JP2005526754A5 - - Google Patents
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- Publication number
- JP2005526754A5 JP2005526754A5 JP2003574133A JP2003574133A JP2005526754A5 JP 2005526754 A5 JP2005526754 A5 JP 2005526754A5 JP 2003574133 A JP2003574133 A JP 2003574133A JP 2003574133 A JP2003574133 A JP 2003574133A JP 2005526754 A5 JP2005526754 A5 JP 2005526754A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- alkylaryl
- cyano
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 3
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 2
- -1 cyano, amino Chemical group 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000004947 alkyl aryl amino group Chemical group 0.000 description 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 1
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 125000001769 aryl amino group Chemical group 0.000 description 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 description 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 description 1
- 125000005110 aryl thio group Chemical group 0.000 description 1
- 125000005200 aryloxy carbonyloxy group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 125000004986 diarylamino group Chemical group 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36265402P | 2002-03-08 | 2002-03-08 | |
| US39549502P | 2002-07-12 | 2002-07-12 | |
| PCT/US2003/007229 WO2003075857A2 (en) | 2002-03-08 | 2003-03-10 | Amino-methyl substituted tetracycline compounds |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008104216A Division JP2008266330A (ja) | 2002-03-08 | 2008-04-14 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010069022A Division JP2010195796A (ja) | 2002-03-08 | 2010-03-25 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010242947A Division JP2011102296A (ja) | 2002-03-08 | 2010-10-29 | アミノメチル置換されたテトラサイクリン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526754A JP2005526754A (ja) | 2005-09-08 |
| JP2005526754A5 true JP2005526754A5 (https=) | 2008-06-26 |
Family
ID=27807973
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574133A Withdrawn JP2005526754A (ja) | 2002-03-08 | 2003-03-10 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2008104216A Ceased JP2008266330A (ja) | 2002-03-08 | 2008-04-14 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010069022A Pending JP2010195796A (ja) | 2002-03-08 | 2010-03-25 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010242947A Pending JP2011102296A (ja) | 2002-03-08 | 2010-10-29 | アミノメチル置換されたテトラサイクリン化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008104216A Ceased JP2008266330A (ja) | 2002-03-08 | 2008-04-14 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010069022A Pending JP2010195796A (ja) | 2002-03-08 | 2010-03-25 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010242947A Pending JP2011102296A (ja) | 2002-03-08 | 2010-10-29 | アミノメチル置換されたテトラサイクリン化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7326696B2 (https=) |
| EP (4) | EP2311451A1 (https=) |
| JP (4) | JP2005526754A (https=) |
| KR (3) | KR101163937B1 (https=) |
| CN (3) | CN102531948A (https=) |
| AU (2) | AU2003220123B2 (https=) |
| CA (1) | CA2478335C (https=) |
| EA (3) | EA201000491A1 (https=) |
| IL (3) | IL163931A0 (https=) |
| WO (1) | WO2003075857A2 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| CA2318580A1 (en) * | 1998-01-23 | 1999-07-29 | Mark L. Nelson | Pharmaceutically active compounds and methods of use thereof |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| EP2327687A3 (en) * | 1999-09-14 | 2012-08-15 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| AU3105801A (en) | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| MXPA02009482A (es) * | 2000-03-31 | 2004-05-14 | Tufts College | Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino. |
| WO2001087824A2 (en) * | 2000-05-15 | 2001-11-22 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20020128238A1 (en) * | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| CN1450989A (zh) * | 2000-07-07 | 2003-10-22 | 塔夫茨大学信托人 | 7－取代的四环素化合物 |
| EA013908B1 (ru) * | 2000-07-07 | 2010-08-30 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
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| EP2311799A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| KR101083498B1 (ko) | 2002-03-21 | 2011-11-16 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
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| CA2503446C (en) * | 2002-10-24 | 2012-12-18 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
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| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| JP4738333B2 (ja) * | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | ９−アミノメチルテトラサイクリン化合物のプロドラッグ |
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| EP2269985A3 (en) * | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2005299294B2 (en) * | 2004-10-25 | 2012-06-07 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
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| PT2120963T (pt) * | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
| PL2109602T3 (pl) * | 2006-12-21 | 2014-09-30 | Paratek Pharm Innc | Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych |
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| TW202216656A (zh) * | 2008-05-19 | 2022-05-01 | 美商Ｐｒｔｋ Ｓｐｖ２公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
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| CA2842838C (en) * | 2011-07-26 | 2017-04-25 | Kbp Biosciences Co., Ltd. | 9-aminomethyl substituted tetracycline compounds |
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| TW202206081A (zh) * | 2016-08-03 | 2022-02-16 | 美商派瑞泰Ｓｐｖ２有限公司 | ９—胺甲基米諾四環素化合物及其用途 |
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| CA3111447A1 (en) | 2018-09-04 | 2020-03-12 | Paratek Pharmaceuticals, Inc. | Methods of treating mycobacterial infections using tetracycline compounds |
| CN113332298A (zh) * | 2021-05-27 | 2021-09-03 | 成都医学院 | 米诺环素作为酪氨酸激酶抑制剂的新用途 |
| CN117088787B (zh) * | 2022-05-13 | 2025-12-19 | 上海医药工业研究院有限公司 | 9位含曼尼希碱的四环素类化合物及其制备方法和应用 |
| CN117486749A (zh) * | 2023-11-23 | 2024-02-02 | 传健生物医药(厦门)有限公司 | 一种奥马环素杂质的制备方法 |
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-
2003
- 2003-03-10 JP JP2003574133A patent/JP2005526754A/ja not_active Withdrawn
- 2003-03-10 EA EA201000491A patent/EA201000491A1/ru unknown
- 2003-03-10 EP EP10184869A patent/EP2311451A1/en not_active Withdrawn
- 2003-03-10 CN CN2011103993027A patent/CN102531948A/zh active Pending
- 2003-03-10 CN CNA038099799A patent/CN1649582A/zh active Pending
- 2003-03-10 KR KR1020117006989A patent/KR101163937B1/ko not_active Expired - Fee Related
- 2003-03-10 EP EP03716416A patent/EP1482926A4/en not_active Withdrawn
- 2003-03-10 KR KR1020047014092A patent/KR101014918B1/ko not_active Expired - Fee Related
- 2003-03-10 IL IL16393103A patent/IL163931A0/xx unknown
- 2003-03-10 AU AU2003220123A patent/AU2003220123B2/en not_active Ceased
- 2003-03-10 WO PCT/US2003/007229 patent/WO2003075857A2/en not_active Ceased
- 2003-03-10 EP EP10184863A patent/EP2316450A1/en not_active Withdrawn
- 2003-03-10 CA CA2478335A patent/CA2478335C/en not_active Expired - Fee Related
- 2003-03-10 KR KR1020107016704A patent/KR101093842B1/ko not_active Expired - Fee Related
- 2003-03-10 EA EA200802365A patent/EA200802365A1/ru unknown
- 2003-03-10 EP EP10184858A patent/EP2301534A1/en not_active Withdrawn
- 2003-03-10 CN CNA2008100962190A patent/CN101307017A/zh active Pending
- 2003-03-10 EA EA200401169A patent/EA013819B1/ru not_active IP Right Cessation
- 2003-12-15 US US10/737,361 patent/US7326696B2/en not_active Expired - Lifetime
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2004
- 2004-09-07 IL IL163931A patent/IL163931A/en not_active IP Right Cessation
-
2007
- 2007-06-05 US US11/810,336 patent/US20080015169A1/en not_active Abandoned
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2008
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- 2009-08-07 AU AU2009208042A patent/AU2009208042B2/en not_active Expired - Fee Related
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2010
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