JP2005521642A5 - - Google Patents
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- JP2005521642A5 JP2005521642A5 JP2003545652A JP2003545652A JP2005521642A5 JP 2005521642 A5 JP2005521642 A5 JP 2005521642A5 JP 2003545652 A JP2003545652 A JP 2003545652A JP 2003545652 A JP2003545652 A JP 2003545652A JP 2005521642 A5 JP2005521642 A5 JP 2005521642A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- hydroxy
- compound
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229910052736 halogen Inorganic materials 0.000 claims 98
- 150000002367 halogens Chemical class 0.000 claims 98
- 150000001875 compounds Chemical class 0.000 claims 94
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 77
- 229910052739 hydrogen Inorganic materials 0.000 claims 74
- 239000001257 hydrogen Substances 0.000 claims 74
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 66
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 62
- 125000003118 aryl group Chemical group 0.000 claims 62
- 150000002431 hydrogen Chemical class 0.000 claims 58
- 125000004093 cyano group Chemical group *C#N 0.000 claims 43
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 40
- 125000005179 haloacetyl group Chemical group 0.000 claims 35
- 125000005862 (C1-C6)alkanoyl group Chemical group 0.000 claims 29
- -1 hydroxy, amino Chemical group 0.000 claims 26
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 24
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 22
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims 17
- 125000004995 haloalkylthio group Chemical group 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 125000001153 fluoro group Chemical group F* 0.000 claims 15
- 125000004438 haloalkoxy group Chemical group 0.000 claims 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 15
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 150000002148 esters Chemical class 0.000 claims 14
- 125000004414 alkyl thio group Chemical group 0.000 claims 13
- 125000001309 chloro group Chemical group Cl* 0.000 claims 13
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 12
- 125000002541 furyl group Chemical group 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 125000004076 pyridyl group Chemical group 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 125000001544 thienyl group Chemical group 0.000 claims 10
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 8
- 239000011593 sulfur Substances 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000001246 bromo group Chemical group Br* 0.000 claims 5
- 125000001589 carboacyl group Chemical group 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 125000005605 benzo group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- IEVFQDJUDLCOQY-UHFFFAOYSA-N 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1h-pyrrolo[2,3-b]pyridin-1-yl)acetic acid Chemical compound C12=CC=CN=C2N(CC(=O)O)C=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 IEVFQDJUDLCOQY-UHFFFAOYSA-N 0.000 claims 2
- PFNREKUNOGSYRJ-UHFFFAOYSA-N 2-[2,4,6-trimethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound CC1=C(CC(O)=O)C(C)=NC(C)=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 PFNREKUNOGSYRJ-UHFFFAOYSA-N 0.000 claims 2
- ZEYIZFXZZQJPGA-UHFFFAOYSA-N 2-[2,5-dimethyl-4-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-3-yl]acetic acid Chemical compound OC(=O)CC1=C(C)SC(C)=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 ZEYIZFXZZQJPGA-UHFFFAOYSA-N 0.000 claims 2
- ZYNSHYPZQCKSSY-UHFFFAOYSA-N 2-[2,6-diphenyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C(C=2C=CC=CC=2)N=C1C1=CC=CC=C1 ZYNSHYPZQCKSSY-UHFFFAOYSA-N 0.000 claims 2
- CAPJMFWBLOUGMW-UHFFFAOYSA-N 2-[2-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-3-yl]acetic acid Chemical compound C1=CSC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C1CC(=O)O CAPJMFWBLOUGMW-UHFFFAOYSA-N 0.000 claims 2
- CTMUUQDXBYFSQW-UHFFFAOYSA-N 2-[2-benzyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=CN=C1CC1=CC=CC=C1 CTMUUQDXBYFSQW-UHFFFAOYSA-N 0.000 claims 2
- XLAFRLAIBZTXCU-UHFFFAOYSA-N 2-[2-ethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound C1=C(CC(O)=O)C(CC)=NC=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 XLAFRLAIBZTXCU-UHFFFAOYSA-N 0.000 claims 2
- PNWUIMAVAPWGSW-UHFFFAOYSA-N 2-[2-phenyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=CN=C1C1=CC=CC=C1 PNWUIMAVAPWGSW-UHFFFAOYSA-N 0.000 claims 2
- SKEWILPHFSWLSN-UHFFFAOYSA-N 2-[4-ethyl-2,6-dimethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound CCC1=C(CC(O)=O)C(C)=NC(C)=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 SKEWILPHFSWLSN-UHFFFAOYSA-N 0.000 claims 2
- KBKBWRFRCGROQC-UHFFFAOYSA-N 2-[5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CN=CC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C1 KBKBWRFRCGROQC-UHFFFAOYSA-N 0.000 claims 2
- OOBMLQZEXUXQJJ-UHFFFAOYSA-N 2-[5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-2-yl]acetic acid Chemical compound S1C(CC(=O)O)=CC=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 OOBMLQZEXUXQJJ-UHFFFAOYSA-N 0.000 claims 2
- JWXQDSJKVIYMHR-UHFFFAOYSA-N 2-[6-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyrrolo[2,3-b]pyridin-1-yl]acetic acid Chemical compound FC1=CC(F)=C2SC(CC=3C4=CC=C(N=C4N(CC(O)=O)C=3)C)=NC2=C1F JWXQDSJKVIYMHR-UHFFFAOYSA-N 0.000 claims 2
- CTIUPEXZVKFZKN-UHFFFAOYSA-N 2-[6-phenyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound N=1C2=C(F)C(F)=CC(F)=C2SC=1CC1=CC(CC(=O)O)=CN=C1C1=CC=CC=C1 CTIUPEXZVKFZKN-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- HYERUDTVJABLSF-UHFFFAOYSA-N 2-[2,6-diethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound C1=C(CC(O)=O)C(CC)=NC(CC)=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 HYERUDTVJABLSF-UHFFFAOYSA-N 0.000 claims 1
- SGWFOCMKXJYHKO-UHFFFAOYSA-N 2-[2,6-dimethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound C1=C(CC(O)=O)C(C)=NC(C)=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 SGWFOCMKXJYHKO-UHFFFAOYSA-N 0.000 claims 1
- QMJVDEUOIVQWQD-UHFFFAOYSA-N 2-[2,6-dipropyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound C1=C(CC(O)=O)C(CCC)=NC(CCC)=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 QMJVDEUOIVQWQD-UHFFFAOYSA-N 0.000 claims 1
- OEORDSXPWKPIKP-UHFFFAOYSA-N 2-[2-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1,3-thiazol-4-yl]acetic acid Chemical compound OC(=O)CC1=CSC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=N1 OEORDSXPWKPIKP-UHFFFAOYSA-N 0.000 claims 1
- QERNHAPUCRXMGR-UHFFFAOYSA-N 2-[2-phenoxy-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound OC(=O)CC1=CC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=CN=C1OC1=CC=CC=C1 QERNHAPUCRXMGR-UHFFFAOYSA-N 0.000 claims 1
- FRMQGFMUXLWFGM-UHFFFAOYSA-N 2-[3-methyl-4-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-2-yl]acetic acid Chemical compound S1C(CC(O)=O)=C(C)C(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C1 FRMQGFMUXLWFGM-UHFFFAOYSA-N 0.000 claims 1
- AWRSPKGLQVNFPD-UHFFFAOYSA-N 2-[4-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-2-yl]acetic acid Chemical compound S1C(CC(=O)O)=CC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C1 AWRSPKGLQVNFPD-UHFFFAOYSA-N 0.000 claims 1
- YKSHWZGJLFPDJQ-UHFFFAOYSA-N 2-[4-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]thiophen-2-yl]acetic acid Chemical compound S1C(CC(=O)O)=CC(CC=2SC3=CC=C(C=C3N=2)C(F)(F)F)=C1 YKSHWZGJLFPDJQ-UHFFFAOYSA-N 0.000 claims 1
- LMPBXDVGTLTTAA-UHFFFAOYSA-N 2-[4-methyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-3-yl]acetic acid Chemical compound OC(=O)CC1=CSC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C1C LMPBXDVGTLTTAA-UHFFFAOYSA-N 0.000 claims 1
- JLCZMVMDODLRLV-UHFFFAOYSA-N 2-[5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-3-yl]acetic acid Chemical compound OC(=O)CC1=CSC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C1 JLCZMVMDODLRLV-UHFFFAOYSA-N 0.000 claims 1
- BPQXOOHODIRJJK-UHFFFAOYSA-N 2-[6-benzyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound N=1C2=C(F)C(F)=CC(F)=C2SC=1CC1=CC(CC(=O)O)=CN=C1CC1=CC=CC=C1 BPQXOOHODIRJJK-UHFFFAOYSA-N 0.000 claims 1
- URZYTJCGTHKZPQ-UHFFFAOYSA-N 2-[6-ethyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyrrolo[2,3-b]pyridin-1-yl]acetic acid Chemical compound FC1=CC(F)=C2SC(CC=3C4=CC=C(N=C4N(CC(O)=O)C=3)CC)=NC2=C1F URZYTJCGTHKZPQ-UHFFFAOYSA-N 0.000 claims 1
- HJUMIRGVLXWEGT-UHFFFAOYSA-N 2-[6-ethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid Chemical compound CCC1=NC=C(CC(O)=O)C=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 HJUMIRGVLXWEGT-UHFFFAOYSA-N 0.000 claims 1
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical group C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 206010007749 Cataract diabetic Diseases 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- KXNQKOAQSGJCQU-UHFFFAOYSA-N benzo[e][1,3]benzothiazole Chemical compound C1=CC=C2C(N=CS3)=C3C=CC2=C1 KXNQKOAQSGJCQU-UHFFFAOYSA-N 0.000 claims 1
- WMUIZUWOEIQJEH-UHFFFAOYSA-N benzo[e][1,3]benzoxazole Chemical compound C1=CC=C2C(N=CO3)=C3C=CC2=C1 WMUIZUWOEIQJEH-UHFFFAOYSA-N 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000007025 diabetic cataract Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- MCAIJPGUXQSZIP-UHFFFAOYSA-N methyl 2-[2,6-diethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetate Chemical compound C1=C(CC(=O)OC)C(CC)=NC(CC)=C1CC1=NC2=C(F)C(F)=CC(F)=C2S1 MCAIJPGUXQSZIP-UHFFFAOYSA-N 0.000 claims 1
- VMWHCGCGFKMESD-UHFFFAOYSA-N methyl 2-[4-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-2-yl]acetate Chemical compound S1C(CC(=O)OC)=CC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C1 VMWHCGCGFKMESD-UHFFFAOYSA-N 0.000 claims 1
- YWUKPLDSOFPSDV-UHFFFAOYSA-N methyl 2-[4-methyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]thiophen-3-yl]acetate Chemical compound COC(=O)CC1=CSC(CC=2SC3=C(F)C=C(F)C(F)=C3N=2)=C1C YWUKPLDSOFPSDV-UHFFFAOYSA-N 0.000 claims 1
- GKPIPLHDIIPTES-UHFFFAOYSA-N methyl 2-[6-benzyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetate Chemical compound N=1C2=C(F)C(F)=CC(F)=C2SC=1CC1=CC(CC(=O)OC)=CN=C1CC1=CC=CC=C1 GKPIPLHDIIPTES-UHFFFAOYSA-N 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- KDZASNPOEXNJBZ-UHFFFAOYSA-N thieno[2,3-d][1,2]thiazole Chemical compound S1N=CC2=C1C=CS2 KDZASNPOEXNJBZ-UHFFFAOYSA-N 0.000 claims 1
- ONCNIMLKGZSAJT-UHFFFAOYSA-N thieno[3,2-b]furan Chemical group S1C=CC2=C1C=CO2 ONCNIMLKGZSAJT-UHFFFAOYSA-N 0.000 claims 1
- VJYJJHQEVLEOFL-UHFFFAOYSA-N thieno[3,2-b]thiophene Chemical group S1C=CC2=C1C=CS2 VJYJJHQEVLEOFL-UHFFFAOYSA-N 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical group C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 claims 1
- 229960002324 trifluoperazine Drugs 0.000 claims 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 229940116269 uric acid Drugs 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 0 C*c1c(C*)c(C)c(CC=C)c(*)n1 Chemical compound C*c1c(C*)c(C)c(CC=C)c(*)n1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33605501P | 2001-11-15 | 2001-11-15 | |
| US37862602P | 2002-05-07 | 2002-05-07 | |
| PCT/US2002/036709 WO2003044015A2 (en) | 2001-11-15 | 2002-11-15 | Substituted heteroarylalkanoic acids and their use as aldose reductase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005521642A JP2005521642A (ja) | 2005-07-21 |
| JP2005521642A5 true JP2005521642A5 (https=) | 2006-01-19 |
Family
ID=26990017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545652A Pending JP2005521642A (ja) | 2001-11-15 | 2002-11-15 | 置換ヘテロアリールアルカン酸及びそのアルドースレダクターゼ阻害剤としての使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7361671B2 (https=) |
| EP (1) | EP1444228B1 (https=) |
| JP (1) | JP2005521642A (https=) |
| AT (1) | ATE396190T1 (https=) |
| AU (1) | AU2002350191A1 (https=) |
| CA (1) | CA2466925A1 (https=) |
| DE (1) | DE60226764D1 (https=) |
| MX (1) | MXPA04004548A (https=) |
| TW (1) | TW200303198A (https=) |
| WO (1) | WO2003044015A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| JP2005272453A (ja) | 2004-02-24 | 2005-10-06 | Sankyo Co Ltd | アミノアルコール化合物 |
| ES2282062T1 (es) | 2004-06-04 | 2007-10-16 | Teva Pharmaceutical Industries Ltd. | Composicion farmaceutica que contiene irbesartan. |
| DK1784404T3 (da) | 2004-09-03 | 2012-02-13 | Yuhan Corp | Pyrrolo[2,3-c]pyridinderivater samt fremgangsmåder til deres fremstilling |
| ATE466013T1 (de) * | 2004-09-03 | 2010-05-15 | Yuhan Corp | Pyrroloä3,2-cüpyridinderivate und verfahren zu deren herstellung |
| FR2876103B1 (fr) * | 2004-10-01 | 2008-02-22 | Aventis Pharma Sa | Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| GB2422830A (en) * | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| GB2422831A (en) * | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| GB2422829A (en) * | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| US7589213B2 (en) * | 2007-04-27 | 2009-09-15 | Old David W | Therapeutic substituted lactams |
| WO2010071865A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| US20100160351A1 (en) * | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| RS57869B1 (sr) | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
| WO2011032175A1 (en) | 2009-09-14 | 2011-03-17 | Nuon Therapeutics, Inc. | Combination formulations of tranilast and allopurinol and methods related thereto |
| WO2011075478A1 (en) | 2009-12-16 | 2011-06-23 | N30 Pharmaceuticals, Llc | Novel thiophene inhibitors of s-nitrosoglutathione reductase |
| AU2011343642A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| AR095883A1 (es) | 2013-04-18 | 2015-11-18 | Astellas Pharma Inc | Compuestos de acetamida heterocíclica |
| RS59144B1 (sr) | 2013-11-13 | 2019-09-30 | Vertex Pharma | Inhibitori replikacije virusa influence |
| HRP20181272T1 (hr) | 2013-11-13 | 2018-10-05 | Vertex Pharmaceuticals Incorporated | Postupci priprave inhibitora replikacije virusa influence |
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| EP3250558A4 (en) | 2015-01-26 | 2018-08-08 | Wake Forest University Health Sciences | Hypdh inhibitors and methods of use for the treatment of kidney stones |
| CA2976310A1 (en) * | 2015-02-25 | 2016-09-01 | Sabic Global Technologies B.V. | Process for removing impurities from acetic acid |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| JP6857617B2 (ja) | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤 |
| EA201890454A1 (ru) | 2015-08-06 | 2018-07-31 | Чимерикс, Инк. | Пирролопиримидиновые нуклеозиды и их аналоги, которые можно использовать в качестве противовирусных средств |
| WO2019060692A1 (en) | 2017-09-21 | 2019-03-28 | Chimerix, Inc. | MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES |
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| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
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| AR207133A1 (es) * | 1973-02-20 | 1976-09-15 | Ciba Geigy Ag | Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano |
| AU4226493A (en) * | 1992-05-01 | 1993-11-29 | Smithkline Beecham Corporation | Leukotriene antagonists |
| IL106156A0 (en) * | 1992-06-30 | 1993-10-20 | Smithkline Beecham Corp | Pyridinyl compounds |
| ES2252063T3 (es) * | 1999-09-28 | 2006-05-16 | Eisai Co., Ltd. | Compuesto de quinuclidina y medicamento que comprende el compuesto como principio activo. |
| EP1222187B1 (en) * | 1999-10-06 | 2004-09-22 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
-
2002
- 2002-11-14 US US10/295,414 patent/US7361671B2/en not_active Expired - Fee Related
- 2002-11-15 AU AU2002350191A patent/AU2002350191A1/en not_active Abandoned
- 2002-11-15 JP JP2003545652A patent/JP2005521642A/ja active Pending
- 2002-11-15 WO PCT/US2002/036709 patent/WO2003044015A2/en not_active Ceased
- 2002-11-15 EP EP02786720A patent/EP1444228B1/en not_active Expired - Lifetime
- 2002-11-15 MX MXPA04004548A patent/MXPA04004548A/es not_active Application Discontinuation
- 2002-11-15 AT AT02786720T patent/ATE396190T1/de not_active IP Right Cessation
- 2002-11-15 DE DE60226764T patent/DE60226764D1/de not_active Expired - Fee Related
- 2002-11-15 TW TW091133509A patent/TW200303198A/zh unknown
- 2002-11-15 CA CA002466925A patent/CA2466925A1/en not_active Abandoned
-
2008
- 2008-04-22 US US12/107,740 patent/US20090163535A1/en not_active Abandoned
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