PT997474E - Agentes antitromboticos - Google Patents
Agentes antitromboticosInfo
- Publication number
- PT997474E PT997474E PT99305978T PT99305978T PT997474E PT 997474 E PT997474 E PT 997474E PT 99305978 T PT99305978 T PT 99305978T PT 99305978 T PT99305978 T PT 99305978T PT 997474 E PT997474 E PT 997474E
- Authority
- PT
- Portugal
- Prior art keywords
- dvt
- occlusion
- coagulation
- grafts
- arterio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9817819.7A GB9817819D0 (en) | 1998-08-14 | 1998-08-14 | Antithrombotic agents |
GB9900801 | 1999-01-14 | ||
US09/372,200 US6180627B1 (en) | 1998-08-14 | 1999-08-11 | Antithrombotic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
PT997474E true PT997474E (pt) | 2004-01-30 |
Family
ID=27269438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99305978T PT997474E (pt) | 1998-08-14 | 1999-07-28 | Agentes antitromboticos |
Country Status (10)
Country | Link |
---|---|
US (1) | US6180627B1 (pt) |
EP (1) | EP0997474B1 (pt) |
JP (1) | JP3258297B2 (pt) |
AT (1) | ATE253076T1 (pt) |
BR (1) | BR9903628A (pt) |
CA (1) | CA2280279C (pt) |
DE (1) | DE69912379T2 (pt) |
DK (1) | DK0997474T3 (pt) |
ES (1) | ES2209337T3 (pt) |
PT (1) | PT997474E (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000026210A1 (en) * | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Thrombin inhibitors |
US6610692B1 (en) * | 1998-10-30 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6458952B1 (en) * | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6750342B1 (en) * | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6906068B1 (en) | 1999-05-19 | 2005-06-14 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants |
US6908919B2 (en) * | 1999-05-19 | 2005-06-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US6653316B1 (en) * | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6867217B1 (en) * | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
AU2001245856A1 (en) | 2000-03-23 | 2001-10-03 | Merck & Co., Inc. | Thrombin inhibitors |
CA2405306A1 (en) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
EP1268463B1 (en) * | 2000-04-05 | 2005-02-16 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
JP2004501077A (ja) * | 2000-04-17 | 2004-01-15 | ファルマシア・コーポレーション | 凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換1,4−キノン |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
EP1351686A2 (en) | 2000-11-20 | 2003-10-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
US20030236257A1 (en) * | 2001-04-04 | 2003-12-25 | South Michael S. | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade |
MXPA03011558A (es) * | 2001-06-12 | 2004-03-26 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de desordenes metabolicos. |
JP2005514332A (ja) * | 2001-10-03 | 2005-05-19 | ファルマシア・コーポレーション | 凝固カスケードの選択阻害に有用な6員不飽和複素環式化合物 |
US7105559B2 (en) | 2001-10-03 | 2006-09-12 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
BR0213092A (pt) | 2001-10-03 | 2004-10-19 | Pharmacia Corp | Compostos heterocìclicos de 6 elementos úteis para a inibição seletiva da cascata de coagulação |
US20040082585A1 (en) * | 2001-10-03 | 2004-04-29 | Pharmacia Corporation | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade |
CA2392486A1 (en) | 2002-07-05 | 2002-12-08 | Duchesnay Inc. | Pharmaceutical dosage form bearing pregnancy-friendly indicia |
US8580782B2 (en) * | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
US8673924B2 (en) * | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
PT1537116E (pt) | 2002-09-04 | 2010-09-03 | Schering Corp | Pirazolopirimidinas adequadas para o tratamento de doenças cancerosas |
CA2649029A1 (en) * | 2006-04-20 | 2007-11-01 | Glaxo Group Limited | 2-substituted 4-benzylphthalazinone derivatives as histamine h1 and h3 antagonists |
EP2091538B1 (en) * | 2006-12-20 | 2010-03-03 | Glaxo Group Limited | 4-benzyl-1(2h)-phthalazinones as h1 receptor antagonists |
JP2011500537A (ja) * | 2007-10-11 | 2011-01-06 | グラクソ グループ リミテッド | H1受容体アンタゴニストとしてのフタラジンおよびピリド[3,4−d]ピリダジン化合物 |
RU2477144C2 (ru) * | 2010-03-22 | 2013-03-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Российской академии медицинских наук | Лекарственное средство с антиаритмическим и антифибрилляторным действием |
RU2613155C1 (ru) * | 2016-05-25 | 2017-03-15 | Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "СФМ") | Способ лечения больных с острыми тромбозами венозного русла нижних конечностей |
JP7263048B2 (ja) | 2019-02-25 | 2023-04-24 | 株式会社フジ医療器 | マッサージ機 |
JP2022538674A (ja) | 2019-07-01 | 2022-09-05 | トニックス ファーマ リミテッド | 抗cd154抗体およびその使用 |
CA3207098A1 (en) | 2021-01-06 | 2022-07-14 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2122397A1 (en) | 1993-05-03 | 1994-11-04 | Spencer D. Kimball | Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors |
GB9322976D0 (en) | 1993-11-08 | 1994-01-05 | Pfizer Ltd | Therapeutic agents |
IL115889A0 (en) * | 1994-11-14 | 1996-01-31 | Rohm & Haas | Pyridazinones and their use as fungicides |
GB9424842D0 (en) * | 1994-12-09 | 1995-02-08 | British Tech Group | Pharmaceutical compositions |
ATE217321T1 (de) | 1994-12-13 | 2002-05-15 | Corvas Int Inc | Aromatische heterocyclische derivate als enzyminhibitoren |
CA2224437A1 (en) | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Pyridinone-thrombin inhibitors |
WO1997030708A1 (en) | 1996-02-22 | 1997-08-28 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
WO1999011267A1 (en) | 1997-09-05 | 1999-03-11 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
CA2252964A1 (en) * | 1996-04-23 | 1997-10-30 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
JP2002511052A (ja) * | 1996-08-29 | 2002-04-09 | メルク エンド カンパニー インコーポレーテッド | インテグリンアンタゴニスト |
WO1998009987A1 (en) | 1996-09-06 | 1998-03-12 | Biochem Pharma, Inc. | Lactam inhibitors of thrombin |
CA2268381A1 (en) | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
ES2191830T3 (es) * | 1996-10-24 | 2003-09-16 | Merck & Co Inc | Inhibidores de trombina. |
IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
-
1999
- 1999-07-28 DE DE69912379T patent/DE69912379T2/de not_active Expired - Fee Related
- 1999-07-28 PT PT99305978T patent/PT997474E/pt unknown
- 1999-07-28 AT AT99305978T patent/ATE253076T1/de not_active IP Right Cessation
- 1999-07-28 ES ES99305978T patent/ES2209337T3/es not_active Expired - Lifetime
- 1999-07-28 DK DK99305978T patent/DK0997474T3/da active
- 1999-07-28 EP EP99305978A patent/EP0997474B1/en not_active Expired - Lifetime
- 1999-08-11 US US09/372,200 patent/US6180627B1/en not_active Expired - Fee Related
- 1999-08-12 CA CA002280279A patent/CA2280279C/en not_active Expired - Fee Related
- 1999-08-13 JP JP22949199A patent/JP3258297B2/ja not_active Expired - Fee Related
- 1999-08-16 BR BR9903628-2A patent/BR9903628A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2280279A1 (en) | 2000-02-14 |
DE69912379T2 (de) | 2004-05-06 |
ATE253076T1 (de) | 2003-11-15 |
ES2209337T3 (es) | 2004-06-16 |
US6180627B1 (en) | 2001-01-30 |
CA2280279C (en) | 2004-02-17 |
DE69912379D1 (de) | 2003-12-04 |
EP0997474A1 (en) | 2000-05-03 |
JP2000063380A (ja) | 2000-02-29 |
EP0997474B1 (en) | 2003-10-29 |
BR9903628A (pt) | 2000-09-26 |
JP3258297B2 (ja) | 2002-02-18 |
DK0997474T3 (da) | 2004-02-09 |
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