JP2004536829A5 - - Google Patents
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- Publication number
- JP2004536829A5 JP2004536829A5 JP2003508337A JP2003508337A JP2004536829A5 JP 2004536829 A5 JP2004536829 A5 JP 2004536829A5 JP 2003508337 A JP2003508337 A JP 2003508337A JP 2003508337 A JP2003508337 A JP 2003508337A JP 2004536829 A5 JP2004536829 A5 JP 2004536829A5
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- pseudoephedrine
- cetirizine
- tablet according
- segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003826 tablet Substances 0.000 claims 64
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims 32
- 229960001803 cetirizine Drugs 0.000 claims 32
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 32
- 229960003908 pseudoephedrine Drugs 0.000 claims 32
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims 32
- 239000002245 particle Substances 0.000 claims 6
- 239000010410 layer Substances 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 239000007884 disintegrant Substances 0.000 claims 3
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical class COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 claims 3
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 3
- 230000003113 alkalizing effect Effects 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000011247 coating layer Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 206010041232 sneezing Diseases 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 206010052140 Eye pruritus Diseases 0.000 claims 1
- 206010022004 Influenza like illness Diseases 0.000 claims 1
- 206010028735 Nasal congestion Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000036284 Rhinitis seasonal Diseases 0.000 claims 1
- 208000036071 Rhinorrhea Diseases 0.000 claims 1
- 206010039101 Rhinorrhoea Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 hydroxypropyl Chemical group 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229960001508 levocetirizine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000007939 sustained release tablet Substances 0.000 claims 1
- 239000006068 taste-masking agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30125001P | 2001-06-28 | 2001-06-28 | |
| EP01115807 | 2001-06-28 | ||
| PCT/EP2002/006342 WO2003002098A1 (en) | 2001-06-28 | 2002-06-10 | Tablet comprising cetirizine and pseudoephedrine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007092969A Division JP2007176958A (ja) | 2001-06-28 | 2007-03-30 | セチリジン及びプソイドエフェドリンを含む錠剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536829A JP2004536829A (ja) | 2004-12-09 |
| JP2004536829A5 true JP2004536829A5 (https=) | 2006-08-24 |
| JP4041460B2 JP4041460B2 (ja) | 2008-01-30 |
Family
ID=56290291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003508337A Expired - Fee Related JP4041460B2 (ja) | 2001-06-28 | 2002-06-10 | セチリジン及びプソイドエフェドリンを含む錠剤 |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1404304B1 (https=) |
| JP (1) | JP4041460B2 (https=) |
| KR (1) | KR100926410B1 (https=) |
| CN (1) | CN100490809C (https=) |
| AT (1) | ATE432068T1 (https=) |
| AU (1) | AU2002345024B2 (https=) |
| BR (1) | BR0210650A (https=) |
| CA (1) | CA2451519C (https=) |
| CZ (1) | CZ20033454A3 (https=) |
| DK (1) | DK1404304T3 (https=) |
| EE (1) | EE05357B1 (https=) |
| ES (1) | ES2324769T3 (https=) |
| HU (1) | HU229803B1 (https=) |
| MX (1) | MXPA03010430A (https=) |
| NZ (1) | NZ530289A (https=) |
| PL (1) | PL206069B1 (https=) |
| PT (1) | PT1404304E (https=) |
| RO (1) | RO122476B1 (https=) |
| RU (1) | RU2286784C2 (https=) |
| SI (1) | SI1404304T1 (https=) |
| SK (1) | SK287645B6 (https=) |
| WO (1) | WO2003002098A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60232445D1 (de) * | 2001-06-28 | 2009-07-09 | Ucb Farchim Sa | Cetirizin und pseudoephedrin enthaltende tablette |
| KR100698400B1 (ko) | 2004-04-14 | 2007-03-23 | 이은주 | 탈모증 및 전립선비대증 치료를 위한 약제학적 조성물 |
| WO2007141743A2 (en) * | 2006-06-06 | 2007-12-13 | Ranbaxy Laboratories Limited | A tablet dosage form comprising cetirizine and pseudoephedrine |
| RU2446796C2 (ru) * | 2006-12-26 | 2012-04-10 | Фармасайкликс, Инк. | Способ использования ингибиторов гистондеацетилазы и мониторинга биомаркеров в комбинированной терапии |
| US8439033B2 (en) | 2007-10-09 | 2013-05-14 | Microdose Therapeutx, Inc. | Inhalation device |
| ES2702753T3 (es) | 2010-01-05 | 2019-03-05 | Microdose Therapeutx Inc | Dispositivo de inhalación |
| KR101193495B1 (ko) | 2010-02-01 | 2012-10-23 | 한미사이언스 주식회사 | 슈도에페드린 및 레보세티리진을 포함하는 경구용 복합 조성물 |
| KR20130050952A (ko) | 2010-06-16 | 2013-05-16 | 브루스 챈들러 메이 | 인플루엔자, 감기 및 염증의 치료에서 레보세티리진 및 몬테루카스트의 용도 |
| CN102302497A (zh) * | 2011-05-18 | 2012-01-04 | 天圣制药集团股份有限公司 | 一种治疗过敏性鼻炎的制剂及其制备方法 |
| KR20130009553A (ko) | 2011-07-15 | 2013-01-23 | 한미약품 주식회사 | 몬테루카스트 또는 이의 약학적으로 허용가능한 염 및 레보세티리진 또는 이의 약학적으로 허용가능한 염을 함유하는 캡슐 제제 |
| AU2011376953B2 (en) | 2011-09-13 | 2017-08-24 | Pharmacyclics Llc | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
| KR101372324B1 (ko) * | 2012-02-09 | 2014-03-13 | 동국대학교 경주캠퍼스 산학협력단 | 알러지성 비염 치료를 위한 한방 치료제 및 슈도에페드린을 함유한 복합서방형의 약제학적 조성물 |
| RU2015134423A (ru) | 2013-03-13 | 2017-04-26 | Инфламматори Респонс Ресёрч, Инк. | Применение левоцитиризина и монтелукаста при лечении аутоиммуных расстройств |
| MX382776B (es) | 2013-03-13 | 2025-03-13 | Inflammatory Response Res Inc | Uso de levocetirizina y montelukast en el tratamiento de lesion traumatica. |
| WO2014164285A2 (en) | 2013-03-13 | 2014-10-09 | Inflammatory Response Research, Inc. | Use of levocetirizine and montelukast in the treatment of vasculitis |
| WO2016044095A1 (en) | 2014-09-15 | 2016-03-24 | Inflammatory Response Research, Inc. | Levocetirizine and montelukast in the treatment of inflammation mediated conditions |
| WO2016140630A1 (en) | 2015-03-05 | 2016-09-09 | PHARMACTIVE ILAÇ SANAYI VE TlCARET A. Ş. | An effervescent composition comprising levocetirizine and pseudoephedrine |
| AU2021217209A1 (en) * | 2020-02-03 | 2022-09-29 | Kenvue Brands Llc | A single layer chewable tablet comprising cetirizine |
| WO2021236518A1 (en) | 2020-05-19 | 2021-11-25 | IRR, Inc. | Levocetirizine and montelukast in the treatment of sepsis and symptoms thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6469009B1 (en) * | 1996-04-08 | 2002-10-22 | Ucb, S.A. | Pharmaceutical compositions for the treatment of rhinitis |
| EP0811374A1 (en) * | 1996-05-29 | 1997-12-10 | Pfizer Inc. | Combination dosage form comprising cetirizine and pseudoephedrine |
| BE1011045A3 (fr) * | 1997-03-14 | 1999-04-06 | Ucb Sa | Compositions pharmaceutiques pour la liberation controlee de substances actives. |
| US6267986B1 (en) * | 1999-09-24 | 2001-07-31 | Ranbaxy Laboratories Limited | Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine |
-
2002
- 2002-06-10 CA CA002451519A patent/CA2451519C/en not_active Expired - Lifetime
- 2002-06-10 SI SI200230844T patent/SI1404304T1/sl unknown
- 2002-06-10 JP JP2003508337A patent/JP4041460B2/ja not_active Expired - Fee Related
- 2002-06-10 MX MXPA03010430A patent/MXPA03010430A/es active IP Right Grant
- 2002-06-10 CN CNB02812975XA patent/CN100490809C/zh not_active Expired - Lifetime
- 2002-06-10 ES ES02743173T patent/ES2324769T3/es not_active Expired - Lifetime
- 2002-06-10 PT PT02743173T patent/PT1404304E/pt unknown
- 2002-06-10 AT AT02743173T patent/ATE432068T1/de active
- 2002-06-10 AU AU2002345024A patent/AU2002345024B2/en not_active Ceased
- 2002-06-10 HU HU0400386A patent/HU229803B1/hu unknown
- 2002-06-10 EP EP02743173A patent/EP1404304B1/en not_active Expired - Lifetime
- 2002-06-10 NZ NZ530289A patent/NZ530289A/en unknown
- 2002-06-10 DK DK02743173T patent/DK1404304T3/da active
- 2002-06-10 SK SK1550-2003A patent/SK287645B6/sk not_active IP Right Cessation
- 2002-06-10 WO PCT/EP2002/006342 patent/WO2003002098A1/en not_active Ceased
- 2002-06-10 CZ CZ20033454A patent/CZ20033454A3/cs unknown
- 2002-06-10 KR KR1020037017054A patent/KR100926410B1/ko not_active Expired - Lifetime
- 2002-06-10 EE EEP200400005A patent/EE05357B1/xx unknown
- 2002-06-10 BR BR0210650-7A patent/BR0210650A/pt not_active Application Discontinuation
- 2002-06-10 PL PL366800A patent/PL206069B1/pl unknown
- 2002-06-10 RO ROA200301062A patent/RO122476B1/ro unknown
- 2002-06-10 RU RU2004101231/15A patent/RU2286784C2/ru active
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