description 3
- 102220040617 rs73070954 Human genes 0.000 description 3
- 102220128472 rs766082334 Human genes 0.000 description 3
- 102220178356 rs769686237 Human genes 0.000 description 3
- 102200069353 rs8103142 Human genes 0.000 description 3
- 102220102892 rs878855278 Human genes 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 3
- 102220626871 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A_Q66A_mutation Human genes 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 230000004850 protein–protein interaction Effects 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18473200P | 2000-02-23 | 2000-02-23 | |
| US60/184,732 | 2000-02-23 | ||
| PCT/US2001/004625 WO2001062919A1 (en) | 2000-02-23 | 2001-02-13 | Modified fluorescent proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003523769A JP2003523769A (ja) | 2003-08-12 |
| JP2003523769A5 true JP2003523769A5 (https=) | 2008-04-10 |
Family
ID=22678112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001562693A Pending JP2003523769A (ja) | 2000-02-23 | 2001-02-13 | 改変された蛍光タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20040171107A1 (https=) |
| EP (1) | EP1259608B1 (https=) |
| JP (1) | JP2003523769A (https=) |
| AT (1) | ATE439441T1 (https=) |
| AU (1) | AU2001238212A1 (https=) |
| CA (1) | CA2400642A1 (https=) |
| DE (1) | DE60139544D1 (https=) |
| HK (1) | HK1049185A1 (https=) |
| WO (1) | WO2001062919A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001096373A2 (en) * | 2000-06-14 | 2001-12-20 | Clontech Laboratories, Inc. | Fluorescent timer proteins and methods for their use |
| US20020048811A1 (en) | 2000-10-16 | 2002-04-25 | Devreotes Peter N. | Receptor mediated activation of heterotrimeric G-proteins |
| JP4215512B2 (ja) | 2001-02-26 | 2009-01-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 非オリゴマー化タンデム蛍光性タンパク質 |
| US7005511B2 (en) * | 2001-02-26 | 2006-02-28 | The Regents Of The University Of California | Fluorescent protein variants and methods for making same |
| US7687614B2 (en) | 2001-02-26 | 2010-03-30 | The Regents Of The University Of California | Monomeric and dimeric fluorescent protein variants and methods for making same |
| US7022826B2 (en) | 2001-02-26 | 2006-04-04 | The Regents Of The University Of California | Non-oligomerizing fluorescent proteins |
| FR2821854B1 (fr) * | 2001-03-09 | 2004-07-16 | Genoway | Cellules et animaux transgeniques d'etude de la polarisation de la reponse immune |
| US7413874B2 (en) | 2002-12-09 | 2008-08-19 | University Of Miami | Nucleic acid encoding fluorescent proteins from aquatic species |
| ATE474922T1 (de) * | 2002-12-26 | 2010-08-15 | Zakrytoe Aktsionernoe Obschest | Fluoreszenzproteine aus copepoda-spezies und verfahren zur verwendung davon |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| GB0327143D0 (en) * | 2003-11-21 | 2003-12-24 | Univ Belfast | Assay |
| EP1645881A1 (en) * | 2004-10-05 | 2006-04-12 | DKFZ Deutsches Krebsforschungszentrum | Screening process for the detection and characterization of protein-protein-interactions in vivo by fluorescence cross correlation spectroscopy |
| CA2614486C (en) * | 2005-07-13 | 2014-09-16 | Georgia State University Research Foundation, Inc. | Contrast agent comprising a scaffold protein and a metal ion chelating site integrated therein |
| JP5377965B2 (ja) | 2005-09-09 | 2013-12-25 | ジョージア ステート ユニバーシティ リサーチ ファウンデーション、インコーポレイテッド | 標的化された造影剤および造影剤を標的化するための方法 |
| KR101834574B1 (ko) | 2009-01-29 | 2018-03-05 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | Ｇ 단백질 커플링 수용체 활성화 측정 |
| WO2012162260A2 (en) | 2011-05-21 | 2012-11-29 | Kdt, Llc. | Transgenic biosensors |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000976A (en) * | 1972-12-07 | 1977-01-04 | G. D. Searle & Co. | Apparatus and method for preparing, diluting and replicating laboratory samples |
| US5196313A (en) * | 1983-01-03 | 1993-03-23 | American Cyanamid Company | Method for the evaluation of anticoccidial activity of compounds using 2,3,5-triphenyltetrazolium chloride and trypan blue indicators |
| US5125748A (en) * | 1986-03-26 | 1992-06-30 | Beckman Instruments, Inc. | Optical detection module for use in an automated laboratory work station |
| US5139744A (en) * | 1986-03-26 | 1992-08-18 | Beckman Instruments, Inc. | Automated laboratory work station having module identification means |
| US5206568A (en) * | 1986-03-26 | 1993-04-27 | Beckman Instruments, Inc. | Coordinated control of stepper motors |
| US5104621A (en) * | 1986-03-26 | 1992-04-14 | Beckman Instruments, Inc. | Automated multi-purpose analytical chemistry processing center and laboratory work station |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5276182A (en) * | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
| DE4039602A1 (de) | 1990-12-12 | 1992-06-17 | Bauer Kurt Heinz Prof Dr | Pharmazeutische formulierungen |
| KR100221695B1 (ko) | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
| US5653962A (en) * | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| KR100300932B1 (ko) * | 1992-07-06 | 2001-10-22 | 조이스 브린톤 | 리포터유전자에융합된세균의스트레스프로모터를이용하여독성을측정하는방법및진단키트 |
| US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5355215A (en) * | 1992-09-30 | 1994-10-11 | Environmental Research Institute Of Michigan | Method and apparatus for quantitative fluorescence measurements |
| AU5612694A (en) | 1992-11-27 | 1994-06-22 | Napro Biotherapeutics, Inc. | Injectable composition |
| US5654286A (en) * | 1993-05-12 | 1997-08-05 | Hostetler; Karl Y. | Nucleotides for topical treatment of psoriasis, and methods for using same |
| US5464758A (en) * | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US5350564A (en) * | 1993-06-28 | 1994-09-27 | Baxter Diagnostics Inc. | Automated chemical analyzer with apparatus and method for conveying and temporary storage of sample tubes |
| US5532130A (en) * | 1993-07-20 | 1996-07-02 | Dyad Pharmaceutical Corporation | Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides |
| EP1475091A1 (en) | 1993-10-01 | 2004-11-10 | Roche Palo Alto LLC | Mycophenolate mofetil - high dose oral suspensions |
| FR2715762B1 (fr) * | 1994-02-01 | 1996-03-29 | Transnucleaire | Dispositif de fixation du fond d'un conteneur de transport et/ou stockage de matières radioactives. |
| US5795737A (en) * | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
| US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
| US5625048A (en) * | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
| US5777079A (en) * | 1994-11-10 | 1998-07-07 | The Regents Of The University Of California | Modified green fluorescent proteins |
| US5589351A (en) * | 1994-12-06 | 1996-12-31 | Nps Pharmaceuticals, Inc. | Fluorescence detection apparatus |
| US5741657A (en) * | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US5653987A (en) * | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| US5667809A (en) | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
| US5676012A (en) * | 1995-12-05 | 1997-10-14 | Spectrum Manufacturing, Inc. | Process for forming endoscopic shaver blade from elongate tube |
| US6803188B1 (en) * | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
| US5804387A (en) * | 1996-02-01 | 1998-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | FACS-optimized mutants of the green fluorescent protein (GFP) |
| US5800690A (en) * | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
| US5998204A (en) * | 1997-03-14 | 1999-12-07 | The Regents Of The University Of California | Fluorescent protein sensors for detection of analytes |
| US5985214A (en) * | 1997-05-16 | 1999-11-16 | Aurora Biosciences Corporation | Systems and methods for rapidly identifying useful chemicals in liquid samples |
| WO2000034326A1 (en) * | 1998-12-11 | 2000-06-15 | Clontech Laboratories, Inc. | Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof |
| JP2003527833A (ja) * | 1999-10-14 | 2003-09-24 | クロンテック・ラボラトリーズ・インコーポレーテッド | 花虫類に由来する発色団／蛍光体、およびそれらの使用法 |
-
2001
- 2001-02-13 AT AT01910621T patent/ATE439441T1/de not_active IP Right Cessation
- 2001-02-13 JP JP2001562693A patent/JP2003523769A/ja active Pending
- 2001-02-13 WO PCT/US2001/004625 patent/WO2001062919A1/en not_active Ceased
- 2001-02-13 US US10/311,030 patent/US20040171107A1/en not_active Abandoned
- 2001-02-13 AU AU2001238212A patent/AU2001238212A1/en not_active Abandoned
- 2001-02-13 CA CA002400642A patent/CA2400642A1/en not_active Abandoned
- 2001-02-13 HK HK03101350.9A patent/HK1049185A1/zh unknown
- 2001-02-13 EP EP01910621A patent/EP1259608B1/en not_active Expired - Lifetime
- 2001-02-13 DE DE60139544T patent/DE60139544D1/de not_active Expired - Lifetime
-
2006
- 2006-03-09 US US11/371,240 patent/US20070099175A1/en not_active Abandoned
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