BR9903628A - Agentes antitrombóticos - Google Patents

Agentes antitrombóticos

Info

Publication number
BR9903628A
BR9903628A BR9903628-2A BR9903628A BR9903628A BR 9903628 A BR9903628 A BR 9903628A BR 9903628 A BR9903628 A BR 9903628A BR 9903628 A BR9903628 A BR 9903628A
Authority
BR
Brazil
Prior art keywords
dvt
occlusion
coagulation
antithrombotic agents
grafts
Prior art date
Application number
BR9903628-2A
Other languages
English (en)
Inventor
Julian Blagg
Alan Daniel Brown
Elisabeth Colette Loui Gautier
Julian Duncan Smith
Andrew Brian Mcelroy
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817819.7A external-priority patent/GB9817819D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of BR9903628A publication Critical patent/BR9903628A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: <B>"AGENTES ANTITROMBóTICOS"<D>. Compostos de fórmula (I): são agentes antitrombóticos, tendo utilidade numa variedade de áreas terapêuticas que incluem a prevenção e/ou tratamento de trombose da veia profunda (DVT) após cirurgia, doença médica principal, paralisia, malignidade, trauma da imobilização prolongada, aplicação de moldes de gesso a membro inferior, ou fraturas dos membros inferiores ou pélvis; DVT recorrente; DVT durante a gravidez quando existe uma sua história anterior; reoclusão que se segue a terapia trombolítica; obstrução arterial crónica; doença vascular periférica; enfarte do miocárdio agudo; angina instável; fibrilação atrial; derrame cerebral trombótico; ataques isquêmicos transientes; coagulação intravascular disseminada; coagulação em circuitos extracorporais; oclusão de <<shunts>> arteriovenosos e enxertos de vaso sang³íneo (incluindo enxertos de <<sobrepasso>> da artéria coronária); e restenose e oclusão que se segue a angioplastia.
BR9903628-2A 1998-08-14 1999-08-16 Agentes antitrombóticos BR9903628A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9817819.7A GB9817819D0 (en) 1998-08-14 1998-08-14 Antithrombotic agents
GB9900801 1999-01-14
US09/372,200 US6180627B1 (en) 1998-08-14 1999-08-11 Antithrombotic agents

Publications (1)

Publication Number Publication Date
BR9903628A true BR9903628A (pt) 2000-09-26

Family

ID=27269438

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9903628-2A BR9903628A (pt) 1998-08-14 1999-08-16 Agentes antitrombóticos

Country Status (10)

Country Link
US (1) US6180627B1 (pt)
EP (1) EP0997474B1 (pt)
JP (1) JP3258297B2 (pt)
AT (1) ATE253076T1 (pt)
BR (1) BR9903628A (pt)
CA (1) CA2280279C (pt)
DE (1) DE69912379T2 (pt)
DK (1) DK0997474T3 (pt)
ES (1) ES2209337T3 (pt)
PT (1) PT997474E (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU747776B2 (en) * 1998-10-30 2002-05-23 Merck & Co., Inc. Thrombin inhibitors
CA2348530A1 (en) * 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
US6906068B1 (en) 1999-05-19 2005-06-14 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6458952B1 (en) * 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6653316B1 (en) * 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6908919B2 (en) * 1999-05-19 2005-06-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
AU2001243598A1 (en) 2000-03-13 2001-09-24 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
AU2001245856A1 (en) 2000-03-23 2001-10-03 Merck & Co., Inc. Thrombin inhibitors
PT1268463E (pt) 2000-04-05 2005-05-31 Pharmacia Corp 4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao
EP1268428A2 (en) * 2000-04-05 2003-01-02 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
WO2001079155A2 (en) * 2000-04-17 2001-10-25 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
CA2430037A1 (en) * 2000-11-20 2002-05-30 Michael S. South Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US20030236257A1 (en) * 2001-04-04 2003-12-25 South Michael S. Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the cogulation cascade
NZ530051A (en) * 2001-06-12 2006-12-22 Wellstat Therapeutics Corp Polycyclic oxy-aromatic acid derivatives for the treatment of metabolic disorders
US6969715B2 (en) 2001-10-03 2005-11-29 Pharmacia Corporation 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
US20040082585A1 (en) * 2001-10-03 2004-04-29 Pharmacia Corporation Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade
US20040106626A1 (en) * 2001-10-03 2004-06-03 Pharmacia Corporation 6-Membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade
MXPA04003170A (es) 2001-10-03 2004-07-08 Pharmacia Corp Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion.
CA2392486A1 (en) 2002-07-05 2002-12-08 Duchesnay Inc. Pharmaceutical dosage form bearing pregnancy-friendly indicia
US8580782B2 (en) * 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) * 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
TWI344468B (en) 2002-09-04 2011-07-01 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
AU2007242842A1 (en) * 2006-04-20 2007-11-01 Glaxo Group Limited 2-substituted 4-benzylphthalazinone derivatives as histamine H1 and H3 antagonists
EP2091538B1 (en) * 2006-12-20 2010-03-03 Glaxo Group Limited 4-benzyl-1(2h)-phthalazinones as h1 receptor antagonists
WO2009047336A1 (en) * 2007-10-11 2009-04-16 Glaxo Group Limited Phthalazine and pyrido [3,4-d] pyridaz ine compounds as h1 receptor antagonists
RU2477144C2 (ru) * 2010-03-22 2013-03-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Российской академии медицинских наук Лекарственное средство с антиаритмическим и антифибрилляторным действием
RU2613155C1 (ru) * 2016-05-25 2017-03-15 Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "СФМ") Способ лечения больных с острыми тромбозами венозного русла нижних конечностей
JP7263048B2 (ja) 2019-02-25 2023-04-24 株式会社フジ医療器 マッサージ機
US20220380478A1 (en) 2019-07-01 2022-12-01 Tonix Pharma Holdings Limited Anti-cd154 antibodies and uses thereof
MX2023008055A (es) 2021-01-06 2023-08-22 Tonix Pharma Ltd Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06329627A (ja) 1993-05-03 1994-11-29 Bristol Myers Squibb Co グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター
GB9322976D0 (en) 1993-11-08 1994-01-05 Pfizer Ltd Therapeutic agents
IL115889A0 (en) * 1994-11-14 1996-01-31 Rohm & Haas Pyridazinones and their use as fungicides
GB9424842D0 (en) * 1994-12-09 1995-02-08 British Tech Group Pharmaceutical compositions
WO1996018644A1 (en) 1994-12-13 1996-06-20 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
CA2224437A1 (en) 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
AU720616B2 (en) 1996-02-22 2000-06-08 Merck & Co., Inc. Pyridinone thrombin inhibitors
EP0900207B1 (en) * 1996-04-23 2001-11-21 Merck & Co., Inc. Pyrazinone thrombin inhibitors
WO1998008840A1 (en) * 1996-08-29 1998-03-05 Merck & Co., Inc. Integrin antagonists
WO1998009987A1 (en) 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin
AU743735B2 (en) 1996-10-11 2002-02-07 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
WO1998017274A1 (en) * 1996-10-24 1998-04-30 Merck & Co., Inc. Thrombin inhibitors
IL123986A (en) * 1997-04-24 2011-10-31 Organon Nv Medicinal compounds
JP2001514227A (ja) 1997-09-05 2001-09-11 メルク エンド カムパニー インコーポレーテッド ピラジノン系トロンビン阻害薬

Also Published As

Publication number Publication date
CA2280279C (en) 2004-02-17
US6180627B1 (en) 2001-01-30
ES2209337T3 (es) 2004-06-16
DK0997474T3 (da) 2004-02-09
EP0997474A1 (en) 2000-05-03
EP0997474B1 (en) 2003-10-29
JP3258297B2 (ja) 2002-02-18
ATE253076T1 (de) 2003-11-15
DE69912379D1 (de) 2003-12-04
DE69912379T2 (de) 2004-05-06
CA2280279A1 (en) 2000-02-14
PT997474E (pt) 2004-01-30
JP2000063380A (ja) 2000-02-29

Similar Documents

Publication Publication Date Title
DE69912379D1 (de) Antithrombosemittel
US6463934B1 (en) Method for providing enhanced blood circulation
DK0964646T3 (da) Kirurgisk spærhage
DE60143909D1 (de) Z und gefässokklusionsverschluss
DE69834724D1 (de) Behandlung von Darm- oder Blasenentzündungen
ES2061853T3 (es) Utilizacion de inhibidores de la eca contra la formacion de neointimas despues de lesion vascular.
FI952593A (fi) Hyytymistä estävä aine
RU96119386A (ru) Антифибриновое антитело для применение в качестве противотромботического средства
ATE498305T1 (de) Vermeidung und behandlung von krankheiten, die mit der blutgerinnung in zusammenhang stehen
RU98107980A (ru) Способ хирургического лечения ишемической болезни сердца
CA2109736A1 (en) Medical appliance
RU2314043C2 (ru) СПОСОБ ЗАБОРА v.Cefalica В КАЧЕСТВЕ ВЕНОЗНОГО ШУНТА ДЛЯ ПРЯМОЙ РЕВАСКУЛЯРИЗАЦИИ КОРОНАРНЫХ АРТЕРИЙ
RU93015924A (ru) Способ лечения трофических язв нижних конечностей
Ikeda et al. Obstruction of the radial artery passing beneath the biceps brachii tendon—a case report
UA43082A (uk) Спосіб покращення артеріального кровообігу при атеросклеротичній оклюзії артерій стегново-підколінного сегмента
UA41150A (uk) Спосіб лікування критичної ішемії нижніх кінцівок
UA31749A (uk) Спосіб лікування множинних оклюзійно-стенотичних уражень артерій нижньої кінцівки
RU93045689A (ru) Способ лечения хронической артериальной недостаточности конечностей
RU97119966A (ru) Способ лечения жировой эмболии при переломах длинных трубчатых костей конечностей
RU98109687A (ru) Способ хирургического лечения облитерирующего эндартериита нижних конечностей
RU99105622A (ru) Способ хирургического лечения ишемической болезни сердца
MD2029F1 (en) Freely combined autoplastic graft
UA24573U (en) Method for carrying out of superficial femoral artery reconstruction
UA55493C2 (uk) Спосіб зниження тромбогенності ендартеректомованої артерії

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements