JP4647309B2 - 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 - Google Patents

複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 Download PDF

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JP4647309B2
JP4647309B2 JP2004513497A JP2004513497A JP4647309B2 JP 4647309 B2 JP4647309 B2 JP 4647309B2 JP 2004513497 A JP2004513497 A JP 2004513497A JP 2004513497 A JP2004513497 A JP 2004513497A JP 4647309 B2 JP4647309 B2 JP 4647309B2
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sequences
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JP2005529610A (ja
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オッテ，アリエ，ピエテル
クルッケベルグ，アーサー，レオ
セワルト，リヒャルド，ジョルジュ，アントニウス，ベルナルドゥス
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クロマジェニックス ビー．ブイ．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/822—Reducing position variability, e.g. by the use of scaffold attachment region/matrix attachment region (SAR/MAR); Use of SAR/MAR to regulate gene expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2004513497A 2002-06-14 2003-06-13 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞 Expired - Fee Related JP4647309B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077350 2002-06-14
PCT/NL2003/000432 WO2003106684A2 (en) 2002-06-14 2003-06-13 A method for simultaneous production of multiple proteins; vectors and cells for use therein

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JP2009184727A Division JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

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JP2005529610A JP2005529610A (ja) 2005-10-06
JP2005529610A5 JP2005529610A5 (enExample) 2006-08-03
JP4647309B2 true JP4647309B2 (ja) 2011-03-09

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JP2004513497A Expired - Fee Related JP4647309B2 (ja) 2002-06-14 2003-06-13 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009184727A Expired - Fee Related JP5095690B2 (ja) 2002-06-14 2009-08-07 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
JP2009203428A Expired - Fee Related JP5095693B2 (ja) 2002-06-14 2009-09-03 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

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JP2009203428A Expired - Fee Related JP5095693B2 (ja) 2002-06-14 2009-09-03 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞

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US (3) US7364878B2 (enExample)
EP (1) EP1513937B1 (enExample)
JP (3) JP4647309B2 (enExample)
AT (1) ATE500331T1 (enExample)
AU (1) AU2003238719B2 (enExample)
CA (3) CA2723500C (enExample)
DE (1) DE60336228D1 (enExample)
DK (1) DK1513937T3 (enExample)
ES (1) ES2362273T3 (enExample)
NZ (1) NZ537073A (enExample)
WO (1) WO2003106684A2 (enExample)

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EP1572994B1 (en) 2002-12-20 2007-02-21 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
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US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
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KR101271884B1 (ko) * 2004-11-08 2013-06-05 크로마제닉스 비.브이. 고수준으로 단백질을 발현하는 숙주세포의 선택
CN101090968B (zh) 2004-11-08 2011-10-26 科罗迈吉尼科斯公司 高水平表达蛋白质的宿主细胞的选择
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US20070042397A1 (en) * 2005-03-03 2007-02-22 International Business Machines Corporation Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof
CN101389763B (zh) * 2006-02-21 2013-01-23 科罗迈吉尼科斯公司 高水平表达蛋白质的宿主细胞的选择
US20080293086A1 (en) * 2006-09-18 2008-11-27 Cobalt Technologies, Inc. A Delaware Corporation Real time monitoring of microbial enzymatic pathways
JP2010504507A (ja) * 2006-09-20 2010-02-12 インスティチュート・パスツール・コリア 細胞におけるターゲットタンパク質候補の発現を検出および／または定量する方法、ならびに小分子モデュレーターのターゲットタンパク質を同定する方法
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AU2010266035B2 (en) 2009-06-26 2015-02-12 Talfryn S.A. Integrated system and process for bioproduct production
EP2582816B1 (en) 2010-06-15 2017-12-20 Cellagenics B.V. Novel intergenic elements for enhancing gene expression
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Publication number Publication date
CA2489475A1 (en) 2003-12-24
US20080227151A1 (en) 2008-09-18
AU2003238719B2 (en) 2008-02-21
EP1513937B1 (en) 2011-03-02
JP5095693B2 (ja) 2012-12-12
NZ537073A (en) 2006-08-31
US20050191723A1 (en) 2005-09-01
WO2003106684A3 (en) 2004-04-08
CA2489475C (en) 2011-03-29
JP2005529610A (ja) 2005-10-06
JP2010004886A (ja) 2010-01-14
JP2010011859A (ja) 2010-01-21
JP5095690B2 (ja) 2012-12-12
EP1513937A2 (en) 2005-03-16
ES2362273T3 (es) 2011-06-30
CA2723500C (en) 2014-10-28
US20080227199A1 (en) 2008-09-18
CA2722998C (en) 2014-12-02
WO2003106684A2 (en) 2003-12-24
US7364878B2 (en) 2008-04-29
DE60336228D1 (de) 2011-04-14
ATE500331T1 (de) 2011-03-15
AU2003238719A1 (en) 2003-12-31
CA2723500A1 (en) 2003-12-24
US7901908B2 (en) 2011-03-08
DK1513937T3 (da) 2011-05-16
US7960143B2 (en) 2011-06-14
CA2722998A1 (en) 2003-12-24

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