JP2005526124A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005526124A5 JP2005526124A5 JP2004503021A JP2004503021A JP2005526124A5 JP 2005526124 A5 JP2005526124 A5 JP 2005526124A5 JP 2004503021 A JP2004503021 A JP 2004503021A JP 2004503021 A JP2004503021 A JP 2004503021A JP 2005526124 A5 JP2005526124 A5 JP 2005526124A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- reovirus
- analgesic
- oncolytic virus
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 241000702263 Reovirus sp. Species 0.000 claims 19
- 244000309459 oncolytic virus Species 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000035269 cancer or benign tumor Diseases 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 5
- 230000000202 analgesic effect Effects 0.000 claims 5
- 239000000730 antalgic agent Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 229940121367 non-opioid analgesics Drugs 0.000 claims 2
- 239000000014 opioid analgesic Substances 0.000 claims 2
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 1
- 241001516406 Avian orthoreovirus Species 0.000 claims 1
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims 1
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims 1
- 229960001736 buprenorphine Drugs 0.000 claims 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 claims 1
- 229960001113 butorphanol Drugs 0.000 claims 1
- 229960004126 codeine Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229960004193 dextropropoxyphene Drugs 0.000 claims 1
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims 1
- 229960003461 dezocine Drugs 0.000 claims 1
- VTMVHDZWSFQSQP-VBNZEHGJSA-N dezocine Chemical compound C1CCCC[C@H]2CC3=CC=C(O)C=C3[C@]1(C)[C@H]2N VTMVHDZWSFQSQP-VBNZEHGJSA-N 0.000 claims 1
- 229960002428 fentanyl Drugs 0.000 claims 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 1
- 229960001410 hydromorphone Drugs 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229960003406 levorphanol Drugs 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 229960001797 methadone Drugs 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 229960000805 nalbuphine Drugs 0.000 claims 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 229960002085 oxycodone Drugs 0.000 claims 1
- 229960005118 oxymorphone Drugs 0.000 claims 1
- VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 claims 1
- 229960005301 pentazocine Drugs 0.000 claims 1
- 229960000482 pethidine Drugs 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37867502P | 2002-05-09 | 2002-05-09 | |
| US60/378,675 | 2002-05-09 | ||
| US44317703P | 2003-01-29 | 2003-01-29 | |
| US60/443,177 | 2003-01-29 | ||
| PCT/CA2003/000674 WO2003094938A1 (en) | 2002-05-09 | 2003-05-07 | Method for reducing pain using oncolytic viruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526124A JP2005526124A (ja) | 2005-09-02 |
| JP2005526124A5 true JP2005526124A5 (https=) | 2006-05-18 |
| JP5241059B2 JP5241059B2 (ja) | 2013-07-17 |
Family
ID=29423642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004503021A Expired - Lifetime JP5241059B2 (ja) | 2002-05-09 | 2003-05-07 | 腫瘍崩壊ウイルスを使用して疼痛を軽減するための方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20040091458A1 (https=) |
| EP (1) | EP1505992B1 (https=) |
| JP (1) | JP5241059B2 (https=) |
| AR (1) | AR039986A1 (https=) |
| AT (1) | ATE404213T1 (https=) |
| AU (1) | AU2003229431B8 (https=) |
| BR (1) | BR0309825A (https=) |
| CA (1) | CA2484398C (https=) |
| DE (2) | DE03722131T1 (https=) |
| DK (1) | DK1505992T3 (https=) |
| ES (1) | ES2239928T3 (https=) |
| IL (1) | IL164695A (https=) |
| MX (1) | MXPA04011007A (https=) |
| NZ (1) | NZ536102A (https=) |
| PT (1) | PT1505992E (https=) |
| SI (1) | SI1505992T1 (https=) |
| TR (1) | TR200501460T3 (https=) |
| TW (1) | TWI316405B (https=) |
| WO (1) | WO2003094938A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| US10260049B2 (en) | 2005-08-01 | 2019-04-16 | Virocure, Inc. | Attenuated reovirus |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| WO2008144067A1 (en) * | 2007-05-21 | 2008-11-27 | Board Of Regents, University Of Texas System | Methods and compositions for treatment of cancer using oncolytic rsv activity |
| US8450106B2 (en) * | 2007-10-17 | 2013-05-28 | The Ohio State University Research Foundation | Oncolytic virus |
| EP2296678A4 (en) * | 2008-05-27 | 2012-03-21 | Oncolytics Biotech Inc | MODULATION OF INTERSTITIAL PRESSURE AND ONCOLYTIC VIRUS RELIEF AND DISTRIBUTION |
| KR20100054358A (ko) * | 2008-11-14 | 2010-05-25 | 김재은 | 스틱 연고 |
| RU2554740C2 (ru) * | 2009-05-01 | 2015-06-27 | Апталис Фарматек, Инк. | Композиции перорально распадающихся таблеток, содержащие комбинации высоко- и низкодозовых лекарственных средств |
| EP2383577A1 (en) * | 2010-04-30 | 2011-11-02 | Deutsches Krebsforschungszentrum | Diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy |
| JP6827467B2 (ja) | 2015-06-19 | 2021-02-10 | シルラジェン，インコーポレイテッド | ウイルス塞栓術のための組成物および方法 |
| EP3417866B1 (en) | 2016-02-16 | 2020-12-23 | Osaka University | Medicinal composition for treating fibrosis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US6110461A (en) * | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| US6136307A (en) * | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| CN101618049A (zh) * | 1997-10-09 | 2010-01-06 | 威尔斯塔特生物公司 | 使用病毒来治疗赘生物 |
| US6428968B1 (en) * | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| TWI289158B (en) * | 2000-08-10 | 2007-11-01 | Oncolytics Biotech Inc | Method of producing infectious reovirus |
-
2003
- 2003-05-07 JP JP2004503021A patent/JP5241059B2/ja not_active Expired - Lifetime
- 2003-05-07 EP EP03722131A patent/EP1505992B1/en not_active Expired - Lifetime
- 2003-05-07 WO PCT/CA2003/000674 patent/WO2003094938A1/en not_active Ceased
- 2003-05-07 TW TW092112420A patent/TWI316405B/zh not_active IP Right Cessation
- 2003-05-07 CA CA2484398A patent/CA2484398C/en not_active Expired - Lifetime
- 2003-05-07 NZ NZ536102A patent/NZ536102A/en unknown
- 2003-05-07 TR TR2005/01460T patent/TR200501460T3/xx unknown
- 2003-05-07 DE DE03722131T patent/DE03722131T1/de active Pending
- 2003-05-07 ES ES03722131T patent/ES2239928T3/es not_active Expired - Lifetime
- 2003-05-07 AU AU2003229431A patent/AU2003229431B8/en not_active Expired
- 2003-05-07 PT PT03722131T patent/PT1505992E/pt unknown
- 2003-05-07 SI SI200331415T patent/SI1505992T1/sl unknown
- 2003-05-07 DE DE60322885T patent/DE60322885D1/de not_active Expired - Lifetime
- 2003-05-07 MX MXPA04011007A patent/MXPA04011007A/es active IP Right Grant
- 2003-05-07 DK DK03722131T patent/DK1505992T3/da active
- 2003-05-07 BR BR0309825-7A patent/BR0309825A/pt not_active IP Right Cessation
- 2003-05-07 AT AT03722131T patent/ATE404213T1/de not_active IP Right Cessation
- 2003-05-08 US US10/431,580 patent/US20040091458A1/en not_active Abandoned
- 2003-05-08 AR ARP030101621A patent/AR039986A1/es unknown
-
2004
- 2004-10-19 IL IL164695A patent/IL164695A/en active IP Right Grant
-
2007
- 2007-06-01 US US11/809,714 patent/US20080081032A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005526124A5 (https=) | ||
| ES2681952T3 (es) | Forma farmacéutica sólida disuasoria del abuso de liberación inmediata con puntaje funcional | |
| JP2005524648A5 (https=) | ||
| JP2010511683A5 (https=) | ||
| CN102341096A (zh) | 新型抗滥用制剂 | |
| RU2011135568A (ru) | Защищенная от применения не по назначению экструдированная из расплава композиция с уменьшенным взаимодействием со спиртом | |
| RU2000109552A (ru) | Синергическая аналгезирующая комбинация опиоидного аналгезирующего средства и ингибитора циклооксигеназы-2 | |
| JP2011519930A5 (https=) | ||
| JP2003113119A (ja) | 投薬フォーム | |
| JP2013541567A5 (https=) | ||
| RU2010106202A (ru) | Составы неопиоидных и ограниченных опиоидных аналгетиков | |
| JP6279547B2 (ja) | オピオイド誘発性有害薬力学的応答を治療するためのシステムおよび方法 | |
| ATE311867T1 (de) | Analgetische zusammensetzung enthaltend antiepileptische arzneistoffe und deren verwendungen | |
| JP2008534564A5 (https=) | ||
| JP2009544619A5 (https=) | ||
| BRPI0619806A2 (pt) | dispositivo para fornecimento de fármacos transmucosal resistente ao abuso | |
| KR960703004A (ko) | 혈장 약물 농도의 신속한 초기 증가량을 시현하는 24시간 경구용 오피오이드 제형을 투여함으로써 통증을 치료하는 방법 | |
| EP1981502A2 (en) | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same | |
| CN102421419A (zh) | 用于持续药物传递的包含地聚合物粘合剂的组合物 | |
| ES2239928T1 (es) | Metodo para reducir el dolor utilizando virus oncoliticos. | |
| WO2017172406A1 (en) | Extended release, abuse deterrent dosage forms | |
| ATE448776T1 (de) | Verfahren zur verabreichung von tiotropium | |
| JP2002521468A5 (https=) | ||
| EA200870182A1 (ru) | Применение комбинации морфина и по меньшей мере одного антагониста опиатов для лечения зависимости от опиатов для предотвращения непероральной опиатомании у наркоманов | |
| CN1674903A (zh) | 经鼻吸收用组合物 |