ES2362273T3 - Método para la producción simultánea de múltiples proteínas; vectores y células para su uso en el mismo. - Google Patents
Método para la producción simultánea de múltiples proteínas; vectores y células para su uso en el mismo. Download PDFInfo
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- ES2362273T3 ES2362273T3 ES03733632T ES03733632T ES2362273T3 ES 2362273 T3 ES2362273 T3 ES 2362273T3 ES 03733632 T ES03733632 T ES 03733632T ES 03733632 T ES03733632 T ES 03733632T ES 2362273 T3 ES2362273 T3 ES 2362273T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/822—Reducing position variability, e.g. by the use of scaffold attachment region/matrix attachment region (SAR/MAR); Use of SAR/MAR to regulate gene expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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- Virology (AREA)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| US5654442A (en) * | 1989-11-14 | 1997-08-05 | The Perkin-Elmer Corporation | 4,7-dichlorofluorescein dyes as molecular probes |
| JP4021197B2 (ja) * | 2000-03-17 | 2007-12-12 | アンチキャンサー， インコーポレイテッド | 遺伝子発現の全身光学イメージングとその使用 |
| CA2812799C (en) | 2001-07-04 | 2016-01-26 | Chromagenics B.V. | Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences |
| WO2003106684A2 (en) | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
| EP1513936A2 (en) * | 2002-06-14 | 2005-03-16 | Chromagenics B.V. | Use of repression blocking sequences in methods for enhancing gene expression |
| SI1523496T1 (sl) | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| EP1573058B1 (en) * | 2002-12-18 | 2011-09-14 | ChromaGenics B.V. | A method for improving protein production |
| EP1572994B1 (en) | 2002-12-20 | 2007-02-21 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
| EP2395017A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP1737971B1 (en) * | 2004-01-20 | 2017-08-16 | Merus N.V. | Mixtures of binding proteins |
| US7825232B2 (en) * | 2004-07-08 | 2010-11-02 | Chromagenics B.V. | Sequence for improving expression of nucleic acid |
| US20060195935A1 (en) * | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| KR101271884B1 (ko) * | 2004-11-08 | 2013-06-05 | 크로마제닉스 비.브이. | 고수준으로 단백질을 발현하는 숙주세포의 선택 |
| CN101090968B (zh) | 2004-11-08 | 2011-10-26 | 科罗迈吉尼科斯公司 | 高水平表达蛋白质的宿主细胞的选择 |
| US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20070042397A1 (en) * | 2005-03-03 | 2007-02-22 | International Business Machines Corporation | Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof |
| CN101389763B (zh) * | 2006-02-21 | 2013-01-23 | 科罗迈吉尼科斯公司 | 高水平表达蛋白质的宿主细胞的选择 |
| US20080293086A1 (en) * | 2006-09-18 | 2008-11-27 | Cobalt Technologies, Inc. A Delaware Corporation | Real time monitoring of microbial enzymatic pathways |
| JP2010504507A (ja) * | 2006-09-20 | 2010-02-12 | インスティチュート・パスツール・コリア | 細胞におけるターゲットタンパク質候補の発現を検出および／または定量する方法、ならびに小分子モデュレーターのターゲットタンパク質を同定する方法 |
| US20090081715A1 (en) * | 2007-09-07 | 2009-03-26 | Cobalt Technologies, Inc., A Delaware Corporation | Engineered Light-Emitting Reporter Genes |
| CA2721076A1 (en) | 2008-04-09 | 2009-10-15 | Cobalt Technologies, Inc. | Immobilized product tolerant microorganisms |
| DK2443239T3 (en) | 2009-06-15 | 2016-02-15 | Cellagenics B V | New stringent selection markers |
| AU2010266035B2 (en) | 2009-06-26 | 2015-02-12 | Talfryn S.A. | Integrated system and process for bioproduct production |
| EP2582816B1 (en) | 2010-06-15 | 2017-12-20 | Cellagenics B.V. | Novel intergenic elements for enhancing gene expression |
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- 2003-06-13 CA CA2723500A patent/CA2723500C/en not_active Expired - Lifetime
- 2003-06-13 DE DE60336228T patent/DE60336228D1/de not_active Expired - Lifetime
- 2003-06-13 JP JP2004513497A patent/JP4647309B2/ja not_active Expired - Fee Related
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- 2003-06-13 CA CA2722998A patent/CA2722998C/en not_active Expired - Lifetime
- 2003-06-13 NZ NZ537073A patent/NZ537073A/en not_active IP Right Cessation
- 2003-06-13 CA CA2489475A patent/CA2489475C/en not_active Expired - Lifetime
- 2003-06-13 DK DK03733632.8T patent/DK1513937T3/da active
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| CA2489475A1 (en) | 2003-12-24 |
| US20080227151A1 (en) | 2008-09-18 |
| AU2003238719B2 (en) | 2008-02-21 |
| EP1513937B1 (en) | 2011-03-02 |
| JP5095693B2 (ja) | 2012-12-12 |
| NZ537073A (en) | 2006-08-31 |
| US20050191723A1 (en) | 2005-09-01 |
| WO2003106684A3 (en) | 2004-04-08 |
| CA2489475C (en) | 2011-03-29 |
| JP2005529610A (ja) | 2005-10-06 |
| JP4647309B2 (ja) | 2011-03-09 |
| JP2010004886A (ja) | 2010-01-14 |
| JP2010011859A (ja) | 2010-01-21 |
| JP5095690B2 (ja) | 2012-12-12 |
| EP1513937A2 (en) | 2005-03-16 |
| CA2723500C (en) | 2014-10-28 |
| US20080227199A1 (en) | 2008-09-18 |
| CA2722998C (en) | 2014-12-02 |
| WO2003106684A2 (en) | 2003-12-24 |
| US7364878B2 (en) | 2008-04-29 |
| DE60336228D1 (de) | 2011-04-14 |
| ATE500331T1 (de) | 2011-03-15 |
| AU2003238719A1 (en) | 2003-12-31 |
| CA2723500A1 (en) | 2003-12-24 |
| US7901908B2 (en) | 2011-03-08 |
| DK1513937T3 (da) | 2011-05-16 |
| US7960143B2 (en) | 2011-06-14 |
| CA2722998A1 (en) | 2003-12-24 |
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