JP2005512574A5 - - Google Patents

Info

Publication number

JP2005512574A5

JP2005512574A5 JP2003554914A JP2003554914A JP2005512574A5 JP 2005512574 A5 JP2005512574 A5 JP 2005512574A5 JP 2003554914 A JP2003554914 A JP 2003554914A JP 2003554914 A JP2003554914 A JP 2003554914A JP 2005512574 A5 JP2005512574 A5 JP 2005512574A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

acid sequence

amino acid

receptor

Prior art date

2002-12-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 229920001184 polypeptide Polymers 0.000 claims 45
• 108090000765 processed proteins & peptides Proteins 0.000 claims 45
• 102000004196 processed proteins & peptides Human genes 0.000 claims 45
• 108010087819 Fc receptors Proteins 0.000 claims 19
• 102000009109 Fc receptors Human genes 0.000 claims 19
• 150000001413 amino acids Chemical group 0.000 claims 19
• 238000000034 method Methods 0.000 claims 19
• 150000007523 nucleic acids Chemical class 0.000 claims 14
• 108020004707 nucleic acids Proteins 0.000 claims 12
• 102000039446 nucleic acids Human genes 0.000 claims 12
• 210000004027 cell Anatomy 0.000 claims 11
• 239000003795 chemical substances by application Substances 0.000 claims 9
• 230000004071 biological effect Effects 0.000 claims 7
• 108010021472 Fc gamma receptor IIB Proteins 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 5
• 108091033319 polynucleotide Proteins 0.000 claims 4
• 102000040430 polynucleotide Human genes 0.000 claims 4
• 239000002157 polynucleotide Substances 0.000 claims 4
• 102100029205 Low affinity immunoglobulin gamma Fc region receptor II-b Human genes 0.000 claims 3
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 102000005962 receptors Human genes 0.000 claims 3
• 108020003175 receptors Proteins 0.000 claims 3
• -1 6-His tag Proteins 0.000 claims 2
• 108010021468 Fc gamma receptor IIA Proteins 0.000 claims 2
• 101000913079 Homo sapiens IgG receptor FcRn large subunit p51 Proteins 0.000 claims 2
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
• 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 2
• 241000282567 Macaca fascicularis Species 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 102000005720 Glutathione transferase Human genes 0.000 claims 1
• 108010070675 Glutathione transferase Proteins 0.000 claims 1
• HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims 1
• 108010073807 IgG Receptors Proteins 0.000 claims 1
• 102000009490 IgG Receptors Human genes 0.000 claims 1
• 108010079246 OMPA outer membrane proteins Proteins 0.000 claims 1
• 241000282577 Pan troglodytes Species 0.000 claims 1
• 102000035195 Peptidases Human genes 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 241000288906 Primates Species 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 102000002933 Thioredoxin Human genes 0.000 claims 1
• VJBCNMFKFZIXHC-UHFFFAOYSA-N azanium;2-(4-methyl-5-oxo-4-propan-2-yl-1h-imidazol-2-yl)quinoline-3-carboxylate Chemical compound N.N1C(=O)C(C(C)C)(C)N=C1C1=NC2=CC=CC=C2C=C1C(O)=O VJBCNMFKFZIXHC-UHFFFAOYSA-N 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 238000002955 isolation Methods 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 235000019833 protease Nutrition 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 210000004989 spleen cell Anatomy 0.000 claims 1
• 108060008226 thioredoxin Proteins 0.000 claims 1
• 229940094937 thioredoxin Drugs 0.000 claims 1
• 230000001988 toxicity Effects 0.000 claims 1
• 231100000419 toxicity Toxicity 0.000 claims 1