JP2005516952A5 - - Google Patents
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- Publication number
- JP2005516952A5 JP2005516952A5 JP2003554664A JP2003554664A JP2005516952A5 JP 2005516952 A5 JP2005516952 A5 JP 2005516952A5 JP 2003554664 A JP2003554664 A JP 2003554664A JP 2003554664 A JP2003554664 A JP 2003554664A JP 2005516952 A5 JP2005516952 A5 JP 2005516952A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- hydrogen
- alkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims 40
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 239000001257 hydrogen Substances 0.000 claims 19
- 125000000217 alkyl group Chemical group 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- -1 morpholino, pyrrolidino Chemical group 0.000 claims 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000004064 dysfunction Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940076279 serotonin Drugs 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- HDYHZDJVNOQYNZ-WINIVTDRSA-N (1s)-1-[2-[(2r)-4-(1,2-dihydroacenaphthylen-5-yl)-2-methylpiperazin-1-yl]ethyl]-3,4-dihydro-1h-isochromene-6-carboxamide Chemical compound C1CC2=CC=CC3=C2C1=CC=C3N1C[C@@H](C)N(CC[C@H]2C3=CC=C(C=C3CCO2)C(N)=O)CC1 HDYHZDJVNOQYNZ-WINIVTDRSA-N 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical group OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 150000002825 nitriles Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 0 CC(C)(C=CC1(C)C)C(C=C*(*)C=C2C)=C2N1I**C[I-] Chemical compound CC(C)(C=CC1(C)C)C(C=C*(*)C=C2C)=C2N1I**C[I-] 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0130339.5A GB0130339D0 (en) | 2001-12-19 | 2001-12-19 | Isochroman compounds |
| PCT/US2002/036148 WO2003053948A1 (en) | 2001-12-19 | 2002-12-06 | Isochroman compounds for treatment of cns disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005516952A JP2005516952A (ja) | 2005-06-09 |
| JP2005516952A5 true JP2005516952A5 (enExample) | 2006-02-02 |
Family
ID=9927920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003554664A Ceased JP2005516952A (ja) | 2001-12-19 | 2002-12-06 | 中枢神経系疾患の治療のためのイソクロマン化合物 |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1458703B1 (enExample) |
| JP (1) | JP2005516952A (enExample) |
| CN (1) | CN1312148C (enExample) |
| AR (1) | AR038662A1 (enExample) |
| AT (1) | ATE355283T1 (enExample) |
| AU (1) | AU2002359378B8 (enExample) |
| BR (1) | BR0214859A (enExample) |
| CA (1) | CA2469278A1 (enExample) |
| CY (1) | CY1106552T1 (enExample) |
| DE (1) | DE60218529T2 (enExample) |
| DK (1) | DK1458703T3 (enExample) |
| ES (1) | ES2280606T3 (enExample) |
| GB (1) | GB0130339D0 (enExample) |
| MX (1) | MXPA04006085A (enExample) |
| PE (1) | PE20030728A1 (enExample) |
| PT (1) | PT1458703E (enExample) |
| SI (1) | SI1458703T1 (enExample) |
| SV (1) | SV2004001441A (enExample) |
| TW (1) | TW200301116A (enExample) |
| WO (1) | WO2003053948A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| NL2000351C2 (nl) | 2005-12-22 | 2007-09-11 | Pfizer Prod Inc | Estrogeen-modulatoren. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247553A (en) * | 1977-10-31 | 1981-01-27 | The Upjohn Company | Methods of treating psychosis |
| ES2133714T3 (es) * | 1993-12-28 | 1999-09-16 | Upjohn Co | Compuestos heterociclicos para el tratamiento de trastornos del snc y cardiovasculares. |
| MX9710260A (es) * | 1995-06-30 | 1998-03-29 | Upjohn Co | Isocromanos 1, 6-disustituidos para el tratamiento de migrañas. |
| GB2370270A (en) * | 2000-12-20 | 2002-06-26 | Lilly Co Eli | Pharmaceutical compounds |
-
2001
- 2001-12-19 GB GBGB0130339.5A patent/GB0130339D0/en not_active Ceased
-
2002
- 2002-11-18 TW TW091133608A patent/TW200301116A/zh unknown
- 2002-12-06 WO PCT/US2002/036148 patent/WO2003053948A1/en not_active Ceased
- 2002-12-06 DK DK02793911T patent/DK1458703T3/da active
- 2002-12-06 DE DE60218529T patent/DE60218529T2/de not_active Expired - Lifetime
- 2002-12-06 EP EP02793911A patent/EP1458703B1/en not_active Expired - Lifetime
- 2002-12-06 SI SI200230528T patent/SI1458703T1/sl unknown
- 2002-12-06 PT PT02793911T patent/PT1458703E/pt unknown
- 2002-12-06 JP JP2003554664A patent/JP2005516952A/ja not_active Ceased
- 2002-12-06 CA CA002469278A patent/CA2469278A1/en not_active Abandoned
- 2002-12-06 MX MXPA04006085A patent/MXPA04006085A/es active IP Right Grant
- 2002-12-06 ES ES02793911T patent/ES2280606T3/es not_active Expired - Lifetime
- 2002-12-06 BR BR0214859-5A patent/BR0214859A/pt not_active IP Right Cessation
- 2002-12-06 CN CNB028281209A patent/CN1312148C/zh not_active Expired - Fee Related
- 2002-12-06 AU AU2002359378A patent/AU2002359378B8/en not_active Ceased
- 2002-12-06 AT AT02793911T patent/ATE355283T1/de not_active IP Right Cessation
- 2002-12-13 PE PE2002001229A patent/PE20030728A1/es not_active Application Discontinuation
- 2002-12-18 AR ARP020104961A patent/AR038662A1/es unknown
- 2002-12-19 SV SV2002001441A patent/SV2004001441A/es not_active Application Discontinuation
-
2007
- 2007-04-26 CY CY20071100573T patent/CY1106552T1/el unknown