JP2005514948A5 - - Google Patents
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- Publication number
- JP2005514948A5 JP2005514948A5 JP2003562288A JP2003562288A JP2005514948A5 JP 2005514948 A5 JP2005514948 A5 JP 2005514948A5 JP 2003562288 A JP2003562288 A JP 2003562288A JP 2003562288 A JP2003562288 A JP 2003562288A JP 2005514948 A5 JP2005514948 A5 JP 2005514948A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- antisense
- seq
- series
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 17
- 239000000074 antisense oligonucleotide Substances 0.000 claims 8
- 238000012230 antisense oligonucleotides Methods 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000000692 anti-sense effect Effects 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 claims 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 102000050770 human IGFBP2 Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101000840566 Homo sapiens Insulin-like growth factor-binding protein 5 Proteins 0.000 claims 1
- 108090000961 Insulin-like growth factor binding protein 5 Proteins 0.000 claims 1
- 102000004371 Insulin-like growth factor binding protein 5 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35004602P | 2002-01-17 | 2002-01-17 | |
| PCT/CA2003/000061 WO2003062421A1 (en) | 2002-01-17 | 2003-01-17 | Bispecific antisense olignucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514948A JP2005514948A (ja) | 2005-05-26 |
| JP2005514948A5 true JP2005514948A5 (enExample) | 2006-01-05 |
| JP4491240B2 JP4491240B2 (ja) | 2010-06-30 |
Family
ID=27613360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003562288A Expired - Fee Related JP4491240B2 (ja) | 2002-01-17 | 2003-01-17 | Ｉｇｆｂｐ−２およびｉｇｆｂｐ−５を阻害する二重特異性アンチセンスオリゴヌクレオチド、並びにこれらの使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (11) | US20030158143A1 (enExample) |
| EP (1) | EP1465995B1 (enExample) |
| JP (1) | JP4491240B2 (enExample) |
| KR (2) | KR101265180B1 (enExample) |
| AT (1) | ATE402999T1 (enExample) |
| AU (1) | AU2003237616B2 (enExample) |
| CA (1) | CA2469685C (enExample) |
| DE (1) | DE60322509D1 (enExample) |
| DK (1) | DK1465995T3 (enExample) |
| ES (1) | ES2307942T3 (enExample) |
| HU (1) | HU229452B1 (enExample) |
| IL (2) | IL162540A0 (enExample) |
| NO (1) | NO333017B1 (enExample) |
| NZ (1) | NZ533126A (enExample) |
| WO (1) | WO2003062421A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6900187B2 (en) | 1999-02-26 | 2005-05-31 | The University Of British Columbia | TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications |
| IL144975A0 (en) | 1999-02-26 | 2002-06-30 | Univ British Columbia | A composition containing an antisense oligonucleotide |
| US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| KR101265180B1 (ko) * | 2002-01-17 | 2013-05-29 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아이지에프비피-2 및 아이지에프비피-5를 억제하는 양특이성 안티센스 올리고뉴클레오티드, 이를 이용하여 약학적 조성물을 제조하는 방법 및 그 약학적 조성물 |
| EP1530636B1 (en) | 2002-08-21 | 2010-08-18 | The University Of British Columbia | Treatment of melanoma by reduction in clusterin levels |
| KR101117673B1 (ko) | 2002-08-21 | 2012-03-07 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브 |
| AU2003297259A1 (en) * | 2002-11-14 | 2004-06-03 | Wyeth | Methods and compositions for treating neurological disorders |
| CA2539727C (en) | 2003-10-01 | 2016-11-01 | The University Of British Columbia | Bispecific oligonucleotide for the treatment of cns malignancies |
| US8710020B2 (en) | 2004-04-02 | 2014-04-29 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
| US7482158B2 (en) * | 2004-07-01 | 2009-01-27 | Mathison Brian H | Composite polynucleic acid therapeutics |
| DK1814595T3 (da) * | 2004-11-23 | 2014-03-31 | Univ British Columbia | Behandling af cancer med en kombination af et middel, som forstyrrer EGF-signalvejen og et oligonucleotid, som reducerer clusterinniveauerne |
| US7315916B2 (en) * | 2004-12-16 | 2008-01-01 | Sandisk Corporation | Scratch pad block |
| JP5376948B2 (ja) | 2005-09-13 | 2013-12-25 | ナショナル リサーチ カウンシル オブ カナダ | 腫瘍細胞活性を調節する方法及び組成物 |
| US8329399B2 (en) * | 2006-10-27 | 2012-12-11 | Siu K W Michael | Endometrial biomarkers |
| WO2011063523A1 (en) | 2009-11-24 | 2011-06-03 | Alethia Biotherapeutics Inc. | Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume |
| WO2011109262A2 (en) | 2010-03-01 | 2011-09-09 | Tau Therapeutics Llc | Cancer diagnosis and imaging |
| WO2012156817A2 (en) * | 2011-05-19 | 2012-11-22 | Teva Pharmaceutical Industries Ltd. | Method for treating non-small cell lung cancer |
| SG10201601917XA (en) | 2011-09-12 | 2016-04-28 | Tau Therapeutics Llc | Antagonists of products of the hs.459642 unigene cluster for the inhibition of proliferation, development or differentiation of stem cells including cancer stem cells |
| CA2862739A1 (en) | 2012-02-22 | 2013-08-29 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
| CA2844640A1 (en) * | 2013-12-06 | 2015-06-06 | The University Of British Columbia | Method for treatment of castration-resistant prostate cancer |
| KR102755601B1 (ko) * | 2015-10-14 | 2025-01-17 | 바이오-패쓰 홀딩스 인크. | 리포좀 제제를 위한 p-에톡시 핵산 |
| FI3364993T3 (fi) | 2015-10-22 | 2023-01-13 | Menetelmiä angelmanin oireyhtymän hoitamiseksi | |
| US10496215B2 (en) * | 2016-04-29 | 2019-12-03 | Synaptics Incorporated | Sensing for touch and force |
| US10927379B2 (en) | 2016-09-16 | 2021-02-23 | Bio-Path Holdings, Inc. | Combination therapy with liposomal antisense oligonucleotides |
| CA3053781A1 (en) | 2017-02-15 | 2018-08-23 | Cavion, Inc. | Benzopyran and naphalene derivatives and their uses as calium channel inhibitors |
| IL269608B2 (en) | 2017-04-19 | 2024-06-01 | Bio Path Holdings Inc | Compositions comprising p-ethoxy nucleic acids for stat3 inhibition for use in treating cancer or autoimmune disease |
| US12234457B2 (en) | 2017-04-19 | 2025-02-25 | Bio-Path Holdings, Inc. | P-ethoxy nucleic acids for BCL2 inhibition |
| CA3061720A1 (en) | 2017-04-26 | 2018-11-01 | Cavion, Inc. | Methods for improving memory and cognition and for treating memory and cognitive disorders |
| KR102068302B1 (ko) | 2018-07-25 | 2020-01-20 | 정준모 | 봉투 고정장치 |
| JP7480131B2 (ja) | 2018-10-03 | 2024-05-09 | カビオン・インコーポレイテッド | （ｒ）－２－（４－イソプロピルフェニル）－ｎ－（１－（５－（２，２，２－トリフルオロエトキシ）ピリジン－２－イル）エチル）アセトアミドを使用した本態性振戦の処置 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06503949A (ja) | 1990-08-28 | 1994-05-12 | カイロン コーポレイション | 新規インシュリン様成長因子結合タンパク質ｉｇｆｂｐ―５ |
| CA2090705A1 (en) | 1990-08-28 | 1992-03-01 | Michael C. Kiefer | Genetic material encoding igfbp-5 |
| US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| US5646042A (en) * | 1992-08-26 | 1997-07-08 | Ribozyme Pharmaceuticals, Inc. | C-myb targeted ribozymes |
| US5417978A (en) * | 1993-07-29 | 1995-05-23 | Board Of Regents, The University Of Texas System | Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use |
| US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| WO1995017507A1 (en) * | 1993-12-23 | 1995-06-29 | Biognostik Gesellschaft für Biomolekulare Diagnostik mbH | ANTISENSE NUCLEIC ACIDS FOR THE PREVENTION AND TREATMENT OF DISORDERS IN WHICH EXPRESSION OF c-erbB PLAYS A ROLE |
| AUPM672594A0 (en) * | 1994-07-08 | 1994-08-04 | Royal Children's Hospital Research Foundation | A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders |
| US5789389A (en) * | 1995-03-17 | 1998-08-04 | Board Of Trustees Of University Of Illinois | BCL2 derived genetic elements associated with sensitivity to chemotherapeutic drugs |
| US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| ES2221039T3 (es) * | 1996-02-14 | 2004-12-16 | Isis Pharmaceuticals, Inc. | Oligonucleotidos abiertos modificados con azucar. |
| US5910583A (en) * | 1996-11-04 | 1999-06-08 | Duke University | Antisense oligonucleotides against ERBB-2 |
| US6383808B1 (en) | 2000-09-11 | 2002-05-07 | Isis Pharmaceuticals, Inc. | Antisense inhibition of clusterin expression |
| US6133246A (en) * | 1997-08-13 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
| US6335194B1 (en) * | 1998-09-29 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Antisense modulation of survivin expression |
| US6210892B1 (en) * | 1998-10-07 | 2001-04-03 | Isis Pharmaceuticals, Inc. | Alteration of cellular behavior by antisense modulation of mRNA processing |
| US6172216B1 (en) * | 1998-10-07 | 2001-01-09 | Isis Pharmaceuticals Inc. | Antisense modulation of BCL-X expression |
| WO2000031048A1 (en) | 1998-11-19 | 2000-06-02 | Warner-Lambert Company | N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases |
| WO2000034469A1 (en) | 1998-12-11 | 2000-06-15 | The Research Foundation Of State University Of New York At Albany | Compositions and methods for altering cell migration |
| IL144975A0 (en) | 1999-02-26 | 2002-06-30 | Univ British Columbia | A composition containing an antisense oligonucleotide |
| US6900187B2 (en) | 1999-02-26 | 2005-05-31 | The University Of British Columbia | TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications |
| US5998148A (en) * | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
| WO2000069454A1 (en) * | 1999-05-17 | 2000-11-23 | Board Of Regents, The University Of Texas System | Suppression of endogenous igfbp-2 to inhibit cancer |
| AU768904B2 (en) * | 1999-06-21 | 2004-01-08 | Murdoch Childrens Research Institute, The | A method for the prophylaxis and/or treatment of medical disorders |
| CA2373721C (en) | 1999-07-02 | 2013-10-15 | Genentech, Inc. | Compounds that bind her2 |
| EP1200579B1 (en) * | 1999-07-19 | 2008-04-23 | The University of British Columbia | Antisense therapy for hormone-regulated tumors |
| US6310047B1 (en) * | 1999-08-24 | 2001-10-30 | Virginia Commonwealth University | High affinity DNA binding compounds as adjuvants in antisense technology |
| WO2001046455A2 (en) | 1999-12-21 | 2001-06-28 | Yale University | Survivin promotion of angiogenesis |
| US7569551B2 (en) * | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| EP1309726B2 (en) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| US7196067B2 (en) * | 2000-09-14 | 2007-03-27 | The University Of British Columbia | Antisense insulin-like growth factor binding protein (IGFBP)-2-oligodeoxynucleotides for prostate and other endocrine tumor therapy |
| RU2322500C2 (ru) * | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
| EP1390472A4 (en) * | 2001-05-29 | 2004-11-17 | Sirna Therapeutics Inc | NUCLEIC ACID TREATMENT OF DISEASES OR SIDES RELATED TO RAS, HER2 AND HIV LEVELS |
| US6750019B2 (en) * | 2001-10-09 | 2004-06-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of insulin-like growth factor binding protein 5 expression |
| DE10152005A1 (de) | 2001-10-22 | 2003-04-30 | Bayer Cropscience Ag | Pyrazolylsubstituierte Heterocyclen |
| US20050123896A1 (en) | 2001-10-25 | 2005-06-09 | Benz Christopher C. | Screening system for modulators of her2 mediated transcription and her2 modulators identified thereby |
| KR101265180B1 (ko) * | 2002-01-17 | 2013-05-29 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아이지에프비피-2 및 아이지에프비피-5를 억제하는 양특이성 안티센스 올리고뉴클레오티드, 이를 이용하여 약학적 조성물을 제조하는 방법 및 그 약학적 조성물 |
| CA2485589A1 (en) * | 2002-05-14 | 2003-11-27 | Baylor College Of Medicine | Small molecule inhibitors of her2 expression |
| EP1530636B1 (en) | 2002-08-21 | 2010-08-18 | The University Of British Columbia | Treatment of melanoma by reduction in clusterin levels |
| KR101117673B1 (ko) * | 2002-08-21 | 2012-03-07 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브 |
| WO2004092378A2 (en) * | 2003-04-18 | 2004-10-28 | The University Of British Columbia | Method for treatment of cancerous angiogenic disorders |
| CA2539727C (en) * | 2003-10-01 | 2016-11-01 | The University Of British Columbia | Bispecific oligonucleotide for the treatment of cns malignancies |
| PE20121495A1 (es) * | 2009-07-30 | 2012-11-19 | Antisense Pharma Gmbh | Combinacion de un agente quimioterapeutico y un inhibidor del sistema tgf-beta |
-
2003
- 2003-01-17 KR KR1020047011085A patent/KR101265180B1/ko not_active Expired - Fee Related
- 2003-01-17 HU HU0402543A patent/HU229452B1/hu not_active IP Right Cessation
- 2003-01-17 AT AT03731644T patent/ATE402999T1/de active
- 2003-01-17 EP EP20030731644 patent/EP1465995B1/en not_active Expired - Lifetime
- 2003-01-17 DK DK03731644T patent/DK1465995T3/da active
- 2003-01-17 KR KR1020117003991A patent/KR101166214B1/ko not_active Expired - Fee Related
- 2003-01-17 WO PCT/CA2003/000061 patent/WO2003062421A1/en not_active Ceased
- 2003-01-17 US US10/346,493 patent/US20030158143A1/en not_active Abandoned
- 2003-01-17 JP JP2003562288A patent/JP4491240B2/ja not_active Expired - Fee Related
- 2003-01-17 DE DE60322509T patent/DE60322509D1/de not_active Expired - Lifetime
- 2003-01-17 IL IL16254003A patent/IL162540A0/xx unknown
- 2003-01-17 ES ES03731644T patent/ES2307942T3/es not_active Expired - Lifetime
- 2003-01-17 NZ NZ533126A patent/NZ533126A/en not_active IP Right Cessation
- 2003-01-17 CA CA 2469685 patent/CA2469685C/en not_active Expired - Fee Related
- 2003-01-17 AU AU2003237616A patent/AU2003237616B2/en not_active Ceased
-
2004
- 2004-06-15 IL IL16254004A patent/IL162540A/en active IP Right Grant
- 2004-08-16 NO NO20043401A patent/NO333017B1/no not_active IP Right Cessation
-
2005
- 2005-11-23 US US11/287,334 patent/US7973017B2/en not_active Expired - Fee Related
-
2008
- 2008-04-25 US US12/109,747 patent/US7928082B2/en not_active Expired - Fee Related
-
2010
- 2010-04-01 US US12/752,581 patent/US9101646B2/en not_active Expired - Fee Related
- 2010-12-27 US US12/978,940 patent/US8389491B2/en not_active Expired - Fee Related
-
2011
- 2011-04-15 US US13/087,618 patent/US8252765B2/en not_active Expired - Fee Related
- 2011-04-15 US US13/087,627 patent/US8470796B2/en not_active Expired - Fee Related
-
2012
- 2012-05-11 US US13/469,402 patent/US8541390B2/en not_active Expired - Fee Related
- 2012-10-11 US US13/649,654 patent/US8580761B2/en not_active Expired - Fee Related
-
2013
- 2013-05-29 US US13/904,457 patent/US8835401B2/en not_active Expired - Fee Related
-
2015
- 2015-07-02 US US14/790,293 patent/US20160002630A1/en not_active Abandoned
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