JP2005525826A5 - - Google Patents
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- Publication number
- JP2005525826A5 JP2005525826A5 JP2004506526A JP2004506526A JP2005525826A5 JP 2005525826 A5 JP2005525826 A5 JP 2005525826A5 JP 2004506526 A JP2004506526 A JP 2004506526A JP 2004506526 A JP2004506526 A JP 2004506526A JP 2005525826 A5 JP2005525826 A5 JP 2005525826A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- nucleic acid
- cell
- compound
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims 36
- 150000007523 nucleic acids Chemical class 0.000 claims 31
- 108020004707 nucleic acids Proteins 0.000 claims 30
- 102000039446 nucleic acids Human genes 0.000 claims 30
- 238000000034 method Methods 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 13
- 239000000523 sample Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 238000001514 detection method Methods 0.000 claims 10
- 208000020816 lung neoplasm Diseases 0.000 claims 10
- 208000037841 lung tumor Diseases 0.000 claims 10
- 238000012360 testing method Methods 0.000 claims 7
- 230000000295 complement effect Effects 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 230000009261 transgenic effect Effects 0.000 claims 4
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 3
- 230000024245 cell differentiation Effects 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 230000006378 damage Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 238000001574 biopsy Methods 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 2
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 2
- 229940000406 drug candidate Drugs 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 230000017854 proteolysis Effects 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 208000007660 Residual Neoplasm Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- -1 antibody Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000013399 early diagnosis Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
- 108700024394 Exon Proteins 0.000 description 3
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 238000012300 Sequence Analysis Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037433 frameshift Effects 0.000 description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 201000005249 lung adenocarcinoma Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020010275 EP1365032B1 (en) | 2002-05-21 | 2002-05-21 | Marker molecules associated with lung tumors |
| PCT/EP2003/050175 WO2003097871A2 (en) | 2002-05-21 | 2003-05-16 | Marker molecules associated with lung tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009240933A Division JP2010017194A (ja) | 2002-05-21 | 2009-10-19 | 肺腫瘍に関連したマーカー分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005525826A JP2005525826A (ja) | 2005-09-02 |
| JP2005525826A5 true JP2005525826A5 (enExample) | 2009-07-16 |
| JP4520848B2 JP4520848B2 (ja) | 2010-08-11 |
Family
ID=29286116
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506526A Expired - Lifetime JP4520848B2 (ja) | 2002-05-21 | 2003-05-16 | 肺腫瘍に関連したマーカー分子 |
| JP2009240933A Withdrawn JP2010017194A (ja) | 2002-05-21 | 2009-10-19 | 肺腫瘍に関連したマーカー分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009240933A Withdrawn JP2010017194A (ja) | 2002-05-21 | 2009-10-19 | 肺腫瘍に関連したマーカー分子 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7355025B2 (enExample) |
| EP (2) | EP1365032B1 (enExample) |
| JP (2) | JP4520848B2 (enExample) |
| AT (2) | ATE414789T1 (enExample) |
| AU (1) | AU2003238077A1 (enExample) |
| CA (1) | CA2486583C (enExample) |
| DE (2) | DE60229920D1 (enExample) |
| ES (2) | ES2316501T3 (enExample) |
| WO (1) | WO2003097871A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11927591B2 (en) | 2016-08-02 | 2024-03-12 | Georgetown University | Methods of identifying novel proteins and antigens in cancer cells |
| WO2021030271A2 (en) | 2019-08-09 | 2021-02-18 | Nutcracker Therapeutics, Inc. | Methods and apparatuses for manufacturing for removing material from a therapeutic composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4281061A (en) | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| US6316208B1 (en) | 1994-01-07 | 2001-11-13 | Memorial Sloan-Kettering Cancer Center | Methods for determining isolated p27 protein levels and uses thereof |
| US6033847A (en) | 1995-02-06 | 2000-03-07 | St. Jude Children's Research Hospital | InK4c-p18 and InK4d-p19, inhibitors of cyclin-dependent kinases CDK4 and CDK6, and uses thereof |
| US5858683A (en) | 1996-08-30 | 1999-01-12 | Matritech, Inc. | Methods and compositions for the detection of cervical cancer |
| CA2378512A1 (en) * | 1999-06-16 | 2000-12-21 | The Johns Hopkins University | Characterization of the yeast transcriptome |
| US6806254B2 (en) | 2000-02-03 | 2004-10-19 | Nuvelo, Inc. | Methods and materials relating to alpha-2-macroglobulin-like polypeptides and polynucleotides |
| US20030049617A1 (en) | 2000-02-17 | 2003-03-13 | Sei-Yu Chen | Methods for diagnosing, monitoring, staging, imaging and treating lung cancer via lung cancer specific genes |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| EP1268856A2 (de) * | 2000-04-07 | 2003-01-02 | Epigenomics AG | Detektion von snp's und cytosin-methylierungen |
| WO2002006294A2 (en) * | 2000-07-13 | 2002-01-24 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the mmp13 gene |
-
2002
- 2002-05-21 EP EP20020010275 patent/EP1365032B1/en not_active Expired - Lifetime
- 2002-05-21 AT AT02010275T patent/ATE414789T1/de not_active IP Right Cessation
- 2002-05-21 ES ES02010275T patent/ES2316501T3/es not_active Expired - Lifetime
- 2002-05-21 DE DE60229920T patent/DE60229920D1/de not_active Expired - Lifetime
-
2003
- 2003-05-16 AU AU2003238077A patent/AU2003238077A1/en not_active Abandoned
- 2003-05-16 US US10/515,477 patent/US7355025B2/en not_active Expired - Lifetime
- 2003-05-16 AT AT03735709T patent/ATE389033T1/de not_active IP Right Cessation
- 2003-05-16 EP EP20030735709 patent/EP1506317B1/en not_active Expired - Lifetime
- 2003-05-16 ES ES03735709T patent/ES2303595T3/es not_active Expired - Lifetime
- 2003-05-16 JP JP2004506526A patent/JP4520848B2/ja not_active Expired - Lifetime
- 2003-05-16 DE DE2003619693 patent/DE60319693T2/de not_active Expired - Lifetime
- 2003-05-16 WO PCT/EP2003/050175 patent/WO2003097871A2/en not_active Ceased
- 2003-05-16 CA CA2486583A patent/CA2486583C/en not_active Expired - Lifetime
-
2008
- 2008-03-17 US US12/050,002 patent/US7883896B2/en not_active Expired - Lifetime
-
2009
- 2009-10-19 JP JP2009240933A patent/JP2010017194A/ja not_active Withdrawn
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