JP2004536829A5 - - Google Patents
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- Publication number
- JP2004536829A5 JP2004536829A5 JP2003508337A JP2003508337A JP2004536829A5 JP 2004536829 A5 JP2004536829 A5 JP 2004536829A5 JP 2003508337 A JP2003508337 A JP 2003508337A JP 2003508337 A JP2003508337 A JP 2003508337A JP 2004536829 A5 JP2004536829 A5 JP 2004536829A5
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- pseudoephedrine
- cetirizine
- tablet according
- segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003826 tablet Substances 0.000 claims 64
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims 32
- 229960001803 cetirizine Drugs 0.000 claims 32
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 32
- 229960003908 pseudoephedrine Drugs 0.000 claims 32
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims 32
- 239000002245 particle Substances 0.000 claims 6
- 239000010410 layer Substances 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 239000007884 disintegrant Substances 0.000 claims 3
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical class COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 claims 3
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 3
- 230000003113 alkalizing effect Effects 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000011247 coating layer Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 206010041232 sneezing Diseases 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 206010052140 Eye pruritus Diseases 0.000 claims 1
- 206010022004 Influenza like illness Diseases 0.000 claims 1
- 206010028735 Nasal congestion Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000036284 Rhinitis seasonal Diseases 0.000 claims 1
- 208000036071 Rhinorrhea Diseases 0.000 claims 1
- 206010039101 Rhinorrhoea Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 hydroxypropyl Chemical group 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229960001508 levocetirizine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000007939 sustained release tablet Substances 0.000 claims 1
- 239000006068 taste-masking agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30125001P | 2001-06-28 | 2001-06-28 | |
| EP01115807 | 2001-06-28 | ||
| PCT/EP2002/006342 WO2003002098A1 (en) | 2001-06-28 | 2002-06-10 | Tablet comprising cetirizine and pseudoephedrine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007092969A Division JP2007176958A (ja) | 2001-06-28 | 2007-03-30 | セチリジン及びプソイドエフェドリンを含む錠剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536829A JP2004536829A (ja) | 2004-12-09 |
| JP2004536829A5 true JP2004536829A5 (https=) | 2006-08-24 |
| JP4041460B2 JP4041460B2 (ja) | 2008-01-30 |
Family
ID=56290291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003508337A Expired - Fee Related JP4041460B2 (ja) | 2001-06-28 | 2002-06-10 | セチリジン及びプソイドエフェドリンを含む錠剤 |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1404304B1 (https=) |
| JP (1) | JP4041460B2 (https=) |
| KR (1) | KR100926410B1 (https=) |
| CN (1) | CN100490809C (https=) |
| AT (1) | ATE432068T1 (https=) |
| AU (1) | AU2002345024B2 (https=) |
| BR (1) | BR0210650A (https=) |
| CA (1) | CA2451519C (https=) |
| CZ (1) | CZ20033454A3 (https=) |
| DK (1) | DK1404304T3 (https=) |
| EE (1) | EE05357B1 (https=) |
| ES (1) | ES2324769T3 (https=) |
| HU (1) | HU229803B1 (https=) |
| MX (1) | MXPA03010430A (https=) |
| NZ (1) | NZ530289A (https=) |
| PL (1) | PL206069B1 (https=) |
| PT (1) | PT1404304E (https=) |
| RO (1) | RO122476B1 (https=) |
| RU (1) | RU2286784C2 (https=) |
| SI (1) | SI1404304T1 (https=) |
| SK (1) | SK287645B6 (https=) |
| WO (1) | WO2003002098A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7014867B2 (en) * | 2001-06-28 | 2006-03-21 | Ucb Farchim Sa | Tablet comprising cetirizine and pseudoephedrine |
| KR100698400B1 (ko) | 2004-04-14 | 2007-03-23 | 이은주 | 탈모증 및 전립선비대증 치료를 위한 약제학적 조성물 |
| WO2007141743A2 (en) * | 2006-06-06 | 2007-12-13 | Ranbaxy Laboratories Limited | A tablet dosage form comprising cetirizine and pseudoephedrine |
| US9408816B2 (en) * | 2006-12-26 | 2016-08-09 | Pharmacyclics Llc | Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy |
| US8439033B2 (en) | 2007-10-09 | 2013-05-14 | Microdose Therapeutx, Inc. | Inhalation device |
| CN105381524A (zh) | 2010-01-05 | 2016-03-09 | 微剂量治疗技术公司 | 吸入设备和方法 |
| KR101193495B1 (ko) * | 2010-02-01 | 2012-10-23 | 한미사이언스 주식회사 | 슈도에페드린 및 레보세티리진을 포함하는 경구용 복합 조성물 |
| KR20130050952A (ko) * | 2010-06-16 | 2013-05-16 | 브루스 챈들러 메이 | 인플루엔자, 감기 및 염증의 치료에서 레보세티리진 및 몬테루카스트의 용도 |
| CN102302497A (zh) * | 2011-05-18 | 2012-01-04 | 天圣制药集团股份有限公司 | 一种治疗过敏性鼻炎的制剂及其制备方法 |
| KR20130009553A (ko) | 2011-07-15 | 2013-01-23 | 한미약품 주식회사 | 몬테루카스트 또는 이의 약학적으로 허용가능한 염 및 레보세티리진 또는 이의 약학적으로 허용가능한 염을 함유하는 캡슐 제제 |
| JP6330118B2 (ja) | 2011-09-13 | 2018-05-30 | ファーマサイクリックス エルエルシー | ベンダムスチンと組み合わせたヒストンデアセチラーゼ阻害剤の製剤とその使用 |
| KR101372324B1 (ko) * | 2012-02-09 | 2014-03-13 | 동국대학교 경주캠퍼스 산학협력단 | 알러지성 비염 치료를 위한 한방 치료제 및 슈도에페드린을 함유한 복합서방형의 약제학적 조성물 |
| ES2654093T3 (es) | 2013-03-13 | 2018-02-12 | Inflammatory Response Research, Inc. | Uso de levocetirizina y montelukast en el tratamiento de trastornos autoinmunes |
| CA2901413A1 (en) | 2013-03-13 | 2014-10-09 | Bruce Chandler May | Use of levocetirizine and montelukast in the treatment of vasculitis |
| RU2672871C2 (ru) | 2013-03-13 | 2018-11-20 | Инфламматори Респонс Ресёрч, Инк. | Применение левоцетиризина и монтелукаста при лечении травматических повреждений |
| JP2017526728A (ja) | 2014-09-15 | 2017-09-14 | インフラマトリー・レスポンス・リサーチ・インコーポレイテッド | 炎症介在性状態の治療におけるレボセチリジン及びモンテルカスト |
| WO2016140630A1 (en) | 2015-03-05 | 2016-09-09 | PHARMACTIVE ILAÇ SANAYI VE TlCARET A. Ş. | An effervescent composition comprising levocetirizine and pseudoephedrine |
| EP4099977A1 (en) * | 2020-02-03 | 2022-12-14 | Johnson & Johnson Consumer Inc. | A single layer chewable tablet comprising cetirizine |
| EP4153178A4 (en) | 2020-05-19 | 2024-06-05 | Irr, Inc. | Levocetirizine and montelukast in the treatment of sepsis and symptoms thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6469009B1 (en) * | 1996-04-08 | 2002-10-22 | Ucb, S.A. | Pharmaceutical compositions for the treatment of rhinitis |
| EP0811374A1 (en) * | 1996-05-29 | 1997-12-10 | Pfizer Inc. | Combination dosage form comprising cetirizine and pseudoephedrine |
| BE1011045A3 (fr) * | 1997-03-14 | 1999-04-06 | Ucb Sa | Compositions pharmaceutiques pour la liberation controlee de substances actives. |
| US6267986B1 (en) * | 1999-09-24 | 2001-07-31 | Ranbaxy Laboratories Limited | Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine |
-
2002
- 2002-06-10 AT AT02743173T patent/ATE432068T1/de active
- 2002-06-10 SI SI200230844T patent/SI1404304T1/sl unknown
- 2002-06-10 WO PCT/EP2002/006342 patent/WO2003002098A1/en not_active Ceased
- 2002-06-10 SK SK1550-2003A patent/SK287645B6/sk not_active IP Right Cessation
- 2002-06-10 RO ROA200301062A patent/RO122476B1/ro unknown
- 2002-06-10 PT PT02743173T patent/PT1404304E/pt unknown
- 2002-06-10 EE EEP200400005A patent/EE05357B1/xx unknown
- 2002-06-10 CA CA002451519A patent/CA2451519C/en not_active Expired - Lifetime
- 2002-06-10 KR KR1020037017054A patent/KR100926410B1/ko not_active Expired - Lifetime
- 2002-06-10 DK DK02743173T patent/DK1404304T3/da active
- 2002-06-10 CZ CZ20033454A patent/CZ20033454A3/cs unknown
- 2002-06-10 HU HU0400386A patent/HU229803B1/hu unknown
- 2002-06-10 JP JP2003508337A patent/JP4041460B2/ja not_active Expired - Fee Related
- 2002-06-10 MX MXPA03010430A patent/MXPA03010430A/es active IP Right Grant
- 2002-06-10 RU RU2004101231/15A patent/RU2286784C2/ru active
- 2002-06-10 CN CNB02812975XA patent/CN100490809C/zh not_active Expired - Lifetime
- 2002-06-10 ES ES02743173T patent/ES2324769T3/es not_active Expired - Lifetime
- 2002-06-10 BR BR0210650-7A patent/BR0210650A/pt not_active Application Discontinuation
- 2002-06-10 AU AU2002345024A patent/AU2002345024B2/en not_active Ceased
- 2002-06-10 NZ NZ530289A patent/NZ530289A/en unknown
- 2002-06-10 PL PL366800A patent/PL206069B1/pl unknown
- 2002-06-10 EP EP02743173A patent/EP1404304B1/en not_active Expired - Lifetime
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