CN1564690A - 四环素衍生物及其使用方法 - Google Patents

四环素衍生物及其使用方法 Download PDF

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Publication number
CN1564690A
CN1564690A CNA028197224A CN02819722A CN1564690A CN 1564690 A CN1564690 A CN 1564690A CN A028197224 A CNA028197224 A CN A028197224A CN 02819722 A CN02819722 A CN 02819722A CN 1564690 A CN1564690 A CN 1564690A
Authority
CN
China
Prior art keywords
alkyl
product
tetracycline
doxycycline
filtered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028197224A
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English (en)
Chinese (zh)
Inventor
约瑟夫·拉弗卡
理查德·J·阿布林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tetragenex Pharmaceuticals Inc
Original Assignee
Tetragenex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetragenex Pharmaceuticals Inc filed Critical Tetragenex Pharmaceuticals Inc
Publication of CN1564690A publication Critical patent/CN1564690A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA028197224A 2001-10-05 2002-10-04 四环素衍生物及其使用方法 Pending CN1564690A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32750201P 2001-10-05 2001-10-05
US60/327,502 2001-10-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2006100992267A Division CN1961885A (zh) 2001-10-05 2002-10-04 四环素衍生物在制药中的应用

Publications (1)

Publication Number Publication Date
CN1564690A true CN1564690A (zh) 2005-01-12

Family

ID=23276795

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA028197224A Pending CN1564690A (zh) 2001-10-05 2002-10-04 四环素衍生物及其使用方法
CNA2006100992267A Pending CN1961885A (zh) 2001-10-05 2002-10-04 四环素衍生物在制药中的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2006100992267A Pending CN1961885A (zh) 2001-10-05 2002-10-04 四环素衍生物在制药中的应用

Country Status (10)

Country Link
US (4) US7214669B2 (enExample)
EP (1) EP1439843A4 (enExample)
JP (1) JP2005505588A (enExample)
CN (2) CN1564690A (enExample)
AU (1) AU2002341970B2 (enExample)
CA (1) CA2462572C (enExample)
MY (1) MY133403A (enExample)
NO (1) NO20041272L (enExample)
RU (1) RU2300380C2 (enExample)
WO (1) WO2003030819A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102631356A (zh) * 2012-04-11 2012-08-15 刘誉 4-去二甲氨基四环素衍生物在抗幽门螺旋杆菌方面的用途
CN107108472A (zh) * 2014-10-23 2017-08-29 四相制药公司 半合成方法
CN110156624A (zh) * 2019-05-29 2019-08-23 李玮 一种米诺环素及其衍生物的合成方法

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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
WO2003030819A2 (en) * 2001-10-05 2003-04-17 Tetragenex Pharmaceuticals, Inc. Tetracycline derivatives and methods of use thereof
US20050026833A1 (en) * 2001-11-08 2005-02-03 Rabbani Shafaat Ahmed PSP-94: use for treatment of hypercalcemia and bone metastasis
EP2311797A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
JP4686189B2 (ja) * 2002-10-24 2011-05-18 パラテック ファーマシューティカルズ インコーポレイテッド Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法
WO2005009943A2 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US8012950B2 (en) * 2003-08-29 2011-09-06 Wisconsin Alumni Research Foundation Method to diagnose and treat degenerative joint disease
EP2332904A3 (en) * 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
KR101171408B1 (ko) 2004-05-21 2012-08-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 테트라사이클린 및 이의 유사체의 합성
JP2008518025A (ja) * 2004-10-25 2008-05-29 パラテック ファーマシューティカルズ インコーポレイテッド ４−アミノテトラサイクリンおよびその使用の方法
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AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
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AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
JP5335664B2 (ja) * 2006-04-07 2013-11-06 プレジデント アンド フェロウズ オブ ハーバード カレッジ テトラサイクリンおよびその類似体の合成
WO2007133797A2 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
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WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
ES2469829T3 (es) * 2009-11-26 2014-06-20 Sandoz Ag Reacción de compuestos orgánicos con bajas cantidades de hidrógeno
US20120329761A1 (en) * 2010-03-10 2012-12-27 University Health Network Use of tigecycline for treatment of cancer
CN104394856A (zh) * 2012-05-21 2015-03-04 Dcb美国公司 以斑马鱼模型进行药物筛选的方法及筛选所得药物
WO2018193114A1 (en) 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
PL4271415T3 (pl) * 2021-02-03 2025-02-10 Skybio Llc Chemicznie związany transporter dopaminy do ośrodkowego układu nerwowego

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102631356A (zh) * 2012-04-11 2012-08-15 刘誉 4-去二甲氨基四环素衍生物在抗幽门螺旋杆菌方面的用途
CN107108472A (zh) * 2014-10-23 2017-08-29 四相制药公司 半合成方法
CN110156624A (zh) * 2019-05-29 2019-08-23 李玮 一种米诺环素及其衍生物的合成方法

Also Published As

Publication number Publication date
US20050245491A9 (en) 2005-11-03
WO2003030819A3 (en) 2004-01-08
RU2004109986A (ru) 2005-02-20
CN1961885A (zh) 2007-05-16
WO2003030819A2 (en) 2003-04-17
EP1439843A2 (en) 2004-07-28
JP2005505588A (ja) 2005-02-24
NO20041272L (no) 2004-07-02
CA2462572A1 (en) 2003-04-17
AU2002341970B2 (en) 2008-02-14
US20070142338A1 (en) 2007-06-21
US20070149488A1 (en) 2007-06-28
US20050267079A1 (en) 2005-12-01
RU2300380C2 (ru) 2007-06-10
US20040067912A1 (en) 2004-04-08
MY133403A (en) 2007-11-30
EP1439843A4 (en) 2007-01-03
CA2462572C (en) 2008-11-18
US7214669B2 (en) 2007-05-08

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