JP2005526124A5 - - Google Patents
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- Publication number
- JP2005526124A5 JP2005526124A5 JP2004503021A JP2004503021A JP2005526124A5 JP 2005526124 A5 JP2005526124 A5 JP 2005526124A5 JP 2004503021 A JP2004503021 A JP 2004503021A JP 2004503021 A JP2004503021 A JP 2004503021A JP 2005526124 A5 JP2005526124 A5 JP 2005526124A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- reovirus
- analgesic
- oncolytic virus
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 241000702263 Reovirus sp. Species 0.000 claims 19
- 244000309459 oncolytic virus Species 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000035269 cancer or benign tumor Diseases 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 5
- 230000000202 analgesic effect Effects 0.000 claims 5
- 239000000730 antalgic agent Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 229940121367 non-opioid analgesics Drugs 0.000 claims 2
- 239000000014 opioid analgesic Substances 0.000 claims 2
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 1
- 241001516406 Avian orthoreovirus Species 0.000 claims 1
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims 1
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims 1
- 229960001736 buprenorphine Drugs 0.000 claims 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 claims 1
- 229960001113 butorphanol Drugs 0.000 claims 1
- 229960004126 codeine Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229960004193 dextropropoxyphene Drugs 0.000 claims 1
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims 1
- 229960003461 dezocine Drugs 0.000 claims 1
- VTMVHDZWSFQSQP-VBNZEHGJSA-N dezocine Chemical compound C1CCCC[C@H]2CC3=CC=C(O)C=C3[C@]1(C)[C@H]2N VTMVHDZWSFQSQP-VBNZEHGJSA-N 0.000 claims 1
- 229960002428 fentanyl Drugs 0.000 claims 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 1
- 229960001410 hydromorphone Drugs 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229960003406 levorphanol Drugs 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 229960001797 methadone Drugs 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 229960000805 nalbuphine Drugs 0.000 claims 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 229960002085 oxycodone Drugs 0.000 claims 1
- 229960005118 oxymorphone Drugs 0.000 claims 1
- VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 claims 1
- 229960005301 pentazocine Drugs 0.000 claims 1
- 229960000482 pethidine Drugs 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37867502P | 2002-05-09 | 2002-05-09 | |
| US60/378,675 | 2002-05-09 | ||
| US44317703P | 2003-01-29 | 2003-01-29 | |
| US60/443,177 | 2003-01-29 | ||
| PCT/CA2003/000674 WO2003094938A1 (en) | 2002-05-09 | 2003-05-07 | Method for reducing pain using oncolytic viruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526124A JP2005526124A (ja) | 2005-09-02 |
| JP2005526124A5 true JP2005526124A5 (https=) | 2006-05-18 |
| JP5241059B2 JP5241059B2 (ja) | 2013-07-17 |
Family
ID=29423642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004503021A Expired - Lifetime JP5241059B2 (ja) | 2002-05-09 | 2003-05-07 | 腫瘍崩壊ウイルスを使用して疼痛を軽減するための方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20040091458A1 (https=) |
| EP (1) | EP1505992B1 (https=) |
| JP (1) | JP5241059B2 (https=) |
| AR (1) | AR039986A1 (https=) |
| AT (1) | ATE404213T1 (https=) |
| AU (1) | AU2003229431B8 (https=) |
| BR (1) | BR0309825A (https=) |
| CA (1) | CA2484398C (https=) |
| DE (2) | DE03722131T1 (https=) |
| DK (1) | DK1505992T3 (https=) |
| ES (1) | ES2239928T3 (https=) |
| IL (1) | IL164695A (https=) |
| MX (1) | MXPA04011007A (https=) |
| NZ (1) | NZ536102A (https=) |
| PT (1) | PT1505992E (https=) |
| SI (1) | SI1505992T1 (https=) |
| TR (1) | TR200501460T3 (https=) |
| TW (1) | TWI316405B (https=) |
| WO (1) | WO2003094938A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| WO2007099401A2 (en) | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Oncolytic attenuated reoviruses for treatment of proliferative disorders |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| US9241998B2 (en) * | 2007-05-21 | 2016-01-26 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oncolytic RSV activity |
| US8450106B2 (en) * | 2007-10-17 | 2013-05-28 | The Ohio State University Research Foundation | Oncolytic virus |
| MX339014B (es) * | 2008-05-27 | 2016-05-09 | Oncolytics Biotech Inc | Modulacion de presion intersticial y suministro y distribucion viral oncolitica. |
| KR20100054358A (ko) * | 2008-11-14 | 2010-05-25 | 김재은 | 스틱 연고 |
| JP5845172B2 (ja) * | 2009-05-01 | 2016-01-20 | アデア ファーマスーティカルズ，インコーポレイテッド | 高および低用量薬物の組み合わせを含む口腔内崩壊錠組成物 |
| EP2383577A1 (en) * | 2010-04-30 | 2011-11-02 | Deutsches Krebsforschungszentrum | Diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy |
| CN108025056B (zh) * | 2015-06-19 | 2022-01-14 | 新罗杰股份有限公司 | 用于病毒栓塞的组合物和方法 |
| JP6875745B2 (ja) * | 2016-02-16 | 2021-05-26 | 国立大学法人大阪大学 | 線維化を治療するための医薬組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US6110461A (en) * | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| US6136307A (en) * | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| IL135507A0 (en) * | 1997-10-09 | 2001-05-20 | Pro Virus Inc | Treatment of neoplasms with viruses |
| US6428968B1 (en) * | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| TWI289158B (en) * | 2000-08-10 | 2007-11-01 | Oncolytics Biotech Inc | Method of producing infectious reovirus |
-
2003
- 2003-05-07 DE DE03722131T patent/DE03722131T1/de active Pending
- 2003-05-07 TR TR2005/01460T patent/TR200501460T3/xx unknown
- 2003-05-07 WO PCT/CA2003/000674 patent/WO2003094938A1/en not_active Ceased
- 2003-05-07 EP EP03722131A patent/EP1505992B1/en not_active Expired - Lifetime
- 2003-05-07 AU AU2003229431A patent/AU2003229431B8/en not_active Expired
- 2003-05-07 TW TW092112420A patent/TWI316405B/zh not_active IP Right Cessation
- 2003-05-07 JP JP2004503021A patent/JP5241059B2/ja not_active Expired - Lifetime
- 2003-05-07 DK DK03722131T patent/DK1505992T3/da active
- 2003-05-07 BR BR0309825-7A patent/BR0309825A/pt not_active IP Right Cessation
- 2003-05-07 MX MXPA04011007A patent/MXPA04011007A/es active IP Right Grant
- 2003-05-07 SI SI200331415T patent/SI1505992T1/sl unknown
- 2003-05-07 DE DE60322885T patent/DE60322885D1/de not_active Expired - Lifetime
- 2003-05-07 PT PT03722131T patent/PT1505992E/pt unknown
- 2003-05-07 ES ES03722131T patent/ES2239928T3/es not_active Expired - Lifetime
- 2003-05-07 AT AT03722131T patent/ATE404213T1/de not_active IP Right Cessation
- 2003-05-07 CA CA2484398A patent/CA2484398C/en not_active Expired - Lifetime
- 2003-05-07 NZ NZ536102A patent/NZ536102A/en unknown
- 2003-05-08 US US10/431,580 patent/US20040091458A1/en not_active Abandoned
- 2003-05-08 AR ARP030101621A patent/AR039986A1/es unknown
-
2004
- 2004-10-19 IL IL164695A patent/IL164695A/en active IP Right Grant
-
2007
- 2007-06-01 US US11/809,714 patent/US20080081032A1/en not_active Abandoned
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