PE20030728A1 - Compuestos de isocromano - Google Patents

Compuestos de isocromano

Info

Publication number
PE20030728A1
PE20030728A1 PE2002001229A PE2002001229A PE20030728A1 PE 20030728 A1 PE20030728 A1 PE 20030728A1 PE 2002001229 A PE2002001229 A PE 2002001229A PE 2002001229 A PE2002001229 A PE 2002001229A PE 20030728 A1 PE20030728 A1 PE 20030728A1
Authority
PE
Peru
Prior art keywords
alkyl
dihydro
compounds
benzopyran
carboxamide
Prior art date
Application number
PE2002001229A
Other languages
English (en)
Inventor
Javier Agejas-Chicharro
Nicholas Paul Camp
Andrew Caerwyn Willians
Carlos Lamas-Pereira
Graham Henry Timms
Jeremy Gilmore
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20030728A1 publication Critical patent/PE20030728A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE ISOCROMANO DE FORMULA I DONDE R1 ES CN, CONR13R14, SO2NR13R14, (CH2)tR21, ENTRE OTROS; R21 ES NR13R14, NR13COR22, ENTRE OTROS; R13, R14, R22 SON H, ALQUILO O JUNTO A N FORMAN MORFOLINO, PIRROLILO, PIPERIDINILO; A ES O, S, t ES 0-2; r ES 0-3; v ES 0-2; R2 ES H, ALQUILO, ALCOXI, HALO; R3, R4, R5, R6, R7, R8 SON H, ALQUILO; R9, R10, R11, R12 SON H, ALQUILO, (CH2)q-OR20; R20 ES ALQUILO; n ES 1-2; p ES 0-2; q ES 1-2; W-V ES CH2-CR25-, O-C(R25), S-C(R25), ENTRE OTROS; R25 ES H, ALQUILO, X-Y ES N(Z)CH2, C(Q)(Z)CH2, C(Z)=CH; Z ES UN GRUPO i, xxi, ENTRE OTROS; T ES CH2, O, S, CO, HC=CH; m Y s SON 0-1; R15, R16, R19 SON H, HALO, ALQUILO, ALCOXI, ENTRE OTROS; Q ES H, HALO, NITRILO, CARBOXI-ALQUILO, HIDROXI, ALQUILO; CUANDO T ES CH2, O, S, CO; (m+s) ES 1-2; R1 ES (CH2)t-R21. SON COMPUESTOS PREFERIDOS (1S)-1-{2-[(2R)-4-(1,2-DIHIDRO-5-ACENAFTILENIL)-2-METILPIPERAZINIL]ETIL}-3,4-DIHIDRO-1H-2-BENZOPIRAN-6-CARBOXAMIDA; (1S)-1-{2-[4-(1,2-DIHIDRO-5-ACENAFTILENIL)-2-METILPIPERAZINIL]ETIL}-3,4-DIHIDRO-1H-2-BENZOPIRAN-6-CARBOXAMIDA; (1S)-1-{2-[(2R)-2-METIL-4-(1H,3H-NAFTO[1,8-cd]PIRAN-6-IL)PIPERAZINIL]ETIL}-3,4-DIHIDRO-1H-2-BENZOPIRAN-6-CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS SON UTILES COMO ANTIPSICOTICOS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE UN TRASTORNO ASOCIADO CON DISFUNCION DE SEROTONINA, SISTEMA NERVIOSO CENTRAL
PE2002001229A 2001-12-19 2002-12-13 Compuestos de isocromano PE20030728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0130339.5A GB0130339D0 (en) 2001-12-19 2001-12-19 Isochroman compounds

Publications (1)

Publication Number Publication Date
PE20030728A1 true PE20030728A1 (es) 2003-08-29

Family

ID=9927920

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001229A PE20030728A1 (es) 2001-12-19 2002-12-13 Compuestos de isocromano

Country Status (20)

Country Link
EP (1) EP1458703B1 (es)
JP (1) JP2005516952A (es)
CN (1) CN1312148C (es)
AR (1) AR038662A1 (es)
AT (1) ATE355283T1 (es)
AU (1) AU2002359378B8 (es)
BR (1) BR0214859A (es)
CA (1) CA2469278A1 (es)
CY (1) CY1106552T1 (es)
DE (1) DE60218529T2 (es)
DK (1) DK1458703T3 (es)
ES (1) ES2280606T3 (es)
GB (1) GB0130339D0 (es)
MX (1) MXPA04006085A (es)
PE (1) PE20030728A1 (es)
PT (1) PT1458703E (es)
SI (1) SI1458703T1 (es)
SV (1) SV2004001441A (es)
TW (1) TW200301116A (es)
WO (1) WO2003053948A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2000351C2 (nl) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogeen-modulatoren.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247553A (en) * 1977-10-31 1981-01-27 The Upjohn Company Methods of treating psychosis
WO1995018118A1 (en) * 1993-12-28 1995-07-06 The Upjohn Company Heterocyclic compounds for the treatment of cns and cardiovascular disorders
EP0836599A1 (en) * 1995-06-30 1998-04-22 PHARMACIA & UPJOHN COMPANY 1,6-disubstituted isochromans for treatment of migraine headaches
GB2370270A (en) * 2000-12-20 2002-06-26 Lilly Co Eli Pharmaceutical compounds

Also Published As

Publication number Publication date
EP1458703B1 (en) 2007-02-28
CY1106552T1 (el) 2012-01-25
CN1312148C (zh) 2007-04-25
AU2002359378B2 (en) 2008-08-21
BR0214859A (pt) 2004-11-03
PT1458703E (pt) 2007-05-31
WO2003053948A1 (en) 2003-07-03
SV2004001441A (es) 2004-05-07
ATE355283T1 (de) 2006-03-15
AU2002359378A1 (en) 2003-07-09
CA2469278A1 (en) 2003-07-03
EP1458703A1 (en) 2004-09-22
GB0130339D0 (en) 2002-02-06
TW200301116A (en) 2003-07-01
AU2002359378B8 (en) 2008-09-11
DE60218529T2 (de) 2007-11-22
JP2005516952A (ja) 2005-06-09
CN1620447A (zh) 2005-05-25
DE60218529D1 (de) 2007-04-12
SI1458703T1 (sl) 2007-08-31
MXPA04006085A (es) 2004-09-27
ES2280606T3 (es) 2007-09-16
DK1458703T3 (da) 2007-06-11
AR038662A1 (es) 2005-01-26

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