JP2005514957A5 - - Google Patents
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- JP2005514957A5 JP2005514957A5 JP2003562314A JP2003562314A JP2005514957A5 JP 2005514957 A5 JP2005514957 A5 JP 2005514957A5 JP 2003562314 A JP2003562314 A JP 2003562314A JP 2003562314 A JP2003562314 A JP 2003562314A JP 2005514957 A5 JP2005514957 A5 JP 2005514957A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- threonine
- binding
- domain
- chimeric protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020001507 fusion proteins Proteins 0.000 claims description 55
- 102000037865 fusion proteins Human genes 0.000 claims description 55
- 108090000623 proteins and genes Proteins 0.000 claims description 49
- 102000004169 proteins and genes Human genes 0.000 claims description 24
- 150000001413 amino acids Chemical group 0.000 claims description 10
- 210000000633 nuclear envelope Anatomy 0.000 claims description 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 27
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 27
- 239000004473 Threonine Substances 0.000 claims 27
- 235000008521 threonine Nutrition 0.000 claims 27
- 230000027455 binding Effects 0.000 claims 22
- 235000018102 proteins Nutrition 0.000 claims 22
- 238000000034 method Methods 0.000 claims 19
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 18
- 239000004475 Arginine Substances 0.000 claims 18
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 18
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 18
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 18
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 18
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 18
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 18
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 18
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 18
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 18
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 18
- 235000009582 asparagine Nutrition 0.000 claims 18
- 229960001230 asparagine Drugs 0.000 claims 18
- 235000003704 aspartic acid Nutrition 0.000 claims 18
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 18
- 235000013922 glutamic acid Nutrition 0.000 claims 18
- 239000004220 glutamic acid Substances 0.000 claims 18
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 18
- 235000004400 serine Nutrition 0.000 claims 18
- 239000011701 zinc Substances 0.000 claims 18
- 229910052725 zinc Inorganic materials 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 15
- 102000023732 binding proteins Human genes 0.000 claims 14
- 108091008324 binding proteins Proteins 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 239000013604 expression vector Substances 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 9
- 229940024606 amino acid Drugs 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 9
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 9
- 235000014304 histidine Nutrition 0.000 claims 9
- 108010034791 Heterochromatin Proteins 0.000 claims 8
- 210000004458 heterochromatin Anatomy 0.000 claims 8
- 210000002353 nuclear lamina Anatomy 0.000 claims 8
- 101710185494 Zinc finger protein Proteins 0.000 claims 6
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 5
- 229930182817 methionine Natural products 0.000 claims 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102100026398 Cyclic AMP-responsive element-binding protein 3 Human genes 0.000 claims 2
- 230000004568 DNA-binding Effects 0.000 claims 2
- 102000009331 Homeodomain Proteins Human genes 0.000 claims 2
- 108010048671 Homeodomain Proteins Proteins 0.000 claims 2
- 101000855520 Homo sapiens Cyclic AMP-responsive element-binding protein 3 Proteins 0.000 claims 2
- 102000006835 Lamins Human genes 0.000 claims 2
- 108010047294 Lamins Proteins 0.000 claims 2
- 101000608671 Mus musculus Uveal autoantigen with coiled-coil domains and ankyrin repeats Proteins 0.000 claims 2
- 108700001094 Plant Genes Proteins 0.000 claims 2
- 102000012425 Polycomb-Group Proteins Human genes 0.000 claims 2
- 108010022429 Polycomb-Group Proteins Proteins 0.000 claims 2
- 108700005077 Viral Genes Proteins 0.000 claims 2
- 239000002870 angiogenesis inducing agent Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000005053 lamin Anatomy 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 102100031673 Corneodesmosin Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 206010059866 Drug resistance Diseases 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 108700001097 Insect Genes Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 229940096437 Protein S Drugs 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 240000003768 Solanum lycopersicum Species 0.000 claims 1
- 244000061456 Solanum tuberosum Species 0.000 claims 1
- 235000002595 Solanum tuberosum Nutrition 0.000 claims 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 235000013339 cereals Nutrition 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 230000002222 downregulating effect Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 230000002123 temporal effect Effects 0.000 claims 1
- 210000004940 nucleus Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35016302P | 2002-01-18 | 2002-01-18 | |
| US35131502P | 2002-01-23 | 2002-01-23 | |
| PCT/US2003/001529 WO2003062447A2 (en) | 2002-01-18 | 2003-01-17 | Nuclear-envelope and nuclear-lamina binding chimeras for modulating gene expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514957A JP2005514957A (ja) | 2005-05-26 |
| JP2005514957A5 true JP2005514957A5 (https=) | 2006-01-05 |
Family
ID=27616763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003562314A Pending JP2005514957A (ja) | 2002-01-18 | 2003-01-17 | 遺伝子発現を調節するための核膜および核ラミナ結合キメラ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050170348A1 (https=) |
| EP (1) | EP1485108A4 (https=) |
| JP (1) | JP2005514957A (https=) |
| CN (1) | CN100584945C (https=) |
| AU (1) | AU2003212816B2 (https=) |
| CA (1) | CA2472729A1 (https=) |
| WO (1) | WO2003062447A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1948807B1 (en) * | 2005-11-07 | 2015-09-30 | CropDesign N.V. | Plants having improved growth characteristics and a method for making the same |
| US9404123B2 (en) | 2011-10-12 | 2016-08-02 | National Centre For Biological Sciences | Nucleic acid assembly, vector, cell, methods and kit thereof |
| CN109112142B (zh) * | 2018-07-30 | 2021-02-12 | 华中农业大学 | OsNMCP1基因在控制水稻耐旱中的应用 |
| CN111793707B (zh) * | 2020-06-23 | 2022-04-22 | 中国农业科学院油料作物研究所 | 一种基因编辑转基因作物编辑位点特异性pcr方法及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004567A1 (en) * | 1992-08-21 | 1994-03-03 | La Jolla Cancer Research Foundation | A matrix-associating dna-protein, nucleic acids encoding the same and methods for detecting the nucleic acids |
| WO1998058955A2 (en) * | 1997-06-20 | 1998-12-30 | University Of Massachusetts | Nuclear matrix targeting peptides and uses therefor |
| US6482646B1 (en) * | 1998-11-06 | 2002-11-19 | E. I. Du Pont De Nemours And Company | Plant proteins that interact with nuclear matrix proteins and function as transcriptional activators |
-
2003
- 2003-01-17 JP JP2003562314A patent/JP2005514957A/ja active Pending
- 2003-01-17 CN CN03802361A patent/CN100584945C/zh not_active Expired - Fee Related
- 2003-01-17 WO PCT/US2003/001529 patent/WO2003062447A2/en not_active Ceased
- 2003-01-17 US US10/500,671 patent/US20050170348A1/en not_active Abandoned
- 2003-01-17 CA CA002472729A patent/CA2472729A1/en not_active Abandoned
- 2003-01-17 EP EP03708851A patent/EP1485108A4/en not_active Withdrawn
- 2003-01-17 AU AU2003212816A patent/AU2003212816B2/en not_active Ceased
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