JP2005529610A5 - - Google Patents

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Publication number
JP2005529610A5
JP2005529610A5 JP2004513497A JP2004513497A JP2005529610A5 JP 2005529610 A5 JP2005529610 A5 JP 2005529610A5 JP 2004513497 A JP2004513497 A JP 2004513497A JP 2004513497 A JP2004513497 A JP 2004513497A JP 2005529610 A5 JP2005529610 A5 JP 2005529610A5
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JP
Japan
Prior art keywords
polypeptide
polypeptide expression
interest
functional
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2004513497A
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English (en)
Japanese (ja)
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JP2005529610A (ja
JP4647309B2 (ja
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Priority claimed from PCT/NL2003/000432 external-priority patent/WO2003106684A2/en
Publication of JP2005529610A publication Critical patent/JP2005529610A/ja
Publication of JP2005529610A5 publication Critical patent/JP2005529610A5/ja
Application granted granted Critical
Publication of JP4647309B2 publication Critical patent/JP4647309B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2004513497A 2002-06-14 2003-06-13 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 Expired - Fee Related JP4647309B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077350 2002-06-14
PCT/NL2003/000432 WO2003106684A2 (en) 2002-06-14 2003-06-13 A method for simultaneous production of multiple proteins; vectors and cells for use therein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009184727A Division JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Publications (3)

Publication Number Publication Date
JP2005529610A JP2005529610A (ja) 2005-10-06
JP2005529610A5 true JP2005529610A5 (enExample) 2006-08-03
JP4647309B2 JP4647309B2 (ja) 2011-03-09

Family

ID=29724494

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004513497A Expired - Fee Related JP4647309B2 (ja) 2002-06-14 2003-06-13 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009184727A Expired - Fee Related JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009203428A Expired - Fee Related JP5095693B2 (ja) 2002-06-14 2009-09-03 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009184727A Expired - Fee Related JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009203428A Expired - Fee Related JP5095693B2 (ja) 2002-06-14 2009-09-03 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

Country Status (11)

Country Link
US (3) US7364878B2 (enExample)
EP (1) EP1513937B1 (enExample)
JP (3) JP4647309B2 (enExample)
AT (1) ATE500331T1 (enExample)
AU (1) AU2003238719B2 (enExample)
CA (3) CA2723500C (enExample)
DE (1) DE60336228D1 (enExample)
DK (1) DK1513937T3 (enExample)
ES (1) ES2362273T3 (enExample)
NZ (1) NZ537073A (enExample)
WO (1) WO2003106684A2 (enExample)

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CA2812799C (en) 2001-07-04 2016-01-26 Chromagenics B.V. Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
WO2003106684A2 (en) 2002-06-14 2003-12-24 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
EP1513936A2 (en) * 2002-06-14 2005-03-16 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
SI1523496T1 (sl) 2002-07-18 2011-11-30 Merus B V Rekombinantno proizvajanje zmesi protiteles
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
EP1573058B1 (en) * 2002-12-18 2011-09-14 ChromaGenics B.V. A method for improving protein production
EP1572994B1 (en) 2002-12-20 2007-02-21 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
EP2395017A3 (en) 2003-05-30 2012-12-19 Merus B.V. Design and use of paired variable regions of specific binding molecules
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1737971B1 (en) * 2004-01-20 2017-08-16 Merus N.V. Mixtures of binding proteins
US7825232B2 (en) * 2004-07-08 2010-11-02 Chromagenics B.V. Sequence for improving expression of nucleic acid
US20060195935A1 (en) * 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
KR101271884B1 (ko) * 2004-11-08 2013-06-05 크로마제닉스 비.브이. 고수준으로 단백질을 발현하는 숙주세포의 선택
CN101090968B (zh) 2004-11-08 2011-10-26 科罗迈吉尼科斯公司 高水平表达蛋白质的宿主细胞的选择
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
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CN101389763B (zh) * 2006-02-21 2013-01-23 科罗迈吉尼科斯公司 高水平表达蛋白质的宿主细胞的选择
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JP2010504507A (ja) * 2006-09-20 2010-02-12 インスティチュート・パスツール・コリア 細胞におけるターゲットタンパク質候補の発現を検出および／または定量する方法、ならびに小分子モデュレーターのターゲットタンパク質を同定する方法
US20090081715A1 (en) * 2007-09-07 2009-03-26 Cobalt Technologies, Inc., A Delaware Corporation Engineered Light-Emitting Reporter Genes
CA2721076A1 (en) 2008-04-09 2009-10-15 Cobalt Technologies, Inc. Immobilized product tolerant microorganisms
DK2443239T3 (en) 2009-06-15 2016-02-15 Cellagenics B V New stringent selection markers
AU2010266035B2 (en) 2009-06-26 2015-02-12 Talfryn S.A. Integrated system and process for bioproduct production
EP2582816B1 (en) 2010-06-15 2017-12-20 Cellagenics B.V. Novel intergenic elements for enhancing gene expression
EP2611915B1 (en) 2010-09-01 2015-04-15 Cellagenics B.V. Nucleic acid fragments from a ribosomal protein promoter for enhancing gene expression
WO2012040793A1 (en) * 2010-10-01 2012-04-05 Csl Limited Method of cloning nucleic acid
WO2013078433A1 (en) 2011-11-23 2013-05-30 University Of Hawaii Auto-processing domains for polypeptide expression
ES2743399T3 (es) 2012-04-20 2020-02-19 Merus Nv Métodos y medios para la producción de moléculas heterodiméricas similares a Ig
BR112016007547A2 (pt) * 2013-10-07 2018-01-23 Prestige Biopharma Pte. Ltd. ?vetor de expressão bicistrônico para expressão de anticorpos e método para a produção de anticorpos usando o mesmo?
WO2024033441A1 (en) * 2022-08-09 2024-02-15 Geg Tech Transient expression system for rna
EP4569107A1 (en) * 2022-08-09 2025-06-18 GEG Tech Transient expression system for rna, for gene editing
WO2024033448A1 (en) * 2022-08-09 2024-02-15 Geg Tech Transient expression system for rna, for vaccination
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CA2812799C (en) * 2001-07-04 2016-01-26 Chromagenics B.V. Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
EP1513936A2 (en) * 2002-06-14 2005-03-16 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
WO2003106684A2 (en) 2002-06-14 2003-12-24 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
EP1573058B1 (en) 2002-12-18 2011-09-14 ChromaGenics B.V. A method for improving protein production
EP1572994B1 (en) 2002-12-20 2007-02-21 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
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