|
US21366A
(en)
|
|
1858-08-31 |
|
Valve-cock |
|
USRE26271E
(en)
*
|
|
1967-09-26 |
|
Reductive alkylation process |
|
US2990331A
(en)
|
1956-11-23 |
1961-06-27 |
Pfizer & Co C |
Stable solutions of salts of tetracyclines for parenteral administration
|
|
US2980584A
(en)
|
1957-10-29 |
1961-04-18 |
Pfizer & Co C |
Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
|
|
US3062717A
(en)
|
1958-12-11 |
1962-11-06 |
Pfizer & Co C |
Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
|
|
US3043875A
(en)
*
|
1959-10-22 |
1962-07-10 |
Pfizer & Co C |
Halogenated tetracycline derivatives and processes for their preparation
|
|
FR1430859A
(https=)
*
|
1960-05-23 |
1966-05-25 |
|
|
|
US3338963A
(en)
|
1960-10-28 |
1967-08-29 |
American Cyanamid Co |
Tetracycline compounds
|
|
US3862225A
(en)
*
|
1961-08-18 |
1975-01-21 |
Pfizer |
D-ring substituted tetracyclines
|
|
US3165531A
(en)
|
1962-03-08 |
1965-01-12 |
Pfizer & Co C |
13-substituted-6-deoxytetracyclines and process utilizing the same
|
|
US3148212A
(en)
*
|
1961-12-22 |
1964-09-08 |
American Cyanamid Co |
Reductive alkylation process
|
|
USRE26253E
(en)
*
|
1963-05-17 |
1967-08-15 |
|
And z-alkylamino-g-deoxytetracycline |
|
US3609188A
(en)
*
|
1964-10-29 |
1971-09-28 |
American Cyanamid Co |
4-dedimethylamino-4-substituted-amino-6-demethyltetracyclines
|
|
US3454697A
(en)
|
1965-06-08 |
1969-07-08 |
American Cyanamid Co |
Tetracycline antibiotic compositions for oral use
|
|
US3304227A
(en)
|
1965-07-15 |
1967-02-14 |
Loyal E Loveless |
Antibiotic-containing animal feed
|
|
US3397230A
(en)
*
|
1966-03-14 |
1968-08-13 |
American Cyanamid Co |
Nitration of tetracyclines
|
|
US3433834A
(en)
|
1966-03-14 |
1969-03-18 |
American Cyanamid Co |
Nitration of 11a-chloro tetracyclines
|
|
US3341585A
(en)
*
|
1966-05-06 |
1967-09-12 |
American Cyanamid Co |
Substituted 7-and/or 9-amino-6-deoxytetracyclines
|
|
NL6607516A
(https=)
|
1966-05-31 |
1967-12-01 |
|
|
|
US3403179A
(en)
*
|
1967-01-10 |
1968-09-24 |
American Cyanamid Co |
Novel 7-(1, 2-bis-substituted-hydrazino)-tetracyclines and methods of preparing same
|
|
US3373196A
(en)
*
|
1967-03-21 |
1968-03-12 |
American Cyanamid Co |
7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines
|
|
US3518306A
(en)
*
|
1968-02-19 |
1970-06-30 |
American Cyanamid Co |
7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
|
|
US3579579A
(en)
*
|
1968-04-18 |
1971-05-18 |
American Cyanamid Co |
Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
|
|
DE1767891C3
(de)
|
1968-06-28 |
1980-10-30 |
Pfizer |
Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
|
|
US3795707A
(en)
*
|
1970-12-28 |
1974-03-05 |
Rachelle Labor Italia Spa |
Manufacture of alpha-6-deoxytetracyclines
|
|
NL158172B
(nl)
|
1972-09-18 |
1978-10-16 |
Farmaceutici Italia |
Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats.
|
|
US3957980A
(en)
|
1972-10-26 |
1976-05-18 |
Pfizer Inc. |
Doxycycline parenteral compositions
|
|
GB1469384A
(en)
|
1974-06-25 |
1977-04-06 |
Farmaceutici Italia |
Tetracyclines
|
|
DE2442829A1
(de)
|
1974-09-06 |
1976-03-18 |
Merck Patent Gmbh |
Tetracyclische verbindungen und verfahren zu ihrer herstellung
|
|
US4018889A
(en)
|
1976-01-02 |
1977-04-19 |
Pfizer Inc. |
Oxytetracycline compositions
|
|
US4126680A
(en)
|
1977-04-27 |
1978-11-21 |
Pfizer Inc. |
Tetracycline antibiotic compositions
|
|
US4704383A
(en)
|
1983-12-29 |
1987-11-03 |
The Research Foundation Of State University Of New York |
Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
|
|
USRE34656E
(en)
|
1983-12-29 |
1994-07-05 |
The Research Foundation Of State University Of New York |
Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency
|
|
US4925833A
(en)
|
1983-12-29 |
1990-05-15 |
The Research Foundation Of State University Of New York |
Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
|
|
US4666897A
(en)
|
1983-12-29 |
1987-05-19 |
Research Foundation Of State University |
Inhibition of mammalian collagenolytic enzymes by tetracyclines
|
|
US4935412A
(en)
|
1983-12-29 |
1990-06-19 |
The Research Foundation Of State University Of New York |
Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
|
|
US4946453A
(en)
*
|
1988-04-14 |
1990-08-07 |
Monson Demetrius A |
Weight reducing athletic garment
|
|
US5388391A
(en)
|
1988-12-19 |
1995-02-14 |
Parker; Richard D. |
Apparatus and process for packaging biohazardous wastes
|
|
US5308839A
(en)
|
1989-12-04 |
1994-05-03 |
The Research Foundation Of State University Of New York |
Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
|
|
JP3016587B2
(ja)
|
1989-12-04 |
2000-03-06 |
ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク |
非ステロイド抗炎症剤及びテトラサイクリンの配合
|
|
US5770588A
(en)
|
1991-02-11 |
1998-06-23 |
The Research Foundation Of State University Of New York |
Non-antibacterial tetracycline compositions of the prevention and treatment of root caries
|
|
US5231017A
(en)
|
1991-05-17 |
1993-07-27 |
Solvay Enzymes, Inc. |
Process for producing ethanol
|
|
DE122006000058I1
(de)
|
1991-10-04 |
2007-01-18 |
Wyeth Corp |
7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
|
|
US5281628A
(en)
|
1991-10-04 |
1994-01-25 |
American Cyanamid Company |
9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
|
|
US5494903A
(en)
*
|
1991-10-04 |
1996-02-27 |
American Cyanamid Company |
7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
|
|
US6756365B2
(en)
*
|
1991-11-06 |
2004-06-29 |
Trustees Of Tufts College |
Reducing tetracycline resistance in living cells
|
|
US5258371A
(en)
|
1992-05-29 |
1993-11-02 |
Kuraray Co., Ltd. |
Method to reduce connective tissue destruction
|
|
US6043225A
(en)
|
1992-06-12 |
2000-03-28 |
Board Of Regents Of The University Of Washington |
Diagnosis and treatment of arterial chlamydial granuloma
|
|
US5328902A
(en)
*
|
1992-08-13 |
1994-07-12 |
American Cyanamid Co. |
7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
|
|
US5284963A
(en)
*
|
1992-08-13 |
1994-02-08 |
American Cyanamid Company |
Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
|
|
US5420272A
(en)
*
|
1992-08-13 |
1995-05-30 |
American Cyanamid Company |
7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
|
|
SG47520A1
(en)
*
|
1992-08-13 |
1998-04-17 |
American Cyanamid Co |
New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
|
|
US5442059A
(en)
*
|
1992-08-13 |
1995-08-15 |
American Cyanamid Company |
9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
|
|
EP0599397B1
(en)
|
1992-11-17 |
1996-08-28 |
The Research Foundation Of State University Of New York |
Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes
|
|
US5523297A
(en)
|
1993-03-02 |
1996-06-04 |
The Research Foundation Of State University Of New York |
Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
|
|
US6043231A
(en)
|
1993-03-02 |
2000-03-28 |
The Research Foundation Of State Univ. Of New York |
Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
|
|
US5371076A
(en)
*
|
1993-04-02 |
1994-12-06 |
American Cyanamid Company |
9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
|
|
US5668122A
(en)
|
1993-07-28 |
1997-09-16 |
Fife; Rose S. |
Method to treat cancer with tetracyclines
|
|
AU1279095A
(en)
|
1994-02-17 |
1995-09-04 |
Pfizer Inc. |
9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
|
|
US5843925A
(en)
*
|
1994-12-13 |
1998-12-01 |
American Cyanamid Company |
Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
|
|
US5834449A
(en)
|
1996-06-13 |
1998-11-10 |
The Research Foundation Of State University Of New York |
Treatment of aortic and vascular aneurysms with tetracycline compounds
|
|
US5827840A
(en)
|
1996-08-01 |
1998-10-27 |
The Research Foundation Of State University Of New York |
Promotion of wound healing by chemically-modified tetracyclines
|
|
US5789395A
(en)
|
1996-08-30 |
1998-08-04 |
The Research Foundation Of State University Of New York |
Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
|
|
US5919774A
(en)
|
1996-12-10 |
1999-07-06 |
Eli Lilly And Company |
Pyrroles as sPLA2 inhibitors
|
|
US5837696A
(en)
|
1997-01-15 |
1998-11-17 |
The Research Foundation Of State University Of New York |
Method of inhibiting cancer growth
|
|
US5773430A
(en)
|
1997-03-13 |
1998-06-30 |
Research Foundation Of State University Of New York |
Serine proteinase inhibitory activity by hydrophobic tetracycline
|
|
US6063775A
(en)
|
1997-04-29 |
2000-05-16 |
Berman; Charles L. |
Retardation of metalloproteinase incidental to HIV and/or AIDS
|
|
US5929055A
(en)
|
1997-06-23 |
1999-07-27 |
The Research Foundation Of State University Of New York |
Therapeutic method for management of diabetes mellitus
|
|
CA2318580A1
(en)
|
1998-01-23 |
1999-07-29 |
Mark L. Nelson |
Pharmaceutically active compounds and methods of use thereof
|
|
US6277061B1
(en)
|
1998-03-31 |
2001-08-21 |
The Research Foundation Of State University Of New York |
Method of inhibiting membrane-type matrix metalloproteinase
|
|
US6015804A
(en)
|
1998-09-11 |
2000-01-18 |
The Research Foundation Of State University Of New York |
Method of using tetracycline compounds to enhance interleukin-10 production
|
|
US5977091A
(en)
|
1998-09-21 |
1999-11-02 |
The Research Foundation Of State University Of New York |
Method of preventing acute lung injury
|
|
KR20010073190A
(ko)
*
|
1998-09-28 |
2001-07-31 |
제임스 알. 데니히 |
백내장 형성 억제제
|
|
US5998390A
(en)
|
1998-09-28 |
1999-12-07 |
The Research Foundation Of State University Of New York |
Combination of bisphosphonate and tetracycline
|
|
ATE336238T1
(de)
*
|
1998-11-18 |
2006-09-15 |
Collagenex Pharm Inc |
Neue 4-dedimethylaminotetracyclinderivate
|
|
US6506740B1
(en)
*
|
1998-11-18 |
2003-01-14 |
Robert A. Ashley |
4-dedimethylaminotetracycline derivatives
|
|
US6849615B2
(en)
*
|
1999-09-14 |
2005-02-01 |
Paratek Pharmaceuticals, Inc. |
13-substituted methacycline compounds
|
|
EP2327687A3
(en)
*
|
1999-09-14 |
2012-08-15 |
Trustees Of Tufts College |
Methods of preparing substituted tetracyclines with transition metal-based chemistries
|
|
US6500812B2
(en)
|
1999-09-14 |
2002-12-31 |
Paratek Pharmaceuticals, Inc. |
13-substituted methacycline compounds
|
|
US8106225B2
(en)
*
|
1999-09-14 |
2012-01-31 |
Trustees Of Tufts College |
Methods of preparing substituted tetracyclines with transition metal-based chemistries
|
|
US6231894B1
(en)
|
1999-10-21 |
2001-05-15 |
Duke University |
Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase
|
|
AU3105801A
(en)
*
|
2000-01-24 |
2001-07-31 |
Trustees Of Tufts College |
Tetracycline compounds for treatment of cryptosporidium parvum related disorders
|
|
WO2001070776A2
(en)
*
|
2000-03-10 |
2001-09-27 |
Trustees Of Tufts College |
Nimr compositions and their methods of use
|
|
MXPA02009482A
(es)
|
2000-03-31 |
2004-05-14 |
Tufts College |
Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino.
|
|
WO2001087824A2
(en)
*
|
2000-05-15 |
2001-11-22 |
Paratek Pharmaceuticals, Inc. |
7-substituted fused ring tetracycline compounds
|
|
US20020132798A1
(en)
|
2000-06-16 |
2002-09-19 |
Nelson Mark L. |
7-phenyl-substituted tetracycline compounds
|
|
US20020128238A1
(en)
|
2000-06-16 |
2002-09-12 |
Nelson Mark L. |
7-phenyl-substituted tetracycline compounds
|
|
WO2001098259A1
(en)
|
2000-06-16 |
2001-12-27 |
Trustees Of Tufts College |
7-phenyl-substituted tetracycline compounds
|
|
US20020128237A1
(en)
|
2000-06-16 |
2002-09-12 |
Nelson Mark L. |
7-N-substituted phenyl tetracycline compounds
|
|
US7094806B2
(en)
*
|
2000-07-07 |
2006-08-22 |
Trustees Of Tufts College |
7, 8 and 9-substituted tetracycline compounds
|
|
US20050143353A1
(en)
*
|
2000-07-07 |
2005-06-30 |
Paratek Pharmaceuticals, Inc. |
13-Substituted methacycline compounds
|
|
EA013908B1
(ru)
|
2000-07-07 |
2010-08-30 |
Трастис Оф Тафтс Коллидж |
Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего
|
|
CN1450989A
(zh)
*
|
2000-07-07 |
2003-10-22 |
塔夫茨大学信托人 |
7－取代的四环素化合物
|
|
JP4963771B2
(ja)
|
2000-07-07 |
2012-06-27 |
トラスティーズ・オブ・タフツ・カレッジ |
７、８および９−置換テトラサイクリン化合物
|
|
US7553828B2
(en)
*
|
2001-03-13 |
2009-06-30 |
Paratek Pharmaceuticals, Inc. |
9-aminomethyl substituted minocycline compounds
|
|
WO2002072506A2
(en)
*
|
2001-03-13 |
2002-09-19 |
Paratek Pharmaceuticals, Inc. |
7-pyrollyl tetracycline compounds and methods of use thereof
|
|
EP1241160A1
(en)
*
|
2001-03-13 |
2002-09-18 |
Glaxo Group Limited |
Tetracycline derivatives and their use as antibiotic agents
|
|
WO2002072532A1
(en)
|
2001-03-13 |
2002-09-19 |
Paratek Pharmaceuticals, Inc. |
7, 9-substituted tetracycline compounds
|
|
WO2002072031A2
(en)
*
|
2001-03-14 |
2002-09-19 |
Paratek Pharmaceuticals, Inc. |
Substituted tetracycline compounds as synergistic antifungal agents
|
|
JP2004530661A
(ja)
*
|
2001-03-14 |
2004-10-07 |
パラテック ファーマシューティカルズ インコーポレイテッド |
抗真菌剤としての置換テトラサイクリン化合物
|
|
AU2002303250B2
(en)
*
|
2001-04-05 |
2006-05-25 |
Collagenex Pharmaceuticals, Inc. |
Methods of treating acne
|
|
EP1399414B1
(en)
*
|
2001-04-24 |
2010-01-13 |
Paratek Pharmaceuticals, Inc. |
Substituted tetracycline compounds for the treatment of malaria
|
|
US7075582B2
(en)
*
|
2001-07-13 |
2006-07-11 |
Paratek Pharmaceuticals, Inc. |
Methods for identifying and using MarR family polypeptide binding compounds
|
|
US20060194773A1
(en)
*
|
2001-07-13 |
2006-08-31 |
Paratek Pharmaceuticals, Inc. |
Tetracyline compounds having target therapeutic activities
|
|
EP2329826A1
(en)
*
|
2001-07-13 |
2011-06-08 |
Paratek Pharmaceuticals, Inc. |
Tetracyclines for the treatment of multiple sclerosis
|
|
RU2300380C2
(ru)
*
|
2001-10-05 |
2007-06-10 |
Тетрадженекс Фармасьютикалс, Инк. |
Производные тетрациклина и способы их применения
|
|
EP2311799A1
(en)
*
|
2002-01-08 |
2011-04-20 |
Paratek Pharmaceuticals, Inc. |
4-dedimethylamino tetracycline compounds
|
|
JP2005526754A
(ja)
*
|
2002-03-08 |
2005-09-08 |
パラテック ファーマシューティカルズ インコーポレイテッド |
アミノメチル置換されたテトラサイクリン化合物
|
|
KR101083498B1
(ko)
*
|
2002-03-21 |
2011-11-16 |
파라테크 파마슈티컬스, 인크. |
치환된 테트라시클린 화합물
|
|
US7553827B2
(en)
*
|
2003-08-13 |
2009-06-30 |
Depuy Spine, Inc. |
Transdiscal administration of cycline compounds
|
|
CA2531728A1
(en)
*
|
2003-07-09 |
2005-02-03 |
Paratek Pharmaceuticals, Inc. |
Substituted tetracycline compounds
|
|
JP4738333B2
(ja)
*
|
2003-07-09 |
2011-08-03 |
パラテック ファーマシューティカルズ インコーポレイテッド |
９−アミノメチルテトラサイクリン化合物のプロドラッグ
|
|
CA2553510C
(en)
*
|
2004-01-15 |
2012-09-25 |
Paratek Pharmaceuticals, Inc. |
Aromatic a-ring derivatives of tetracycline compounds
|
|
AU2005299294B2
(en)
*
|
2004-10-25 |
2012-06-07 |
Paratek Pharmaceuticals, Inc. |
4-aminotetracyclines and methods of use thereof
|
|
EP2269985A3
(en)
*
|
2004-10-25 |
2011-09-21 |
Paratek Pharmaceuticals, Inc. |
Substituted tetracycline compounds
|
|
JP2009502809A
(ja)
*
|
2005-07-21 |
2009-01-29 |
パラテック ファーマシューティカルズ インコーポレイテッド |
１０−置換テトラサイクリンおよびその使用方法
|