JP2005526816A - 抗ヒスタミン薬および抗アレルギー薬としてのアザインドリルピペリジン誘導体 - Google Patents

抗ヒスタミン薬および抗アレルギー薬としてのアザインドリルピペリジン誘導体 Download PDF

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Publication number
JP2005526816A
JP2005526816A JP2003580332A JP2003580332A JP2005526816A JP 2005526816 A JP2005526816 A JP 2005526816A JP 2003580332 A JP2003580332 A JP 2003580332A JP 2003580332 A JP2003580332 A JP 2003580332A JP 2005526816 A JP2005526816 A JP 2005526816A
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JP
Japan
Prior art keywords
pyrrolo
pyridin
ylmethyl
piperidin
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2003580332A
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English (en)
Japanese (ja)
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JP2005526816A5 (https=
Inventor
シルビア・フォンケルナ・ポウ
ルイス・ミゲル・パヘス・サンタカナ
カルロス・プイグ・ドゥラン
ホセ・マヌエル・プリエト・ソト
アランサス・カルドゥス・フィゲラス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall Prodesfarma Sosiedad Anonima
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Almirall Prodesfarma Sosiedad Anonima
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Application filed by Almirall Prodesfarma Sosiedad Anonima filed Critical Almirall Prodesfarma Sosiedad Anonima
Publication of JP2005526816A publication Critical patent/JP2005526816A/ja
Publication of JP2005526816A5 publication Critical patent/JP2005526816A5/ja
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003580332A 2002-04-01 2003-04-01 抗ヒスタミン薬および抗アレルギー薬としてのアザインドリルピペリジン誘導体 Ceased JP2005526816A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200200753A ES2201899B1 (es) 2002-04-01 2002-04-01 Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
PCT/EP2003/003377 WO2003082867A1 (en) 2002-04-01 2003-04-01 Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents

Publications (2)

Publication Number Publication Date
JP2005526816A true JP2005526816A (ja) 2005-09-08
JP2005526816A5 JP2005526816A5 (https=) 2006-04-27

Family

ID=28459671

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003580332A Ceased JP2005526816A (ja) 2002-04-01 2003-04-01 抗ヒスタミン薬および抗アレルギー薬としてのアザインドリルピペリジン誘導体

Country Status (10)

Country Link
US (1) US7622480B2 (https=)
EP (1) EP1497292B1 (https=)
JP (1) JP2005526816A (https=)
AT (1) ATE329916T1 (https=)
AU (1) AU2003226765A1 (https=)
DE (1) DE60306138T2 (https=)
DK (1) DK1497292T3 (https=)
ES (2) ES2201899B1 (https=)
PT (1) PT1497292E (https=)
WO (1) WO2003082867A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010507621A (ja) * 2006-10-27 2010-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規な置換ピペリジル−プロパン−チオール
JP2010507620A (ja) * 2006-10-27 2010-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピペリジル−プロパン−チオールｃｃｒ３モジュレーター

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005049559A2 (en) * 2003-11-17 2005-06-02 Boehringer Ingelheim International Gmbh Novel piperidine-substituted indoles- or hetero-derivatives thereof and their use as modulators of chemokine receptor (ccr-3)
JP5049267B2 (ja) * 2005-04-26 2012-10-17 ハイプニオン・インコーポレイテッド ベンズイソオキサゾールピペラジン化合物およびその使用方法
JP5080450B2 (ja) * 2005-04-30 2012-11-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なピペリジン置換インドール
AU2006306497A1 (en) * 2005-10-24 2007-05-03 Janssen Pharmaceutica, N.V. 3-piperidin-4-yl-indole ORL-1 receptor modulators
EP2714688B1 (en) * 2011-05-26 2016-02-24 Daiichi Sankyo Company, Limited Heterocyclic compounds as protein kinase inhibitors
MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
CA2969974C (en) 2014-12-15 2020-08-04 The Regents Of The University Of Michigan Small molecule inhibitors of egfr and pi3k
KR101660863B1 (ko) * 2015-04-03 2016-09-28 주식회사 녹십자 IKKε 및 TBK1 억제제로서의 7-아자인돌 또는 4,7-다이아자인돌 유도체 및 이를 포함하는 약학적 조성물
WO2022140456A1 (en) 2020-12-22 2022-06-30 Mekanistic Therapeutics Llc Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018505A1 (fr) * 1991-04-23 1992-10-29 Toray Industries, Inc. Derive de triazole tricyclique, production et utilisation de ce derive
WO1997049706A1 (en) * 1996-06-25 1997-12-31 Novartis Ag SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF
WO2000075130A1 (en) * 1999-06-04 2000-12-14 Almirall Prodesfarma, S.A. Indolylpiperidine derivatives as antihistaminic and antiallergic agents
WO2002014317A2 (en) * 2000-08-14 2002-02-21 Ortho Mcneil Pharmaceutical, Inc. Substituted pyrazoles
WO2002020013A2 (en) * 2000-09-06 2002-03-14 Ortho Mcneil Pharmaceutical, Inc. A method for treating allergies using substituted pyrazoles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
ES2172436B1 (es) 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
MXPA03005432A (es) 2000-12-22 2003-09-10 Wyeth Corp Compuestos de heterociclilindazol y -azaindazol como ligandos de 5-hidroxitriptamina-6.
WO2002079151A1 (en) 2001-03-29 2002-10-10 Smithkline Beecham P.L.C. 3-substituted indoels or fused pyrroles as antagonists of the chemokine mcp-1 (ccr2b) receptor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018505A1 (fr) * 1991-04-23 1992-10-29 Toray Industries, Inc. Derive de triazole tricyclique, production et utilisation de ce derive
WO1997049706A1 (en) * 1996-06-25 1997-12-31 Novartis Ag SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF
WO2000075130A1 (en) * 1999-06-04 2000-12-14 Almirall Prodesfarma, S.A. Indolylpiperidine derivatives as antihistaminic and antiallergic agents
WO2002014317A2 (en) * 2000-08-14 2002-02-21 Ortho Mcneil Pharmaceutical, Inc. Substituted pyrazoles
WO2002020013A2 (en) * 2000-09-06 2002-03-14 Ortho Mcneil Pharmaceutical, Inc. A method for treating allergies using substituted pyrazoles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010507621A (ja) * 2006-10-27 2010-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規な置換ピペリジル−プロパン−チオール
JP2010507620A (ja) * 2006-10-27 2010-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピペリジル−プロパン−チオールｃｃｒ３モジュレーター

Also Published As

Publication number Publication date
EP1497292B1 (en) 2006-06-14
ES2201899A1 (es) 2004-03-16
DK1497292T3 (da) 2006-10-16
WO2003082867A8 (en) 2004-11-04
EP1497292A1 (en) 2005-01-19
US7622480B2 (en) 2009-11-24
ATE329916T1 (de) 2006-07-15
WO2003082867A1 (en) 2003-10-09
DE60306138T2 (de) 2007-05-03
US20050176751A1 (en) 2005-08-11
PT1497292E (pt) 2006-10-31
AU2003226765A1 (en) 2003-10-13
DE60306138D1 (de) 2006-07-27
AU2003226765A8 (en) 2003-10-13
ES2201899B1 (es) 2005-06-01
ES2265577T3 (es) 2007-02-16

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