|
US7235537B2
(en)
*
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
MXPA04008893A
(es)
|
2002-03-13 |
2005-06-20 |
Array Biopharma Inc |
Derivados de bencimidazol n3 alquilados como inhibidores de mek.
|
|
JP4896717B2
(ja)
*
|
2003-07-24 |
2012-03-14 |
ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー |
Ｎ−メチル−置換ベンゾアミダゾール
|
|
US7144907B2
(en)
*
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
US7538120B2
(en)
*
|
2003-09-03 |
2009-05-26 |
Array Biopharma Inc. |
Method of treating inflammatory diseases
|
|
US7781595B2
(en)
|
2003-09-22 |
2010-08-24 |
S*Bio Pte Ltd. |
Benzimidazole derivatives: preparation and pharmaceutical applications
|
|
US7732616B2
(en)
|
2003-11-19 |
2010-06-08 |
Array Biopharma Inc. |
Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
|
|
US7517994B2
(en)
*
|
2003-11-19 |
2009-04-14 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
BRPI0416692A
(pt)
*
|
2003-11-19 |
2007-01-30 |
Array Biopharma Inc |
inibidores heterocìclicos de mek e métodos de emprego destes
|
|
CN102786482A
(zh)
*
|
2003-11-21 |
2012-11-21 |
阿雷生物药品公司 |
Akt蛋白激酶抑制剂
|
|
WO2005058341A2
(en)
*
|
2003-12-11 |
2005-06-30 |
Theravance, Inc. |
Compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
|
|
KR101318012B1
(ko)
|
2004-10-20 |
2013-10-14 |
메르크 세로노 에스.에이. |
3-아릴아미노 피리딘 유도체
|
|
ES2330872T3
(es)
*
|
2004-12-01 |
2009-12-16 |
Merck Serono Sa |
Derivados de (1,2,4)triazolo(4,3-a)piridina para el tratamiento de enfermedades hiperproliferativas.
|
|
NZ563707A
(en)
|
2005-05-18 |
2011-01-28 |
Array Biopharma Inc |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
JP5237798B2
(ja)
|
2005-06-23 |
2013-07-17 |
アレイ バイオファーマ、インコーポレイテッド |
ベンズイミダゾール化合物の調製方法
|
|
US8101799B2
(en)
|
2005-07-21 |
2012-01-24 |
Ardea Biosciences |
Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
|
|
CA3052368A1
(en)
|
2005-10-07 |
2007-04-19 |
Exelixis, Inc. |
Azetidines as mek inhibitors
|
|
EP1966155A1
(en)
*
|
2005-12-21 |
2008-09-10 |
AstraZeneca AB |
Tosylate salt of 6- (4-br0m0-2-chl0r0phenylamin0) -7-fluoro-n- (2-hydroxyethoxy) -3-methyl-3h-benzimi dazole- 5 - carboxamide , mek inhibitor useful in the treatment of cancer
|
|
GB0601962D0
(en)
|
2006-01-31 |
2006-03-15 |
Ucb Sa |
Therapeutic agents
|
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
ATE493418T1
(de)
|
2006-07-06 |
2011-01-15 |
Array Biopharma Inc |
Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
|
|
ES2372955T3
(es)
|
2006-07-06 |
2012-01-30 |
Array Biopharma, Inc. |
Ciclopenta[d]pirimidinas como inhibidores de la proteína cinasa akt.
|
|
JP5231411B2
(ja)
|
2006-07-06 |
2013-07-10 |
アレイ バイオファーマ、インコーポレイテッド |
Ａｋｔプロテインキナーゼ阻害剤としてのジヒドロチエノピリミジン
|
|
JP5349306B2
(ja)
|
2006-08-21 |
2013-11-20 |
ジェネンテック， インコーポレイテッド |
アザベンゾチオフェニル化合物および使用方法
|
|
ATE531720T1
(de)
*
|
2006-08-21 |
2011-11-15 |
Genentech Inc |
Aza-benzofuranylverbindungen und anwendungsverfahren dafür
|
|
ZA200901009B
(en)
*
|
2006-08-21 |
2010-05-26 |
Genentech Inc |
Aza-benzothiophenyl compounds and methods of use
|
|
WO2008076415A1
(en)
|
2006-12-14 |
2008-06-26 |
Exelixis, Inc. |
Methods of using mek inhibitors
|
|
JO2985B1
(ar)
|
2006-12-20 |
2016-09-05 |
Takeda Pharmaceuticals Co |
مثبطات كينازmapk/erk
|
|
US8258152B2
(en)
|
2007-06-12 |
2012-09-04 |
Genentech, Inc. |
N-substituted azaindoles and methods of use
|
|
US8377937B2
(en)
|
2007-07-05 |
2013-02-19 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
NZ582692A
(en)
|
2007-07-05 |
2012-05-25 |
Array Biopharma Inc |
Pyrimidyl cyclopentanes as akt protein kinase inhibitors
|
|
GB0714384D0
(en)
|
2007-07-23 |
2007-09-05 |
Ucb Pharma Sa |
theraputic agents
|
|
ES2456966T3
(es)
|
2007-11-12 |
2014-04-24 |
Takeda Pharmaceutical Company Limited |
Inhibidores de MAPK/ERK cinasa
|
|
PT2222675E
(pt)
*
|
2007-12-19 |
2013-11-13 |
Genentech Inc |
5-anilinoimidazopiridinas e métodos de utilização
|
|
AU2008343062B2
(en)
|
2007-12-19 |
2013-03-07 |
Genentech, Inc. |
8-Anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents
|
|
ES2387707T3
(es)
|
2007-12-21 |
2012-09-28 |
Genentech, Inc. |
Azaindolizinas y procedimientos de uso
|
|
WO2009089459A1
(en)
*
|
2008-01-09 |
2009-07-16 |
Array Biopharma Inc. |
Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
|
|
CA2711692A1
(en)
|
2008-01-09 |
2009-07-16 |
Array Biopharma Inc. |
Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
|
|
WO2009093008A1
(en)
|
2008-01-21 |
2009-07-30 |
Ucb Pharma S.A. |
Thieno-pyridine derivatives as mek inhibitors
|
|
GB0811304D0
(en)
|
2008-06-19 |
2008-07-30 |
Ucb Pharma Sa |
Therapeutic agents
|
|
CN102137847B
(zh)
|
2008-07-01 |
2015-06-10 |
健泰科生物技术公司 |
作为mek激酶抑制剂的二环杂环
|
|
CA2727252A1
(en)
|
2008-07-01 |
2010-01-07 |
Genentech, Inc. |
Isoindolone derivatives as mek kinase inhibitors and methods of use
|
|
WO2010017051A1
(en)
|
2008-08-04 |
2010-02-11 |
Merck Serono S.A. |
Novel phenylamino isonicotinamide compounds
|
|
EP2346818B1
(en)
|
2008-11-10 |
2012-12-05 |
Bayer Intellectual Property GmbH |
Substituted sulphonamido phenoxybenzamides
|
|
JP5651125B2
(ja)
|
2008-12-10 |
2015-01-07 |
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド |
Ｍｅｋ阻害剤に対する耐性を付与するｍｅｋ突然変異
|
|
US20120269803A1
(en)
|
2009-10-21 |
2012-10-25 |
Bayer Intellectual Property Gmbh |
Substituted benzosulphonamides
|
|
CA2777304A1
(en)
|
2009-10-21 |
2011-04-28 |
Marion Hitchcock |
Substituted benzosulphonamides
|
|
WO2011047796A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Schering Pharma Aktiengesellschaft |
Substituted halophenoxybenzamide derivatives
|
|
ES2576061T3
(es)
|
2010-02-25 |
2016-07-05 |
Dana-Farber Cancer Institute, Inc. |
Mutaciones de BRAF que confieren resistencia a inhibidores de BRAF
|
|
MX343368B
(es)
|
2010-03-09 |
2016-11-01 |
The Broad Inst Inc * |
Metodo de diagnostico y tratamiento de cancer en pacientes que tienen o desarrollan resistencia a una primera terapia de cancer.
|
|
PT2624696T
(pt)
|
2010-10-06 |
2017-03-21 |
Glaxosmithkline Llc |
Derivados de benzimidazole como inibidores da cinase pi3
|
|
US9045429B2
(en)
|
2010-10-29 |
2015-06-02 |
Bayer Intellectual Property Gmbh |
Substituted phenoxypyridines
|
|
CA2831932A1
(en)
|
2011-04-01 |
2012-10-04 |
Genentech, Inc. |
Combinations of akt and mek inhibitor compounds, and methods of use
|
|
RS56759B2
(sr)
|
2011-04-01 |
2024-10-31 |
Genentech Inc |
Kombinacija akt inhibitor jedinjenja i abiraterona za upotrebu pri terapeutskim tretiranjima
|
|
US9833439B2
(en)
|
2011-05-25 |
2017-12-05 |
Universite Paris Descartes |
ERK inhibitors for use in treating spinal muscular atrophy
|
|
WO2013082511A1
(en)
|
2011-12-02 |
2013-06-06 |
Genentech, Inc. |
Methods for overcoming tumor resistance to vegf antagonists
|
|
CN103204822B
(zh)
|
2012-01-17 |
2014-12-03 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途
|
|
US20150141470A1
(en)
|
2012-05-08 |
2015-05-21 |
The Broad Institute, Inc. |
Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
|
|
WO2013178581A1
(en)
|
2012-05-31 |
2013-12-05 |
Bayer Pharma Aktiengesellschaft |
Biomarkers for determining effective response of treatments of hepatocellular carcinoma (hcc) patients
|
|
TR201807861T4
(tr)
|
2012-10-12 |
2018-06-21 |
Exelixis Inc |
Kanser tedavisinde kullanım için bileşikler yapmak için yeni işlem.
|
|
SG11201507730UA
(en)
|
2013-03-21 |
2015-10-29 |
Novartis Ag |
Combination therapy comprising a b-raf inhibitor and a second inhibitor
|
|
EP3043822A1
(en)
|
2013-09-11 |
2016-07-20 |
The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone |
Compositions for preparing cardiomyocytes
|
|
CN105384754B
(zh)
*
|
2014-09-02 |
2018-04-20 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
|
|
WO2017033113A1
(en)
|
2015-08-21 |
2017-03-02 |
Acerta Pharma B.V. |
Therapeutic combinations of a mek inhibitor and a btk inhibitor
|
|
AR108257A1
(es)
|
2016-05-02 |
2018-08-01 |
Mei Pharma Inc |
Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas
|
|
EP3712133B1
(en)
|
2017-11-14 |
2025-12-24 |
Shenzhen TargetRx, Inc. |
Substituted benzimidazole compound and composition comprising same
|
|
JP2022526713A
(ja)
|
2019-03-21 |
2022-05-26 |
オンクセオ |
がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子
|
|
KR20220098759A
(ko)
|
2019-11-08 |
2022-07-12 |
인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) |
키나제 억제제에 대해 내성을 획득한 암의 치료 방법
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
JP2024521788A
(ja)
|
2021-05-27 |
2024-06-04 |
ミラティ セラピューティクス， インコーポレイテッド |
併用療法
|
|
TW202342018A
(zh)
|
2022-03-04 |
2023-11-01 |
美商奇奈特生物製藥公司 |
Mek激酶抑制劑
|
|
WO2025073765A1
(en)
|
2023-10-03 |
2025-04-10 |
Institut National de la Santé et de la Recherche Médicale |
Methods of prognosis and treatment of patients suffering from melanoma
|