JP2005526754A5 - - Google Patents
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- Publication number
- JP2005526754A5 JP2005526754A5 JP2003574133A JP2003574133A JP2005526754A5 JP 2005526754 A5 JP2005526754 A5 JP 2005526754A5 JP 2003574133 A JP2003574133 A JP 2003574133A JP 2003574133 A JP2003574133 A JP 2003574133A JP 2005526754 A5 JP2005526754 A5 JP 2005526754A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- alkylaryl
- cyano
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 3
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 2
- -1 cyano, amino Chemical group 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000004947 alkyl aryl amino group Chemical group 0.000 description 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 1
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 125000001769 aryl amino group Chemical group 0.000 description 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 description 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 description 1
- 125000005110 aryl thio group Chemical group 0.000 description 1
- 125000005200 aryloxy carbonyloxy group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 125000004986 diarylamino group Chemical group 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36265402P | 2002-03-08 | 2002-03-08 | |
| US39549502P | 2002-07-12 | 2002-07-12 | |
| PCT/US2003/007229 WO2003075857A2 (en) | 2002-03-08 | 2003-03-10 | Amino-methyl substituted tetracycline compounds |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008104216A Division JP2008266330A (ja) | 2002-03-08 | 2008-04-14 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010069022A Division JP2010195796A (ja) | 2002-03-08 | 2010-03-25 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010242947A Division JP2011102296A (ja) | 2002-03-08 | 2010-10-29 | アミノメチル置換されたテトラサイクリン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526754A JP2005526754A (ja) | 2005-09-08 |
| JP2005526754A5 true JP2005526754A5 (https=) | 2008-06-26 |
Family
ID=27807973
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574133A Withdrawn JP2005526754A (ja) | 2002-03-08 | 2003-03-10 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2008104216A Ceased JP2008266330A (ja) | 2002-03-08 | 2008-04-14 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010069022A Pending JP2010195796A (ja) | 2002-03-08 | 2010-03-25 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010242947A Pending JP2011102296A (ja) | 2002-03-08 | 2010-10-29 | アミノメチル置換されたテトラサイクリン化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008104216A Ceased JP2008266330A (ja) | 2002-03-08 | 2008-04-14 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010069022A Pending JP2010195796A (ja) | 2002-03-08 | 2010-03-25 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010242947A Pending JP2011102296A (ja) | 2002-03-08 | 2010-10-29 | アミノメチル置換されたテトラサイクリン化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7326696B2 (https=) |
| EP (4) | EP2311451A1 (https=) |
| JP (4) | JP2005526754A (https=) |
| KR (3) | KR101014918B1 (https=) |
| CN (3) | CN1649582A (https=) |
| AU (2) | AU2003220123B2 (https=) |
| CA (1) | CA2478335C (https=) |
| EA (3) | EA201000491A1 (https=) |
| IL (3) | IL163931A0 (https=) |
| WO (1) | WO2003075857A2 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| WO1999037306A1 (en) * | 1998-01-23 | 1999-07-29 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| EA016099B1 (ru) * | 1999-09-14 | 2012-02-28 | Трастис Оф Тафтс Коллидж | Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина |
| AU3105801A (en) * | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| EA200201046A1 (ru) * | 2000-03-31 | 2003-04-24 | Трастис Оф Тафтс Коллидж | 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное |
| CA2409063A1 (en) * | 2000-05-15 | 2001-11-22 | Mark L. Nelson | 7-substituted fused ring tetracycline compounds |
| AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| EA009175B1 (ru) * | 2000-07-07 | 2007-12-28 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| IL153672A0 (en) * | 2000-07-07 | 2003-07-06 | Tufts College | 7-substituted tetracycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| EP1381372A2 (en) * | 2001-03-14 | 2004-01-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP2327409A1 (en) * | 2001-07-13 | 2011-06-01 | Paratek Pharmaceuticals, Inc. | Tetracycline compound having target therapeutic activities |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| AU2002365120A1 (en) * | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| ES2551708T3 (es) * | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| EP1503981A4 (en) * | 2002-03-21 | 2007-08-15 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS |
| AU2003261161B2 (en) * | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
| CA2503446C (en) | 2002-10-24 | 2012-12-18 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
| EP1556007A4 (en) * | 2002-10-24 | 2008-12-17 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA |
| US20050143352A1 (en) | 2003-07-09 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| AU2004259661B2 (en) * | 2003-07-09 | 2011-11-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| JP5010284B2 (ja) * | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族ａ環誘導体 |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| EP2033950A1 (en) * | 2004-10-25 | 2009-03-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1805134B1 (en) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| CA2597212A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| EP2431469A3 (en) * | 2006-05-15 | 2012-05-30 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| WO2008079339A2 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| CA2892739A1 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| AU2008239606A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| EP2216323A3 (en) * | 2007-04-27 | 2010-12-29 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| EP2176216B1 (en) | 2007-07-06 | 2012-04-25 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing 9-substituted minocycline |
| WO2009073056A1 (en) * | 2007-09-07 | 2009-06-11 | Dr. Reddy's Laboratories Ltd. | Novel tetracycline derivatives as antibacterial agents |
| ES2388958T3 (es) | 2007-11-29 | 2012-10-22 | Actelion Pharmaceuticals Ltd. | Derivados de acido fosfonico y su uso como antagonista del receptor P2Y12 |
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| CA2718056A1 (en) * | 2008-03-13 | 2009-09-17 | The Regents Of The University Of California | Use of epicatechin and derivatives and salts thereof for cardiac protection of ischemic myocardium and to ameliorate adverse cardiac remodeling |
| PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| WO2009128913A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| TWI680117B (zh) * | 2008-05-19 | 2019-12-21 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| KR101746795B1 (ko) * | 2008-08-08 | 2017-06-13 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | Ｃ７-플루오로 치환된 테트라시클린 화합물 |
| US20100190755A1 (en) * | 2008-09-19 | 2010-07-29 | Paul Abato | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
| WO2010129057A2 (en) | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| NO2470500T3 (https=) | 2009-08-28 | 2018-03-03 | ||
| AR082633A1 (es) * | 2010-08-12 | 2012-12-19 | Tetraphase Pharmaceuticals Inc | Analogos de tetraciclina |
| KR101732084B1 (ko) | 2011-07-26 | 2017-05-02 | 케이비피 바이오사이언시즈 씨오., 엘티디. | 9-아미노메틸 치환된 테트라사이클린 화합물 |
| CA2883238C (en) | 2012-08-31 | 2021-11-23 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| CA2904387C (en) | 2013-03-15 | 2021-12-07 | Melinta Therapeutics, Inc. | Methods of treating infections in overweight and obese patients using antibiotics |
| TW202206081A (zh) * | 2016-08-03 | 2022-02-16 | 美商派瑞泰Ｓｐｖ２有限公司 | ９—胺甲基米諾四環素化合物及其用途 |
| GB201615693D0 (en) * | 2016-09-15 | 2016-11-02 | Combinatorx Infection Ltd | Combinations |
| HUE066360T2 (hu) | 2016-10-19 | 2024-07-28 | Tetraphase Pharmaceuticals Inc | Eravaciklin kristályformái |
| BR112019008897A2 (pt) | 2016-11-01 | 2019-08-13 | Paratek Pharm Innc | método para tratar pneumonia bacteriana adquirida na comunidade. |
| EP3846805A4 (en) | 2018-09-04 | 2022-08-24 | Paratek Pharmaceuticals, Inc. | Methods of treating mycobacterial infections using tetracycline compounds |
| CN113332298A (zh) * | 2021-05-27 | 2021-09-03 | 成都医学院 | 米诺环素作为酪氨酸激酶抑制剂的新用途 |
| CN117088787B (zh) * | 2022-05-13 | 2025-12-19 | 上海医药工业研究院有限公司 | 9位含曼尼希碱的四环素类化合物及其制备方法和应用 |
| CN117486749A (zh) * | 2023-11-23 | 2024-02-02 | 传健生物医药(厦门)有限公司 | 一种奥马环素杂质的制备方法 |
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-
2003
- 2003-03-10 EP EP10184869A patent/EP2311451A1/en not_active Withdrawn
- 2003-03-10 CN CNA038099799A patent/CN1649582A/zh active Pending
- 2003-03-10 KR KR1020047014092A patent/KR101014918B1/ko not_active Expired - Fee Related
- 2003-03-10 KR KR1020117006989A patent/KR101163937B1/ko not_active Expired - Fee Related
- 2003-03-10 AU AU2003220123A patent/AU2003220123B2/en not_active Ceased
- 2003-03-10 KR KR1020107016704A patent/KR101093842B1/ko not_active Expired - Fee Related
- 2003-03-10 EP EP10184858A patent/EP2301534A1/en not_active Withdrawn
- 2003-03-10 CN CN2011103993027A patent/CN102531948A/zh active Pending
- 2003-03-10 IL IL16393103A patent/IL163931A0/xx unknown
- 2003-03-10 CN CNA2008100962190A patent/CN101307017A/zh active Pending
- 2003-03-10 WO PCT/US2003/007229 patent/WO2003075857A2/en not_active Ceased
- 2003-03-10 EP EP10184863A patent/EP2316450A1/en not_active Withdrawn
- 2003-03-10 CA CA2478335A patent/CA2478335C/en not_active Expired - Fee Related
- 2003-03-10 EA EA201000491A patent/EA201000491A1/ru unknown
- 2003-03-10 EA EA200802365A patent/EA200802365A1/ru unknown
- 2003-03-10 EA EA200401169A patent/EA013819B1/ru not_active IP Right Cessation
- 2003-03-10 EP EP03716416A patent/EP1482926A4/en not_active Withdrawn
- 2003-03-10 JP JP2003574133A patent/JP2005526754A/ja not_active Withdrawn
- 2003-12-15 US US10/737,361 patent/US7326696B2/en not_active Expired - Lifetime
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2004
- 2004-09-07 IL IL163931A patent/IL163931A/en not_active IP Right Cessation
-
2007
- 2007-06-05 US US11/810,336 patent/US20080015169A1/en not_active Abandoned
-
2008
- 2008-04-14 JP JP2008104216A patent/JP2008266330A/ja not_active Ceased
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2009
- 2009-08-07 AU AU2009208042A patent/AU2009208042B2/en not_active Expired - Fee Related
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2010
- 2010-03-25 JP JP2010069022A patent/JP2010195796A/ja active Pending
- 2010-10-29 JP JP2010242947A patent/JP2011102296A/ja active Pending
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2011
- 2011-05-30 IL IL213220A patent/IL213220A0/en unknown
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