JP2005505588A5 - - Google Patents

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Publication number
JP2005505588A5
JP2005505588A5 JP2003533853A JP2003533853A JP2005505588A5 JP 2005505588 A5 JP2005505588 A5 JP 2005505588A5 JP 2003533853 A JP2003533853 A JP 2003533853A JP 2003533853 A JP2003533853 A JP 2003533853A JP 2005505588 A5 JP2005505588 A5 JP 2005505588A5
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JP
Japan
Prior art keywords
compound
base
cancer
treating cancer
hydroxytetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003533853A
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English (en)
Japanese (ja)
Other versions
JP2005505588A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/031730 external-priority patent/WO2003030819A2/en
Publication of JP2005505588A publication Critical patent/JP2005505588A/ja
Publication of JP2005505588A5 publication Critical patent/JP2005505588A5/ja
Pending legal-status Critical Current

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JP2003533853A 2001-10-05 2002-10-04 テトラサイクリン誘導体、及びそれを使用する方法 Pending JP2005505588A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32750201P 2001-10-05 2001-10-05
PCT/US2002/031730 WO2003030819A2 (en) 2001-10-05 2002-10-04 Tetracycline derivatives and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2005505588A JP2005505588A (ja) 2005-02-24
JP2005505588A5 true JP2005505588A5 (enExample) 2006-09-07

Family

ID=23276795

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003533853A Pending JP2005505588A (ja) 2001-10-05 2002-10-04 テトラサイクリン誘導体、及びそれを使用する方法

Country Status (10)

Country Link
US (4) US7214669B2 (enExample)
EP (1) EP1439843A4 (enExample)
JP (1) JP2005505588A (enExample)
CN (2) CN1564690A (enExample)
AU (1) AU2002341970B2 (enExample)
CA (1) CA2462572C (enExample)
MY (1) MY133403A (enExample)
NO (1) NO20041272L (enExample)
RU (1) RU2300380C2 (enExample)
WO (1) WO2003030819A2 (enExample)

Families Citing this family (31)

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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP2298732A1 (en) * 2001-03-13 2011-03-23 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
RU2300380C2 (ru) * 2001-10-05 2007-06-10 Тетрадженекс Фармасьютикалс, Инк. Производные тетрациклина и способы их применения
US20050026833A1 (en) * 2001-11-08 2005-02-03 Rabbani Shafaat Ahmed PSP-94: use for treatment of hypercalcemia and bone metastasis
EP2311797A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
WO2004038000A2 (en) * 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP1648859B1 (en) * 2003-07-09 2013-02-27 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US8012950B2 (en) * 2003-08-29 2011-09-06 Wisconsin Alumni Research Foundation Method to diagnose and treat degenerative joint disease
EP2332904A3 (en) * 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
CN101027279B (zh) * 2004-05-21 2013-03-27 哈佛大学校长及研究员协会 四环素及其类似物的合成
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP1848685A1 (en) 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AU2007235279B2 (en) * 2006-04-07 2012-12-06 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
CA2652347A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US7763735B2 (en) * 2006-10-11 2010-07-27 President And Fellows Of Harvard College Synthesis of enone intermediate
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
SI2327676T1 (sl) * 2009-11-26 2014-07-31 Sandoz Ag Reakcije organskih spojin z nizkimi količinami vodika
US20120329761A1 (en) * 2010-03-10 2012-12-27 University Health Network Use of tigecycline for treatment of cancer
CN102631356B (zh) * 2012-04-11 2014-03-12 广州市东来生物科技有限公司 4-去二甲氨基四环素衍生物在抗幽门螺旋杆菌方面的用途
SG10201701145UA (en) * 2012-05-21 2017-03-30 Dcb Usa Llc Methods for drug screen using zebrafish model and the compounds screened therefrom
MA40836A (fr) 2014-10-23 2017-08-29 Tetraphase Pharmaceuticals Inc Procédures de semi-synthèse
US11098073B2 (en) 2017-04-20 2021-08-24 Oxford University Innovation Limited Triphenylphosphonium-tethered tetracyclines for use in treating cancer
CN110156624B (zh) * 2019-05-29 2022-03-08 河北冀衡药业股份有限公司 一种米诺环素及其衍生物的合成方法
KR20230154834A (ko) * 2021-02-03 2023-11-09 스카이바이오 엘엘씨 중추 신경계 내로의 저-소수성 생체활성 약물을 위한 화학적으로 커플링된 운반체

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US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
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CA2103189C (en) * 1992-11-17 2005-05-03 Lorne M. Golub Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes
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US5837696A (en) * 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth
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