JP2004533262A5 - - Google Patents

Download PDF

Info

Publication number
JP2004533262A5
JP2004533262A5 JP2003510461A JP2003510461A JP2004533262A5 JP 2004533262 A5 JP2004533262 A5 JP 2004533262A5 JP 2003510461 A JP2003510461 A JP 2003510461A JP 2003510461 A JP2003510461 A JP 2003510461A JP 2004533262 A5 JP2004533262 A5 JP 2004533262A5
Authority
JP
Japan
Prior art keywords
sequence
star
gene
dna
transcription
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003510461A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004533262A (ja
JP4500044B2 (ja
Filing date
Publication date
Priority claimed from EP01202581A external-priority patent/EP1273666A1/en
Application filed filed Critical
Priority claimed from PCT/NL2002/000390 external-priority patent/WO2003004704A2/en
Publication of JP2004533262A publication Critical patent/JP2004533262A/ja
Publication of JP2004533262A5 publication Critical patent/JP2004533262A5/ja
Application granted granted Critical
Publication of JP4500044B2 publication Critical patent/JP4500044B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2003510461A 2001-07-04 2002-06-14 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法 Expired - Fee Related JP4500044B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01202581A EP1273666A1 (en) 2001-07-04 2001-07-04 Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
US30319901P 2001-07-05 2001-07-05
PCT/NL2002/000390 WO2003004704A2 (en) 2001-07-04 2002-06-14 Method of selecting dna sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
US10/190,312 US7192741B2 (en) 2001-07-04 2002-07-05 DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2010008591A Division JP5014443B2 (ja) 2001-07-04 2010-01-18 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法
JP2010008592A Division JP5014444B2 (ja) 2001-07-04 2010-01-18 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法

Publications (3)

Publication Number Publication Date
JP2004533262A JP2004533262A (ja) 2004-11-04
JP2004533262A5 true JP2004533262A5 (enExample) 2005-12-22
JP4500044B2 JP4500044B2 (ja) 2010-07-14

Family

ID=47915807

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003510461A Expired - Fee Related JP4500044B2 (ja) 2001-07-04 2002-06-14 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法
JP2010008591A Expired - Lifetime JP5014443B2 (ja) 2001-07-04 2010-01-18 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法
JP2010008592A Expired - Lifetime JP5014444B2 (ja) 2001-07-04 2010-01-18 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2010008591A Expired - Lifetime JP5014443B2 (ja) 2001-07-04 2010-01-18 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法
JP2010008592A Expired - Lifetime JP5014444B2 (ja) 2001-07-04 2010-01-18 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法

Country Status (21)

Country Link
US (9) US7192741B2 (enExample)
EP (8) EP1842919B1 (enExample)
JP (3) JP4500044B2 (enExample)
KR (2) KR100942117B1 (enExample)
CN (1) CN1266282C (enExample)
AT (8) ATE466944T1 (enExample)
AU (3) AU2002314629B2 (enExample)
BR (1) BRPI0210771B8 (enExample)
CA (2) CA2812799C (enExample)
CY (1) CY1107678T1 (enExample)
DE (8) DE60215502T2 (enExample)
DK (8) DK1808488T3 (enExample)
ES (8) ES2344073T3 (enExample)
IL (4) IL159674A0 (enExample)
MX (1) MXPA03011801A (enExample)
NO (1) NO338477B1 (enExample)
NZ (1) NZ530218A (enExample)
PT (1) PT1600510E (enExample)
SG (1) SG143066A1 (enExample)
WO (1) WO2003004704A2 (enExample)
ZA (1) ZA200309599B (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2812799C (en) 2001-07-04 2016-01-26 Chromagenics B.V. Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
EP1513936A2 (en) 2002-06-14 2005-03-16 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
WO2003106684A2 (en) * 2002-06-14 2003-12-24 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
SI1523496T1 (sl) 2002-07-18 2011-11-30 Merus B V Rekombinantno proizvajanje zmesi protiteles
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
EP1573058B1 (en) 2002-12-18 2011-09-14 ChromaGenics B.V. A method for improving protein production
EP1572994B1 (en) 2002-12-20 2007-02-21 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
EP2395017A3 (en) 2003-05-30 2012-12-19 Merus B.V. Design and use of paired variable regions of specific binding molecules
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1670925B1 (en) 2003-10-02 2013-05-01 Crucell Holland B.V. Packaging cells for recombinant adenovirus
WO2005059149A2 (en) * 2003-12-12 2005-06-30 Chromagenics B.V. Improved protein production
EP1737971B1 (en) 2004-01-20 2017-08-16 Merus N.V. Mixtures of binding proteins
US7825232B2 (en) * 2004-07-08 2010-11-02 Chromagenics B.V. Sequence for improving expression of nucleic acid
DK1786908T3 (da) * 2004-08-18 2010-06-07 Bayer Cropscience Ag Planter med forøget plastidisk aktivitet af stivelsesphosphorylerende R3-enzym
KR101271884B1 (ko) 2004-11-08 2013-06-05 크로마제닉스 비.브이. 고수준으로 단백질을 발현하는 숙주세포의 선택
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
CN101090968B (zh) * 2004-11-08 2011-10-26 科罗迈吉尼科斯公司 高水平表达蛋白质的宿主细胞的选择
US20060195935A1 (en) * 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
KR100984602B1 (ko) * 2004-11-18 2010-09-30 고쿠리츠다이가쿠호진 히로시마다이가쿠 유전자 증폭에 의해 형성된 반복서열로부터, 발현이 억제된단백질을 발현시키는 방법, 키트, 및 형질전환체
WO2007107578A1 (en) 2006-03-20 2007-09-27 Chromagenics B.V. Expression augmenting dna fragments, use thereof, and methods for finding thereof
US20080124760A1 (en) 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
EP2109674A2 (en) * 2007-01-08 2009-10-21 Millipore Corporation High expression cell line that eliminates gene amplification
DK2443239T3 (en) 2009-06-15 2016-02-15 Cellagenics B V New stringent selection markers
US8566596B2 (en) 2010-08-24 2013-10-22 Cisco Technology, Inc. Pre-association mechanism to provide detailed description of wireless services
EP2611915B1 (en) 2010-09-01 2015-04-15 Cellagenics B.V. Nucleic acid fragments from a ribosomal protein promoter for enhancing gene expression
ES2743399T3 (es) 2012-04-20 2020-02-19 Merus Nv Métodos y medios para la producción de moléculas heterodiméricas similares a Ig
CN104736174B (zh) 2012-07-06 2019-06-14 根马布私人有限公司 具有三重突变的二聚体蛋白质
US10358492B2 (en) 2012-09-27 2019-07-23 Merus N.V. Bispecific IgG antibodies as T cell engagers
US10417380B1 (en) 2013-12-31 2019-09-17 Mckesson Corporation Systems and methods for determining and communicating a prescription benefit coverage denial to a prescriber
US10489552B2 (en) 2014-02-14 2019-11-26 Mckesson Corporation Systems and methods for determining and communicating patient incentive information to a prescriber
SG11201607109QA (en) 2014-02-28 2016-09-29 Merus Nv Antibodies that bind egfr and erbb3
SI3110849T1 (sl) 2014-02-28 2021-01-29 Merus N.V. Protitelo, ki veže ERBB-2 in ERBB-3
US10157262B1 (en) 2015-03-10 2018-12-18 Mckesson Corporation Systems and methods for determining patient financial responsibility for multiple prescription products
EP3345928B1 (en) 2015-07-10 2020-06-24 Merus N.V. Human cd3 binding antibody
BR112018008068A2 (en) 2015-10-23 2018-11-13 Merus N.V. binding molecules that inhibit cancer growth
US11514137B1 (en) 2016-03-30 2022-11-29 Mckesson Corporation Alternative therapy identification system
US10999224B1 (en) 2017-02-01 2021-05-04 Mckesson Corporation Method and apparatus for parsing an electronic message and constructing multiple differently prioritized messages therefrom
CA3058343A1 (en) 2017-03-31 2018-10-04 Merus N.V. Erbb-2 and erbb-3 binding bispecific antibodies for use in the treatment of cells that have an nrg1 fusion gene
US12195551B2 (en) 2017-05-17 2025-01-14 Merus N.V. Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer
HUE071182T2 (hu) 2017-08-09 2025-08-28 Merus Nv EGFR és CMET kötõ antitestek
US10862832B1 (en) 2018-07-24 2020-12-08 Mckesson Corporation Computing system and method for automatically reversing an action indicated by an electronic message
US11043437B2 (en) 2019-01-07 2021-06-22 Applied Materials, Inc. Transparent substrate with light blocking edge exclusion zone
US11562437B1 (en) 2019-06-26 2023-01-24 Mckesson Corporation Method, apparatus, and computer program product for providing estimated prescription costs
US12469040B1 (en) 2019-06-26 2025-11-11 Mckesson Corporation Method, apparatus, and computer program product for providing real-time pricing information
US11636548B1 (en) 2019-06-26 2023-04-25 Mckesson Corporation Method, apparatus, and computer program product for providing estimated prescription costs
EP3772518A1 (en) 2019-08-07 2021-02-10 Merus N.V. Modified human variable domains
US20230104317A1 (en) * 2020-01-31 2023-04-06 The Board Of Trustees Of The Leland Stanford Junior University Systems and Methods to Identify Genetic Silencers and Applications Thereof
US11610240B1 (en) 2020-02-17 2023-03-21 Mckesson Corporation Method, apparatus, and computer program product for partitioning prescription transaction costs in an electronic prescription transaction
US12229834B1 (en) 2020-02-17 2025-02-18 Mckesson Corporation Method, apparatus, and computer program product for partitioning prescription transaction costs in an electronic prescription transaction
US12229833B1 (en) 2020-02-17 2025-02-18 Mckesson Corporation Method, apparatus, and computer program product for reformatting an electronic prescription transaction
EP4153315A1 (en) 2020-05-21 2023-03-29 Merus N.V. Methods and means for the production of ig-like molecules
US11587657B2 (en) 2020-09-04 2023-02-21 Mckesson Corporation Method, apparatus, and computer program product for performing an alternative evaluation procedure in response to an electronic message
US12367954B1 (en) 2021-01-08 2025-07-22 Mckesson Corporation Method, apparatus, and computer program product for estimating a target quantitative measure based upon historical electronic messages
CN113539357B (zh) * 2021-06-10 2024-04-30 阿里巴巴达摩院(杭州)科技有限公司 基因检测方法、模型训练方法、装置、设备及系统
US12197972B1 (en) 2022-03-28 2025-01-14 Mckesson Corporation Method, apparatus, and computer program product for generating alternative evaluation messages

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US719271A (en) * 1902-01-13 1903-01-27 Solomon P Smith Furnace.
US5610053A (en) 1993-04-07 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells
US5972605A (en) 1994-07-07 1999-10-26 Geron Corporation Assays for regulators of mammalian telomerase expression
EP0818536A4 (en) * 1995-03-24 2000-09-06 Shionogi & Co DNA MOLECULE DRAWN ON THE SUPPRESSION OF THE GENE EXPRESSION AND CORRESPONDING PROTEIN
DE19539493A1 (de) * 1995-10-24 1997-04-30 Thomae Gmbh Dr K Starker homologer Promotor aus Hamster
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
US6037525A (en) * 1996-08-01 2000-03-14 North Carolina State University Method for reducing expression variability of transgenes in plant cells
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
WO2000005393A2 (en) 1998-07-21 2000-02-03 Cobra Therapeutics Limited A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)
US6872524B1 (en) 1998-08-14 2005-03-29 Chromagenics B.V. Method of detecting an expression-enhancing sequence
US6800457B2 (en) 1998-09-22 2004-10-05 Bristol-Myers Squibb Company Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
US6521419B1 (en) 1998-09-22 2003-02-18 Kanakaraju Koduri Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
WO2000023606A1 (en) 1998-10-22 2000-04-27 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
NZ529329A (en) * 1999-08-25 2005-06-24 Immunex Corp Compositions and methods for improved cell culture
US6586205B1 (en) 2000-02-11 2003-07-01 Millennium Pharmaceuticals, Inc. 43239 a novel GPCR-like molecule and uses thereof
AU2001238178A1 (en) 2000-02-11 2001-08-20 Millennium Pharmaceuticals, Inc. Seven-transmembrane proteins/g-protein coupled receptors
KR100996016B1 (ko) 2000-09-20 2010-11-22 밀리포어 코포레이션 폴리뉴클레오티드
EP1273666A1 (en) 2001-07-04 2003-01-08 Chromagenics B.V. Method of selecting a DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
CA2812799C (en) 2001-07-04 2016-01-26 Chromagenics B.V. Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
EP1513936A2 (en) * 2002-06-14 2005-03-16 Chromagenics B.V. Use of repression blocking sequences in methods for enhancing gene expression
WO2003106684A2 (en) * 2002-06-14 2003-12-24 Chromagenics B.V. A method for simultaneous production of multiple proteins; vectors and cells for use therein
EP1573058B1 (en) 2002-12-18 2011-09-14 ChromaGenics B.V. A method for improving protein production
EP1572994B1 (en) 2002-12-20 2007-02-21 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors

Similar Documents

Publication Publication Date Title
JP4500044B2 (ja) 遺伝子転写を調節する特性を含むdna配列及びそのようなdna配列を検出し且つ使用するための方法
JP2004533262A5 (enExample)
AU2002314629A1 (en) Method of selecting DNA sequence with transcription modulating activity using a vector comprising an element with a gene transcription repressing activity
CA2812821C (en) Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences
HK1076837A (en) Dna sequences having anti-repressor activity