JP2005519866A5 - - Google Patents

Download PDF

Info

Publication number
JP2005519866A5
JP2005519866A5 JP2003532466A JP2003532466A JP2005519866A5 JP 2005519866 A5 JP2005519866 A5 JP 2005519866A5 JP 2003532466 A JP2003532466 A JP 2003532466A JP 2003532466 A JP2003532466 A JP 2003532466A JP 2005519866 A5 JP2005519866 A5 JP 2005519866A5
Authority
JP
Japan
Prior art keywords
membered
ring
heterocyclic
aromatic ring
amidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003532466A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005519866A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/031769 external-priority patent/WO2003029216A1/en
Publication of JP2005519866A publication Critical patent/JP2005519866A/ja
Publication of JP2005519866A5 publication Critical patent/JP2005519866A5/ja
Pending legal-status Critical Current

Links

JP2003532466A 2001-10-03 2002-10-03 凝固カスケードの選択阻害に有用な６員複素環式化合物 Pending JP2005519866A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US32672101P 2001-10-03 2001-10-03
US33862301P 2001-10-24 2001-10-24
US33285701P 2001-11-06 2001-11-06
US35005201P 2001-11-07 2001-11-07
US33210701P 2001-11-21 2001-11-21
US33189101P 2001-11-21 2001-11-21
PCT/US2002/031769 WO2003029216A1 (en) 2001-10-03 2002-10-03 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade

Publications (2)

Publication Number Publication Date
JP2005519866A JP2005519866A (ja) 2005-07-07
JP2005519866A5 true JP2005519866A5 (https=) 2006-01-12

Family

ID=27559729

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003532466A Pending JP2005519866A (ja) 2001-10-03 2002-10-03 凝固カスケードの選択阻害に有用な６員複素環式化合物

Country Status (7)

Country Link
US (2) US6969715B2 (https=)
EP (1) EP1438292A1 (https=)
JP (1) JP2005519866A (https=)
BR (1) BR0213092A (https=)
CA (1) CA2462305A1 (https=)
MX (1) MXPA04003163A (https=)
WO (1) WO2003029216A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103917529B (zh) 2011-11-11 2016-08-17 辉瑞大药厂 2-硫代嘧啶酮类
US9522892B2 (en) 2011-11-29 2016-12-20 Perosphere Inc. Anticoagulant reversal agents
AU2016257179A1 (en) 2015-05-05 2017-11-02 Pfizer Inc. 2-thiopyrimidinones
CN110117257B (zh) * 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5910541A (ja) * 1982-07-09 1984-01-20 Takeda Chem Ind Ltd キノン化合物
JPS60255749A (ja) * 1984-05-31 1985-12-17 Univ Nagoya キノン誘導体
US5304658A (en) * 1984-08-01 1994-04-19 Takeda Chemical Industries, Ltd. Quinone derivatives, their production and use
IL81264A (en) * 1986-01-30 1990-11-05 Takeda Chemical Industries Ltd Quinone derivatives,their production and pharmaceutical compositions containing them
DE3826846A1 (de) 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
GB9216272D0 (en) 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles
DE69314169T2 (de) 1992-04-16 1998-01-15 Zeneca Ltd Peptide mit eine alphaaminoboronaire gruppe and ihre verwendung als elastasehemmer
US5441960A (en) * 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US6011158A (en) * 1994-12-13 2000-01-04 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5656645A (en) 1994-12-13 1997-08-12 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
MX9704439A (es) 1994-12-13 1997-10-31 Corvas Int Inc Derivados heterociclicos aromaticos como inhibidores de enzima.
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
EP0826671B1 (en) 1995-04-27 2004-12-29 Mitsubishi Pharma Corporation Heterocyclic amide compounds and medicinal use of the same
US5612378A (en) 1995-06-06 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors
US5741819A (en) * 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
CA2224437A1 (en) 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
EP0923372A4 (en) 1996-02-22 2001-09-05 Merck & Co Inc INHIBITORS OF PYRIDINONE THROMBIN
AU714985B2 (en) 1996-04-23 2000-01-13 Merck & Co., Inc. Pyrazinone thrombin inhibitors
US5668289A (en) * 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors
JP2002511052A (ja) 1996-08-29 2002-04-09 メルク エンド カンパニー インコーポレーテッド インテグリンアンタゴニスト
AU4172397A (en) 1996-09-06 1998-03-26 Biochem Pharma Inc. Lactam inhibitors of thrombin
KR20000068354A (ko) 1996-09-06 2000-11-25 다께다 가즈히꼬 신규 아세트아미드 유도체 및 프로테아제 저해제
US5872138A (en) * 1996-09-13 1999-02-16 Merck & Co., Inc. Thrombin inhibitors
WO1998010763A1 (en) 1996-09-13 1998-03-19 Merck & Co., Inc. Thrombin inhibitors
WO1998016547A1 (en) 1996-10-11 1998-04-23 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
JP2001502674A (ja) 1996-10-11 2001-02-27 シーオーアール・セラピューティックス・インコーポレーテッド 選択的Ｘａ因子阻害物質
US5869487A (en) * 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
ATE234091T1 (de) 1996-10-24 2003-03-15 Merck & Co Inc Thrombin inhibitoren
EP0940400A4 (en) 1996-10-25 2002-10-02 Mitsubishi Pharma Corp HETEROCYCLIC AMID COMPOUNDS AND THEIR MEDICAL APPLICATION
EP0971891A4 (en) 1997-01-22 2000-04-19 Merck & Co Inc Thrombin inhibitors
US5792779A (en) * 1997-02-19 1998-08-11 Merck & Co., Inc. Pyridinone thrombin inhibitors
WO1998042342A1 (en) 1997-03-24 1998-10-01 Merck & Co., Inc. Thrombin inhibitors
US5866573A (en) * 1997-04-21 1999-02-02 Merck & Co., Inc. Pyrazinone thrombin inhibitors
IL123986A (en) 1997-04-24 2011-10-31 Organon Nv Medicinal compounds
NZ500620A (en) 1997-05-02 2000-10-27 Akzo Nobel Nv Synthetic peptides which inhibit serine proteases, specifically thrombin, factor VIIa tissue factor and factor Xa
JP2002512633A (ja) 1997-06-26 2002-04-23 イーライ・リリー・アンド・カンパニー 抗血栓剤
US6313151B1 (en) 1997-06-26 2001-11-06 Eli Lilly And Company Antithrombotic agents
ES2241151T3 (es) 1997-06-26 2005-10-16 Eli Lilly And Company Agentes antitromboticos.
JP2001514227A (ja) 1997-09-05 2001-09-11 メルク エンド カムパニー インコーポレーテッド ピラジノン系トロンビン阻害薬
WO1999026926A1 (en) * 1997-11-26 1999-06-03 3-Dimensional Pharmaceuticals, Inc. Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
WO1999026920A1 (en) 1997-11-26 1999-06-03 Corvas International, Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (ii)
PT1049703E (pt) 1998-01-20 2003-06-30 Warner Lambert Co Aldeido do acido n-¬2-(5-benziloxicarbonilamino-6-oxo-2-(4-fluorofenil)-1,6-di-hidro-1-pirimidinil)acetoxil|-l-aspartico como inibidor da enzima de conversao da interleucina-1beta in vivo
AU2881199A (en) 1998-02-26 1999-09-15 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
GB9806102D0 (en) 1998-03-20 1998-05-20 Merck Sharp & Dohme Therapeutic agents
AU753479B2 (en) 1998-05-19 2002-10-17 Merck & Co., Inc. Pyrazinone thrombin inhibitors
AU742178B2 (en) 1998-05-26 2001-12-20 Merck & Co., Inc. Imidazopyridine thrombin inhibitors
WO2000032216A1 (en) 1998-06-03 2000-06-08 Cortech Inc. Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
NZ508669A (en) 1998-06-11 2003-06-30 Dimensional Pharm Inc Pyrazinone protease inhibitors
PT997474E (pt) 1998-08-14 2004-01-30 Pfizer Agentes antitromboticos
EP1117660A4 (en) 1998-09-28 2002-01-09 Merck & Co Inc Thrombin Inhibitors
WO2000026211A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
EP1124823A1 (en) 1998-10-30 2001-08-22 Merck & Co., Inc. Thrombin inhibitors
DE19851421A1 (de) 1998-11-07 2000-05-11 Boehringer Ingelheim Pharma Neue Pyrimidine, deren Herstellung und Verwendung
FR2786482B1 (fr) 1998-11-27 2002-08-09 Synthelabo Nouveaux derives de 2-pyridone, leur preparation et leur application en therapeutique
CA2348740A1 (en) 1998-12-23 2000-07-06 Ruth R. Wexler Thrombin or factor xa inhibitors
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
NZ514877A (en) 1999-05-19 2004-10-29 Pharmacia Corp Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
BR0010758A (pt) 1999-05-19 2003-06-10 Pharmacia Corp Aril e heteroaril pirimidinonas policìclicas substituìdas úteis como anti coagulantes
IL146244A0 (en) 1999-05-19 2002-07-25 Pharmacia Corp Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
WO2001068605A1 (en) * 2000-03-13 2001-09-20 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
CA2405306A1 (en) * 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
AU2001249870A1 (en) 2000-04-05 2001-10-23 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
CA2405684A1 (en) * 2000-04-17 2001-10-25 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
WO2001087842A1 (en) * 2000-05-18 2001-11-22 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
WO2001087851A1 (en) * 2000-05-18 2001-11-22 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
MXPA03004458A (es) * 2000-11-20 2005-01-25 Pharmacia Corp Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion.

Similar Documents

Publication Publication Date Title
NO330968B1 (no) Ny fremgangsmate for syntesen av (1S)-4,5-dimetoksy-1-(metylaminometyl)-benzocyklobutan og addisjonssalter derav, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre
GEP20104895B (en) Preparation of pregabalin and related compounds
CO5160253A1 (es) Complejo de 1,4-benzodiazepinas sustituidas y sulfobutileter -7-ciclodextrina o 2-hidroxipropil-b-ciclodextrina .
SI2228064T1 (sl) Farmacevtski sestavek, ki vsebuje glikopirolat in agonist adrenoceptorja beta2
EP1505061A4 (en) CONNECTION WITH PGD-2 RECEPTOR ANTAGONISM
NO20024869D0 (no) Oksygenatomdanningsprosess
EP1719761A4 (en) NEW HETEROCYCLIC CONNECTION
MX2009006315A (es) Compuesto heterociclico fusionado.
NO20052529L (no) Forbindelse og sammensetning, og anvendelse av samme
DE60239170D1 (de) Bicyclische Verbindungen
NO20022976L (no) 2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet
WO2003004497A1 (en) Novel heterocyclic compound
EP1743695A4 (en) OXYGEN ABSORBER COMPOSITION
PT1202954E (pt) Novas aminobenzofenonas
ATE224358T1 (de) Diaminocyclobuten-3,4-dionderivate, deren herstellung und deren verwendung
JP2005519866A5 (https=)
DE60311887D1 (de) Multifunktionelle kationische photoinitiatoren, deren herstellung und verwendung
TR200103855T2 (tr) Melagatranın büyük ölçüde kristalin bir formu.
GB0201882D0 (en) Organic compounds
MXPA05006957A (es) Nuevos derivados de fosforamida.
DE60312123D1 (de) (5-(pyridin-3-yl)-1-azabicyclo(3.2.1) octan derivate, deren herstellung und deren verwendung in therapeutika"
MXPA05013034A (es) N-alquinil-2-heteroariloxialquilamidas para uso como fungicidas.
ATE374778T1 (de) Organosiliziumverbindungen und deren verwendung
ATE344264T1 (de) Porphyrin-verbindung, deren albumin- einschlussverbindung und künstlicher sauerstoffträger
ATE300280T1 (de) Verwendung von kreatinin und/oder kreatinin- derivaten zur aufhellung der haut und milderung von pigmentstörungen