JP2003523769A5 - - Google Patents
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- Publication number
- JP2003523769A5 JP2003523769A5 JP2001562693A JP2001562693A JP2003523769A5 JP 2003523769 A5 JP2003523769 A5 JP 2003523769A5 JP 2001562693 A JP2001562693 A JP 2001562693A JP 2001562693 A JP2001562693 A JP 2001562693A JP 2003523769 A5 JP2003523769 A5 JP 2003523769A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorescent protein
- functional
- red fluorescent
- protein
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010054624 red fluorescent protein Proteins 0.000 description 33
- 102000039446 nucleic acids Human genes 0.000 description 14
- 108020004707 nucleic acids Proteins 0.000 description 14
- 150000007523 nucleic acids Chemical class 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 11
- 241000238631 Hexapoda Species 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 9
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 9
- 239000005090 green fluorescent protein Substances 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 108091006047 fluorescent proteins Proteins 0.000 description 4
- 102000034287 fluorescent proteins Human genes 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 102220479067 CD5 antigen-like_Y72F_mutation Human genes 0.000 description 3
- 102220485980 Dihydropteridine reductase_Q66R_mutation Human genes 0.000 description 3
- 102220507725 GTP-binding protein RAD_Q66P_mutation Human genes 0.000 description 3
- 102220547511 Glucocorticoid receptor_F65V_mutation Human genes 0.000 description 3
- 102220545761 HLA class II histocompatibility antigen, DQ alpha 1 chain_V73L_mutation Human genes 0.000 description 3
- 102220465273 Interferon alpha-8_F65Y_mutation Human genes 0.000 description 3
- 102220481503 Podocan_V73A_mutation Human genes 0.000 description 3
- 102220481306 Podocan_V73I_mutation Human genes 0.000 description 3
- 102220481317 Podocan_V73S_mutation Human genes 0.000 description 3
- 102220527094 Polycomb group RING finger protein 6_S69A_mutation Human genes 0.000 description 3
- 102220548995 Translin-associated factor X-interacting protein 1_Q64T_mutation Human genes 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 102220364176 c.205T>A Human genes 0.000 description 3
- 102220361662 c.208A>C Human genes 0.000 description 3
- 102220201129 rs1010098398 Human genes 0.000 description 3
- 102220244622 rs1555369198 Human genes 0.000 description 3
- 102200033503 rs1555826433 Human genes 0.000 description 3
- 102200133077 rs199473646 Human genes 0.000 description 3
- 102220068408 rs57932685 Human genes 0.000 description 3
- 102220049906 rs587783531 Human genes 0.000 description 3
- 102220040617 rs73070954 Human genes 0.000 description 3
- 102220128472 rs766082334 Human genes 0.000 description 3
- 102220178356 rs769686237 Human genes 0.000 description 3
- 102200069353 rs8103142 Human genes 0.000 description 3
- 102220102892 rs878855278 Human genes 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 3
- 102220626871 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A_Q66A_mutation Human genes 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 230000004850 protein–protein interaction Effects 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18473200P | 2000-02-23 | 2000-02-23 | |
| US60/184,732 | 2000-02-23 | ||
| PCT/US2001/004625 WO2001062919A1 (en) | 2000-02-23 | 2001-02-13 | Modified fluorescent proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003523769A JP2003523769A (ja) | 2003-08-12 |
| JP2003523769A5 true JP2003523769A5 (enExample) | 2008-04-10 |
Family
ID=22678112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001562693A Pending JP2003523769A (ja) | 2000-02-23 | 2001-02-13 | 改変された蛍光タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20040171107A1 (enExample) |
| EP (1) | EP1259608B1 (enExample) |
| JP (1) | JP2003523769A (enExample) |
| AT (1) | ATE439441T1 (enExample) |
| AU (1) | AU2001238212A1 (enExample) |
| CA (1) | CA2400642A1 (enExample) |
| DE (1) | DE60139544D1 (enExample) |
| HK (1) | HK1049185A1 (enExample) |
| WO (1) | WO2001062919A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6842401A (en) * | 2000-06-14 | 2001-12-24 | Clontech Lab Inc | Fluorescent timer proteins and methods for their use |
| US20020048811A1 (en) | 2000-10-16 | 2002-04-25 | Devreotes Peter N. | Receptor mediated activation of heterotrimeric G-proteins |
| WO2002068605A2 (en) | 2001-02-26 | 2002-09-06 | The Regents Of The University Of California | Non-oligomerizing tandem fluorescent proteins |
| US7005511B2 (en) | 2001-02-26 | 2006-02-28 | The Regents Of The University Of California | Fluorescent protein variants and methods for making same |
| US7687614B2 (en) | 2001-02-26 | 2010-03-30 | The Regents Of The University Of California | Monomeric and dimeric fluorescent protein variants and methods for making same |
| US7022826B2 (en) | 2001-02-26 | 2006-04-04 | The Regents Of The University Of California | Non-oligomerizing fluorescent proteins |
| FR2821854B1 (fr) * | 2001-03-09 | 2004-07-16 | Genoway | Cellules et animaux transgeniques d'etude de la polarisation de la reponse immune |
| US7413874B2 (en) | 2002-12-09 | 2008-08-19 | University Of Miami | Nucleic acid encoding fluorescent proteins from aquatic species |
| WO2004058973A1 (en) * | 2002-12-26 | 2004-07-15 | Zakrytoe Aktsionernoe Obschestvo 'evrogen' | Fluorescent proteins from copepoda species and methods for using same |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| GB0327143D0 (en) * | 2003-11-21 | 2003-12-24 | Univ Belfast | Assay |
| EP1645881A1 (en) * | 2004-10-05 | 2006-04-12 | DKFZ Deutsches Krebsforschungszentrum | Screening process for the detection and characterization of protein-protein-interactions in vivo by fluorescence cross correlation spectroscopy |
| US9339559B2 (en) | 2005-09-09 | 2016-05-17 | Georgia State University Research Foundation, Inc. | Targeted contrast agents and methods for targeting contrast agents |
| US8173105B2 (en) * | 2005-07-13 | 2012-05-08 | Georgia State University Research Foundation | Contrast agents and methods for preparing contrast agents |
| KR101834574B1 (ko) | 2009-01-29 | 2018-03-05 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | Ｇ 단백질 커플링 수용체 활성화 측정 |
| US8937213B2 (en) | 2011-05-21 | 2015-01-20 | Christopher E. Hopkins | Transgenic biosensors |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000976A (en) * | 1972-12-07 | 1977-01-04 | G. D. Searle & Co. | Apparatus and method for preparing, diluting and replicating laboratory samples |
| US5196313A (en) * | 1983-01-03 | 1993-03-23 | American Cyanamid Company | Method for the evaluation of anticoccidial activity of compounds using 2,3,5-triphenyltetrazolium chloride and trypan blue indicators |
| US5125748A (en) * | 1986-03-26 | 1992-06-30 | Beckman Instruments, Inc. | Optical detection module for use in an automated laboratory work station |
| US5206568A (en) * | 1986-03-26 | 1993-04-27 | Beckman Instruments, Inc. | Coordinated control of stepper motors |
| US5104621A (en) * | 1986-03-26 | 1992-04-14 | Beckman Instruments, Inc. | Automated multi-purpose analytical chemistry processing center and laboratory work station |
| US5139744A (en) * | 1986-03-26 | 1992-08-18 | Beckman Instruments, Inc. | Automated laboratory work station having module identification means |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5276182A (en) | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
| DE4039602A1 (de) * | 1990-12-12 | 1992-06-17 | Bauer Kurt Heinz Prof Dr | Pharmazeutische formulierungen |
| KR100221695B1 (ko) | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
| US5683676A (en) | 1991-12-12 | 1997-11-04 | Glaxo Group Limited | Canister containing aerosol formulations containing P134a and particulate medicaments |
| JP3456703B2 (ja) * | 1992-07-06 | 2003-10-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | リポーター遺伝子に融合した細菌のストレスプロモーターを用いる毒性を測定するための方法および診断用キット |
| US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5355215A (en) * | 1992-09-30 | 1994-10-11 | Environmental Research Institute Of Michigan | Method and apparatus for quantitative fluorescence measurements |
| CA2149150C (en) | 1992-11-27 | 2000-08-01 | David R. Carver | Injectable taxol composition with improved stability |
| US5654286A (en) | 1993-05-12 | 1997-08-05 | Hostetler; Karl Y. | Nucleotides for topical treatment of psoriasis, and methods for using same |
| US5464758A (en) * | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US5350564A (en) * | 1993-06-28 | 1994-09-27 | Baxter Diagnostics Inc. | Automated chemical analyzer with apparatus and method for conveying and temporary storage of sample tubes |
| US5532130A (en) * | 1993-07-20 | 1996-07-02 | Dyad Pharmaceutical Corporation | Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides |
| ES2248793T3 (es) | 1993-10-01 | 2006-03-16 | Roche Palo Alto Llc | Suspensiones orales de alta dosis de mofetil micofenolato. |
| FR2715762B1 (fr) * | 1994-02-01 | 1996-03-29 | Transnucleaire | Dispositif de fixation du fond d'un conteneur de transport et/ou stockage de matières radioactives. |
| US5795737A (en) * | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
| US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
| US5777079A (en) * | 1994-11-10 | 1998-07-07 | The Regents Of The University Of California | Modified green fluorescent proteins |
| US5625048A (en) * | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
| US5589351A (en) * | 1994-12-06 | 1996-12-31 | Nps Pharmaceuticals, Inc. | Fluorescence detection apparatus |
| US5741657A (en) * | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US5653987A (en) * | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| US5726181A (en) | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| US5667809A (en) | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
| US5676012A (en) * | 1995-12-05 | 1997-10-14 | Spectrum Manufacturing, Inc. | Process for forming endoscopic shaver blade from elongate tube |
| US6803188B1 (en) * | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
| US5804387A (en) * | 1996-02-01 | 1998-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | FACS-optimized mutants of the green fluorescent protein (GFP) |
| US5800690A (en) * | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
| US5998204A (en) * | 1997-03-14 | 1999-12-07 | The Regents Of The University Of California | Fluorescent protein sensors for detection of analytes |
| US5985214A (en) * | 1997-05-16 | 1999-11-16 | Aurora Biosciences Corporation | Systems and methods for rapidly identifying useful chemicals in liquid samples |
| WO2000034326A1 (en) * | 1998-12-11 | 2000-06-15 | Clontech Laboratories, Inc. | Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof |
| WO2001027150A2 (en) * | 1999-10-14 | 2001-04-19 | Clontech Laboratories Inc. | Anthozoa derived chromo/fluoroproteins and methods for using the same |
-
2001
- 2001-02-13 CA CA002400642A patent/CA2400642A1/en not_active Abandoned
- 2001-02-13 US US10/311,030 patent/US20040171107A1/en not_active Abandoned
- 2001-02-13 AU AU2001238212A patent/AU2001238212A1/en not_active Abandoned
- 2001-02-13 JP JP2001562693A patent/JP2003523769A/ja active Pending
- 2001-02-13 AT AT01910621T patent/ATE439441T1/de not_active IP Right Cessation
- 2001-02-13 DE DE60139544T patent/DE60139544D1/de not_active Expired - Lifetime
- 2001-02-13 WO PCT/US2001/004625 patent/WO2001062919A1/en not_active Ceased
- 2001-02-13 HK HK03101350.9A patent/HK1049185A1/zh unknown
- 2001-02-13 EP EP01910621A patent/EP1259608B1/en not_active Expired - Lifetime
-
2006
- 2006-03-09 US US11/371,240 patent/US20070099175A1/en not_active Abandoned
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