JP2016511260A5 - - Google Patents
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- JP2016511260A5 JP2016511260A5 JP2015560380A JP2015560380A JP2016511260A5 JP 2016511260 A5 JP2016511260 A5 JP 2016511260A5 JP 2015560380 A JP2015560380 A JP 2015560380A JP 2015560380 A JP2015560380 A JP 2015560380A JP 2016511260 A5 JP2016511260 A5 JP 2016511260A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- disease
- mitochondrial
- peptide
- gene mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 18
- 206010064571 Gene mutation Diseases 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 208000012268 mitochondrial disease Diseases 0.000 claims description 10
- 230000006705 mitochondrial oxidative phosphorylation Effects 0.000 claims description 10
- 210000003205 muscle Anatomy 0.000 claims description 8
- 201000001119 neuropathy Diseases 0.000 claims description 8
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 7
- 230000004064 dysfunction Effects 0.000 claims description 7
- 230000007823 neuropathy Effects 0.000 claims description 7
- 208000011580 syndromic disease Diseases 0.000 claims description 7
- 208000023434 Alpers-Huttenlocher syndrome Diseases 0.000 claims description 6
- 206010003591 Ataxia Diseases 0.000 claims description 6
- 208000004986 Diffuse Cerebral Sclerosis of Schilder Diseases 0.000 claims description 6
- 210000004962 mammalian cell Anatomy 0.000 claims description 6
- 201000011540 mitochondrial DNA depletion syndrome 4a Diseases 0.000 claims description 6
- 230000002438 mitochondrial effect Effects 0.000 claims description 6
- 230000000750 progressive effect Effects 0.000 claims description 6
- 206010010904 Convulsion Diseases 0.000 claims description 5
- 206010033799 Paralysis Diseases 0.000 claims description 5
- 101150081019 surf1 gene Proteins 0.000 claims description 5
- 208000024891 symptom Diseases 0.000 claims description 5
- 206010015037 epilepsy Diseases 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 208000000044 Amnesia Diseases 0.000 claims description 3
- 206010003805 Autism Diseases 0.000 claims description 3
- 208000020706 Autistic disease Diseases 0.000 claims description 3
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 claims description 3
- 206010008748 Chorea Diseases 0.000 claims description 3
- 206010010774 Constipation Diseases 0.000 claims description 3
- 102000016903 DNA Polymerase gamma Human genes 0.000 claims description 3
- 108010014080 DNA Polymerase gamma Proteins 0.000 claims description 3
- 206010012289 Dementia Diseases 0.000 claims description 3
- 206010012559 Developmental delay Diseases 0.000 claims description 3
- 208000014094 Dystonic disease Diseases 0.000 claims description 3
- 102000015782 Electron Transport Complex III Human genes 0.000 claims description 3
- 108010024882 Electron Transport Complex III Proteins 0.000 claims description 3
- 208000013016 Hypoglycemia Diseases 0.000 claims description 3
- 208000020358 Learning disease Diseases 0.000 claims description 3
- 208000026139 Memory disease Diseases 0.000 claims description 3
- 208000016285 Movement disease Diseases 0.000 claims description 3
- 208000007101 Muscle Cramp Diseases 0.000 claims description 3
- 208000010428 Muscle Weakness Diseases 0.000 claims description 3
- 206010028372 Muscular weakness Diseases 0.000 claims description 3
- 208000005392 Spasm Diseases 0.000 claims description 3
- 206010044565 Tremor Diseases 0.000 claims description 3
- 230000001919 adrenal effect Effects 0.000 claims description 3
- 208000008784 apnea Diseases 0.000 claims description 3
- 208000029560 autism spectrum disease Diseases 0.000 claims description 3
- 208000012601 choreatic disease Diseases 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000010118 dystonia Diseases 0.000 claims description 3
- 208000028329 epileptic seizure Diseases 0.000 claims description 3
- 230000006870 function Effects 0.000 claims description 3
- 208000019622 heart disease Diseases 0.000 claims description 3
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 3
- 238000011065 in-situ storage Methods 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 208000017169 kidney disease Diseases 0.000 claims description 3
- 208000006443 lactic acidosis Diseases 0.000 claims description 3
- 201000003723 learning disability Diseases 0.000 claims description 3
- 208000019423 liver disease Diseases 0.000 claims description 3
- 230000006984 memory degeneration Effects 0.000 claims description 3
- 208000023060 memory loss Diseases 0.000 claims description 3
- 230000003340 mental effect Effects 0.000 claims description 3
- 108010007425 oligomycin sensitivity conferring protein Proteins 0.000 claims description 3
- 210000000056 organ Anatomy 0.000 claims description 3
- 230000000241 respiratory effect Effects 0.000 claims description 3
- 230000035807 sensation Effects 0.000 claims description 3
- 230000009747 swallowing Effects 0.000 claims description 3
- 230000006016 thyroid dysfunction Effects 0.000 claims description 3
- 208000024806 Brain atrophy Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 17
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000010627 oxidative phosphorylation Effects 0.000 claims 1
- 208000021090 palsy Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 25
- 230000006378 damage Effects 0.000 description 3
- -1 Complex IV Proteins 0.000 description 2
- 208000012239 Developmental disease Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 206010016165 failure to thrive Diseases 0.000 description 2
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 2
- 206010008096 Cerebral atrophy Diseases 0.000 description 1
- 208000006136 Leigh Disease Diseases 0.000 description 1
- 208000017507 Leigh syndrome Diseases 0.000 description 1
- 206010058799 Mitochondrial encephalomyopathy Diseases 0.000 description 1
- 102000046669 Surf-1 Human genes 0.000 description 1
- 108060007963 Surf-1 Proteins 0.000 description 1
- 206010030875 ophthalmoplegia Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771642P | 2013-03-01 | 2013-03-01 | |
| US201361771534P | 2013-03-01 | 2013-03-01 | |
| US61/771,534 | 2013-03-01 | ||
| US61/771,642 | 2013-03-01 | ||
| PCT/US2014/019645 WO2014134562A1 (en) | 2013-03-01 | 2014-02-28 | Methods for the treatment of mitochondrial disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019133638A Division JP2019214580A (ja) | 2013-03-01 | 2019-07-19 | ミトコンドリア疾患の治療のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511260A JP2016511260A (ja) | 2016-04-14 |
| JP2016511260A5 true JP2016511260A5 (enExample) | 2017-04-06 |
| JP6839490B2 JP6839490B2 (ja) | 2021-03-10 |
Family
ID=51428871
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560380A Active JP6839490B2 (ja) | 2013-03-01 | 2014-02-28 | ミトコンドリア疾患の治療のための方法 |
| JP2019133638A Pending JP2019214580A (ja) | 2013-03-01 | 2019-07-19 | ミトコンドリア疾患の治療のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019133638A Pending JP2019214580A (ja) | 2013-03-01 | 2019-07-19 | ミトコンドリア疾患の治療のための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10793597B2 (enExample) |
| EP (2) | EP3673913A1 (enExample) |
| JP (2) | JP6839490B2 (enExample) |
| CN (5) | CN117752766A (enExample) |
| CA (1) | CA2916884C (enExample) |
| DK (1) | DK2961378T3 (enExample) |
| ES (1) | ES2755134T3 (enExample) |
| HU (1) | HUE046596T2 (enExample) |
| WO (1) | WO2014134562A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2788013A4 (en) * | 2011-12-09 | 2015-08-19 | Stealth Peptides Int Inc | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
| CN115990242A (zh) | 2013-03-01 | 2023-04-21 | 康德生物医疗有限公司 | 预防或治疗巴斯综合征的方法和组合物 |
| CN117752766A (zh) * | 2013-03-01 | 2024-03-26 | 康德生物医疗有限公司 | 治疗线粒体疾病的方法 |
| WO2014209905A2 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods and compositions for detecting and diagnosing diseases and conditions |
| US10576124B2 (en) | 2014-05-28 | 2020-03-03 | Stealth Biotherapeutics Corp | Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof |
| CN109476700A (zh) * | 2016-03-11 | 2019-03-15 | 隐形生物治疗公司 | 结晶盐形式 |
| AU2017249218B2 (en) | 2016-04-11 | 2020-08-27 | Arcuate Therapeutics, Inc. | Chiral peptides |
| EP4000690A1 (en) * | 2016-05-19 | 2022-05-25 | Stealth BioTherapeutics Inc. | Compositions and methods for the prevention and treatment of mitochondrial myopathies |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| WO2020074777A1 (en) * | 2018-10-10 | 2020-04-16 | Helsingin Yliopisto | Biomarkers for mitochondrial diseases and related methods |
| WO2020214518A1 (en) * | 2019-04-18 | 2020-10-22 | Arcuate Therapeutics, Inc. | Methods of treating renal conditions using peptides that improve mitochondrial function |
| WO2022055811A1 (en) * | 2020-09-09 | 2022-03-17 | Social Profit Network | Methods and compositions for delivery of biotin to mitochondria |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| CA2457391A1 (en) * | 2001-08-06 | 2003-02-20 | Vanderbilt University | Device and methods for detecting the response of a plurality of cells to at least one analyte of interest |
| BRPI0105509B8 (pt) | 2001-11-05 | 2021-05-25 | Univ Minas Gerais | formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga |
| EP2865385B1 (en) * | 2003-02-04 | 2016-11-16 | Cornell Research Foundation, Inc. | Uses of aromatic-cationic peptide |
| SI1599216T1 (sl) * | 2003-02-04 | 2014-02-28 | Cornell Research Foundation, Inc. | Postopek za preprečevanje mitohondrijskega permeabilnostnega prehoda |
| AU2004210013A1 (en) | 2003-02-10 | 2004-08-19 | Autogen Research Pty Ltd | Therapeutic molecules |
| WO2005023274A1 (en) * | 2003-09-05 | 2005-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium |
| CA2971928C (en) * | 2004-01-23 | 2019-01-08 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| US8500720B2 (en) | 2005-05-09 | 2013-08-06 | Medtronic, Inc | Method and apparatus for treatment of cardiac disorders |
| US20070265216A1 (en) | 2005-10-05 | 2007-11-15 | Gross Richard W | Enhanced medical treatment in diabetic cardiomyopathy |
| AU2007237899A1 (en) | 2006-04-18 | 2007-10-25 | Cortendo Invest, Ab | Methods and compositions for treating barth syndrome, cardiomyopathy, mitochondrial diseases and other conditions |
| WO2008137035A1 (en) * | 2007-05-02 | 2008-11-13 | The Mclean Hospital Corporation | Methods and compositions for mitochondrial replacement therapy |
| US20080318909A1 (en) | 2007-06-14 | 2008-12-25 | Sparagna Genevieve C | Use Of Linoleic Compounds Against Heart Failure |
| WO2008156654A2 (en) * | 2007-06-15 | 2008-12-24 | Massachusetts Institute Of Technology | Cytoskeleton modulators for treating metabolic disorders |
| JP5677096B2 (ja) * | 2008-02-26 | 2015-02-25 | コーネル ユニヴァーシティー | 急性腎障害を予防および治療するための方法 |
| WO2009149307A2 (en) | 2008-06-04 | 2009-12-10 | San Diego State University Research Foundation | Compositions and methods for restoring mitochondrial electron transfer function |
| EP2318433A4 (en) | 2008-08-07 | 2012-08-08 | Ipsen Pharma Sas | GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGUES (GIP) MODIFIED AT THE N-TERMINAL END |
| EP3563862B1 (en) * | 2009-03-20 | 2021-05-05 | The General Hospital Corporation d/b/a Massachusetts General Hospital | D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries |
| US20120122957A1 (en) * | 2009-04-17 | 2012-05-17 | The Salk Institute For Biological Studies | Regulation of aging by modulation of mitochondrial function |
| US20120046363A1 (en) | 2009-05-11 | 2012-02-23 | University Of Maryland, Baltimore | Docosahexaenoic acid for the treatment of heart failure |
| CN105031605A (zh) * | 2009-08-12 | 2015-11-11 | 康奈尔大学 | 预防或治疗代谢综合症的方法 |
| EP3150215A1 (en) * | 2009-08-24 | 2017-04-05 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating opthalmic conditions |
| CN102711785A (zh) * | 2009-10-05 | 2012-10-03 | 康奈尔大学 | 预防或治疗心力衰竭的方法 |
| EP2519232A1 (en) * | 2009-12-31 | 2012-11-07 | Edison Pharmaceuticals, Inc. | Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones |
| CN103751763A (zh) | 2009-12-31 | 2014-04-30 | 康肽德生物医药技术有限公司 | 用于预防或治疗血管阻塞损伤的方法 |
| US8719939B2 (en) | 2009-12-31 | 2014-05-06 | Mcafee, Inc. | Malware detection via reputation system |
| JP4643749B1 (ja) | 2010-02-03 | 2011-03-02 | 昭和電工株式会社 | 表面被覆サーメット部材の耐酸化膜形成用の処理液 |
| WO2011106717A1 (en) | 2010-02-26 | 2011-09-01 | University Of Florida Research Foundation, Inc. | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP3560508A1 (en) | 2010-03-15 | 2019-10-30 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| EP3290433A1 (en) * | 2010-05-03 | 2018-03-07 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| WO2012009171A2 (en) * | 2010-07-15 | 2012-01-19 | The Schepens Eye Research Institute, Inc. | Compositions and methods of treatment of corneal endothelium disorders |
| US20140031432A1 (en) * | 2010-08-06 | 2014-01-30 | Ampere Life Sciences, Inc. | Treatment of mitochondrial diseases with vitamin k |
| US20130345312A1 (en) * | 2010-08-06 | 2013-12-26 | Orion D. Jankowski | Treatment of mitochondrial diseases with naphthoquinones |
| US9241933B2 (en) * | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| EP3488941A1 (en) * | 2011-03-24 | 2019-05-29 | Cornell University | Aromatic-cationic peptides and uses of same |
| CN107496899A (zh) | 2011-09-29 | 2017-12-22 | 梅约医学教育与研究基金会 | 芳族阳离子肽和使用它们的方法 |
| WO2013059071A1 (en) * | 2011-10-17 | 2013-04-25 | Cornell University | Aromatic-cationic peptides and uses of same |
| KR20190077124A (ko) | 2011-10-21 | 2019-07-02 | 스템제닉스 인코포레이티드 | 생물학적 활성 분자의 세포내 전달을 위한 작용화 나노입자 |
| EP3078384A1 (en) * | 2012-02-22 | 2016-10-12 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating ophthalmic conditions |
| WO2013126775A1 (en) * | 2012-02-23 | 2013-08-29 | Cornell University | Aromatic-cationic peptides and uses of same |
| WO2014059029A1 (en) * | 2012-10-09 | 2014-04-17 | President And Fellows Of Harvard College | Treatment of age-related and mitochondrial diseases by inhibition of hif-1 alpha function |
| MX2015005102A (es) | 2012-10-22 | 2016-02-09 | Stealth Peptides Int Inc | Metodos para la reduccion de los riesgos asociados con el insuficiencia cardiaca y factores asociado con el mismo. |
| CN115990242A (zh) | 2013-03-01 | 2023-04-21 | 康德生物医疗有限公司 | 预防或治疗巴斯综合征的方法和组合物 |
| CN117752766A (zh) * | 2013-03-01 | 2024-03-26 | 康德生物医疗有限公司 | 治疗线粒体疾病的方法 |
| WO2014209905A2 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods and compositions for detecting and diagnosing diseases and conditions |
-
2014
- 2014-02-28 CN CN202311795418.1A patent/CN117752766A/zh active Pending
- 2014-02-28 CA CA2916884A patent/CA2916884C/en active Active
- 2014-02-28 EP EP19199765.9A patent/EP3673913A1/en active Pending
- 2014-02-28 DK DK14757000T patent/DK2961378T3/da active
- 2014-02-28 CN CN202310407669.1A patent/CN116474071A/zh active Pending
- 2014-02-28 HU HUE14757000A patent/HUE046596T2/hu unknown
- 2014-02-28 EP EP14757000.6A patent/EP2961378B1/en active Active
- 2014-02-28 ES ES14757000T patent/ES2755134T3/es active Active
- 2014-02-28 WO PCT/US2014/019645 patent/WO2014134562A1/en not_active Ceased
- 2014-02-28 JP JP2015560380A patent/JP6839490B2/ja active Active
- 2014-02-28 CN CN201480022764.9A patent/CN105517533A/zh active Pending
- 2014-02-28 CN CN202310408404.3A patent/CN116440247A/zh active Pending
- 2014-02-28 CN CN201910589605.1A patent/CN110339339A/zh active Pending
- 2014-02-28 US US14/771,411 patent/US10793597B2/en active Active
-
2019
- 2019-07-19 JP JP2019133638A patent/JP2019214580A/ja active Pending
-
2020
- 2020-07-15 US US16/930,028 patent/US20200407396A1/en not_active Abandoned
-
2022
- 2022-10-11 US US17/963,697 patent/US20230279051A1/en active Pending
-
2024
- 2024-09-19 US US18/890,079 patent/US20250109167A1/en active Pending
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