NO20041272L - Tetracycline derivatives and methods of use thereof - Google Patents

Tetracycline derivatives and methods of use thereof

Info

Publication number
NO20041272L
NO20041272L NO20041272A NO20041272A NO20041272L NO 20041272 L NO20041272 L NO 20041272L NO 20041272 A NO20041272 A NO 20041272A NO 20041272 A NO20041272 A NO 20041272A NO 20041272 L NO20041272 L NO 20041272L
Authority
NO
Norway
Prior art keywords
methods
tetracycline derivatives
tetracycline
derivatives
Prior art date
Application number
NO20041272A
Other languages
English (en)
Norwegian (no)
Inventor
Joseph John Hlavka
Richard D Ablin
Original Assignee
Tetragenex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetragenex Pharmaceuticals Inc filed Critical Tetragenex Pharmaceuticals Inc
Publication of NO20041272L publication Critical patent/NO20041272L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20041272A 2001-10-05 2004-03-26 Tetracycline derivatives and methods of use thereof NO20041272L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32750201P 2001-10-05 2001-10-05
PCT/US2002/031730 WO2003030819A2 (en) 2001-10-05 2002-10-04 Tetracycline derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
NO20041272L true NO20041272L (no) 2004-07-02

Family

ID=23276795

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20041272A NO20041272L (no) 2001-10-05 2004-03-26 Tetracycline derivatives and methods of use thereof

Country Status (10)

Country Link
US (4) US7214669B2 (enExample)
EP (1) EP1439843A4 (enExample)
JP (1) JP2005505588A (enExample)
CN (2) CN1564690A (enExample)
AU (1) AU2002341970B2 (enExample)
CA (1) CA2462572C (enExample)
MY (1) MY133403A (enExample)
NO (1) NO20041272L (enExample)
RU (1) RU2300380C2 (enExample)
WO (1) WO2003030819A2 (enExample)

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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP2298732A1 (en) * 2001-03-13 2011-03-23 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
RU2300380C2 (ru) * 2001-10-05 2007-06-10 Тетрадженекс Фармасьютикалс, Инк. Производные тетрациклина и способы их применения
US20050026833A1 (en) * 2001-11-08 2005-02-03 Rabbani Shafaat Ahmed PSP-94: use for treatment of hypercalcemia and bone metastasis
EP2311797A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
WO2004038000A2 (en) * 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP1648859B1 (en) * 2003-07-09 2013-02-27 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US8012950B2 (en) * 2003-08-29 2011-09-06 Wisconsin Alumni Research Foundation Method to diagnose and treat degenerative joint disease
EP2332904A3 (en) * 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
CN101027279B (zh) * 2004-05-21 2013-03-27 哈佛大学校长及研究员协会 四环素及其类似物的合成
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP1848685A1 (en) 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AU2007235279B2 (en) * 2006-04-07 2012-12-06 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
CA2652347A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US7763735B2 (en) * 2006-10-11 2010-07-27 President And Fellows Of Harvard College Synthesis of enone intermediate
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
SI2327676T1 (sl) * 2009-11-26 2014-07-31 Sandoz Ag Reakcije organskih spojin z nizkimi količinami vodika
US20120329761A1 (en) * 2010-03-10 2012-12-27 University Health Network Use of tigecycline for treatment of cancer
CN102631356B (zh) * 2012-04-11 2014-03-12 广州市东来生物科技有限公司 4-去二甲氨基四环素衍生物在抗幽门螺旋杆菌方面的用途
SG10201701145UA (en) * 2012-05-21 2017-03-30 Dcb Usa Llc Methods for drug screen using zebrafish model and the compounds screened therefrom
MA40836A (fr) 2014-10-23 2017-08-29 Tetraphase Pharmaceuticals Inc Procédures de semi-synthèse
US11098073B2 (en) 2017-04-20 2021-08-24 Oxford University Innovation Limited Triphenylphosphonium-tethered tetracyclines for use in treating cancer
CN110156624B (zh) * 2019-05-29 2022-03-08 河北冀衡药业股份有限公司 一种米诺环素及其衍生物的合成方法
KR20230154834A (ko) * 2021-02-03 2023-11-09 스카이바이오 엘엘씨 중추 신경계 내로의 저-소수성 생체활성 약물을 위한 화학적으로 커플링된 운반체

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Also Published As

Publication number Publication date
CA2462572A1 (en) 2003-04-17
MY133403A (en) 2007-11-30
CA2462572C (en) 2008-11-18
CN1961885A (zh) 2007-05-16
CN1564690A (zh) 2005-01-12
RU2300380C2 (ru) 2007-06-10
US7214669B2 (en) 2007-05-08
EP1439843A4 (en) 2007-01-03
AU2002341970B2 (en) 2008-02-14
WO2003030819A2 (en) 2003-04-17
US20050267079A1 (en) 2005-12-01
RU2004109986A (ru) 2005-02-20
JP2005505588A (ja) 2005-02-24
WO2003030819A3 (en) 2004-01-08
EP1439843A2 (en) 2004-07-28
US20070149488A1 (en) 2007-06-28
US20040067912A1 (en) 2004-04-08
US20070142338A1 (en) 2007-06-21
US20050245491A9 (en) 2005-11-03

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