JP2005512946A5 - - Google Patents

Info

Publication number

JP2005512946A5

JP2005512946A5 JP2002586931A JP2002586931A JP2005512946A5 JP 2005512946 A5 JP2005512946 A5 JP 2005512946A5 JP 2002586931 A JP2002586931 A JP 2002586931A JP 2002586931 A JP2002586931 A JP 2002586931A JP 2005512946 A5 JP2005512946 A5 JP 2005512946A5

Authority

JP

Japan

Prior art keywords

pimecrolimus

less

epithelial inflammatory

epithelial

treatment

Prior art date

2002-05-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 45
• 208000027866 inflammatory disease Diseases 0.000 claims 31
• KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 claims 24
• 229960005330 pimecrolimus Drugs 0.000 claims 24
• 239000003814 drug Substances 0.000 claims 21
• 230000036765 blood level Effects 0.000 claims 15
• 230000002265 prevention Effects 0.000 claims 14
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 13
• 208000006673 asthma Diseases 0.000 claims 11
• 230000001506 immunosuppresive effect Effects 0.000 claims 10
• 230000009885 systemic effect Effects 0.000 claims 10
• 241000282412 Homo Species 0.000 claims 9
• 229940079593 drug Drugs 0.000 claims 9
• 208000024891 symptom Diseases 0.000 claims 7
• 239000003862 glucocorticoid Substances 0.000 claims 4
• 108090000695 Cytokines Proteins 0.000 claims 2
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108010002350 Interleukin-2 Proteins 0.000 claims 2
• 238000003571 reporter gene assay Methods 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 claims 1
• 229930105110 Cyclosporin A Natural products 0.000 claims 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
• 108010036949 Cyclosporine Proteins 0.000 claims 1
• 241000792859 Enema Species 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 208000030289 Lymphoproliferative disease Diseases 0.000 claims 1
• 208000001388 Opportunistic Infections Diseases 0.000 claims 1
• 239000000695 adrenergic alpha-agonist Substances 0.000 claims 1
• 230000002411 adverse Effects 0.000 claims 1
• 239000000443 aerosol Substances 0.000 claims 1
• 229940113720 aminosalicylate Drugs 0.000 claims 1
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
• 229960002170 azathioprine Drugs 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 244000052616 bacterial pathogen Species 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229960001265 ciclosporin Drugs 0.000 claims 1
• 239000003246 corticosteroid Substances 0.000 claims 1
• 229960000265 cromoglicic acid Drugs 0.000 claims 1
• IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 239000007920 enema Substances 0.000 claims 1
• 229940095399 enema Drugs 0.000 claims 1
• 244000053095 fungal pathogen Species 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 229960000598 infliximab Drugs 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 230000003902 lesion Effects 0.000 claims 1
• 230000003211 malignant effect Effects 0.000 claims 1
• 229940126601 medicinal product Drugs 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229940127557 pharmaceutical product Drugs 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 239000000829 suppository Substances 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1
• 239000003826 tablet Substances 0.000 claims 1
• 230000037317 transdermal delivery Effects 0.000 claims 1
• 244000052613 viral pathogen Species 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1