JP2005514334A5 - - Google Patents
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- Publication number
- JP2005514334A5 JP2005514334A5 JP2003535802A JP2003535802A JP2005514334A5 JP 2005514334 A5 JP2005514334 A5 JP 2005514334A5 JP 2003535802 A JP2003535802 A JP 2003535802A JP 2003535802 A JP2003535802 A JP 2003535802A JP 2005514334 A5 JP2005514334 A5 JP 2005514334A5
- Authority
- JP
- Japan
- Prior art keywords
- benzamide
- prop
- ynyl
- phenyl
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 3- (4-methoxy-phenyl) -prop-1-ynyl Chemical group 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940127557 pharmaceutical product Drugs 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- XLBCEMUGMYDSRN-UHFFFAOYSA-N 3-(2-phenylethynyl)-n-[(4-sulfamoylphenyl)methyl]benzamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1CNC(=O)C1=CC=CC(C#CC=2C=CC=CC=2)=C1 XLBCEMUGMYDSRN-UHFFFAOYSA-N 0.000 claims 1
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- GQKUGTWMEZWVAM-UHFFFAOYSA-N 4-[[[3-(3-pyridin-3-ylprop-1-ynyl)benzoyl]amino]methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1CNC(=O)C1=CC=CC(C#CCC=2C=NC=CC=2)=C1 GQKUGTWMEZWVAM-UHFFFAOYSA-N 0.000 claims 1
- VAMZQGYMTJNWBX-UHFFFAOYSA-N 4-[[[3-(3-pyridin-4-ylprop-1-ynyl)benzoyl]amino]methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1CNC(=O)C1=CC=CC(C#CCC=2C=CN=CC=2)=C1 VAMZQGYMTJNWBX-UHFFFAOYSA-N 0.000 claims 1
- MZGJMFQQVDXRTB-UHFFFAOYSA-N 4-[[[3-[3-(2-methoxypyridin-4-yl)prop-1-ynyl]benzoyl]amino]methyl]benzoic acid Chemical compound C1=NC(OC)=CC(CC#CC=2C=C(C=CC=2)C(=O)NCC=2C=CC(=CC=2)C(O)=O)=C1 MZGJMFQQVDXRTB-UHFFFAOYSA-N 0.000 claims 1
- WVQMWJAOKFFFEQ-UHFFFAOYSA-N 4-[[[3-[3-(4-chlorophenyl)prop-1-ynyl]benzoyl]amino]methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1CNC(=O)C1=CC=CC(C#CCC=2C=CC(Cl)=CC=2)=C1 WVQMWJAOKFFFEQ-UHFFFAOYSA-N 0.000 claims 1
- NFICNNZYWGKBEK-UHFFFAOYSA-N 4-[[[3-[3-(4-fluorophenyl)prop-1-ynyl]benzoyl]amino]methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1CNC(=O)C1=CC=CC(C#CCC=2C=CC(F)=CC=2)=C1 NFICNNZYWGKBEK-UHFFFAOYSA-N 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 1
- ZPCOCTGRERLUOF-UHFFFAOYSA-N 4-ethynyl-2-methyl-3-(2-phenylethyl)-n-pyridin-4-ylbenzamide Chemical compound CC1=C(C(=O)NC=2C=CN=CC=2)C=CC(C#C)=C1CCC1=CC=CC=C1 ZPCOCTGRERLUOF-UHFFFAOYSA-N 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 1
- VNWSHLWRKWRHEV-UHFFFAOYSA-N n-[(4-cyanophenyl)methyl]-3-(2-phenylethynyl)benzamide Chemical compound C=1C=CC(C#CC=2C=CC=CC=2)=CC=1C(=O)NCC1=CC=C(C#N)C=C1 VNWSHLWRKWRHEV-UHFFFAOYSA-N 0.000 claims 1
- KSJYWNSZYXHQMB-UHFFFAOYSA-N n-[(4-cyanophenyl)methyl]-3-[3-(1,2,4-triazol-1-yl)prop-1-ynyl]benzamide Chemical compound C=1C=CC(C#CCN2N=CN=C2)=CC=1C(=O)NCC1=CC=C(C#N)C=C1 KSJYWNSZYXHQMB-UHFFFAOYSA-N 0.000 claims 1
- IHHZCYSICNZRTD-UHFFFAOYSA-N n-[(4-cyanophenyl)methyl]-3-[3-(triazol-1-yl)prop-1-ynyl]benzamide Chemical compound C=1C=CC(C#CCN2N=NC=C2)=CC=1C(=O)NCC1=CC=C(C#N)C=C1 IHHZCYSICNZRTD-UHFFFAOYSA-N 0.000 claims 1
- OUEIAOCZSKBRSX-UHFFFAOYSA-N n-[(4-methylsulfonylphenyl)methyl]-3-(3-pyridin-3-ylprop-1-ynyl)benzamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1CNC(=O)C1=CC=CC(C#CCC=2C=NC=CC=2)=C1 OUEIAOCZSKBRSX-UHFFFAOYSA-N 0.000 claims 1
- JAGGBXDPVUHPSM-UHFFFAOYSA-N n-[(4-methylsulfonylphenyl)methyl]-3-(3-pyridin-4-ylprop-1-ynyl)benzamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1CNC(=O)C1=CC=CC(C#CCC=2C=CN=CC=2)=C1 JAGGBXDPVUHPSM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32921601P | 2001-10-12 | 2001-10-12 | |
| US60/329,216 | 2001-10-12 | ||
| PCT/IB2002/003057 WO2003032999A1 (en) | 2001-10-12 | 2002-08-02 | Alkyne matrix metalloproteinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514334A JP2005514334A (ja) | 2005-05-19 |
| JP2005514334A5 true JP2005514334A5 (enExample) | 2005-12-22 |
| JP4164028B2 JP4164028B2 (ja) | 2008-10-08 |
Family
ID=23284384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535802A Expired - Fee Related JP4164028B2 (ja) | 2001-10-12 | 2002-08-02 | アルキンマトリックスメタロプロテイナーゼ阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6849648B2 (enExample) |
| EP (1) | EP1434585A1 (enExample) |
| JP (1) | JP4164028B2 (enExample) |
| BR (1) | BR0213233A (enExample) |
| CA (1) | CA2462442A1 (enExample) |
| DO (1) | DOP2002000473A (enExample) |
| GT (1) | GT200200210A (enExample) |
| HN (1) | HN2002000291A (enExample) |
| MX (1) | MXPA04002537A (enExample) |
| PA (1) | PA8556201A1 (enExample) |
| PE (1) | PE20030607A1 (enExample) |
| SV (1) | SV2004001291A (enExample) |
| UY (1) | UY27481A1 (enExample) |
| WO (1) | WO2003032999A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
| DOP2002000334A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz |
| EP1368323B1 (en) | 2001-02-14 | 2010-06-30 | Warner-Lambert Company LLC | Pyrimidine matrix metalloproteinase inhibitors |
| US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US20040006077A1 (en) * | 2002-06-25 | 2004-01-08 | Bernard Gaudilliere | Thiazine and oxazine derivatives as MMP-13 inhibitors |
| EP1531904A1 (en) * | 2002-07-17 | 2005-05-25 | Warner-Lambert Company LLC | Combination of an allosteric inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
| JP2006502114A (ja) * | 2002-07-17 | 2006-01-19 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | マトリクスメタロプロテイナーゼ−１３のアロステリックアルキン阻害薬とセレコキシブまたはバルデコキシブとの組合せ |
| MXPA05000729A (es) * | 2002-07-17 | 2005-04-08 | Warner Lambert Co | Combinacion de un inhibidor alosterico de metaloproteinasa-13 de matriz con celecoxib o valdecoxib. |
| CA2491820A1 (en) * | 2002-07-17 | 2004-01-22 | Warner-Lambert Company Llc | Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
| AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| WO2004014868A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors |
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| WO2004014378A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors |
| WO2004014866A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Azaisoquinoline derivatives as matrix metalloproteinase inhibitors |
| AU2003250482A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Phthalimide derivatives as matrix metalloproteinase inhibitors |
| AU2003249539A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors |
| AU2003250475A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | 5,6-fused 3,4-dihydropyrimidine-2-one derivatives as matrix metalloproteinase inhibitors |
| PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
| WO2004014908A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
| WO2004014388A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 6,6-fused heteroaryl derivatives as matrix metalloproteinase inhibitors |
| WO2004014375A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused bicyclic metalloproteinase inhibitors |
| EP1394159A1 (fr) * | 2002-08-13 | 2004-03-03 | Warner-Lambert Company LLC | Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
| AU2003250470A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidinone fused bicyclic metalloproteinase inhibitors |
| BR0313384A (pt) | 2002-08-13 | 2005-07-12 | Warner Lambert Co | Derivados de cromona como inibidores de metaloproteinases de matriz |
| AU2003253186A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
| CA2492019A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Isoquinoline derivatives as matrix metalloproteinase inhibitors |
| BR0313459A (pt) | 2002-08-13 | 2005-06-21 | Warner Lambert Co | Derivados monocìclicos como inibidores de metaloproteinases de matriz |
| US20040142950A1 (en) * | 2003-01-17 | 2004-07-22 | Bunker Amy Mae | Amide and ester matrix metalloproteinase inhibitors |
| WO2005002585A1 (en) * | 2003-07-02 | 2005-01-13 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
| WO2005016926A1 (en) * | 2003-08-19 | 2005-02-24 | Warner-Lambert Company Llc | Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors |
| US20060247231A1 (en) * | 2003-12-18 | 2006-11-02 | Warner-Lambert Company Llc | Amide and ester matrix metalloproteinase inhibitors |
| CN1997638B (zh) * | 2004-04-07 | 2011-07-06 | 默克雪兰诺有限公司 | 作为ptp1-b抑制剂的1,1'-(1,2-乙炔二基)双苯衍生物 |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| PT1773816E (pt) * | 2004-06-24 | 2015-04-29 | Vertex Pharma | Moduladores de transportadores de cassete de ligação de atp |
| WO2006061715A2 (en) * | 2004-12-08 | 2006-06-15 | Warner-Lambert Company Llc | Methylene inhibitors of matrix metalloproteinase |
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| EP1979367A2 (en) * | 2005-12-24 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Quinolin-4-one derivatives as modulators of abc transporters |
| RS55940B1 (sr) | 2005-12-28 | 2017-09-29 | Vertex Pharma | Čvrsti oblici n-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksohinolin-3-karboksamida |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| JP4831190B2 (ja) * | 2009-03-09 | 2011-12-07 | パナソニック株式会社 | ドラム式洗濯機 |
| EP2821400B1 (en) | 2009-03-20 | 2017-09-27 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| MX2014010253A (es) | 2012-02-27 | 2014-11-12 | Vertex Pharma | Composicion farmaceutica y administraciones de la misma. |
| PL3087051T3 (pl) * | 2013-12-24 | 2021-02-22 | Oncotartis Inc. | Związki benzamidowe i nikotynamidowe oraz sposoby ich stosowania |
| WO2015130922A2 (en) * | 2014-02-26 | 2015-09-03 | The Trustees Of The University Of Pennsylvania | Small molecule hsp70 inhibitors |
| RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
| CN113773277B (zh) * | 2021-09-18 | 2023-12-05 | 兰州大学 | 一种4h-1,2,4-苯并噻二嗪-1,1-二氧化物衍生物的合成方法 |
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| KR20030061825A (ko) | 2000-10-26 | 2003-07-22 | 화이자 프로덕츠 인크. | 피리미딘-2,4,6-트리온 메탈로프로테이나제 억제제 |
| KR20040004412A (ko) | 2000-10-26 | 2004-01-13 | 화이자 프로덕츠 인크. | 스피로-피리미딘-2,4,6-트리온 메탈로프로테이나제 억제제 |
| MXPA03005870A (es) | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibirores de benzotiadiazina de metaloproteinasas de la matriz. |
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| PA8539301A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Inhibidores de la metaloproteinasa de la matriz |
| EP1368323B1 (en) | 2001-02-14 | 2010-06-30 | Warner-Lambert Company LLC | Pyrimidine matrix metalloproteinase inhibitors |
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| DOP2002000333A (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
| PA8539401A1 (es) | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| MXPA04003008A (es) | 2001-10-12 | 2004-07-16 | Warner Lambert Co | Compuestos pirimidina de anillo fusionado alquinilado como inhibidores de metaloproteasa 13 de la matriz. |
| DE10160357A1 (de) | 2001-12-08 | 2003-06-18 | Aventis Pharma Gmbh | Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen |
| PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
| WO2004014868A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors |
| BR0313459A (pt) | 2002-08-13 | 2005-06-21 | Warner Lambert Co | Derivados monocìclicos como inibidores de metaloproteinases de matriz |
| AU2003249539A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors |
-
2002
- 2002-08-02 MX MXPA04002537A patent/MXPA04002537A/es active IP Right Grant
- 2002-08-02 JP JP2003535802A patent/JP4164028B2/ja not_active Expired - Fee Related
- 2002-08-02 CA CA002462442A patent/CA2462442A1/en not_active Abandoned
- 2002-08-02 WO PCT/IB2002/003057 patent/WO2003032999A1/en not_active Ceased
- 2002-08-02 BR BR0213233-8A patent/BR0213233A/pt not_active IP Right Cessation
- 2002-08-02 EP EP02751510A patent/EP1434585A1/en not_active Withdrawn
- 2002-09-27 DO DO2002000473A patent/DOP2002000473A/es unknown
- 2002-10-04 US US10/264,764 patent/US6849648B2/en not_active Expired - Fee Related
- 2002-10-09 HN HN2002000291A patent/HN2002000291A/es unknown
- 2002-10-09 UY UY27481A patent/UY27481A1/es not_active Application Discontinuation
- 2002-10-11 SV SV2002001291A patent/SV2004001291A/es not_active Application Discontinuation
- 2002-10-11 PE PE2002001006A patent/PE20030607A1/es not_active Application Discontinuation
- 2002-10-11 PA PA20028556201A patent/PA8556201A1/es unknown
- 2002-10-11 GT GT200200210A patent/GT200200210A/es unknown
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