JP2005529610A5 - - Google Patents

Download PDF

Info

Publication number
JP2005529610A5
JP2005529610A5 JP2004513497A JP2004513497A JP2005529610A5 JP 2005529610 A5 JP2005529610 A5 JP 2005529610A5 JP 2004513497 A JP2004513497 A JP 2004513497A JP 2004513497 A JP2004513497 A JP 2004513497A JP 2005529610 A5 JP2005529610 A5 JP 2005529610A5
Authority
JP
Japan
Prior art keywords
polypeptide
polypeptide expression
interest
functional
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004513497A
Other languages
English (en)
Japanese (ja)
Other versions
JP4647309B2 (ja
JP2005529610A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/NL2003/000432 external-priority patent/WO2003106684A2/en
Publication of JP2005529610A publication Critical patent/JP2005529610A/ja
Publication of JP2005529610A5 publication Critical patent/JP2005529610A5/ja
Application granted granted Critical
Publication of JP4647309B2 publication Critical patent/JP4647309B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2004513497A 2002-06-14 2003-06-13 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 Expired - Fee Related JP4647309B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077350 2002-06-14
PCT/NL2003/000432 WO2003106684A2 (en) 2002-06-14 2003-06-13 A method for simultaneous production of multiple proteins; vectors and cells for use therein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009184727A Division JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Publications (3)

Publication Number Publication Date
JP2005529610A JP2005529610A (ja) 2005-10-06
JP2005529610A5 true JP2005529610A5 (enExample) 2006-08-03
JP4647309B2 JP4647309B2 (ja) 2011-03-09

Family

ID=29724494

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004513497A Expired - Fee Related JP4647309B2 (ja) 2002-06-14 2003-06-13 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009184727A Expired - Fee Related JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009203428A Expired - Fee Related JP5095693B2 (ja) 2002-06-14 2009-09-03 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009184727A Expired - Fee Related JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009203428A Expired - Fee Related JP5095693B2 (ja) 2002-06-14 2009-09-03 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Country Status (11)

Country Link
US (3) US7364878B2 (enExample)
EP (1) EP1513937B1 (enExample)
JP (3) JP4647309B2 (enExample)
AT (1) ATE500331T1 (enExample)
AU (1) AU2003238719B2 (enExample)
CA (3) CA2489475C (enExample)
DE (1) DE60336228D1 (enExample)
DK (1) DK1513937T3 (enExample)
ES (1) ES2362273T3 (enExample)
NZ (1) NZ537073A (enExample)
WO (1) WO2003106684A2 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654442A (en) * 1989-11-14 1997-08-05 The Perkin-Elmer Corporation 4,7-dichlorofluorescein dyes as molecular probes
CA2403090C (en) * 2000-03-17 2014-06-10 Anticancer, Inc. Whole-body optical imaging of gene expression and uses thereof
DE60237048D1 (de) * 2001-07-04 2010-08-26 Chromagenics Bv DNS-Sequenzen mit Anti-Repressor-Aktivität
WO2003106674A2 (en) * 2002-06-14 2003-12-24 Chromagenics B.V. Means and methods for regulating gene expression
CA2489475C (en) 2002-06-14 2011-03-29 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
NZ537277A (en) 2002-07-18 2008-04-30 Crucell Holland Bv Recombinant production of mixtures of antibodies
DK1573058T3 (da) * 2002-12-18 2012-01-16 Chromagenics Bv Fremgangsmåde til forbedring af proteinproduktion
DK1572994T3 (da) 2002-12-20 2007-05-29 Chromagenics Bv Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
WO2004106375A1 (en) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Fab library for the preparation of anti vegf and anti rabies virus fabs
EP1737971B1 (en) * 2004-01-20 2017-08-16 Merus N.V. Mixtures of binding proteins
DE602005003369T2 (de) 2004-07-08 2009-03-05 Chromagenics B.V. Neue sequenz um die expression einer nukleinsäure zu erhöhen
US20060195935A1 (en) * 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
NZ553700A (en) 2004-11-08 2010-09-30 Chromagenics Bv Selection of host cells expressing protein at high levels using a selectable marker with a non-optimal start codon
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
BRPI0517380A (pt) 2004-11-08 2008-10-07 Chromagenics Bv molécula de dna, cassete de expressão, célula hospedeira, e, métodos para gerar uma célula hospedeira que expressa um polipeptìdeo de interesse e para produzir um polipeptìdeo de interesse
US20070042397A1 (en) * 2005-03-03 2007-02-22 International Business Machines Corporation Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof
SI1987150T1 (sl) * 2006-02-21 2011-09-30 Chromagenics Bv Selekcija gostiteljskih celic, ki eksprimirajo protein pri visokih nivojih
US20080293086A1 (en) * 2006-09-18 2008-11-27 Cobalt Technologies, Inc. A Delaware Corporation Real time monitoring of microbial enzymatic pathways
JP2010504507A (ja) * 2006-09-20 2010-02-12 インスティチュート・パスツール・コリア 細胞におけるターゲットタンパク質候補の発現を検出および／または定量する方法、ならびに小分子モデュレーターのターゲットタンパク質を同定する方法
US20090081715A1 (en) * 2007-09-07 2009-03-26 Cobalt Technologies, Inc., A Delaware Corporation Engineered Light-Emitting Reporter Genes
CA2721076A1 (en) 2008-04-09 2009-10-15 Cobalt Technologies, Inc. Immobilized product tolerant microorganisms
CN102459607B (zh) 2009-06-15 2014-08-06 萨拉基尼克有限公司 新的严格的可选择的标志物
MX2011013974A (es) 2009-06-26 2012-04-30 Cobalt Technologies Inc Sistema y proceso integrados para la produccion de bioproductos.
BR112012031694A2 (pt) 2010-06-15 2016-02-16 Cellagenics B V fragmento de ácido nucleíco, construto de ácido nucleíco, vetor de expressão, célula hospedeira, método de geração de uma célula hospedeira para a expressão de um produto gênico de interesse, e, método de expresão de um produto de gene de interesse
CN103180443B (zh) 2010-09-01 2016-01-13 萨拉基尼克有限公司 用于增强基因表达的来自核糖体蛋白启动子的核酸片段
US9617329B2 (en) 2010-10-01 2017-04-11 Csl Limited Method of cloning nucleic acid
WO2013078433A1 (en) 2011-11-23 2013-05-30 University Of Hawaii Auto-processing domains for polypeptide expression
WO2013157953A1 (en) 2012-04-20 2013-10-24 Merus B.V. Methods and means for the production of ig-like molecules
EP3683314A1 (en) * 2013-10-07 2020-07-22 Prestige Biopharma Pte. Ltd. Bicistronic expression vector for antibody expression and method for producing antibody using same
WO2024033448A1 (en) * 2022-08-09 2024-02-15 Geg Tech Transient expression system for rna, for vaccination
EP4569106A1 (en) * 2022-08-09 2025-06-18 GEG Tech Transient expression system for rna, for cosmetic uses
WO2024033441A1 (en) * 2022-08-09 2024-02-15 Geg Tech Transient expression system for rna
WO2024033446A1 (en) * 2022-08-09 2024-02-15 Geg Tech Transient expression system for rna, for gene editing

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228458A1 (de) * 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
US5610053A (en) * 1993-04-07 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells
US5972605A (en) 1994-07-07 1999-10-26 Geron Corporation Assays for regulators of mammalian telomerase expression
US5773695A (en) * 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
US5888809A (en) * 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
US6149212A (en) * 1997-07-02 2000-11-21 Eagle Inventors, Llc Adjustable door stop
WO2000005393A2 (en) 1998-07-21 2000-02-03 Cobra Therapeutics Limited A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)
IL141371A0 (en) * 1998-08-14 2002-03-10 Stichting Tech Wetenschapp Method of detecting a dna sequence, a dna sequence, a method of making a dna construct and the use thereof
US6521419B1 (en) * 1998-09-22 2003-02-18 Kanakaraju Koduri Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
US6800457B2 (en) * 1998-09-22 2004-10-05 Bristol-Myers Squibb Company Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
AU1128400A (en) 1998-10-22 2000-05-08 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
US6586205B1 (en) 2000-02-11 2003-07-01 Millennium Pharmaceuticals, Inc. 43239 a novel GPCR-like molecule and uses thereof
WO2001059117A2 (en) * 2000-02-11 2001-08-16 Millennium Pharmaceuticals, Inc. Seven-transmembrane proteins/g-protein coupled receptors
KR100996016B1 (ko) 2000-09-20 2010-11-22 밀리포어 코포레이션 폴리뉴클레오티드
EP1273666A1 (en) 2001-07-04 2003-01-08 Chromagenics B.V. Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
DE60237048D1 (de) * 2001-07-04 2010-08-26 Chromagenics Bv DNS-Sequenzen mit Anti-Repressor-Aktivität
CA2489475C (en) 2002-06-14 2011-03-29 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
WO2003106674A2 (en) * 2002-06-14 2003-12-24 Chromagenics B.V. Means and methods for regulating gene expression
DK1573058T3 (da) 2002-12-18 2012-01-16 Chromagenics Bv Fremgangsmåde til forbedring af proteinproduktion
DK1572994T3 (da) 2002-12-20 2007-05-29 Chromagenics Bv Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer
US7384878B2 (en) * 2004-05-20 2008-06-10 International Business Machines Corporation Method for applying a layer to a hydrophobic surface

Similar Documents

Publication Publication Date Title
Rinne et al. Chilling of dormant buds hyperinduces FLOWERING LOCUS T and recruits GA-inducible 1, 3-β-glucanases to reopen signal conduits and release dormancy in Populus
Oyake et al. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
Primrose et al. Principles of gene manipulation and genomics
Das et al. Construction of transposon Tn3phoA: its application in defining the membrane topology of the Agrobacterium tumefaciens DNA transfer proteins
JP2006515520A5 (enExample)
CA2489475A1 (en) A method for simultaneous production of multiple proteins; vectors and cells for use therein
KR930702521A (ko) 효율적인 유전적 억제요소를 얻는 방법 및 그 용도
RU2006127314A (ru) Вакцина, стимулирующая рост, основанная на нейтрализующем эпитопе
Harris et al. Evidence that F‐plasmid proteins TraV, TraK and TraB assemble into an envelope‐spanning structure in Escherichia coli
CN109400714B (zh) 抗体靶向的重组融合蛋白以及其在表观遗传学中的应用
RU2005114367A (ru) Кольцевая молекула днк, характеризующаяся зависимой от условий точкой начала репликации, способ их получения и их применение в генной терапии
Kobayashi et al. Both a unique motif at the C terminus and an N-terminal HEAT repeat contribute to G-quadruplex binding and origin regulation by the Rif1 protein
Garcia-Cano et al. Interaction of Arabidopsis trihelix-domain transcription factors VFP3 and VFP5 with Agrobacterium virulence protein VirF
JP2005509420A5 (enExample)
JP2003523769A5 (enExample)
WO2006040154A2 (en) Prokaryotic two hybrid system
JP2011505850A5 (enExample)
Sanmartín et al. GLR‐dependent calcium and electrical signals are not coupled to systemic, oxylipin‐based wound‐induced gene expression in Marchantia polymorpha
Val-Calvo et al. pLS20 is the archetype of a new family of conjugative plasmids harboured by Bacillus species
Kumar et al. Functional analysis of the Agrobacterium tumefaciens T-DNA transport pore protein VirB8
Kawata et al. A cDNA clone encoding HBP-1b homologue in Arabidopsis thaliana
JP2005507648A5 (enExample)
JP2004532037A5 (enExample)
Trojanowska et al. The bacteriophage T4 regA gene: primary sequence of a translational repressor
JP2006502738A5 (enExample)