JP2005529610A5 - - Google Patents

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Publication number
JP2005529610A5
JP2005529610A5 JP2004513497A JP2004513497A JP2005529610A5 JP 2005529610 A5 JP2005529610 A5 JP 2005529610A5 JP 2004513497 A JP2004513497 A JP 2004513497A JP 2004513497 A JP2004513497 A JP 2004513497A JP 2005529610 A5 JP2005529610 A5 JP 2005529610A5
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JP
Japan
Prior art keywords
polypeptide
polypeptide expression
interest
functional
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2004513497A
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English (en)
Japanese (ja)
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JP2005529610A (ja
JP4647309B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/NL2003/000432 external-priority patent/WO2003106684A2/en
Publication of JP2005529610A publication Critical patent/JP2005529610A/ja
Publication of JP2005529610A5 publication Critical patent/JP2005529610A5/ja
Application granted granted Critical
Publication of JP4647309B2 publication Critical patent/JP4647309B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2004513497A 2002-06-14 2003-06-13 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 Expired - Fee Related JP4647309B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077350 2002-06-14
PCT/NL2003/000432 WO2003106684A2 (en) 2002-06-14 2003-06-13 A method for simultaneous production of multiple proteins; vectors and cells for use therein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009184727A Division JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Publications (3)

Publication Number Publication Date
JP2005529610A JP2005529610A (ja) 2005-10-06
JP2005529610A5 true JP2005529610A5 (enExample) 2006-08-03
JP4647309B2 JP4647309B2 (ja) 2011-03-09

Family

ID=29724494

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004513497A Expired - Fee Related JP4647309B2 (ja) 2002-06-14 2003-06-13 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009184727A Expired - Fee Related JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009203428A Expired - Fee Related JP5095693B2 (ja) 2002-06-14 2009-09-03 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009184727A Expired - Fee Related JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009203428A Expired - Fee Related JP5095693B2 (ja) 2002-06-14 2009-09-03 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Country Status (11)

Country Link
US (3) US7364878B2 (enExample)
EP (1) EP1513937B1 (enExample)
JP (3) JP4647309B2 (enExample)
AT (1) ATE500331T1 (enExample)
AU (1) AU2003238719B2 (enExample)
CA (3) CA2489475C (enExample)
DE (1) DE60336228D1 (enExample)
DK (1) DK1513937T3 (enExample)
ES (1) ES2362273T3 (enExample)
NZ (1) NZ537073A (enExample)
WO (1) WO2003106684A2 (enExample)

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EP1806407B1 (en) 2001-07-04 2010-05-05 Chromagenics B.V. DNA sequences having anti-repressor activity
DK1513937T3 (da) 2002-06-14 2011-05-16 Chromagenics Bv Fremgangsmåde til den samtidige produktion af multiple proteiner; vektorer og celler til anvendelse derved
EP1513936A2 (en) * 2002-06-14 2005-03-16 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
EP2314629B2 (en) 2002-07-18 2022-11-16 Merus N.V. Recombinant production of mixtures of antibodies
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
CA2510179C (en) * 2002-12-18 2013-04-23 Chromagenics B.V. A method for improving protein production
ATE354645T1 (de) 2002-12-20 2007-03-15 Chromagenics Bv Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
WO2004106375A1 (en) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Fab library for the preparation of anti vegf and anti rabies virus fabs
AU2005205412B2 (en) 2004-01-20 2011-08-11 Merus N.V. Mixtures of binding proteins
WO2006005718A2 (en) * 2004-07-08 2006-01-19 Chromagenics B.V. Novel sequence for improving expression of nucleic acid
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
PL1809750T3 (pl) * 2004-11-08 2012-08-31 Chromagenics Bv Selekcja komórki gospodarza eksprymującej białko na wysokich poziomach
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
CN101090968B (zh) 2004-11-08 2011-10-26 科罗迈吉尼科斯公司 高水平表达蛋白质的宿主细胞的选择
US20070042397A1 (en) * 2005-03-03 2007-02-22 International Business Machines Corporation Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof
CA2637271C (en) * 2006-02-21 2014-12-09 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20080293086A1 (en) * 2006-09-18 2008-11-27 Cobalt Technologies, Inc. A Delaware Corporation Real time monitoring of microbial enzymatic pathways
JP2010504507A (ja) * 2006-09-20 2010-02-12 インスティチュート・パスツール・コリア 細胞におけるターゲットタンパク質候補の発現を検出および／または定量する方法、ならびに小分子モデュレーターのターゲットタンパク質を同定する方法
US20090081715A1 (en) * 2007-09-07 2009-03-26 Cobalt Technologies, Inc., A Delaware Corporation Engineered Light-Emitting Reporter Genes
CL2009000879A1 (es) 2008-04-09 2010-05-07 Talfryn S A Metodo para fabricar un producto en un biorreactor que comprende cultivar microorganismos que son adaptados o mutagenizados para que exhiban por lo menos un 150% de tolerancia al producto; sistema para fabricar un producto; biorreactor.
EP2443239B1 (en) 2009-06-15 2015-11-25 Cellagenics B.V. Novel stringent selectable markers
CN102482690A (zh) 2009-06-26 2012-05-30 钴技术有限公司 生物产物生产的集成系统和方法
US9790517B2 (en) 2010-06-15 2017-10-17 Cellagenics B.V. Intergenic elements for enhancing gene expression
US9650630B2 (en) 2010-09-01 2017-05-16 Cellagenics B.V. Nucleic acid fragments from a ribosomal protein promoter for enhancing gene expression
WO2012040793A1 (en) * 2010-10-01 2012-04-05 Csl Limited Method of cloning nucleic acid
US8945876B2 (en) 2011-11-23 2015-02-03 University Of Hawaii Auto-processing domains for polypeptide expression
DK2838918T3 (da) 2012-04-20 2019-08-12 Merus Nv Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler
WO2015053523A1 (ko) * 2013-10-07 2015-04-16 한화케미칼 주식회사 항체 발현용 바이시스트로닉 발현벡터 및 이를 이용한 항체의 생산 방법
EP4569107A1 (en) * 2022-08-09 2025-06-18 GEG Tech Transient expression system for rna, for gene editing
US20260041746A1 (en) * 2022-08-09 2026-02-12 Geg Tech Transient expression system for rna, for vaccination
WO2024033444A1 (en) * 2022-08-09 2024-02-15 Geg Tech Transient expression system for rna, for cosmetic uses
EP4569105A1 (en) * 2022-08-09 2025-06-18 GEG Tech Transient expression system for rna

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US5773695A (en) * 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
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DK1104490T3 (da) * 1998-08-14 2008-01-02 Chromagenics Bv Fremgangsmåde til påvisning af en DNA-sekvens, DNA-sekvens, fremgangsmåde til fremstilling af en DNA-konstruktion samt anvendelse deraf
US6800457B2 (en) * 1998-09-22 2004-10-05 Bristol-Myers Squibb Company Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
US6521419B1 (en) * 1998-09-22 2003-02-18 Kanakaraju Koduri Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
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US20030166042A1 (en) * 2000-02-11 2003-09-04 Millennium Pharmaceuticals, Inc. Novel seven-transmembrane proteins/G-protein coupled receptors
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EP1806407B1 (en) * 2001-07-04 2010-05-05 Chromagenics B.V. DNA sequences having anti-repressor activity
EP1273666A1 (en) 2001-07-04 2003-01-08 Chromagenics B.V. Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
EP1513936A2 (en) * 2002-06-14 2005-03-16 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
DK1513937T3 (da) 2002-06-14 2011-05-16 Chromagenics Bv Fremgangsmåde til den samtidige produktion af multiple proteiner; vektorer og celler til anvendelse derved
CA2510179C (en) 2002-12-18 2013-04-23 Chromagenics B.V. A method for improving protein production
ATE354645T1 (de) 2002-12-20 2007-03-15 Chromagenics Bv Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können
US7384878B2 (en) * 2004-05-20 2008-06-10 International Business Machines Corporation Method for applying a layer to a hydrophobic surface

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